The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27261179 |
11 |
Identification of potent and selective retinoic acid receptor gamma (RAR¿) antagonists for the treatment of osteoarthritis pain using structure based drug design. |
Eli Lilly |
| 26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
| 25838141 |
8 |
Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-a agonistic activity. |
Aichi Gakuin University |
| 24831826 |
59 |
Small molecule inhibitors targeting activator protein 1 (AP-1). |
University of Texas Medical Branch |
| 25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
| 24457093 |
12 |
Inhibition of I¿B kinase-ß and I¿B kinase-a by heterocyclic adamantyl arotinoids. |
Universidade De Vigo |
| 23685180 |
1 |
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures. |
Research Foundation Itsuu Laboratory |
| 19239230 |
42 |
Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands. |
Acadia Pharmaceuticals |
| 21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research and Development |
| | 27 |
Synthesis and biological activities of new heterocyclic aromatic retinoids |
TBA |
| 20925433 |
21 |
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. |
Aristotle University of Thessaloniki |
| 20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
| 19502054 |
3 |
Identification of a chromone-based retinoid containing a polyolefinic side chain via facile synthetic routes. |
Temple University |
| | 61 |
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands |
TBA |
| | 99 |
Synthesis and structure-activity relationships of potent retinoid X receptor ligands |
TBA |
| | 56 |
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid |
TBA |
| | 22 |
Synthesis and receptor binding affinity of conformationally restricted retinoic acid analogues |
TBA |
| | 83 |
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere |
TBA |
| | 31 |
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs |
TBA |
| | 54 |
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids |
TBA |
| | 35 |
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs |
TBA |
| 19058965 |
30 |
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. |
University of Lille |
| 15615521 |
28 |
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. |
University of Maryland |
| 15056000 |
82 |
Structure-based design of potent retinoid X receptor alpha agonists. |
Glaxosmithkline |
| 15006411 |
126 |
Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
Ligand Pharmaceuticals |
| 14592510 |
150 |
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
Ligand Pharmaceuticals |
| 12482435 |
75 |
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid. |
Ligand Pharmaceuticals |
| 12372520 |
37 |
Synthesis and biological activity of retinoic acid receptor-alpha specific amides. |
Allergan |
| 11428923 |
39 |
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
Allergan |
| 11354380 |
3 |
Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists. |
Eisai |
| 11277515 |
51 |
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
Allergan |
| 10762039 |
3 |
Syntheses and evaluation of naphthalenyl- and chromenyl-pyrrolyl-benzoic acids as potent and selective retinoic acid receptor alpha agonists. |
Eisai |
| 10762038 |
3 |
Novel retinoic acid receptor alpha agonists: syntheses and evaluation of pyrazole derivatives. |
Eisai |
| 30702885 |
256 |
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. |
Goethe University Frankfurt |
| 10669568 |
27 |
Syntheses and structure-activity relationships of 5,6,7, 8-tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline derivatives with retinoic acid receptor alpha agonistic activity. |
Eisai |
| 10585206 |
45 |
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid. |
Università |
| 10543887 |
12 |
Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. |
University of Oklahoma Health Sciences Center |
| 10479291 |
12 |
Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. |
University of Oklahoma Health Sciences Center |
| 10201840 |
33 |
A new class of potent RAR antagonists: dihydroanthracenyl, benzochromenyl and benzothiochromenyl retinoids. |
Allergan |
| 10098670 |
24 |
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands. |
Allergan |
| 10098666 |
48 |
High affinity retinoic acid receptor antagonists: analogs of AGN 193109. |
Allergan |
| 10052980 |
138 |
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells. |
Ligand Pharmaceuticals |
| 9733501 |
33 |
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. |
University of Oklahoma Health Sciences Center |
| 9435893 |
46 |
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. |
University of Tokyo |
| 8978832 |
18 |
Identification of retinoic acid receptor beta subtype specific agonists. |
Allergan |
| 8784454 |
76 |
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. |
Allergan |
| 8765503 |
39 |
Identification of the first retinoid X, receptor homodimer antagonist. |
Ligand Pharmaceuticals |
| 8759622 |
15 |
Identification of a retinoic acid receptor alpha subtype specific agonist. |
Allergan |
| 8709094 |
41 |
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. |
Ligand Pharmaceuticals |
| 8691435 |
33 |
Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids. |
Pharmaceutical Research Institute |
| 8544175 |
75 |
Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. |
Cird Galderma |
| 8410972 |
52 |
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. |
Sri International |
| 8308867 |
72 |
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. |
Ligand Pharmaceuticals |
| 8071941 |
240 |
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. |
Ligand Pharmaceuticals |
| 7650690 |
64 |
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
Sri International |
| 7636843 |
40 |
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
Allergan |
| 7490725 |
9 |
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. |
Allergan |
| 9258350 |
18 |
Identification of highly potent retinoic acid receptor alpha-selective antagonists. |
Allergan |
| 29439915 |
18 |
Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids. |
Helwan University |
| 29706423 |
84 |
Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. |
Nestle Skin Health |
| 29288071 |
16 |
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist. |
King'S College |
| 28850227 |
85 |
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry. |
St. John'S University |
| 15509719 |
17 |
[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor. |
Section of Pharmacology |
| 10379421 |
134 |
Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. |
TBA |
| 10421757 |
5 |
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. |
Institute of Genetics and Molecular and Cellular Biology (Igbmc) |
| 19361210 |
44 |
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. |
Bristol-Myers Squibb |
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