BindingDB PrimarySearch

BDBM50250399 5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one::5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one::CHEMBL463914::manoalide

SMILES: C\C(CCC1=C(C)CCCC1(C)C)=C/CCC1=CC[C@@H](O[C@H]1O)C1=CC(=O)O[C@H]1O

InChI Key: InChIKey=FGJIDQWRRLDGDB-CPIXEKRISA-N

Data: 21 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50250399
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phospholipase A2, acidic (Naja naja)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of Naja naja venom group1 sPLA2 at 10 uM by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of California-San Diego Curated by ChEMBL					Assay Description Inhibition of bee venom PLA2				J Nat Prod 55: 1701-17 (1992) Article DOI: 10.1021/np50090a001 BindingDB Entry DOI: 10.7270/Q2H70JMC
University of California-San Diego Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of bee venom group3 sPLA2 by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair
Phospholipase A2, membrane associated (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Napoli Federico II Curated by ChEMBL					Assay Description Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation counting				J Nat Prod 64: 612-5 (2001) BindingDB Entry DOI: 10.7270/Q28915MQ
					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Napoli Federico II Curated by ChEMBL					Assay Description Inhibition of bee venom group 3 secretory phospholipase A2 by liquid scintillation counting				J Nat Prod 64: 612-5 (2001) BindingDB Entry DOI: 10.7270/Q28915MQ
					More data for this Ligand-Target Pair
Phospholipase A2 alpha (Crotalus adamanteus)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
UMR 5154 CNRS Curated by ChEMBL					Assay Description Inhibition of Crotalus adamanteus venom phospholipase A2 by fluorometric assay				J Nat Prod 69: 1676-9 (2006) Article DOI: 10.1021/np060132r BindingDB Entry DOI: 10.7270/Q26W99VS
UMR 5154 CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Muséum National d'Histoire Naturelle Curated by ChEMBL					Assay Description Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis				Bioorg Med Chem 18: 6006-11 (2010) Article DOI: 10.1016/j.bmc.2010.06.066 BindingDB Entry DOI: 10.7270/Q24F1QXH
Muséum National d'Histoire Naturelle Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of bee venom phospholipase A2 after 5 mins by spectrophotometric analysis				Bioorg Med Chem Lett 21: 1261-4 (2011) Article DOI: 10.1016/j.bmcl.2010.12.056 BindingDB Entry DOI: 10.7270/Q2125SZK
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 group IIA (Rattus norvegicus)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of rat secretory Phospholipase A2 (group II).				J Med Chem 39: 5183-91 (1997) Article DOI: 10.1021/jm960437a BindingDB Entry DOI: 10.7270/Q2K64JQH
Shionogi& Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2, membrane associated (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+6	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibition of human recombinant secretory Phospholipase A2 (group II).				J Med Chem 39: 5183-91 (1997) Article DOI: 10.1021/jm960437a BindingDB Entry DOI: 10.7270/Q2K64JQH
Shionogi& Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Salerno Curated by ChEMBL					Assay Description Inhibitory activity against bee secretory Phospholipase A2 enzyme				J Med Chem 41: 3232-8 (1998) Article DOI: 10.1021/jm980027h BindingDB Entry DOI: 10.7270/Q2ZP46SH
Universit£ di Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2, membrane associated (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Salerno Curated by ChEMBL					Assay Description Inhibitory activity against human synovial recombinant Phospholipase enzyme				J Med Chem 41: 3232-8 (1998) Article DOI: 10.1021/jm980027h BindingDB Entry DOI: 10.7270/Q2ZP46SH
Universit£ di Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase kappa (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Connecticut Health Center Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...				J Med Chem 59: 9321-9336 (2016) BindingDB Entry DOI: 10.7270/Q2ZC84TJ
University of Connecticut Health Center Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase kappa (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Connecticut Health Center Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...				J Med Chem 59: 9321-9336 (2016) BindingDB Entry DOI: 10.7270/Q2ZC84TJ
University of Connecticut Health Center Curated by ChEMBL					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Napoli"Federico II" Curated by ChEMBL					Assay Description Inhibition of bee venom secretory PLA2				J Nat Prod 61: 571-5 (1998) Article DOI: 10.1021/np9704922 BindingDB Entry DOI: 10.7270/Q2M32WN8
					More data for this Ligand-Target Pair
Phospholipase A2 (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Napoli"Federico II" Curated by ChEMBL					Assay Description Inhibition of human synovial secretory PLA2				J Nat Prod 61: 571-5 (1998) Article DOI: 10.1021/np9704922 BindingDB Entry DOI: 10.7270/Q2M32WN8
					More data for this Ligand-Target Pair
Phospholipase A2, membrane associated (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of human synovial group2 sPLA2 at 10 uM by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair
Phospholipase A2 group IIA (Rattus norvegicus)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.84E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of rat air pouch group2 sPLA2 at 10 uM by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair
Phospholipase A2 (Bee) (Apis mellifera)	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of bee venom group3 sPLA2 at 10 uM by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair
Group IID secretory phospholipase A2 (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Concentration required for in vitro inhibitory activity against human type II phospholipase A2				Citation and Details Article DOI: 10.1016/0960-894X(95)00215-F BindingDB Entry DOI: 10.7270/Q2C53PJB
TBA					More data for this Ligand-Target Pair
Phospholipase A2, membrane associated (Homo sapiens (Human))	BDBM50250399 (5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Istituto per la Chimica di Molecole di Interesse Biologico CNR Curated by ChEMBL					Assay Description Inhibition of human synovial group2 sPLA2 by liquid scintillation counting				J Nat Prod 61: 931-5 (1998) Article DOI: 10.1021/np980122t BindingDB Entry DOI: 10.7270/Q2BK1D8H
					More data for this Ligand-Target Pair