Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Activin receptor type-1 (Mus musculus) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284 | US1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM102618 (LDN-212854) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase receptor R3 (Mus musculus) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.48 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase receptor R3 (Mus musculus) | BDBM102618 (LDN-212854) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Mus musculus) | BDBM102619 (K02288a | US10688093, Compound 382_0087_0284 | US1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.65 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM143311 (US10017516, Compound 11 | US9682983, 11) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM143311 (US10017516, Compound 11 | US9682983, 11) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM50056508 (CHEMBL3341945) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM161920 (US10017516, Compound 53 | US9682983, 52 | US968298...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50056506 (CHEMBL3341943 | US10688093, Compound 382_0087_6488...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM50056507 (CHEMBL3341944) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM161920 (US10017516, Compound 53 | US9682983, 52 | US968298...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM143311 (US10017516, Compound 11 | US9682983, 11) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM143311 (US10017516, Compound 11 | US9682983, 11) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161920 (US10017516, Compound 53 | US9682983, 52 | US968298...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161920 (US10017516, Compound 53 | US9682983, 52 | US968298...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161920 (US10017516, Compound 53 | US9682983, 52 | US968298...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human)) | BDBM143311 (US10017516, Compound 11 | US9682983, 11) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM50262685 (6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9.76 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50056680 (CHEMBL3341794) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50056508 (CHEMBL3341945) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM111123 (US10017516, Compound 2 | US9682983, 2) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM108945 (US10017516, Compound 48 | US9682983, 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM108945 (US10017516, Compound 48 | US9682983, 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM127883 (US10017516, Compound 6 | US9682983, 6) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Mus musculus) | BDBM36354 (4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161910 (US10017516, Compound 42 | US9682983, 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50056510 (CHEMBL3341947) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161910 (US10017516, Compound 42 | US9682983, 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1A (Mus musculus) | BDBM50262079 (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology | ACS Chem Biol 8: 1291-302 (2013) Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM148348 (US10017516, Compound 22 | US9682983, 22) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM160069 (US10017516, Compound 39 | US9682983, 39) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM50056675 (CHEMBL3341787) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology Curated by ChEMBL | Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P] | J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM160069 (US10017516, Compound 39 | US9682983, 39) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM148348 (US10017516, Compound 22 | US9682983, 22) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161914 (US10017516, Compound 46 | US9682983, 46) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM118134 (US10017516, Compound 3 | US9682983, 3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM143566 (US10017516, Compound 13 | US9682983, 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
The Brigham and Women's Hospital, Inc. US Patent | Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ... | US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM118134 (US10017516, Compound 3 | US9682983, 3) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM161914 (US10017516, Compound 46 | US9682983, 46) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.5 | n/a |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair |
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