The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 533888 |
1 |
Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. |
TBA |
| 23260349 |
51 |
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. |
Pfizer |
| 23623673 |
119 |
7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors. |
Dainippon Sumitomo Pharma |
| | 17 |
Synthesis and pharmacological evaluation of combined thromboxane receptor antagonist/synthase inhibitors: pyridine-containing sulphonamido acids |
TBA |
| | 43 |
Synthesis and pharmacological evaluation of combined Thromboxane receptor antagonists/thromboxane synthase inhibitors: Pyridine-containing amino-prostanoids |
TBA |
| 18029174 |
10 |
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| 16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
| 7658441 |
89 |
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities. |
Biofor |
| 7932529 |
37 |
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives. |
Eisai |
| 8021921 |
28 |
Dual angiotensin converting enzyme/thromboxane synthase inhibitors. |
Ciba-Geigy |
| 1447736 |
17 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds. |
Ciba-Geigy |
| 2299629 |
24 |
Design of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl-substituted dihydropyridines. |
Wyeth Research |
| 3681898 |
53 |
Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. |
Medical Research Division of American Cyanamid |
| 2879917 |
29 |
N-(heterocyclic alkyl)pyrido[2,1-b]quinazoline-8-carboxamides as orally active antiallergy agents. |
TBA |
| 4038746 |
74 |
Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids. |
TBA |
| 3918169 |
24 |
Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors. |
TBA |
| 7199089 |
25 |
Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives. |
TBA |
| 7199088 |
50 |
Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives. |
TBA |
| 21295979 |
91 |
Trisubstituted ureas as potent and selective mPGES-1 inhibitors. |
Merck Frosst Center For Therapeutic Research |
| 20144869 |
90 |
Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. |
Pfizer |
| 19748780 |
70 |
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| | 11 |
Design of dual-acting thromboxane antagonist-synthase inhibitors by a mutual prodrug approach |
TBA |
| | 4 |
Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel. |
TBA |
| | 9 |
Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists. |
TBA |
| | 9 |
Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I |
TBA |
| | 16 |
Oxa-prostanoid analogs. Identification of an orally effective, dual thromboxane receptor antagonist /thromboxane synthase inhibitor |
TBA |
| | 24 |
Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluation |
TBA |
| | 8 |
Discovery of dual activity molecules with thromboxane antagonist and thromboxane synthase inhibitory activity |
TBA |
| | 5 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 7. pyridinylalkyl-substituted arylsulfonylamino arylalkanoic acids. |
TBA |
| | 5 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 6. 4-substituted 3-pyridinylalkanoic acids. |
TBA |
| | 13 |
Dual-acting thromboxane receptor antagonist/synthase inhibitors: heterocyclic variations |
TBA |
| 18459759 |
9 |
Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target. |
Merck Frosst Centre For Therapeutic Research |
| 15953724 |
38 |
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. |
Merck Frosst Centre For Therapeutic Research |
| 11992782 |
6 |
Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI). |
Nikken Chemicals |
| 11858999 |
21 |
Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI). |
Nikken Chemicals |
| 11814792 |
18 |
Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs. |
Nikken Chemicals |
| 11327579 |
3 |
Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition. |
FacultéS Universitaires N.D. De La Paix |
| 11087568 |
55 |
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). |
University of The Saarland |
| 10197967 |
70 |
Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. |
Boehringer Ingelheim Pharma |
| 9876106 |
49 |
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds. |
Eli Lilly |
| 9873486 |
1 |
Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[[(4-chlorophenyl)sulfonyl]-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists. |
Pfizer |
| 9873463 |
39 |
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives. |
Eli Lilly |
| 9871770 |
16 |
New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors. |
Centre De Recherches De Croissy |
| 9341919 |
29 |
Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists. |
Pfizer |
| 8831771 |
64 |
On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel. |
University of Innsbruck |
| 8496929 |
12 |
Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule. |
Kyowa Hakko Kogyo |
| 8423593 |
6 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 5. Synthesis and evaluation of enantiomers of 8-[[(4-chlorophenyl)sulfonyl]amino]-4-(3-pyridinylalkyl)octanoic acid. |
Ciba-Geigy |
| 8289199 |
105 |
6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors. |
Dr. Karl Thomae |
| 8258828 |
15 |
Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones. |
Chugai Pharmaceutical |
| 7861416 |
90 |
Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids. |
Zeneca Pharmaceuticals |
| 7752186 |
29 |
A novel approach to dual-acting thromboxane receptor antagonist/synthase inhibitors based on the link of 1,3-dioxane-thromboxane receptor antagonists and -thromboxane synthase inhibitors. |
Zeneca Pharmaceuticals |
| 3930740 |
60 |
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. |
TBA |
| 3746813 |
19 |
Selective thromboxane synthetase inhibitors. 3. 1H-imidazol-1-yl-substituted benzo[b]furan-, benzo[b]thiophene-, and indole-2- and -3-carboxylic acids. |
TBA |
| 3656356 |
18 |
Thromboxane synthase inhibitors. Synthesis and pharmacological activity of (R)-, (S)-, and (+/-)-2,2-dimethyl-6-[2-(1H-imidazol-1-yl)-1-[[(4-methoxyphenyl)- methoxy]methyl]ethoxy]hexanoic acids. |
Searle Research and Development |
| 3305945 |
27 |
Structure-activity relationships in an imidazole-based series of thromboxane synthase inhibitors. |
TBA |
| 3091830 |
41 |
Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene. |
TBA |
| 3081722 |
47 |
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. |
TBA |
| 2970551 |
1 |
Synthesis and in vitro activity of various derivatives of a novel thromboxane receptor antagonist, (+/-)-(5Z)-7-[3-endo-[(phenylsulfonyl)amino]bicyclo[2.2.1] hept-2-exo-yl]heptenoic acid. |
Shionogi |
| 2724299 |
20 |
Synthesis and thromboxane synthetase inhibitory activity of di- or tetrahydrobenzo[b]thiophenecarboxylic acid derivatives. |
Sankyo |
| 2704033 |
13 |
[(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors. |
Syntex Research |
| 2547071 |
27 |
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists. |
Roche Research Center |
| 1992126 |
54 |
Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. |
Takeda Chemical Industries |
| 1829485 |
15 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids. |
Ciba-Geigy |
| 1447738 |
26 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs. |
Ciba-Geigy |
| 1447737 |
7 |
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids. |
Ciba-Geigy |
| 1388207 |
72 |
Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1. |
Kyowa Hakko Kogyo |
| 1311763 |
14 |
3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. |
Syntex Research |
| 16420054 |
24 |
Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. |
Bryn Mawr College |
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