| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase SMURF1 [420-757] |
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| Ligand | BDBM239132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.4±n/a nM |
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| Comments | extracted |
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| Citation |  Bala, KJ; Brearley, A; Dale, J; Edwards, A; Ahmed, M; Porter, D; Pulz, RA; Rooney, LA; Sandham, DA; Shaw, D; Smith, N; Taylor, JL; Taylor, RJ; Troxler, TJ; Wrigglesworth, J Carboxamide derivatives US Patent US9403810 Publication Date 8/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase SMURF1 [420-757] |
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| Name: | E3 ubiquitin-protein ligase SMURF1 [420-757] |
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| Synonyms: | HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMUF1_HUMAN | SMURF1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39188.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | HECTdomain amino acid 420-757 |
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| Residue: | 338 |
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| Sequence: | RPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDS
SINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSL
VWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG
IEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIV
RWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNL
PKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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| BDBM239132 |
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| n/a |
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| Name | BDBM239132 |
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| Synonyms: | US9403810, 22c |
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| Type | Small organic molecule |
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| Emp. Form. | C22H32N4O4 |
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| Mol. Mass. | 416.5139 |
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| SMILES | C[C@@H]1CC[C@H](OC1)c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |
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| Structure | 
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