152 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28011425	92	Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.	University of Auckland
28003141	65	Identification and optimization of a novel series of indoleamine 2,3-dioxygenase inhibitors.	Bristol-Myers Squibb Research and Development
28523098	28	INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.	Incyte
28280261	84	Non-kinase targets of protein kinase inhibitors.	The University of Sydney
27994758	130	Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors.	Indian Institute of Technology
27769672	2	Discovery and preliminary structure-activity relationship of 1H-indazoles with promising indoleamine-2,3-dioxygenase 1 (IDO1) inhibition properties.	Xihua University
26717206	64	O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.	Bryn Mawr College
26653033	27	Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.	National Health Research Institutes
26642377	22	Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.	National Health Research Institutes
26348881	54	Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.	National Health Research Institutes
26207924	32	Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.	Colorado College
25264478	6	Indoleamine 2,3-dioxygenase inhibitors: potential treatment for cancer, sepsis, and more.	Therachem Research Medilab (India)
25036789	45	Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.	Swiss Institute of Bioinformatics
24939758	72	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.	National Health Research Institutes
25313323	23	Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.	Dainippon Sumitomo Pharma
24878638	32	Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties.	University of Namur (Unamur)
24262887	11	Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).	University of Auckland
24099220	40	Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice.	Fudan University
23337802	21	Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.	Toho University
23218716	20	Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.	University of Namur
23521768	3	Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.	University of Nottingham
22873824	4	Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase.	University of British Columbia
22616902	165	Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.	Ludwig Center For Cancer Research of The University of Lausanne
22304006	1	Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.	Paris-Sud University
21726069	98	Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.	University of Namur
20688518	84	S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.	University of Shizuoka
20055453	80	Rational design of indoleamine 2,3-dioxygenase inhibitors.	Institute For Cancer Research
19507862	42	Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.	Incyte
22112538	22	Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen.	Macquarie University
21925773	22	Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors.	Fudan University
21419531	3	Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.	University of Namur
21391610	139	Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.	Vertex Pharmaceuticals
21269836	27	Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.	University of Namur
20580138	17	Identification of potent virtual leads to design novel indoleamine 2,3-dioxygenase inhibitors: pharmacophore modeling and molecular docking studies.	Gyeongsang National University
18677305	3	Biomimetic synthesis of the IDO inhibitors exiguamine A and B.	University of California
18715787	5	Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.	The University of Tokushima
17067170	9	Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.	University of British Columbia
32088128	40	Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy.	Fudan University
32832022	33	Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.	Merck
32247733	43	Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase.	Tongji University
31882299	34	Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.	Fudan University
32292563	12	Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).	Merck
30858027	38	Design, synthesis and biological evaluation of 2,5-dimethylfuran-3-carboxylic acid derivatives as potential IDO1 inhibitors.	China Pharmaceutical University
27469130	20	1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2).	Sib Swiss Institute For Bioinformatics
31525930	22	Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).	Sib Swiss Institute of Bioinformatics
31749906	52	Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.	Merck
31610376	28	Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors.	China Pharmaceutical University
31445231	56	Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.	Nanjing Medical University
31431359	24	Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity.	Osaka University
31095389	29	Diketopiperazine-Type Alkaloids from a Deep-Sea-Derived Aspergillus puniceus Fungus and Their Effects on Liver X Receptor ?.	Chinese Academy of Sciences
30321802	48	Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.	Fudan University
30300845	43	1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.	Universit£
31999451	63	Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.	Guangxi Normal University
31961685	23	Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.	National Health Research Institutes
31622096	49	Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.	Fudan University
30773421	10	4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.	Xihua University
31264862	231	Discovery of Clinical Candidate (1	Newlink Genetics
31223453	103	Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors.	Shanghai Hengrui Pharmaceutical
32150677	32	Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to	Universit£
32073266	33	DNA-Encoded Library Technology-Based Discovery, Lead Optimization, and Prodrug Strategy toward Structurally Unique Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors.	Glaxosmithkline
31580660	120	-Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase.	Fudan University
31233921	50	Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.	Shanghai Institute of Materia Medica (Simm)
32292562	73	Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.	Genentech
31178268	12	Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.	Shenyang Pharmaceutical University
32071686	64	Discovery of Hydroxyamidine Based Inhibitors of IDO1 for Cancer Immunotherapy with Reduced Potential for Glucuronidation.	Phenex Pharmaceuticals
30472603	11	Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors.	Zhengzhou University
30469041	114	Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.	Bryn Mawr College
25970480	26	Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors.	Sib Swiss Institute of Bioinformatics
30103191	45	Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors.	Peking University
29670692	29	Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.	East China University of Science and Technology
30170925	40	Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors.	Peking University
30055888	1	Cyclic analogue of S-benzylisothiourea that suppresses kynurenine production without inhibiting indoleamine 2,3-dioxygenase activity.	Okayama University
29475581	39	Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.	China Pharmaceutical University
28963992	25	Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies.	China Pharmaceutical University
28667875	35	Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches.	China Pharmaceutical University
29398544	11	A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.	Universit£
29398543	23	Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.	Bristol-Myers Squibb Research and Development
29456801	52	Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold.	University Health Network
29220788	33	Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy.	China Pharmaceutical University
29031064	23	Fragment-based approach to identify IDO1 inhibitor building blocks.	University of Perugia
28406643	3	Polyketides and Anthranilic Acid Possessing 6-Deoxy-?-l-talopyranose from a Streptomyces Species.	Korea Research Institute of Bioscience and Biotechnology
29111717	64	Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.	Iteos Therapeutics
28651980	8	Synthesis of 4- and 5-arylthiazolinethiones as inhibitors of indoleamine 2,3-dioxygenase.	University of Namur
28720329	7	Recent synthetic and medicinal perspectives of tryptanthrin.	Indo-Soviet Friendship College of Pharmacy (Isfcp)
28526475	16	Identification and preliminary structure-activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.	Fudan University
17174378	12	Novel amidino-substituted benzimidazoles: synthesis of compounds and inhibition of dipeptidyl peptidase III.	The Josip Juraj Strossmayer University
7853174	25	In vivo receptor occupancy of the angiotensin II receptor by nonpeptide antagonists: relationship to in vitro affinities and in vivo pharmacologic potency.	Merck Research Laboratories
7562497	127	Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.	R. W. Johnson Pharmaceutical Research Institute
21867918	4	Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus.	The University of Chicago
21700210	6	Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.	Riken Advanced Science Institute
995128	168	Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes.	TBA
17656313	14	Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.	The Johns Hopkins University
19143569	36	Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.	Abbott Laboratories
18234496	12	Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).	Bristol-Myers Squibb
18590272	33	Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity.	University of Bath
15537346	15	Design of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase with Improved Drug Resistance Properties. 1.	University of Oxford
16451058	16	Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates.	Istituto Di Cristallografia
8021916	11	Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.	Bristol-Myers Squibb