Reaction Details |
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Target | SUMO-activating enzyme subunit 1 |
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Ligand | BDBM462813 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Assay |
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IC50 | <10±n/a nM |
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Citation | Duffey, MO; England, D; Freeze, BS; Hu, Z; Langston, S; McIntyre, C; Mizutani, H; Ono, K; Xu, H Heteroaryl compounds useful as inhibitors of SUMO activating enzyme US Patent US10780090 Publication Date 9/22/2020 |
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More Info.: | Get all data from this article, Assay Method |
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SUMO-activating enzyme subunit 1 |
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Name: | SUMO-activating enzyme subunit 1 |
Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38440.84 |
Organism: | Homo sapiens (Human) |
Description: | gi_17390638 |
Residue: | 346 |
Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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BDBM462813 |
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n/a |
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Name | BDBM462813 |
Synonyms: | US10780090, Compound I-140 | {(1R,2S,4R)-4-[(5-{[4-(cyclohex-1-en-1-ylmethyl)-2-thienyl]carbonyl}pyrimidin-4- yl)amino]-2-hydroxycyclopentyl}methyl sulfamate |
Type | Small organic molecule |
Emp. Form. | C22H28N4O5S2 |
Mol. Mass. | 492.612 |
SMILES | NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1cc(CC2=CCCCC2)cs1 |t:27| |
Structure |
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