Reaction Details |
| Report a problem with these data |
Target | Beta-secretase 1 |
---|
Ligand | BDBM136549 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Electrochemiluminescence (ECL) Assay |
---|
pH | 6.5±n/a |
---|
IC50 | 14000±n/a nM |
---|
Comments | extracted |
---|
Citation | Liu, K; Stachel, SJ; Coburn, CA; Steele, TG; Soll, R; Wu, H; Peng, X; Cai, Y; Du, X; Li, J Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease US Patent US8865701 Publication Date 10/21/2014 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 1 |
---|
Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
BDBM136549 |
---|
n/a |
---|
Name | BDBM136549 |
Synonyms: | US8865701, 30 | US9505739, 30 |
Type | Small organic molecule |
Emp. Form. | C24H27BrN2O |
Mol. Mass. | 439.388 |
SMILES | Brc1ccc2c(CC[C@]22CNC[C@H]2C(=O)N2CCC(CC2)c2ccccc2)c1 |r| |
Structure |
|