Reaction Details |
| Report a problem with these data |
Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
---|
Ligand | BDBM284768 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Phosphodiesterase (PDE) 2A and 10 Assay |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 60.0±n/a nM |
---|
Comments | extracted |
---|
Citation | Hoenke, C; Bertani, B; Ferrara, M; Fossati, G; Frattini, S; Giovannini, R; Hobson, S Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide US Patent US10023575 Publication Date 7/17/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cGMP-dependent 3',5'-cyclic phosphodiesterase |
---|
Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 105691.58 |
Organism: | Homo sapiens (Human) |
Description: | O00408 |
Residue: | 941 |
Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
|
|
BDBM284768 |
---|
n/a |
---|
Name | BDBM284768 |
Synonyms: | US10023575, Example 59 | US10479794, Example 59 | US10875867, Example 59 | US11691977, Example 59 |
Type | Small organic molecule |
Emp. Form. | C20H19F3N4O3 |
Mol. Mass. | 420.3851 |
SMILES | Cc1cnc2c(cnn2c1)C(=O)NC1(CCOCC1O)c1ccc(cc1)C(F)(F)F |
Structure |
|