152 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28199108	106	Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.	Vernalis (R&D)
10340605	5	Synthesis and evaluation of geldanamycin-estradiol hybrids.	Sloan-Kettering Institute For Cancer Research
27783977	12	Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.	Keimyung University
27914802	12	Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.	Korea University
27913182	5	Virtual screening and biophysical studies lead to HSP90 inhibitors.	University of Auckland
27003516	78	Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.	The University of Kansas
26112442	74	Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.	Chengdu University of Tcm
25799158	6	Volume of Distribution in Drug Design.	Pharmacokinetics
25901531	211	Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.	Sloan-Kettering Institute For Cancer Research
25677667	17	Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.	Vertex Pharmaceuticals
25105924	5	Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.	Shandong University
25368984	14	Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.	Novartis Institutes For Biomedical Research
25313505	35	Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.	Chinese Academy of Sciences
25277067	7	Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.	Shandong University
24751441	18	Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.	Chinese Academy of Sciences
24588105	56	Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.	Universit£
24580531	6	Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.	University of Geneva
24565573	35	4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.	Universit£
24673104	185	Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.	Vertex Pharmaceuticals
23362862	13	A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.	Universit£
22938030	22	EC144 is a potent inhibitor of the heat shock protein 90.	Biogen Idec
21438541	45	Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyr	Pfizer
20055425	29	Heat shock protein 90: inhibitors in clinical trials.	Biogen Idec
19231864	6	Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.	Kosan Biosciences
16854066	44	Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.	Infinity Pharmaceuticals
16165354	19	Structure-based design of 7-carbamate analogs of geldanamycin.	Kosan Biosciences
9925731	4	Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.	University College London
22192591	17	Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.	Chugai Pharmaceutical
21875802	33	Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.	Chugai Pharmaceutical
21920765	12	Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.	Trinity College
21715165	31	Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.	Pfizer
21106457	41	N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.	Abbott Laboratories
21605975	31	Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.	Pfizer
21420297	19	Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.	Pfizer
20609590	10	Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.	Hokkaido University
19168355	7	5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.	Fermentas
16797988	4	Synthesis of a red-shifted fluorescence polarization probe for Hsp90.	Memorial Sloan-Kettering Cancer Center
16621545	6	Synthesis of Hsp90 dimerization modulators.	Memorial Sloan-Kettering Cancer Center
16530412	13	High-throughput screening for Hsp90 ATPase inhibitors.	The University of Kansas
16480864	38	4-Amino derivatives of the Hsp90 inhibitor CCT018159.	Vernalis
15828828	136	Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.	Memorial Sloan-Kettering Cancer Center
15713410	2	Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.	Genomics Institute of The Novartis Research Foundation
15239664	92	Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.	Conforma Therapeutics
14698151	14	Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.	Ribotargets
14592488	2	Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.	Memorial Sloan-Kettering Cancer Center
32305165	72	Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity.	Seoul National University
32222339	5	Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.	Fujian Medical University (Fmu)
32832020	1	From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.	The University of Notre Dame
32527461	1	Enzymatic biosynthesis and biological evaluation of novel 17-AAG glucoside as potential anti-cancer agents.	Bengbu Medical College
32324396	17	p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators.	China Pharmaceutical University
32273216	6	Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities.	South China Sea Institute of Oceanology
11294389	27	LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.	Department of Molecular Oncogenesis
31839539	60	Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.	Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)
27485604	5	Blinded predictions of binding modes and energies of HSP90-? ligands for the 2015 D3R grand challenge.	University of Edinburgh
27527413	25	Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity.	China Pharmaceutical University
27476419	70	C15-methoxyphenylated 18-deoxy-herbimycin A analogues, their in vitro anticancer activity and heat shock protein 90 binding affinity.	Peking Union Medical College & Chinese Academy of Medical Sciences
26844689	22	Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.	Chinese Academy of Sciences
30839211	12	Fusicoccane Diterpenes from Hypoestes forsskaolii as Heat Shock Protein 90 (Hsp90) Modulators.	Universit£
30597326	50	High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.	Jiangsu Normal University
31663736	15	Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.	China Pharmaceutical University
31469962	122	Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors.	Korea University
31935086	19	Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.	China Pharmaceutical University
31655430	56	N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.	Taipei Medical University
30525599	33	Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.	Taiho Pharmaceutical
32352777	8	Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation.	East China Normal University
30769242	14	Clinical candidates modulating protein-protein interactions: The fragment-based experience.	Taros Chemicals
30784881	8	Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.	China Pharmaceutical University
31188592	39	Why Some Targets Benefit from beyond Rule of Five Drugs.	Boston University
30048133	1	Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design.	Istituto Di Chimica Del Riconoscimento Molecolare
31519378	1	C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action.	Heinrich Heine University D£Sseldorf
27818030	5	Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.	China Pharmaceutical University
25141341	1	Progress in the discovery and development of heat shock protein 90 (Hsp90) inhibitors.	Montclair State University
24499352	3	Bioactive limonoids from the leaves of Azaridachta indica (Neem).	Universidad De Los Andes
24369839	18	Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors.	Chugai Pharmaceutical
24125885	2	Targeting the hydrophobic region of Hsp90's ATP binding pocket with novel 1,3,5-triazines.	Kyungpook National University
23859777	5	Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.	University of Arizona
23520985	12	Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.	Universit£
23606927	11	3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.	The University of Kansas
22877636	60	Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.	Exelixis
22913511	91	Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.	Myrexis
21486005	3	Gambogic acid, a natural product inhibitor of Hsp90.	Oklahoma State University
21612924	10	Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.	Pfizer
20718493	29	Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.	Astex Therapeutics
20655237	8	Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.	Universit£
20570149	4	Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.	The University of Kansas
19908836	11	Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.	Pfizer
19395259	28	Discovery of 5-substituted 2-amino-4-chloro-8-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6(5H)-ones as potent and selective Hsp90 inhibitors.	Poniard Pharmaceuticals
19552433	49	Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.	Serenex
18929486	41	Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.	Pfizer
19101151	34	Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.	The University of Kansas
18762423	20	Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.	Emory University
18571929	45	Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.	Emory University
18020309	1	Derrubone, an inhibitor of the Hsp90 protein folding machinery.	The University of Kansas
29202402	24	Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors.	Keimyung University
29567459	49	1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.	Taipei Medical University
29545103	27	Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90).	National University of Singapore
29701469	52	Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.	University of Vienna
30351001	16	Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.	China Pharmaceutical University
29698859	30	Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.	Chinese Academy of Sciences
28482218	3	Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.	China Pharmaceutical University
29057043	40	Resorcinol-Based Grp94-Selective Inhibitors.	The University of Kansas
29807796	12	New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.	University of Ferrara
29528635	14	Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.	Hauptman-Woodward Medical Research Institute
27688186	31	Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors.	China Pharmaceutical University
28426997	4	Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90.	Ocean University of China
28933546	1	Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.	University of Minnesota
28816449	14	Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.	Ulsan National Institutes of Science and Technology (Unist)
28500957	30	Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.	Cairo University
10498829	62	Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.	Cerebrus
19374444	45	Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.	Csic
18921992	9	Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.	Pfizer
17125252	60	Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.	Human Biomolecular Research Institute
12694187	9	Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.	Uppsala University
16420031	46	Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.	Instituto De Quimica Medica (Csic)