The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27709945 |
62 |
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selectivea |
Chinese Academy of Sciences |
| 26238322 |
26 |
Indolylpiperidine derivatives as potent and selectivea1B adrenoceptor antagonists. |
Toray Industries |
| 11462977 |
21 |
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes. |
University of Bologna |
| 20934789 |
27 |
Synthesis anda1-adrenoceptor antagonist activity of tamsulosin analogues. |
Universit£ |
| 20813529 |
48 |
Search for influence of spatial properties on affinity ata1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin. |
Jagiellonian University Medical College |
| 19719240 |
25 |
Doxazosin-related alpha1-adrenoceptor antagonists with prostate antitumor activity. |
University of Camerino |
| 9548813 |
53 |
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. |
Smithkline Beecham Pharmaceuticals |
| 21486038 |
177 |
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. |
H. Lundbeck |
| 21549456 |
10 |
Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-adrenergic receptor blocking properties. |
Universidade Federal Do Rio De Janeiro |
| 23124215 |
72 |
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selectivea1B-adrenoceptor antagonist. |
Universit£ |
| 16723224 |
26 |
Design and synthesis of selective alpha1B adrenoceptor antagonists. |
Toray Industries |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 12954071 |
109 |
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. |
Alcon Research |
| 12930145 |
77 |
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. |
Universit£ |
| 10602703 |
73 |
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. |
Warner-Lambert |
| 10579843 |
81 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series. |
Synaptic Pharmaceutical |
| 10579840 |
88 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones. |
Synaptic Pharmaceutical |
| 10447960 |
20 |
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography. |
Universidad De Valencia |
| 9703460 |
52 |
Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists. |
National Taiwan University |
| 9135028 |
114 |
Pharmacological options in the treatment of benign prostatic hyperplasia. |
Pfizer |
| 1573641 |
60 |
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. |
Searle Research and Development |
| 1976813 |
83 |
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. |
Wyeth-Ayerst Research |
| 11354357 |
61 |
Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. |
Abbott Laboratories |
| 19762239 |
18 |
Structure-activity relationship study on alpha1 adrenergic receptor antagonists from beer. |
University of Shizuoka and Global Coe Program |
| 19788200 |
7 |
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain. |
Dipartimento Di Scienze Farmaceutiche |
| | 14 |
Marine sponge bis(indole) alkaloids that displace ligand binding to α1 adrenergic receptors |
TBA |
| 18160289 |
119 |
1-Aminoindanes as novel motif with potential atypical antipsychotic properties. |
Pfizer |
| 17976986 |
80 |
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route. |
Pfizer |
| 16513345 |
45 |
Vasorelaxant activity of phthalazinones and related compounds. |
Universidad De Salamanca |
| 16250661 |
13 |
11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors. |
University of Milano/Bicocca |
| 15055991 |
265 |
Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. |
Recordati |
| 12361399 |
17 |
Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. |
Universita Di Camerino |
| 12238918 |
22 |
N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
Abbott Laboratories |
| 11384242 |
126 |
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. |
Abbott Laboratories |
| 10956183 |
19 |
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. |
Synaptic Pharmaceutical |
| 10780916 |
134 |
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH). |
Abbott Laboratories |
| 10021947 |
44 |
4-Oxospiro[benzopyran-2,4'-piperidines] as selective alpha 1a-adrenergic receptor antagonists. |
Merck |
| 9986714 |
105 |
Synthesis, pharmacological evaluation, and structure-activity relationship and quantitative structure-activity relationship studies on novel derivatives of 2,4-diamino-6,7-dimethoxyquinazoline alpha1-adrenoceptor antagonists. |
Recordati |
| 9876110 |
58 |
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). |
Centro De InvestigacióN Grupo Ferrer |
| 9572880 |
44 |
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. |
University of Camerino |
| 9548811 |
55 |
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist. |
Merck |
| 9379432 |
36 |
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign pr |
Abbott Laboratories |
| 9258372 |
40 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 3.1 2-[omega-(4-arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2-c]imidazoles and -perhydroimidazo[1,5-a]pyridines: study of the influence of the terminal amide fragment on 5-HT1A affinity/selectivity. |
Universidad Complutense |
| 8809161 |
90 |
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole. |
H. Lundbeck |
| 8667368 |
42 |
Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist. |
University of Camerino |
| 7909336 |
27 |
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. |
R. W. Johnson Pharmaceutical Research Institute |
| 7658428 |
94 |
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. |
Smithkline Beecham Pharmaceuticals |
| 15163201 |
189 |
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
Abbott Laboratories |
| 8917649 |
60 |
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist. |
University of Camerino |
| 8831777 |
48 |
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
Abbott Laboratories |
| 29128116 |
3 |
Design and synthesis of small molecule agonists of EphA2 receptor. |
Case Western Reserve University School of Medicine |
| 28958623 |
35 |
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H |
Glaxosmithkline |
| 1648138 |
33 |
Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. |
Universitá |
| 1336054 |
63 |
Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles. |
H. Lundbeck |
| 1336053 |
86 |
Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles. |
H. Lundbeck |
| 26943478 |
16 |
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. |
Chulabhorn Research Institute |
| 26851737 |
36 |
One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies. |
University of Karachi |
| 26218629 |
26 |
Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). |
Oregon Health & Science University |
| 26364932 |
22 |
Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. |
University of North Carolina At Chapel Hill |
| 25590533 |
245 |
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. |
University of North Carolina At Chapel Hill |
| 10747922 |
12 |
Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study. |
Swiss Federal Institute of Technology |
Search and Browse
