The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28245116 |
2 |
Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking. |
The Ohio State University |
| 27816267 |
1 |
4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway. |
Soochow University |
| 27352042 |
45 |
Neuroactive and Anti-inflammatory Frankincense Cembranes: A Structure-Activity Study. |
Universit£ |
| 27381083 |
73 |
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. |
University of Pittsburgh |
| 26788588 |
1 |
Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid. |
Universit£ |
| 26508550 |
1 |
Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential. |
Research Institute of Hygiene |
| 26352675 |
1 |
Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors. |
University of Franche-Comt£ |
| 26331426 |
11 |
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importina-2 Expression, and Induce Antitumor Effects against Human Glioma. |
University of Hawaii At Hilo |
| 26241032 |
5 |
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. |
Taipei Medical University |
| 25288188 |
64 |
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. |
University of Pittsburgh |
| 25895106 |
11 |
Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. |
Chungbuk National University |
| 25419444 |
28 |
Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein. |
University of Toronto Mississauga |
| 24920381 |
77 |
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. |
University Jena |
| 24485121 |
12 |
A perylene derivative regulates HIF-1a and Stat3 signaling pathways. |
Baylor College of Medicine |
| 24900612 |
5 |
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. |
University of Toronto At Mississauga |
| 23968501 |
85 |
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma. |
University of Toronto Mississauga |
| 23791367 |
3 |
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones. |
The Ohio State University |
| 23651330 |
1 |
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. |
The Ohio State University |
| 23434226 |
4 |
Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. |
Fudan University |
| 23376248 |
3 |
Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening. |
Fudan University |
| 22650325 |
39 |
Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. |
University of Southern California |
| 22309250 |
3 |
STAT-3 inhibitory bisabolanes from Carthamus glaucus. |
Universit£ |
| 22148584 |
30 |
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. |
University of Toronto |
| 21138246 |
44 |
Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. |
Astrazeneca R&D |
| 19348465 |
1 |
Cucurbitane-type triterpenoids from the stems of Cucumis melo. |
Chinese Academy of Sciences |
| 21788134 |
28 |
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. |
University of Toronto Mississauga |
| 21486047 |
17 |
Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. |
University of Texas M. D. Anderson Cancer Center |
| 24900231 |
22 |
Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. |
TBA |
| 24900220 |
9 |
Identification of a New Series of STAT3 Inhibitors by Virtual Screening. |
TBA |
| 21035336 |
42 |
5-amino-pyrazoles as potent and selective p38a inhibitors. |
Bristol-Myers Squibb Research and Development |
| 21030257 |
1 |
A novel small-molecule inhibitor of IL-6 signalling. |
University of London |
| 19728728 |
50 |
Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3. |
The University of Texas M.D. Anderson Cancer Center |
| 19334714 |
35 |
Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling. |
The University of Texas M.D. Anderson Cancer Center |
| 19317452 |
155 |
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4. |
Wyeth Research |
| 18768317 |
2 |
Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening. |
Wyeth Pharmaceuticals |
| 18578470 |
5 |
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. |
Wyeth Research |
| 17509878 |
6 |
New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors. |
Université |
| 17113289 |
3 |
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics. |
The University of Texas |
| 31992476 |
2 |
A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors. |
Punjabi University |
| 32044231 |
4 |
STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae. |
Kindai University |
| 30817889 |
11 |
Allosteric Modulator Discovery: From Serendipity to Structure-Based Design. |
Shanghai Jiao-Tong University School of Medicine |
| 31254923 |
7 |
Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3. |
Wenzhou Medical University |
| 30472602 |
1 |
A novel series of napabucasin derivatives as orally active inhibitors of signal transducer and activator of transcription 3 (STAT3). |
Sichuan University |
| 31999451 |
63 |
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3. |
Guangxi Normal University |
| 31747516 |
13 |
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. |
TBA |
| 30447888 |
1 |
Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives. |
Federal Medical Biological Agency |
| 24073326 |
34 |
Development of new |
Moffitt Cancer Center |
| 30145375 |
7 |
Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. |
Chinese Academy of Medical Sciences and Peking Union Medical College |
| 29807795 |
2 |
Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells. |
Chungnam National University |
| 28753294 |
35 |
Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study. |
Universit£ |
| 30228000 |
157 |
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. |
University of Macau |
| 30003778 |
4 |
Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells. |
Westphalian Wilhelms University |
| 29140705 |
26 |
Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis. |
Beijing University of Chinese Medicine |
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