| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 1 |
|---|
| Ligand | BDBM136545 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Electrochemiluminescence (ECL) Assay |
|---|
| pH | 6.5±n/a |
|---|
| IC50 | 22000±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Liu, K; Stachel, SJ; Coburn, CA; Steele, TG; Soll, R; Wu, H; Peng, X; Cai, Y; Du, X; Li, J Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease US Patent US8865701 Publication Date 10/21/2014 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 1 |
|---|
| Name: | Beta-secretase 1 |
|---|
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55755.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P56817 |
|---|
| Residue: | 501 |
|---|
| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
|---|
| BDBM136545 |
|---|
| n/a |
|---|
| Name | BDBM136545 |
|---|
| Synonyms: | US8865701, 7 | US9505739, 7 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H36N2O |
|---|
| Mol. Mass. | 416.5982 |
|---|
| SMILES | CC(C)[C@@H]1C[C@@H](CCN1C(=O)[C@@H]1CNC[C@]11CCCc2ccccc12)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
