Reaction Details |
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Target | N-lysine methyltransferase SMYD2 |
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Ligand | BDBM283168 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Scintillation Proximity Assay (SPA) for Detection of SMYD2 Enzymatic Inhibition |
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pH | 9±n/a |
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IC50 | 59.5±n/a nM |
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Comments | extracted |
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Citation | Mowat, JS; Stellfeld, T; Stresemann, C; Hillig, R; Köhr, S; Stöckigt, D; Weiske, J; Brumby, T; Barak, N; Christ, C; Ter Laak, A; Badock, V; Crampton, RH; Stefanuti, I Aryl-cyanoguanidine compounds US Patent US10023539 Publication Date 7/17/2018 |
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More Info.: | Get all data from this article, Assay Method |
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N-lysine methyltransferase SMYD2 |
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Name: | N-lysine methyltransferase SMYD2 |
Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 49689.57 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRG4 |
Residue: | 433 |
Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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BDBM283168 |
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n/a |
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Name | BDBM283168 |
Synonyms: | Rac-N-[1-(N′-cyano-N-{3-[2-(dimethylamino)ethoxy]phenyl}carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethylglycinamide | US10023539, Example 17 |
Type | Small organic molecule |
Emp. Form. | C25H30Cl2N8O2 |
Mol. Mass. | 545.464 |
SMILES | CCN(C1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OCCN(C)C)c1)=N/C#N)C(=O)CN |w:3.2,c:6| |
Structure |
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