Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18390 ((3R,5S)-6-[(3-{[(2,3-difluorophenyl)methyl]carbamo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18427 ((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3R)-3-phenylpip...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18372 ((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18425 ((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methylphenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18388 ((3R,5S)-6-{[3-(benzylcarbamoyl)-1-(4-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18426 ((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3-fluorophenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18420 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3R)-3-phenylpi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18394 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methylphenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18389 ((3R,5S)-6-({3-[benzyl(methyl)carbamoyl]-1-(4-fluor...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18400 ((3R,5S)-6-[(3-{[(3-chlorophenyl)methyl]carbamoyl}-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18409 ((3R,5S)-6-[(3-{[(3,4-difluorophenyl)methyl](methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18417 ((3R,5S)-6-({3-[(cyclohexylmethyl)(methyl)carbamoyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18424 ((3R,5R)-7-{3-[benzyl(methyl)carbamoyl]-1-(4-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18399 ((3R,5S)-6-[(3-{[(4-chlorophenyl)methyl]carbamoyl}-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18405 ((3R,5S)-6-[(3-{[(3-chlorophenyl)methyl](methyl)car...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18410 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-fluorophenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18401 ((3R,5S)-6-[(3-{[(2-chlorophenyl)methyl]carbamoyl}-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18419 ((3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18396 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18404 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-fluorophenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18391 ((3R,5S)-6-[(3-{[(2,3-difluorophenyl)methyl](methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18418 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-[(2-phenylpyrroli...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18414 ((3R,5S)-6-({3-[benzyl(ethyl)carbamoyl]-1-(4-fluoro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18393 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-methylphenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18413 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-[(2-phenylethyl)c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18402 ((3R,5S)-6-[(3-{[(3-ethoxyphenyl)methyl](methyl)car...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18397 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18395 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-methylphenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18415 ((3R,5S)-6-({3-[(cyclohexylmethyl)carbamoyl]-1-(4-f...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18411 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(4-fluorophenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18408 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18412 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(1R)-1-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18398 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(2-methoxypheny...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18422 ((3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM34017 (CHEMBL104850 | phenylpropanoic acid derivative, 7) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 29 | n/a | 26 | n/a | n/a | 7.4 | 23 |
Pfizer | Assay Description Human 6His-PPAR gamma ligand-binding domain was added to the mixture containing radioligand and test compound, followed by yttrium silicate polylysin... | Bioorg Med Chem 16: 4883-907 (2008) Article DOI: 10.1016/j.bmc.2008.03.043 BindingDB Entry DOI: 10.7270/Q2SN0797 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18423 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-({[3-(methoxymeth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18407 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-[methyl({[3-(trif...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18406 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(3-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18392 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-{methyl[(4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18403 ((3R,5S)-6-[(3-{[(3,5-dimethoxyphenyl)methyl](methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.2 | 37 |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18421 ((3R,5S)-6-{[1-(4-fluorophenyl)-3-(piperidin-1-ylca...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM18416 ((3R,5S)-6-{[3-(butylcarbamoyl)-1-(4-fluorophenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source... | Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM33284 (BMC164883 Compound 53 | phenylpropanoic acid deriv...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 185 | n/a | 140 | n/a | n/a | 7.4 | 23 |
Pfizer | Assay Description Human 6His-PPAR gamma ligand-binding domain was added to the mixture containing radioligand and test compound, followed by yttrium silicate polylysin... | Bioorg Med Chem 16: 4883-907 (2008) Article DOI: 10.1016/j.bmc.2008.03.043 BindingDB Entry DOI: 10.7270/Q2SN0797 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM34025 (phenylpropanoic acid derivative, 40) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 255 | n/a | 102 | n/a | n/a | 7.4 | 23 |
Pfizer | Assay Description Human 6His-PPAR gamma ligand-binding domain was added to the mixture containing radioligand and test compound, followed by yttrium silicate polylysin... | Bioorg Med Chem 16: 4883-907 (2008) Article DOI: 10.1016/j.bmc.2008.03.043 BindingDB Entry DOI: 10.7270/Q2SN0797 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM34018 (phenylpropanoic acid derivative, 28) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 293 | n/a | 173 | n/a | n/a | 7.4 | 23 |
Pfizer | Assay Description Human 6His-PPAR gamma ligand-binding domain was added to the mixture containing radioligand and test compound, followed by yttrium silicate polylysin... | Bioorg Med Chem 16: 4883-907 (2008) Article DOI: 10.1016/j.bmc.2008.03.043 BindingDB Entry DOI: 10.7270/Q2SN0797 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human)) | BDBM50286969 (CHEMBL367410 | N-{4-[2-(3,4-Dihydroxy-phenyl)-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity of the compound against reticulocyte 15-lipoxygenase in rabbit was evaluated. | Bioorg Med Chem Lett 6: 93-96 (1996) Article DOI: 10.1016/0960-894X(95)00565-B BindingDB Entry DOI: 10.7270/Q2VM4C7S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human)) | BDBM50286954 (CHEMBL176689 | N-{4-[3-(3,4-Dihydroxy-phenyl)-prop...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydropero... | Bioorg Med Chem Lett 6: 93-96 (1996) Article DOI: 10.1016/0960-894X(95)00565-B BindingDB Entry DOI: 10.7270/Q2VM4C7S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human)) | BDBM50286964 (CHEMBL177100 | N-{4-[4-(3,4-Dihydroxy-phenyl)-buty...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydropero... | Bioorg Med Chem Lett 6: 93-96 (1996) Article DOI: 10.1016/0960-894X(95)00565-B BindingDB Entry DOI: 10.7270/Q2VM4C7S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Rattus norvegicus) | BDBM22372 (4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity of the compound against rat basophilic leukemia cell 5-lipoxygenase | Bioorg Med Chem Lett 6: 93-96 (1996) Article DOI: 10.1016/0960-894X(95)00565-B BindingDB Entry DOI: 10.7270/Q2VM4C7S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX15 (Homo sapiens (Human)) | BDBM50286956 (1-Hydroxy-naphthalene-2-carboxylic acid {4-[2-(3,4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydropero... | Bioorg Med Chem Lett 6: 93-96 (1996) Article DOI: 10.1016/0960-894X(95)00565-B BindingDB Entry DOI: 10.7270/Q2VM4C7S | |||||||||||
More data for this Ligand-Target Pair |
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