Reaction Details |
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Target | Lysine-specific demethylase 5D [1-775] |
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Ligand | BDBM191598 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Demethylase AlphaScreen Assay |
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pH | 7.5±n/a |
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IC50 | 15±n/a nM |
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Comments | extracted |
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Citation | Johansson, C; Velupillai, S; Tumber, A; Szykowska, A; Hookway, ES; Nowak, RP; Strain-Damerell, C; Gileadi, C; Philpott, M; Burgess-Brown, N; Wu, N; Kopec, J; Nuzzi, A; Steuber, H; Egner, U; Badock, V; Munro, S; LaThangue, NB; Westaway, S; Brown, J; Athanasou, N; Prinjha, R; Brennan, PE; Oppermann, U Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol12:539-45 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific demethylase 5D [1-775] |
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Name: | Lysine-specific demethylase 5D [1-775] |
Synonyms: | HY | HYA | JARID1D | KDM5D | KDM5D_HUMAN | KIAA0234 | Lysine-specific demethylase 5D (KDM5D) | SMCY |
Type: | Protein |
Mol. Mass.: | 89076.46 |
Organism: | Homo sapiens (Human) |
Description: | Human KDM5D (1-775 aa) |
Residue: | 775 |
Sequence: | MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI
EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP
FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG
PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM
QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK
CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS
SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI
NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK
MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN
FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM
FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC
LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVED
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BDBM191598 |
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n/a |
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Name | BDBM191598 |
Synonyms: | 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid (KDM5-C49) | KDM5-C49 | KDOAM-20 |
Type | Small organic molecule |
Emp. Form. | C15H24N4O3 |
Mol. Mass. | 308.3761 |
SMILES | CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O |
Structure |
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