| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1027-1711] |
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| Ligand | BDBM235890 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA-Based Assay |
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| IC50 | 0.7817±n/a nM |
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| Citation |  Dai, X; Liu, H; Palani, A; He, S; Nargund, R; Xiao, D; Zorn, N; Dang, Q; McComas, CC; Peng, X; Li, P; Soll, R Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases US Patent US9364482 Publication Date 6/14/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1027-1711] |
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| Name: | Genome polyprotein [1027-1711] |
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| Synonyms: | NS3-NS4A Protease | POLG_HCVBK |
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| Type: | Enzyme |
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| Mol. Mass.: | 73097.29 |
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| Organism: | Hepatitis C virus genotype 1b (isolate BK) (HCV) |
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| Description: | amino acids 1027 to 1711 |
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| Residue: | 685 |
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| Sequence: | APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAG
SKTLAAPKGPITQMYTNVDQDLVGWPKPPGARSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPVSYLKGSSGGPLLCPFGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMR
SPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGA
YMSKAHGIDPNIRTGVRTITTGAPVTYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTI
LGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSNTGEIPFYGKAIPIEAIR
GGRHLIFCHSKKKCDELAAKLSGLGINAVAYYRGLDVSVIPTIGDVVVVATDALMTGYTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLT
HIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLY
RLGAVQNEVTLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRI
ILSGRPAIVPDRELLYQEFDEMEEC
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| BDBM235890 |
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| n/a |
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| Name | BDBM235890 |
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| Synonyms: | US9364482, 71 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H27F2N5O6S |
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| Mol. Mass. | 659.659 |
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| SMILES | CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1cc(OC)c2nnn(Cc3ccc(F)cc3)c(=O)c2c1)-c1ccc(F)cc1 |
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| Structure | 
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