The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28011425 |
92 |
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. |
University of Auckland |
28003141 |
65 |
Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors. |
Bristol-Myers Squibb Research and Development |
28523098 |
28 |
INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. |
Incyte |
28280261 |
84 |
Non-kinase targets of protein kinase inhibitors. |
The University of Sydney |
27994758 |
130 |
Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors. |
Indian Institute of Technology |
27769672 |
2 |
Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties. |
Xihua University |
26717206 |
64 |
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. |
Bryn Mawr College |
26653033 |
27 |
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy. |
National Health Research Institutes |
26642377 |
22 |
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. |
National Health Research Institutes |
26348881 |
54 |
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening. |
National Health Research Institutes |
26207924 |
32 |
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. |
Colorado College |
25264478 |
6 |
Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more. |
Therachem Research Medilab (India) |
25036789 |
45 |
Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
Swiss Institute of Bioinformatics |
24939758 |
72 |
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors. |
National Health Research Institutes |
25313323 |
23 |
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. |
Dainippon Sumitomo Pharma |
24878638 |
32 |
Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties. |
University of Namur (Unamur) |
24262887 |
11 |
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). |
University of Auckland |
24099220 |
40 |
Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. |
Fudan University |
23337802 |
21 |
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors. |
Toho University |
23218716 |
20 |
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A. |
University of Namur |
23521768 |
3 |
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A. |
University of Nottingham |
22873824 |
4 |
Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase. |
University of British Columbia |
22616902 |
165 |
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. |
Ludwig Center For Cancer Research of The University of Lausanne |
22304006 |
1 |
Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells. |
Paris-Sud University |
21726069 |
98 |
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. |
University of Namur |
20688518 |
84 |
S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. |
University of Shizuoka |
20055453 |
80 |
Rational design of indoleamine 2,3-dioxygenase inhibitors. |
Institute For Cancer Research |
19507862 |
42 |
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. |
Incyte |
22112538 |
22 |
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. |
Macquarie University |
21925773 |
22 |
Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors. |
Fudan University |
21419531 |
3 |
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. |
University of Namur |
21391610 |
139 |
Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors. |
Vertex Pharmaceuticals |
21269836 |
27 |
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. |
University of Namur |
20580138 |
17 |
Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies. |
Gyeongsang National University |
18677305 |
3 |
Biomimetic synthesis of the IDO inhibitors exiguamine A and B. |
University of California |
18715787 |
5 |
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors. |
The University of Tokushima |
17067170 |
9 |
Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. |
University of British Columbia |
32088128 |
40 |
Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy. |
Fudan University |
32832022 |
33 |
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors. |
Merck |
32247733 |
43 |
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. |
Tongji University |
31882299 |
34 |
Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
Fudan University |
32292563 |
12 |
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1). |
Merck |
30858027 |
38 |
Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors. |
China Pharmaceutical University |
27469130 |
20 |
1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2). |
Sib Swiss Institute For Bioinformatics |
31525930 |
22 |
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1). |
Sib Swiss Institute of Bioinformatics |
31749906 |
52 |
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy. |
Merck |
31610376 |
28 |
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors. |
China Pharmaceutical University |
31445231 |
56 |
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer. |
Nanjing Medical University |
31431359 |
24 |
Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity. |
Osaka University |
31095389 |
29 |
Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?. |
Chinese Academy of Sciences |
30321802 |
48 |
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives. |
Fudan University |
30300845 |
43 |
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio. |
Universit£ |
31999451 |
63 |
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
Guangxi Normal University |
31961685 |
23 |
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors. |
National Health Research Institutes |
31622096 |
49 |
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives. |
Fudan University |
30773421 |
10 |
4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors. |
Xihua University |
31264862 |
231 |
Discovery of Clinical Candidate (1 |
Newlink Genetics |
31223453 |
103 |
Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. |
Shanghai Hengrui Pharmaceutical |
32150677 |
32 |
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to |
Universit£ |
32073266 |
33 |
DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors. |
Glaxosmithkline |
31580660 |
120 |
-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase. |
Fudan University |
31233921 |
50 |
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors. |
Shanghai Institute of Materia Medica (Simm) |
32292562 |
73 |
Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors. |
Genentech |
31178268 |
12 |
Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors. |
Shenyang Pharmaceutical University |
32071686 |
64 |
Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation. |
Phenex Pharmaceuticals |
30472603 |
11 |
Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors. |
Zhengzhou University |
30469041 |
114 |
Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase. |
Bryn Mawr College |
25970480 |
26 |
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. |
Sib Swiss Institute of Bioinformatics |
30103191 |
45 |
Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors. |
Peking University |
29670692 |
29 |
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors. |
East China University of Science and Technology |
30170925 |
40 |
Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors. |
Peking University |
30055888 |
1 |
Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity. |
Okayama University |
29475581 |
39 |
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. |
China Pharmaceutical University |
28963992 |
25 |
Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies. |
China Pharmaceutical University |
28667875 |
35 |
Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches. |
China Pharmaceutical University |
29398544 |
11 |
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies. |
Universit£ |
29398543 |
23 |
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. |
Bristol-Myers Squibb Research and Development |
29456801 |
52 |
Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold. |
University Health Network |
29220788 |
33 |
Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy. |
China Pharmaceutical University |
29031064 |
23 |
Fragment-based approach to identify IDO1 inhibitor building blocks. |
University of Perugia |
28406643 |
3 |
Polyketides and Anthranilic Acid Possessing 6-Deoxy-?-l-talopyranose from a Streptomyces Species. |
Korea Research Institute of Bioscience and Biotechnology |
29111717 |
64 |
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate. |
Iteos Therapeutics |
28651980 |
8 |
Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase. |
University of Namur |
28720329 |
7 |
Recent synthetic and medicinal perspectives of tryptanthrin. |
Indo-Soviet Friendship College of Pharmacy (Isfcp) |
28526475 |
16 |
Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors. |
Fudan University |
17174378 |
12 |
Novel amidino-substituted benzimidazoles: synthesis of compounds and inhibition of dipeptidyl peptidase III. |
The Josip Juraj Strossmayer University |
7853174 |
25 |
In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency. |
Merck Research Laboratories |
7562497 |
127 |
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. |
R. W. Johnson Pharmaceutical Research Institute |
21867918 |
4 |
Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus. |
The University of Chicago |
21700210 |
6 |
Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. |
Riken Advanced Science Institute |
995128 |
168 |
Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes. |
TBA |
17656313 |
14 |
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. |
The Johns Hopkins University |
19143569 |
36 |
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. |
Abbott Laboratories |
18234496 |
12 |
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
Bristol-Myers Squibb |
18590272 |
33 |
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. |
University of Bath |
15537346 |
15 |
Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1. |
University of Oxford |
16451058 |
16 |
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates. |
Istituto Di Cristallografia |
8021916 |
11 |
Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR. |
Bristol-Myers Squibb |