Reaction Details |
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Target | Tyrosine-protein kinase BTK |
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Ligand | BDBM377751 |
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Substrate/Competitor | n/a |
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Meas. Tech. | LanthaScreen Assay |
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IC50 | 0.810±n/a nM |
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Citation | Springer, JR; Devadas, B; Garland, DJ; Grapperhaus, ML; Han, S; Hockerman, SL; Hughes, RO; Saiah, E; Schnute, ME; Selness, SR; Walker, DP; Wan, Z; Xing, L; Zapf, CW; Schmidt, MA Bruton's tyrosine kinase inhibitors US Patent US10815213 Publication Date 10/27/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase BTK |
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Name: | Tyrosine-protein kinase BTK |
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
Type: | Enzyme |
Mol. Mass.: | 76289.95 |
Organism: | Homo sapiens (Human) |
Description: | Q06187 |
Residue: | 659 |
Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
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BDBM377751 |
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n/a |
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Name | BDBM377751 |
Synonyms: | 5-amino-3-[4-(2-chloro-5-fluoro- phenoxy)phenyl]-1-(1- cyanopiperidin-3-yl)-1H-pyrazole- 4-carboxamide | US10266513, Example 45 | US10815213, Example 45 |
Type | Small organic molecule |
Emp. Form. | C22H20ClFN6O2 |
Mol. Mass. | 454.885 |
SMILES | NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)ccc2Cl)cc1)C1CCCN(C1)C#N |
Structure |
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