The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28045525 |
54 |
A Macrocyclic Agouti-Related Protein/[Nle |
University Of Minnesota |
| 26959173 |
85 |
An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers. |
University Of Minnesota |
| 26433448 |
10 |
A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist. |
University Of Minnesota |
| 26005535 |
28 |
Synthesis and Pharmacology ofa/ß(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence. |
University Of Minnesota |
| 25898270 |
88 |
Discovery of aß-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology. |
University Of Minnesota |
| 25699138 |
38 |
Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor. |
University Of Minnesota |
| 25347033 |
93 |
1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity. |
University Of Cergy-Pontoise |
| 24517312 |
98 |
Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). |
University Of Florida |
| 23432160 |
78 |
Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R). |
University Of Florida |
| 19635667 |
110 |
Semi-rigid tripeptide agonists of melanocortin receptors. |
University Of Cincinnati |
| 18800761 |
69 |
Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. |
University Of Florida |
| 18220330 |
28 |
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity. |
The Hebrew University Of Jerusalem |
| 18271518 |
43 |
The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies. |
University Of Florida |
| 15615519 |
42 |
Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist. |
University Of Florida |
| 15857138 |
64 |
N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes. |
University Of Florida |
| 15828845 |
93 |
Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template. |
University Of Florida |
| 15084118 |
79 |
Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands. |
University Of Florida |
| 14998337 |
68 |
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach. |
University Of Arizona |
| 12477357 |
96 |
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position. |
University Of Florida |
| 12086493 |
120 |
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position. |
University Of Florida |
| 12061882 |
83 |
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position. |
University Of Florida |
| 11405661 |
61 |
Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors. |
University Of Florida |
| 14643357 |
29 |
Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence. |
University Of Florida |
| 14552781 |
45 |
Aryl piperazine melanocortin MC4 receptor agonists. |
Neurocrine Biosciences |
| 12781199 |
64 |
Urea small molecule agonists on mouse melanocortin receptors. |
University Of Florida |
| 20598882 |
76 |
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity. |
Merck Research Laboratories |
| 21306168 |
36 |
Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR. |
University Of Florida |
| 20621473 |
56 |
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. |
Merck Research Laboratories |
| 20207541 |
18 |
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist. |
Merck Research Laboratories |
| 20056544 |
50 |
The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. |
The Hebrew University Of Jerusalem |
| 18417348 |
82 |
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. |
Neurocrine Biosciences |
| 17994683 |
55 |
Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor. |
Neurocrine Biosciences |
| 17964151 |
107 |
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor. |
Neurocrine Biosciences |
| 17918824 |
39 |
Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia. |
Neurocrine Biosciences |
| 17822895 |
110 |
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. |
Neurocrine Biosciences |
| 17544282 |
39 |
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. |
Neurocrine Biosciences |
| 15982875 |
46 |
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist. |
Merck Research Laboratories |
| 15509165 |
6 |
Structural characterization and pharmacology of a potent (Cys101-Cys119, Cys110-Cys117) bicyclic agouti-related protein (AGRP) melanocortin receptor antagonist. |
University Of Florida |
| 15027849 |
7 |
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. |
Millennium Pharmaceuticals |
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