Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50445691![]() (CHEMBL243677) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM7461![]() (5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50157555![]() (2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50445690![]() (CHEMBL457821) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM50312650![]() (5,4'-dihydroxyflavone | 5-hydroxy-2-(4-hydroxyphen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM7460![]() (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM7459![]() (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.22E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Seed linoleate 13S-lipoxygenase-1 (Glycine max (soybean)) | BDBM7458![]() (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.78E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM7459![]() (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50157555![]() (2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50077325![]() (2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fructose-1,6-bisphosphatase 1 (Homo sapiens (Human)) | BDBM18137![]() (AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | J Nat Prod 83: 1541-1552 (2020) Article DOI: 10.1021/acs.jnatprod.0c00014 BindingDB Entry DOI: 10.7270/Q2ZW1QH2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM50445691![]() (CHEMBL243677) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human)) | BDBM7460![]() (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade do Porto Curated by ChEMBL | Assay Description Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ... | Eur J Med Chem 72: 137-45 (2014) Article DOI: 10.1016/j.ejmech.2013.11.030 BindingDB Entry DOI: 10.7270/Q27H1M2P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fructose-1,6-bisphosphatase 1 (Homo sapiens (Human)) | BDBM50304350![]() (CHEMBL611029 | Herbacetin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | J Nat Prod 83: 1541-1552 (2020) Article DOI: 10.1021/acs.jnatprod.0c00014 BindingDB Entry DOI: 10.7270/Q2ZW1QH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fructose-1,6-bisphosphatase 1 (Homo sapiens (Human)) | BDBM26655![]() (2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-ch...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | J Nat Prod 83: 1541-1552 (2020) Article DOI: 10.1021/acs.jnatprod.0c00014 BindingDB Entry DOI: 10.7270/Q2ZW1QH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fructose-1,6-bisphosphatase 1 (Homo sapiens (Human)) | BDBM50009001![]() (5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | J Nat Prod 83: 1541-1552 (2020) Article DOI: 10.1021/acs.jnatprod.0c00014 BindingDB Entry DOI: 10.7270/Q2ZW1QH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fructose-1,6-bisphosphatase 1 (Homo sapiens (Human)) | BDBM23411![]() (5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Porto Curated by ChEMBL | Assay Description Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | J Nat Prod 83: 1541-1552 (2020) Article DOI: 10.1021/acs.jnatprod.0c00014 BindingDB Entry DOI: 10.7270/Q2ZW1QH2 | |||||||||||
More data for this Ligand-Target Pair |