Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM212272 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Immunoassay |
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pH | 7±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 13.3±n/a nM |
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Comments | extracted |
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Citation | Blomgren, PA; Clarke, A; Currie, KS; Di Paolo, J; Kropf, JE; Lee, SH; Lo, JR; Mitchell, SA; Schmitt, AC; Swaminathan, S; Xiong, J; Xu, J; Zhao, Z Syk inhibitors US Patent US9504684 Publication Date 11/29/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM212272 |
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n/a |
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Name | BDBM212272 |
Synonyms: | (R)-(4-(4-((6-(6-aminopyrazin-2-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)morpholin-2-yl)methanol | US10342794, Example Ex.-3 | US10828299, Example Ex.-3 | US11517570, Example Ex.-3: | US9290505, Ex.-3 | US9504684, Ex.-3 | US9931338, Ex.-3 |
Type | Small organic molecule |
Emp. Form. | C21H22N8O2 |
Mol. Mass. | 418.4518 |
SMILES | Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCO[C@@H](CO)C2)n1 |
Structure |
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