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Compile Data Set for Download or QSAR

Found 60 hits with Last Name = 'cossette' and Initial = 'c'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465693
PNG
(CHEMBL4283608)
Show SMILES C[C@H](CC(O)=O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO3/c1-19(17-26(31)32)16-25(30)27-22-18-21(28)14-15-23(22)29(2)24(27)13-9-4-3-6-10-20-11-7-5-8-12-20/h5,7-8,11-12,14-15,18-19H,3-4,6,9-10,13,16-17H2,1-2H3,(H,31,32)/t19-/m0/s1
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n/an/a 0.120n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465682
PNG
(CHEMBL4287941)
Show SMILES CC(CC(O)=O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12
Show InChI InChI=1S/C27H32ClNO3/c1-19(17-26(31)32)16-25(30)27-22-18-21(28)14-15-23(22)29(2)24(27)13-9-4-3-6-10-20-11-7-5-8-12-20/h5,7-8,11-12,14-15,18-19H,3-4,6,9-10,13,16-17H2,1-2H3,(H,31,32)
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n/an/a 0.280n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465685
PNG
(CHEMBL4281149)
Show SMILES C[C@H](CC(O)=O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO4/c1-18(16-25(32)33)15-24(31)26-21-17-20(28)13-14-22(21)29(2)27(26)23(30)12-8-4-7-11-19-9-5-3-6-10-19/h3,5-6,9-10,13-14,17-18,23,30H,4,7-8,11-12,15-16H2,1-2H3,(H,32,33)/t18-,23-/m0/s1
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n/an/a 0.380n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465690
PNG
(CHEMBL4282356)
Show SMILES CC(CC(O)=O)CC(=O)n1c(CCCCCc2ccccc2)cc2ccc(Cl)cc12
Show InChI InChI=1S/C25H28ClNO3/c1-18(15-25(29)30)14-24(28)27-22(16-20-12-13-21(26)17-23(20)27)11-7-3-6-10-19-8-4-2-5-9-19/h2,4-5,8-9,12-13,16-18H,3,6-7,10-11,14-15H2,1H3,(H,29,30)
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n/an/a 2.10n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50054793
PNG
(CHEMBL3341972)
Show SMILES CCCCCCc1c(C(=O)C[C@H](C)CC(O)=O)c2cc(Cl)ccc2n1C |r|
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)/t14-/m0/s1
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Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446952
PNG
(CHEMBL3115775)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2cc(Cl)ccc2n1C
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 6n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465692
PNG
(CHEMBL4284672)
Show SMILES CC(CC(O)=O)CC(=O)c1c(CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12
Show InChI InChI=1S/C26H30ClNO3/c1-18(16-25(30)31)15-24(29)26-21-17-20(27)13-14-22(21)28(2)23(26)12-8-4-7-11-19-9-5-3-6-10-19/h3,5-6,9-10,13-14,17-18H,4,7-8,11-12,15-16H2,1-2H3,(H,30,31)
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n/an/a 11n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465681
PNG
(CHEMBL4277299)
Show SMILES CC(CC(O)=O)CC(=O)n1c(CCCCCCc2ccccc2)cc2ccc(Cl)cc12
Show InChI InChI=1S/C26H30ClNO3/c1-19(16-26(30)31)15-25(29)28-23(17-21-13-14-22(27)18-24(21)28)12-8-3-2-5-9-20-10-6-4-7-11-20/h4,6-7,10-11,13-14,17-19H,2-3,5,8-9,12,15-16H2,1H3,(H,30,31)
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n/an/a 12n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446952
PNG
(CHEMBL3115775)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2cc(Cl)ccc2n1C
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 17n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465695
PNG
(CHEMBL4291346)
Show SMILES CC(CC(O)=O)CC(=O)n1c(CCCCc2ccccc2)cc2ccc(Cl)cc12
Show InChI InChI=1S/C24H26ClNO3/c1-17(14-24(28)29)13-23(27)26-21(15-19-11-12-20(25)16-22(19)26)10-6-5-9-18-7-3-2-4-8-18/h2-4,7-8,11-12,15-17H,5-6,9-10,13-14H2,1H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465684
PNG
(CHEMBL4291464)
Show SMILES C[C@@H](CC(O)=O)CC(=O)c1c(CCCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO3/c1-19(17-26(31)32)16-25(30)27-22-18-21(28)14-15-23(22)29(2)24(27)13-9-4-3-6-10-20-11-7-5-8-12-20/h5,7-8,11-12,14-15,18-19H,3-4,6,9-10,13,16-17H2,1-2H3,(H,31,32)/t19-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446954
PNG
(CHEMBL3115793)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2cc(Br)ccc2n1C
Show InChI InChI=1S/C21H28BrNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 26n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446961
PNG
(CHEMBL3115786)
Show SMILES CCCCCCc1cc2ccc(Br)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26BrNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 30n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 30n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin ...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446952
PNG
(CHEMBL3115775)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2cc(Cl)ccc2n1C
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 33n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in anti-CD49d-labeled eosinophils assessed as inhibition of 5-oxo-ETE-induced F-actin ...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465683
PNG
(CHEMBL4279605)
Show SMILES CC(CC(O)=O)CC(=O)c1c(CCCCc2ccccc2)n(C)c2ccc(Cl)cc12
Show InChI InChI=1S/C25H28ClNO3/c1-17(15-24(29)30)14-23(28)25-20-16-19(26)12-13-21(20)27(2)22(25)11-7-6-10-18-8-4-3-5-9-18/h3-5,8-9,12-13,16-17H,6-7,10-11,14-15H2,1-2H3,(H,29,30)
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n/an/a 38n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465680
PNG
(CHEMBL4278772)
Show SMILES CC(CC(O)=O)CC(=O)c1c(CCCCCC(F)(F)F)n(C)c2ccc(Cl)cc12
Show InChI InChI=1S/C21H25ClF3NO3/c1-13(11-19(28)29)10-18(27)20-15-12-14(22)7-8-16(15)26(2)17(20)6-4-3-5-9-21(23,24)25/h7-8,12-13H,3-6,9-11H2,1-2H3,(H,28,29)
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n/an/a 38n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446955
PNG
(CHEMBL3115792)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2ccc(Cl)cc2n1C
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-17-21(19(24)11-14(2)12-20(25)26)16-10-9-15(22)13-18(16)23(17)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 81n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446965
PNG
(CHEMBL3115782)
Show SMILES CCCCCCc1cc2ccccc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H27NO3/c1-3-4-5-6-10-17-14-16-9-7-8-11-18(16)21(17)19(22)12-15(2)13-20(23)24/h7-9,11,14-15H,3-6,10,12-13H2,1-2H3,(H,23,24)
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n/an/a 90n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465686
PNG
(CHEMBL4277207)
Show SMILES C[C@@H](CC(O)=O)CC(=O)c1c([C@@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO4/c1-18(16-25(32)33)15-24(31)26-21-17-20(28)13-14-22(21)29(2)27(26)23(30)12-8-4-7-11-19-9-5-3-6-10-19/h3,5-6,9-10,13-14,17-18,23,30H,4,7-8,11-12,15-16H2,1-2H3,(H,32,33)/t18-,23+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446964
PNG
(CHEMBL3115783)
Show SMILES CCCCCCc1c(C)c2ccccc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C21H29NO3/c1-4-5-6-7-11-18-16(3)17-10-8-9-12-19(17)22(18)20(23)13-15(2)14-21(24)25/h8-10,12,15H,4-7,11,13-14H2,1-3H3,(H,24,25)
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n/an/a 136n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446962
PNG
(CHEMBL3115785)
Show SMILES CCCCCCc1cc2cc(Cl)ccc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-13-15-12-16(21)8-9-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 141n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465691
PNG
(CHEMBL4280693)
Show SMILES CC(CC(O)=O)CC(=O)n1c(CCCc2ccccc2)cc2ccc(Cl)cc12
Show InChI InChI=1S/C23H24ClNO3/c1-16(13-23(27)28)12-22(26)25-20(9-5-8-17-6-3-2-4-7-17)14-18-10-11-19(24)15-21(18)25/h2-4,6-7,10-11,14-16H,5,8-9,12-13H2,1H3,(H,27,28)
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n/an/a 210n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465688
PNG
(CHEMBL4287509)
Show SMILES CC(CC(O)=O)CC(=O)c1c(CCCc2ccccc2)n(C)c2ccc(Cl)cc12
Show InChI InChI=1S/C24H26ClNO3/c1-16(14-23(28)29)13-22(27)24-19-15-18(25)11-12-20(19)26(2)21(24)10-6-9-17-7-4-3-5-8-17/h3-5,7-8,11-12,15-16H,6,9-10,13-14H2,1-2H3,(H,28,29)
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n/an/a 223n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465689
PNG
(CHEMBL4285167)
Show SMILES C[C@H](CC(O)=O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO4/c1-18(16-25(32)33)15-24(31)26-21-17-20(28)13-14-22(21)29(2)27(26)23(30)12-8-4-7-11-19-9-5-3-6-10-19/h3,5-6,9-10,13-14,17-18,23,30H,4,7-8,11-12,15-16H2,1-2H3,(H,32,33)/t18-,23+/m0/s1
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n/an/a 260n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446956
PNG
(CHEMBL3115791)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2ccccc2n1C
Show InChI InChI=1S/C21H29NO3/c1-4-5-6-7-12-18-21(19(23)13-15(2)14-20(24)25)16-10-8-9-11-17(16)22(18)3/h8-11,15H,4-7,12-14H2,1-3H3,(H,24,25)
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n/an/a 314n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446960
PNG
(CHEMBL3115787)
Show SMILES CCCCCCc1cc2ccc(OC)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C21H29NO4/c1-4-5-6-7-8-17-13-16-9-10-18(26-3)14-19(16)22(17)20(23)11-15(2)12-21(24)25/h9-10,13-15H,4-8,11-12H2,1-3H3,(H,24,25)
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n/an/a 323n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 402n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs ...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446952
PNG
(CHEMBL3115775)
Show SMILES CCCCCCc1c(C(=O)CC(C)CC(O)=O)c2cc(Cl)ccc2n1C
Show InChI InChI=1S/C21H28ClNO3/c1-4-5-6-7-8-18-21(19(24)11-14(2)12-20(25)26)16-13-15(22)9-10-17(16)23(18)3/h9-10,13-14H,4-8,11-12H2,1-3H3,(H,25,26)
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n/an/a 454n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in neutrophils assessed as inhibition of 5-oxo-ETE-induced cell migration after 2 hrs ...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465687
PNG
(CHEBI:34146 | CHEMBL1526258)
Show SMILES CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446976
PNG
(CHEMBL3115777 | CHEMBL3115778)
Show SMILES CCCCC\C=C/C[C@H](O)\C=C\C=CC=CC(=O)CCCC(O)=O |r,w:15.15,13.13|
Show InChI InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18,21H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7?,9-6-,14-10+,15-11?/t18-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric anal...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446969
PNG
(CHEMBL3115800)
Show SMILES CCCCCCCCC\C=C/c1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C24H33NO3/c1-2-3-4-5-6-7-8-9-10-15-21-19-20-14-11-12-16-22(20)25(21)23(26)17-13-18-24(27)28/h10-12,14-16,19H,2-9,13,17-18H2,1H3,(H,27,28)/b15-10-
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n/an/a 550n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446957
PNG
(CHEMBL3115790)
Show SMILES CCCCCCc1c(C(=O)CCCC(O)=O)c2cc(Cl)ccc2n1C
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-8-17-20(18(23)9-7-10-19(24)25)15-13-14(21)11-12-16(15)22(17)2/h11-13H,3-10H2,1-2H3,(H,24,25)
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n/an/a 566n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446971
PNG
(CHEMBL3115798)
Show SMILES CCCCCCCCc1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C21H29NO3/c1-2-3-4-5-6-7-12-18-16-17-11-8-9-13-19(17)22(18)20(23)14-10-15-21(24)25/h8-9,11,13,16H,2-7,10,12,14-15H2,1H3,(H,24,25)
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n/an/a 570n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446963
PNG
(CHEMBL3115784)
Show SMILES CCCCCCc1cc2cc(Br)ccc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26BrNO3/c1-3-4-5-6-7-17-13-15-12-16(21)8-9-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 638n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446970
PNG
(CHEMBL3115799)
Show SMILES CCCCCCCCCCCc1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C24H35NO3/c1-2-3-4-5-6-7-8-9-10-15-21-19-20-14-11-12-16-22(20)25(21)23(26)17-13-18-24(27)28/h11-12,14,16,19H,2-10,13,15,17-18H2,1H3,(H,27,28)
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n/an/a 700n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446972
PNG
(CHEMBL3115797)
Show SMILES CCCCCCCc1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C20H27NO3/c1-2-3-4-5-6-11-17-15-16-10-7-8-12-18(16)21(17)19(22)13-9-14-20(23)24/h7-8,10,12,15H,2-6,9,11,13-14H2,1H3,(H,23,24)
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n/an/a 750n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50465694
PNG
(CHEMBL4292357)
Show SMILES C[C@@H](CC(O)=O)CC(=O)c1c([C@H](O)CCCCCc2ccccc2)n(C)c2ccc(Cl)cc12 |r|
Show InChI InChI=1S/C27H32ClNO4/c1-18(16-25(32)33)15-24(31)26-21-17-20(28)13-14-22(21)29(2)27(26)23(30)12-8-4-7-11-19-9-5-3-6-10-19/h3,5-6,9-10,13-14,17-18,23,30H,4,7-8,11-12,15-16H2,1-2H3,(H,32,33)/t18-,23-/m1/s1
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n/an/a 750n/an/an/an/an/an/a



Florida Institute of Technology

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization incubated for 2 mins follow...

J Med Chem 61: 5934-5948 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00154
BindingDB Entry DOI: 10.7270/Q22F7R48
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50431184
PNG
(CHEMBL2332567)
Show SMILES CCCCCCc1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C19H25NO3/c1-2-3-4-5-10-16-14-15-9-6-7-11-17(15)20(16)18(21)12-8-13-19(22)23/h6-7,9,11,14H,2-5,8,10,12-13H2,1H3,(H,22,23)
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n/an/a 1.13E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446967
PNG
(CHEMBL3115780)
Show SMILES CCCCCCc1cc2ccccc2n1C(=O)CC1(CC(O)=O)CC1
Show InChI InChI=1S/C21H27NO3/c1-2-3-4-5-9-17-13-16-8-6-7-10-18(16)22(17)19(23)14-21(11-12-21)15-20(24)25/h6-8,10,13H,2-5,9,11-12,14-15H2,1H3,(H,24,25)
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n/an/a 1.63E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50210259
PNG
((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hex...)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O
Show InChI InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
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n/an/a 2.00E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid s...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50242349
PNG
((5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic ...)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
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n/an/a 2.00E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid s...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50269535
PNG
((11Z,14Z,17Z)-Eicosa-11,14,17-trienoic acid | (11Z...)
Show SMILES CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O
Show InChI InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10H,2,5,8,11-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-
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n/an/a 2.00E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid s...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50269534
PNG
((8Z,11Z,14Z)-Icosatrienoic acid | (8Z,11Z,14Z)-ico...)
Show SMILES CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
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n/an/a 2.00E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at human OXE receptor fused with G-alphai assessed as inhibition of 5-oxo-ETE-induced GTPgammaS binding after 60 mins by liquid s...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446974
PNG
(CHEMBL3115795)
Show SMILES CCCCCc1cc2ccccc2n1C(=O)CCCC(O)=O
Show InChI InChI=1S/C18H23NO3/c1-2-3-4-9-15-13-14-8-5-6-10-16(14)19(15)17(20)11-7-12-18(21)22/h5-6,8,10,13H,2-4,7,9,11-12H2,1H3,(H,21,22)
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n/an/a 2.15E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 2.17E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446953
PNG
(CHEMBL3115774)
Show SMILES CCCCCCc1cc2ccc(Cl)cc2n1C(=O)CC(C)CC(O)=O
Show InChI InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
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n/an/a 2.18E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor (unknown origin) expressed in indo-1 loaded neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobil...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
Oxoeicosanoid receptor 1


(Homo sapiens (Human))		BDBM50446976
PNG
(CHEMBL3115777 | CHEMBL3115778)
Show SMILES CCCCC\C=C/C[C@H](O)\C=C\C=CC=CC(=O)CCCC(O)=O |r,w:15.15,13.13|
Show InChI InChI=1S/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18,21H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7?,9-6-,14-10+,15-11?/t18-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



McGill University

Curated by ChEMBL


Assay Description
Antagonist activity at OXE receptor in human neutrophils assessed as inhibition of 5-oxo-ETE-induced calcium mobilization by spectrofluorometric anal...

J Med Chem 57: 364-77 (2014)


Article DOI: 10.1021/jm401292m
BindingDB Entry DOI: 10.7270/Q2N87C82
More data for this
Ligand-Target Pair
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