| Reaction Details |
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 | Report a problem with these data |
| Target | Lactoylglutathione lyase |
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| Ligand | BDBM224012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GLO1 Activity Assay |
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| pH | 7±0 |
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| Temperature | 298.15±0 K |
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| IC50 | 4.28e+4± 2.2e+3 nM |
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| Citation |  Li, J; Yakushi, T; Parlati, F; Mackinnon, AL; Perez, C; Ma, Y; Carter, KP; Colayco, S; Magnuson, G; Brown, B; Nguyen, K; Vasile, S; Suyama, E; Smith, LH; Sergienko, E; Pinkerton, AB; Chung, TDY; Palmer, AE; Pass, I; Hess, S; Cohen, SM; Deshaies, RJ Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol13:486-493 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lactoylglutathione lyase |
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| Name: | Lactoylglutathione lyase |
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| Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
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| Type: | Enzyme |
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| Mol. Mass.: | 20772.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04760 |
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| Residue: | 184 |
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| Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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| BDBM224012 |
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| n/a |
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| Name | BDBM224012 |
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| Synonyms: | Capzimin | US10005735, Compound 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N3OS2 |
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| Mol. Mass. | 315.413 |
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| SMILES | Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1 |
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| Structure | 
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