The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27964881 |
23 |
Bivalent SIRT1 inhibitors. |
Jiangsu University |
| 27707605 |
61 |
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N |
Jiangsu University |
| 27669815 |
4 |
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity. |
University of Paris |
| 27153347 |
53 |
How much successful are the medicinal chemists in modulation of SIRT1: A critical review. |
Guru Jambheshwar University of Science and Technology |
| 26982234 |
252 |
5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. |
University of Minnesota |
| 26874402 |
27 |
Simple N(e)-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition. |
Jiangsu University |
| 26696402 |
49 |
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study. |
Albert-Ludwigs-University of Freiburg |
| 26633734 |
1 |
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1. |
Gause Institute of New Antibiotics |
| 26310895 |
29 |
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. |
University of Genoa |
| 26081291 |
18 |
Novel thiourea-based sirtuin inhibitory warheads. |
Jiangsu University |
| 26025875 |
3 |
New indole-isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies. |
National Institute of Technology Karnataka |
| 25971769 |
25 |
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. |
Methylgene |
| 25905694 |
24 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. |
Istituto Ortopedico Rizzoli (Ior) |
| 25549554 |
37 |
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity. |
National University of Singapore |
| 24880902 |
50 |
Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole. |
Chinese Academy of Sciences |
| 25515955 |
24 |
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. |
The University of Tokyo |
| 25275824 |
62 |
Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. |
University of Minnesota |
| 24992072 |
10 |
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. |
Universiti Sains Malaysia |
| 24785705 |
12 |
Discovery of novel and selective SIRT6 inhibitors. |
University of Bologna |
| 24697269 |
18 |
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. |
Fred Hutchinson Cancer Research Center |
| 24675380 |
9 |
Identification of novel SIRT2-selective inhibitors using a click chemistry approach. |
Nagoya City University |
| 24387981 |
8 |
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities. |
Universiti Sains Malaysia |
| 24269123 |
1 |
Evaluation of benzoic acid derivatives as sirtuin inhibitors. |
San Francisco State University |
| 23927550 |
9 |
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells. |
University of Eastern Finland |
| 23570514 |
120 |
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. |
Sirtris A Gsk |
| 23316803 |
43 |
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. |
Chinese Academy of Sciences |
| 23318905 |
23 |
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action. |
Chinese Academy of Sciences |
| 23311358 |
2 |
The 2.5Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. |
Eli Lilly |
| 23167691 |
4 |
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A. |
San Francisco State University |
| 24900427 |
68 |
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. |
TBA |
| 23189967 |
17 |
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. |
Sapienza University of Rome |
| 22929231 |
3 |
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1. |
University of Hyderabad Campus |
| 22931526 |
31 |
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. |
Sapienza University of Rome |
| 21080630 |
37 |
SIRT1 modulation as a novel approach to the treatment of diseases of aging. |
Sirtris A Gsk |
| 22642300 |
160 |
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. |
Kyoto Prefectural University of Medicine |
| 22541394 |
30 |
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors. |
Guru Ghasidas University |
| 22464458 |
8 |
Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies. |
Birla Institute of Technology |
| 19734050 |
38 |
Identification and characterization of novel sirtuin inhibitor scaffolds. |
Institute |
| 20030343 |
11 |
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins). |
Ludwig-Maximilians-Universit£T M£Nchen |
| 18046409 |
13 |
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. |
Sirtris Pharmaceuticals |
| 17329104 |
10 |
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors. |
University of Kuopio |
| 22304848 |
44 |
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins. |
University of St. Andrews |
| 21895016 |
41 |
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2. |
University of Eastern Finland |
| 21752644 |
9 |
A mechanism-based potent sirtuin inhibitor containing Ne-thiocarbamoyl-lysine (TuAcK). |
University of Akron |
| 21315612 |
17 |
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins). |
Ernst-Moritz-Arndt University Greifswald |
| 21306906 |
6 |
After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. |
Cemm-Research Center For Molecular Medicine of The Austrian Academy of Sciences |
| 21306905 |
14 |
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile. |
Sapienza University of Rome |
| 21528845 |
7 |
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD). |
University of East Anglia |
| 20630764 |
28 |
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2. |
University of Eastern Finland |
| 20041717 |
24 |
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues. |
Institute of Psychiatry and Neuroscience of Paris |
| 19700324 |
6 |
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine. |
Nagoya City University |
| 19616958 |
10 |
Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors. |
Nagoya City University |
| 19199480 |
6 |
Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. |
Sirtris Pharmaceuticals |
| 19296597 |
48 |
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors. |
University of Kuopio |
| 18642893 |
11 |
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors. |
University of Kuopio |
| 17588900 |
27 |
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. |
Harvard Medical School |
| 17149860 |
39 |
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. |
Albert-Ludwigs-University of Freiburg |
| 16697640 |
2 |
Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation. |
University of Akron |
| 16335928 |
42 |
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. |
Elixir Pharmaceuticals |
| 16302818 |
15 |
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. |
Sapienza University of Rome |
| 32067892 |
30 |
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring N |
Fudan University |
| 32787077 |
23 |
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity. |
Sichuan University |
| 32631504 |
29 |
Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors. |
Sichuan University |
| 32061485 |
27 |
Unexpected small molecules as novel SIRT2 suicide inhibitors. |
Engineering Research Center For The Development and Application of Ethnic Medicine and Tcm (Ministry of Education) |
| 30622025 |
10 |
Recent applications of hydantoin and thiohydantoin in medicinal chemistry. |
College of Pharmacy and Gachon Institute of Pharmaceutical Science |
| 30342425 |
48 |
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators. |
Sichuan University |
| 30986062 |
40 |
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. |
TBA |
| 31812033 |
42 |
Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. |
Cairo University |
| 31223439 |
25 |
Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling. |
Umr Cnrs 7285 |
| 31655430 |
56 |
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression. |
Taipei Medical University |
| 30578034 |
13 |
Cyclic tripeptide-based potent human SIRT7 inhibitors. |
Jiangsu University |
| 31855601 |
73 |
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors. |
Chinese Academy of Sciences |
| 31144814 |
10 |
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD |
Kyoto Prefectural University of Medicine |
| 28135086 |
105 |
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. |
Imperial College |
| 26220157 |
62 |
Human SIRT3 tripeptidic inhibitors containing N(?)-thioacetyl-lysine. |
Jiangsu University |
| 24340169 |
11 |
The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors. |
Imperial College London |
| 31117516 |
102 |
Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin. |
Nagoya City University |
| 30395713 |
7 |
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development. |
University of Bayreuth |
| 30122227 |
113 |
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma. |
Nestle Skin Health R&D |
| 28379698 |
22 |
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). |
University of Freiburg |
| 28241112 |
30 |
Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. |
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£ |
| 28958848 |
12 |
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. |
University of Genoa |
| 29957526 |
85 |
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. |
West China School of Pharmacy |
| 29921476 |
25 |
The mimics of N |
School of Pharmacy |
| 28475330 |
26 |
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. |
H�Pital Kirchberg |
| 29304284 |
59 |
(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo. |
Taipei Medical University |
| 28415012 |
6 |
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. |
Xihua University |
| 22468750 |
3 |
Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz. |
Jeju National University |
| 24114842 |
25 |
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity. |
Soochow University |
| 8663568 |
17 |
Cloning and expression of a novel neuropeptide Y receptor. |
Merck Research Laboratories |
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