| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal Pro-X carboxypeptidase |
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| Ligand | BDBM50382886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity Assay |
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| pH | 5.5±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 0.9±0.0 nM |
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| Citation |  Graham, TH; Liu, W; Sebhat, IK; Shen, D; Shi, Z Prolylcarboxypeptidase inhibitors US Patent US8569299 Publication Date 10/29/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Lysosomal Pro-X carboxypeptidase |
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| Name: | Lysosomal Pro-X carboxypeptidase |
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| Synonyms: | Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55805.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42785 |
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| Residue: | 496 |
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| Sequence: | MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
GFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFA
EHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSY
GGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRS
WDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQP
LPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWS
YQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHT
NIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRH
MKNWIRDFYDSAGKQH
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| BDBM50382886 |
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| n/a |
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| Name | BDBM50382886 |
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| Synonyms: | CHEMBL2024198 | US8569299, 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H36ClF2N5O |
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| Mol. Mass. | 556.09 |
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| SMILES | Cc1nc(C2CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)n(n1)-c1ccc(Cl)c(C)c1 |r| |
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| Structure | 
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