Found 977 hits with Last Name = 'trivedi' and Initial = 'd' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134955
(CHEMBL2370968 | H-Tyr-Val-Nle-Gly-Pro-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:4.4,79.84,65.68,54.57,wD:35.37,8.8,39.40,98.103,87.92,12.12,(2.89,-5.82,;3.92,-6.96,;3.45,-8.43,;4.48,-9.57,;4,-11.03,;2.49,-11.35,;1.46,-10.21,;1.94,-8.75,;-.04,-10.53,;-1.07,-9.39,;-2.58,-9.71,;-3.06,-11.17,;-3.61,-8.56,;-3.13,-7.1,;-5.12,-8.88,;-6.15,-7.74,;-5.67,-6.27,;-6.7,-5.13,;-8.21,-5.45,;-9.24,-4.3,;-8.68,-6.91,;-7.65,-8.06,;-.52,-12,;.51,-13.14,;-2.03,-12.32,;5.03,-12.18,;4.55,-13.64,;6.54,-11.86,;7.57,-13,;9.07,-12.68,;9.55,-11.22,;10.1,-13.83,;9.78,-15.33,;11.12,-16.1,;12.26,-15.07,;11.64,-13.67,;12.41,-12.33,;13.95,-12.33,;11.64,-11,;12.41,-9.67,;11.64,-8.33,;10.1,-8.33,;9.33,-9.67,;7.79,-9.67,;7.02,-8.33,;5.48,-8.33,;4.71,-7,;5.48,-5.66,;7.02,-5.66,;7.79,-7,;9.33,-7,;13.95,-9.67,;13.78,-8.13,;14.72,-11,;16.26,-11,;17.03,-9.67,;16.26,-8.33,;14.72,-8.33,;13.95,-7,;14.72,-5.66,;13.95,-4.33,;16.26,-5.66,;17.03,-12.33,;16.26,-13.67,;18.57,-12.33,;19.34,-11,;18.57,-9.67,;19.34,-8.33,;20.87,-8.17,;21.19,-6.66,;19.85,-5.89,;19.53,-4.39,;18.07,-3.91,;16.92,-4.94,;17.24,-6.45,;18.71,-6.92,;20.88,-11,;21.65,-9.67,;21.65,-12.33,;23.19,-12.33,;23.96,-11,;25.5,-11,;26.27,-9.67,;26.27,-12.33,;23.96,-13.67,;23.19,-15,;25.5,-13.67,;26.27,-15,;25.5,-16.33,;23.96,-16.33,;23.19,-17.67,;23.96,-19,;23.19,-20.33,;23.96,-21.67,;21.65,-20.33,;27.81,-15,;28.58,-13.67,;28.58,-16.33,;30.12,-16.33,;30.89,-17.67,;30.12,-19,;28.58,-19,;27.81,-20.33,;28.58,-21.67,;30.12,-21.67,;30.89,-20.33,;30.89,-15,;32.43,-15,;30.12,-13.67,;30.89,-12.33,;30.12,-11,;28.58,-11,;30.89,-9.67,)| Show InChI InChI=1S/C78H104N20O15/c1-4-5-21-55(92-76(113)66(44(2)3)97-67(104)53(79)36-46-27-30-51(99)31-28-46)68(105)89-43-64(101)98-34-15-25-62(98)75(112)96-59(38-47-26-29-48-18-9-10-19-49(48)35-47)72(109)90-57(24-14-33-86-78(83)84)71(108)94-60(39-50-41-87-54-22-12-11-20-52(50)54)73(110)95-61(40-65(102)103)74(111)91-56(23-13-32-85-77(81)82)70(107)93-58(69(106)88-42-63(80)100)37-45-16-7-6-8-17-45/h6-12,16-20,22,26-31,35,41,44,53,55-62,66,87,99H,4-5,13-15,21,23-25,32-34,36-40,42-43,79H2,1-3H3,(H2,80,100)(H,88,106)(H,89,105)(H,90,109)(H,91,111)(H,92,113)(H,93,107)(H,94,108)(H,95,110)(H,96,112)(H,97,104)(H,102,103)(H4,81,82,85)(H4,83,84,86)/t53-,55-,56-,57-,58-,59?,60-,61-,62-,66-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134955
(CHEMBL2370968 | H-Tyr-Val-Nle-Gly-Pro-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:4.4,79.84,65.68,54.57,wD:35.37,8.8,39.40,98.103,87.92,12.12,(2.89,-5.82,;3.92,-6.96,;3.45,-8.43,;4.48,-9.57,;4,-11.03,;2.49,-11.35,;1.46,-10.21,;1.94,-8.75,;-.04,-10.53,;-1.07,-9.39,;-2.58,-9.71,;-3.06,-11.17,;-3.61,-8.56,;-3.13,-7.1,;-5.12,-8.88,;-6.15,-7.74,;-5.67,-6.27,;-6.7,-5.13,;-8.21,-5.45,;-9.24,-4.3,;-8.68,-6.91,;-7.65,-8.06,;-.52,-12,;.51,-13.14,;-2.03,-12.32,;5.03,-12.18,;4.55,-13.64,;6.54,-11.86,;7.57,-13,;9.07,-12.68,;9.55,-11.22,;10.1,-13.83,;9.78,-15.33,;11.12,-16.1,;12.26,-15.07,;11.64,-13.67,;12.41,-12.33,;13.95,-12.33,;11.64,-11,;12.41,-9.67,;11.64,-8.33,;10.1,-8.33,;9.33,-9.67,;7.79,-9.67,;7.02,-8.33,;5.48,-8.33,;4.71,-7,;5.48,-5.66,;7.02,-5.66,;7.79,-7,;9.33,-7,;13.95,-9.67,;13.78,-8.13,;14.72,-11,;16.26,-11,;17.03,-9.67,;16.26,-8.33,;14.72,-8.33,;13.95,-7,;14.72,-5.66,;13.95,-4.33,;16.26,-5.66,;17.03,-12.33,;16.26,-13.67,;18.57,-12.33,;19.34,-11,;18.57,-9.67,;19.34,-8.33,;20.87,-8.17,;21.19,-6.66,;19.85,-5.89,;19.53,-4.39,;18.07,-3.91,;16.92,-4.94,;17.24,-6.45,;18.71,-6.92,;20.88,-11,;21.65,-9.67,;21.65,-12.33,;23.19,-12.33,;23.96,-11,;25.5,-11,;26.27,-9.67,;26.27,-12.33,;23.96,-13.67,;23.19,-15,;25.5,-13.67,;26.27,-15,;25.5,-16.33,;23.96,-16.33,;23.19,-17.67,;23.96,-19,;23.19,-20.33,;23.96,-21.67,;21.65,-20.33,;27.81,-15,;28.58,-13.67,;28.58,-16.33,;30.12,-16.33,;30.89,-17.67,;30.12,-19,;28.58,-19,;27.81,-20.33,;28.58,-21.67,;30.12,-21.67,;30.89,-20.33,;30.89,-15,;32.43,-15,;30.12,-13.67,;30.89,-12.33,;30.12,-11,;28.58,-11,;30.89,-9.67,)| Show InChI InChI=1S/C78H104N20O15/c1-4-5-21-55(92-76(113)66(44(2)3)97-67(104)53(79)36-46-27-30-51(99)31-28-46)68(105)89-43-64(101)98-34-15-25-62(98)75(112)96-59(38-47-26-29-48-18-9-10-19-49(48)35-47)72(109)90-57(24-14-33-86-78(83)84)71(108)94-60(39-50-41-87-54-22-12-11-20-52(50)54)73(110)95-61(40-65(102)103)74(111)91-56(23-13-32-85-77(81)82)70(107)93-58(69(106)88-42-63(80)100)37-45-16-7-6-8-17-45/h6-12,16-20,22,26-31,35,41,44,53,55-62,66,87,99H,4-5,13-15,21,23-25,32-34,36-40,42-43,79H2,1-3H3,(H2,80,100)(H,88,106)(H,89,105)(H,90,109)(H,91,111)(H,92,113)(H,93,107)(H,94,108)(H,95,110)(H,96,112)(H,97,104)(H,102,103)(H4,81,82,85)(H4,83,84,86)/t53-,55-,56-,57-,58-,59?,60-,61-,62-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114077
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES C[C@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O Show InChI InChI=1S/C36H51N13O7/c1-20-32(53)48-26(10-6-14-42-36(38)39)33(54)49-27(15-21-17-43-24-8-3-2-7-23(21)24)35(56)47-25(31(37)52)9-4-5-13-41-29(50)11-12-30(51)46-28(34(55)45-20)16-22-18-40-19-44-22/h2-3,7-8,17-20,25-28,43H,4-6,9-16H2,1H3,(H2,37,52)(H,40,44)(H,41,50)(H,45,55)(H,46,51)(H,47,56)(H,48,53)(H,49,54)(H4,38,39,42)/t20-,25-,26+,27-,28+/m1/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114085
((O)C-(C6H4)-C(O)-c[His-D-Phe-Arg-Trp-Lys]-NH2) (MK...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2ccccc2C(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H55N13O7/c47-39(60)34-17-8-9-19-51-40(61)31-14-4-5-15-32(31)41(62)57-38(23-29-25-50-26-54-29)45(66)58-36(21-27-11-2-1-3-12-27)43(64)56-35(18-10-20-52-46(48)49)42(63)59-37(44(65)55-34)22-28-24-53-33-16-7-6-13-30(28)33/h1-7,11-16,24-26,34-38,53H,8-10,17-23H2,(H2,47,60)(H,50,54)(H,51,61)(H,55,65)(H,56,64)(H,57,62)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36-,37-,38+/m1/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114083
(9-Benzyl-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3...)Show SMILES C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C39H48N10O7/c1-23-36(53)48-31(18-25-20-43-28-12-6-5-11-27(25)28)38(55)47-29(35(40)52)13-7-8-16-42-33(50)14-15-34(51)46-32(19-26-21-41-22-44-26)39(56)49-30(37(54)45-23)17-24-9-3-2-4-10-24/h2-6,9-12,20-23,29-32,43H,7-8,13-19H2,1H3,(H2,40,52)(H,41,44)(H,42,50)(H,45,54)(H,46,51)(H,47,55)(H,48,53)(H,49,56)/t23-,29+,30+,31+,32-/m0/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114077
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES C[C@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O Show InChI InChI=1S/C36H51N13O7/c1-20-32(53)48-26(10-6-14-42-36(38)39)33(54)49-27(15-21-17-43-24-8-3-2-7-23(21)24)35(56)47-25(31(37)52)9-4-5-13-41-29(50)11-12-30(51)46-28(34(55)45-20)16-22-18-40-19-44-22/h2-3,7-8,17-20,25-28,43H,4-6,9-16H2,1H3,(H2,37,52)(H,40,44)(H,41,50)(H,45,55)(H,46,51)(H,47,56)(H,48,53)(H,49,54)(H4,38,39,42)/t20-,25-,26+,27-,28+/m1/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114088
(9-Benzyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)Show SMILES C[C@@H]1NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O Show InChI InChI=1S/C39H53N11O7/c1-23-35(54)49-30(20-24-10-3-2-4-11-24)37(56)48-29(15-9-19-44-39(41)42)36(55)50-31(21-25-22-45-27-13-6-5-12-26(25)27)38(57)47-28(34(40)53)14-7-8-18-43-32(51)16-17-33(52)46-23/h2-6,10-13,22-23,28-31,45H,7-9,14-21H2,1H3,(H2,40,53)(H,43,51)(H,46,52)(H,47,57)(H,48,56)(H,49,54)(H,50,55)(H4,41,42,44)/t23-,28+,29-,30+,31+/m0/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114083
(9-Benzyl-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3...)Show SMILES C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C39H48N10O7/c1-23-36(53)48-31(18-25-20-43-28-12-6-5-11-27(25)28)38(55)47-29(35(40)52)13-7-8-16-42-33(50)14-15-34(51)46-32(19-26-21-41-22-44-26)39(56)49-30(37(54)45-23)17-24-9-3-2-4-10-24/h2-6,9-12,20-23,29-32,43H,7-8,13-19H2,1H3,(H2,40,52)(H,41,44)(H,42,50)(H,45,54)(H,46,51)(H,47,55)(H,48,53)(H,49,56)/t23-,29+,30+,31+,32-/m0/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114077
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES C[C@H]1NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O Show InChI InChI=1S/C36H51N13O7/c1-20-32(53)48-26(10-6-14-42-36(38)39)33(54)49-27(15-21-17-43-24-8-3-2-7-23(21)24)35(56)47-25(31(37)52)9-4-5-13-41-29(50)11-12-30(51)46-28(34(55)45-20)16-22-18-40-19-44-22/h2-3,7-8,17-20,25-28,43H,4-6,9-16H2,1H3,(H2,37,52)(H,40,44)(H,41,50)(H,45,55)(H,46,51)(H,47,56)(H,48,53)(H,49,54)(H4,38,39,42)/t20-,25-,26+,27-,28+/m1/s1 | PDB
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| <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114079
(15-(2-Acetylamino-hexanoylamino)-9-benzyl-6-(3-gua...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O |r| Show InChI InChI=1S/C51H71N15O9/c1-3-4-17-37(60-30(2)67)45(70)66-42-26-43(68)56-21-12-6-9-19-36(44(52)69)61-48(73)40(24-32-27-58-35-18-11-10-16-34(32)35)64-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-5-8-15-31)63-49(74)41(65-50(42)75)25-33-28-55-29-59-33/h5,7-8,10-11,14-16,18,27-29,36-42,58H,3-4,6,9,12-13,17,19-26H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57) | PDB
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114079
(15-(2-Acetylamino-hexanoylamino)-9-benzyl-6-(3-gua...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O |r| Show InChI InChI=1S/C51H71N15O9/c1-3-4-17-37(60-30(2)67)45(70)66-42-26-43(68)56-21-12-6-9-19-36(44(52)69)61-48(73)40(24-32-27-58-35-18-11-10-16-34(32)35)64-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-5-8-15-31)63-49(74)41(65-50(42)75)25-33-28-55-29-59-33/h5,7-8,10-11,14-16,18,27-29,36-42,58H,3-4,6,9,12-13,17,19-26H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57) | PDB
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| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134947
(CHEMBL2370963 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-D-Na...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:42.44,8.22,87.92,wD:79.84,32.33,64.67,98.103,12.13,53.56,4.3,(.12,-14.56,;-1.22,-13.8,;-1.21,-12.3,;-2.57,-11.56,;-2.54,-10.05,;-3.91,-9.29,;-5.27,-10.03,;-5.27,-11.53,;-6.6,-9.26,;-7.96,-10.02,;-9.3,-9.26,;-9.3,-7.76,;-10.66,-10,;-11.99,-9.23,;-10.69,-11.5,;-9.33,-12.24,;-9.33,-13.76,;-7.99,-14.51,;-6.64,-13.77,;-5.3,-14.54,;-6.63,-12.27,;-7.97,-11.52,;-6.6,-7.77,;-5.24,-7.04,;-7.94,-7.01,;-1.19,-9.31,;-1.18,-7.8,;.15,-10.05,;1.51,-9.32,;2.85,-10.08,;2.84,-11.59,;4.21,-9.34,;5.54,-10.08,;5.54,-11.6,;6.89,-12.35,;8.32,-11.76,;9.34,-12.89,;8.55,-14.17,;7.05,-13.86,;6.9,-9.36,;6.92,-7.86,;8.26,-10.13,;9.62,-9.37,;9.6,-7.87,;10.7,-6.81,;10.28,-5.37,;11.38,-4.29,;12.89,-4.68,;13.29,-6.13,;12.21,-7.19,;10.96,-10.11,;10.93,-11.6,;12.31,-9.37,;13.66,-10.13,;13.66,-11.63,;14.99,-12.38,;14.98,-13.88,;16.32,-14.65,;16.31,-16.15,;17.66,-16.91,;14.96,-16.89,;15.02,-9.37,;15.02,-7.89,;16.35,-10.14,;17.71,-9.4,;17.73,-7.87,;16.95,-6.53,;15.41,-6.53,;14.62,-5.19,;15.39,-3.84,;14.62,-2.5,;15.39,-1.14,;16.95,-1.14,;17.73,-2.5,;16.95,-3.84,;17.73,-5.17,;19.08,-10.14,;19.07,-11.64,;20.43,-9.4,;21.77,-10.17,;21.77,-11.67,;23.11,-12.43,;24.47,-11.67,;23.11,-13.93,;23.13,-9.43,;23.13,-7.93,;24.47,-10.19,;25.83,-9.43,;25.83,-7.94,;27.21,-7.21,;27.22,-5.7,;28.57,-4.97,;28.58,-3.46,;29.93,-2.72,;27.24,-2.7,;27.18,-10.2,;27.16,-11.7,;28.52,-9.46,;29.89,-10.22,;29.88,-11.73,;31.22,-12.48,;32.57,-11.75,;33.92,-12.49,;33.92,-14,;32.55,-14.74,;31.21,-13.97,;31.24,-9.48,;31.25,-7.98,;32.58,-10.22,;33.94,-9.51,;35.28,-10.25,;36.64,-9.51,;35.28,-11.76,)| Show InChI InChI=1S/C77H103N21O15/c1-4-5-22-54(93-75(113)65(44(2)3)98-66(104)53(78)34-47-26-29-52(99)30-27-47)67(105)88-42-63(101)90-60(38-51-40-84-43-89-51)73(111)96-58(36-46-18-10-7-11-19-46)71(109)91-56(24-15-32-86-77(82)83)70(108)95-59(37-48-25-28-49-20-12-13-21-50(49)33-48)72(110)97-61(39-64(102)103)74(112)92-55(23-14-31-85-76(80)81)69(107)94-57(68(106)87-41-62(79)100)35-45-16-8-6-9-17-45/h6-13,16-21,25-30,33,40,43-44,53-61,65,99H,4-5,14-15,22-24,31-32,34-39,41-42,78H2,1-3H3,(H2,79,100)(H,84,89)(H,87,106)(H,88,105)(H,90,101)(H,91,109)(H,92,112)(H,93,113)(H,94,107)(H,95,108)(H,96,111)(H,97,110)(H,98,104)(H,102,103)(H4,80,81,85)(H4,82,83,86)/t53-,54-,55-,56-,57-,58-,59?,60-,61-,65-/m0/s1 | PDB
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PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134954
(CHEMBL439128 | H-Tyr-Val-Nle-c[Cys-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C77H105N23O14S2/c1-4-5-21-53(94-75(114)64(43(2)3)100-65(104)51(78)31-46-25-27-49(101)28-26-46)70(109)98-60-40-115-116-41-61(74(113)93-55(24-15-30-86-77(82)83)68(107)95-56(66(105)88-38-62(79)102)32-44-16-8-6-9-17-44)99-72(111)58(34-47-36-87-52-22-13-12-20-50(47)52)97-69(108)54(23-14-29-85-76(80)81)92-71(110)57(33-45-18-10-7-11-19-45)96-73(112)59(35-48-37-84-42-90-48)91-63(103)39-89-67(60)106/h6-13,16-20,22,25-28,36-37,42-43,51,53-61,64,87,101H,4-5,14-15,21,23-24,29-35,38-41,78H2,1-3H3,(H2,79,102)(H,84,90)(H,88,105)(H,89,106)(H,91,103)(H,92,110)(H,93,113)(H,94,114)(H,95,107)(H,96,112)(H,97,108)(H,98,109)(H,99,111)(H,100,104)(H4,80,81,85)(H4,82,83,86)/t51-,53-,54-,55-,56-,57+,58-,59-,60+,61-,64-/m0/s1 | PDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50131874
(Ac-c[Cys-Glu-His-D-Nal(2')-Arg-Trp-Gly-Cys]-Pro-Pr...)Show SMILES CC(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)CN1CCC[C@H]1C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(O)=O)C(N)=O Show InChI InChI=1S/C74H99N19O17S2/c1-41(94)48-38-111-112-39-57(73(110)93-26-10-18-59(93)62(97)37-92-25-9-17-58(92)61(96)35-82-50(15-6-7-23-75)60(95)34-83-53(66(76)103)31-65(101)102)86-63(98)36-84-68(105)55(29-45-32-81-49-14-5-4-13-47(45)49)90-69(106)51(16-8-24-80-74(77)78)88-71(108)54(28-42-19-20-43-11-2-3-12-44(43)27-42)89-72(109)56(30-46-33-79-40-85-46)91-70(107)52(87-67(48)104)21-22-64(99)100/h2-5,11-14,19-20,27,32-33,40,48,50-59,81-83H,6-10,15-18,21-26,28-31,34-39,75H2,1H3,(H2,76,103)(H,79,85)(H,84,105)(H,86,98)(H,87,104)(H,88,108)(H,89,109)(H,90,106)(H,91,107)(H,99,100)(H,101,102)(H4,77,78,80)/t48-,50-,51-,52+,53-,54-,55+,56-,57-,58-,59-/m0/s1 | PDB
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| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibitory activity against human melanocortin receptor human Melanocortin 4 receptor was determined |
J Med Chem 46: 3728-33 (2003)
Article DOI: 10.1021/jm030111j
BindingDB Entry DOI: 10.7270/Q2125TDT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134950
(CHEMBL2370967 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:8.22,91.97,wD:83.89,32.33,42.44,68.72,102.108,12.13,57.61,4.3,(.36,-20.35,;-.98,-19.59,;-.98,-18.08,;-2.32,-17.35,;-2.31,-15.84,;-3.66,-15.08,;-5.02,-15.82,;-5.03,-17.32,;-6.35,-15.06,;-7.72,-15.79,;-9.06,-15.03,;-9.06,-13.54,;-10.42,-15.79,;-11.76,-15.03,;-10.43,-17.29,;-9.08,-18.04,;-7.73,-17.3,;-6.38,-18.05,;-6.41,-19.56,;-5.05,-20.32,;-7.75,-20.31,;-9.08,-19.56,;-6.35,-13.55,;-7.69,-12.79,;-5,-12.81,;-.96,-15.09,;-.95,-13.58,;.39,-15.85,;1.74,-15.11,;3.08,-15.87,;3.06,-17.39,;4.45,-15.14,;5.79,-15.89,;5.44,-17.36,;5.44,-18.84,;4.02,-19.45,;4.16,-20.93,;5.68,-21.27,;6.48,-19.97,;7.13,-15.15,;7.16,-13.64,;8.48,-15.9,;9.83,-15.17,;9.83,-13.63,;9.42,-12.13,;10.52,-11.02,;10.11,-9.54,;8.61,-9.15,;8.2,-7.65,;6.69,-7.27,;5.62,-8.38,;6.02,-9.86,;7.53,-10.26,;7.94,-11.75,;11.19,-15.9,;11.17,-17.4,;12.53,-15.17,;13.87,-15.92,;13.87,-17.43,;15.21,-18.19,;15.2,-19.68,;16.54,-20.46,;16.53,-21.95,;17.88,-22.7,;15.18,-22.7,;15.24,-15.18,;15.24,-13.69,;16.57,-15.93,;17.94,-15.21,;17.94,-13.67,;17.53,-12.17,;18.64,-11.07,;18.22,-9.57,;16.72,-9.18,;16.3,-7.68,;14.8,-7.3,;13.71,-8.41,;14.13,-9.89,;15.61,-10.3,;16.04,-11.78,;19.27,-15.96,;19.26,-17.46,;20.63,-15.23,;21.98,-15.98,;21.97,-17.49,;23.28,-18.25,;24.65,-17.49,;23.28,-19.74,;23.33,-15.24,;23.34,-13.74,;24.68,-15.99,;26.02,-15.25,;26.03,-13.75,;27.4,-13.02,;27.41,-11.51,;28.75,-10.76,;28.78,-9.27,;30.11,-8.52,;27.43,-8.49,;27.37,-16.02,;27.37,-17.52,;28.72,-15.26,;30.07,-16.04,;30.05,-17.53,;31.39,-18.29,;32.76,-17.56,;34.09,-18.32,;34.09,-19.82,;32.73,-20.55,;31.39,-19.8,;31.42,-15.29,;31.44,-13.78,;32.76,-16.05,;34.12,-15.31,;35.46,-16.08,;36.82,-15.32,;35.46,-17.58,)| Show InChI InChI=1S/C81H105N21O15/c1-4-5-21-58(97-79(117)69(46(2)3)102-70(108)57(82)36-48-26-30-56(103)31-27-48)71(109)92-44-67(105)94-64(40-55-42-88-45-93-55)77(115)100-62(38-49-24-28-51-17-9-11-19-53(51)34-49)75(113)95-60(23-14-33-90-81(86)87)74(112)99-63(39-50-25-29-52-18-10-12-20-54(52)35-50)76(114)101-65(41-68(106)107)78(116)96-59(22-13-32-89-80(84)85)73(111)98-61(72(110)91-43-66(83)104)37-47-15-7-6-8-16-47/h6-12,15-20,24-31,34-35,42,45-46,57-65,69,103H,4-5,13-14,21-23,32-33,36-41,43-44,82H2,1-3H3,(H2,83,104)(H,88,93)(H,91,110)(H,92,109)(H,94,105)(H,95,113)(H,96,116)(H,97,117)(H,98,111)(H,99,112)(H,100,115)(H,101,114)(H,102,108)(H,106,107)(H4,84,85,89)(H4,86,87,90)/t57-,58-,59-,60-,61-,62?,63?,64-,65-,69-/m0/s1 | PDB
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| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134951
(CHEMBL409636 | H-Tyr-Val-Nle-c[Asp-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C79H109N23O14/c1-4-5-23-55(96-77(116)66(45(2)3)102-67(106)53(80)35-48-28-30-51(103)31-29-48)70(109)101-63-40-65(105)87-32-15-14-25-56(69(108)93-57(26-16-33-88-78(82)83)71(110)97-59(68(107)91-43-64(81)104)36-46-18-8-6-9-19-46)94-74(113)61(38-49-41-90-54-24-13-12-22-52(49)54)99-72(111)58(27-17-34-89-79(84)85)95-73(112)60(37-47-20-10-7-11-21-47)98-75(114)62(100-76(63)115)39-50-42-86-44-92-50/h6-13,18-22,24,28-31,41-42,44-45,53,55-63,66,90,103H,4-5,14-17,23,25-27,32-40,43,80H2,1-3H3,(H2,81,104)(H,86,92)(H,87,105)(H,91,107)(H,93,108)(H,94,113)(H,95,112)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,115)(H,101,109)(H,102,106)(H4,82,83,88)(H4,84,85,89)/t53-,55-,56+,57-,58-,59-,60+,61+,62-,63-,66-/m0/s1 | PDB
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| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114087
(9-Benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C42H55N13O7/c43-37(58)30-13-6-7-17-47-35(56)15-16-36(57)51-34(21-27-23-46-24-50-27)41(62)54-32(19-25-9-2-1-3-10-25)39(60)53-31(14-8-18-48-42(44)45)38(59)55-33(40(61)52-30)20-26-22-49-29-12-5-4-11-28(26)29/h1-5,9-12,22-24,30-34,49H,6-8,13-21H2,(H2,43,58)(H,46,50)(H,47,56)(H,51,57)(H,52,61)(H,53,60)(H,54,62)(H,55,59)(H4,44,45,48)/t30-,31+,32-,33-,34+/m1/s1 | PDB
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| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134946
(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:68.72,8.22,90.96,wD:82.88,32.33,42.44,101.107,12.13,57.61,4.3,(2.47,-9.76,;1.17,-9.01,;1.19,-7.5,;-.16,-6.75,;-.14,-5.24,;-1.49,-4.47,;-2.84,-5.23,;-2.85,-6.73,;-4.17,-4.45,;-5.53,-5.2,;-6.86,-4.44,;-6.86,-2.92,;-8.22,-5.18,;-9.55,-4.42,;-8.24,-6.7,;-6.9,-7.44,;-5.56,-6.71,;-4.2,-7.47,;-4.23,-8.99,;-2.87,-9.75,;-5.57,-9.73,;-6.91,-8.97,;-4.17,-2.95,;-5.5,-2.19,;-2.82,-2.2,;1.2,-4.49,;1.22,-2.98,;2.54,-5.26,;3.9,-4.5,;5.23,-5.27,;5.21,-6.79,;6.58,-4.52,;7.92,-5.29,;7.92,-6.79,;9.25,-7.55,;10.69,-6.96,;11.71,-8.09,;10.92,-9.39,;9.41,-9.05,;9.28,-4.55,;9.3,-3.03,;10.61,-5.31,;11.96,-4.56,;11.96,-3.02,;11.17,-1.68,;9.62,-1.68,;8.85,-.34,;9.62,1.02,;8.85,2.36,;9.61,3.72,;11.17,3.72,;11.95,2.36,;11.17,1.02,;11.95,-.32,;13.31,-5.32,;13.29,-6.82,;14.65,-4.56,;15.99,-5.32,;15.98,-6.85,;17.32,-7.61,;17.3,-9.11,;18.65,-9.89,;18.63,-11.4,;19.98,-12.15,;17.29,-12.13,;17.35,-4.59,;17.36,-3.08,;18.69,-5.35,;20.05,-4.61,;20.05,-3.09,;21.4,-2.35,;22.81,-2.98,;23.86,-1.85,;23.1,-.55,;23.58,.89,;22.56,2.03,;21.03,1.71,;20.53,.28,;21.57,-.85,;21.37,-5.37,;21.37,-6.88,;22.73,-4.62,;24.06,-5.4,;24.06,-6.9,;25.41,-7.67,;26.74,-6.9,;25.39,-9.17,;25.41,-4.64,;25.43,-3.14,;26.76,-5.4,;28.12,-4.66,;28.13,-3.15,;29.48,-2.4,;29.48,-.89,;30.83,-.15,;30.84,1.36,;32.2,2.11,;29.51,2.12,;29.46,-5.43,;29.45,-6.93,;30.8,-4.67,;32.14,-5.44,;32.13,-6.95,;33.47,-7.71,;34.83,-6.96,;36.17,-7.72,;36.15,-9.24,;34.8,-9.99,;33.47,-9.22,;33.5,-4.69,;33.5,-3.19,;34.83,-5.46,;36.18,-4.72,;37.53,-5.48,;38.89,-4.73,;37.51,-6.99,)| Show InChI InChI=1S/C79H104N22O15/c1-4-5-20-56(96-77(116)67(44(2)3)101-68(107)54(80)33-46-25-28-52(102)29-26-46)69(108)91-42-65(104)93-62(37-51-40-86-43-92-51)75(114)98-60(35-47-24-27-48-17-9-10-18-49(48)32-47)73(112)94-58(23-14-31-88-79(84)85)72(111)99-61(36-50-39-89-55-21-12-11-19-53(50)55)74(113)100-63(38-66(105)106)76(115)95-57(22-13-30-87-78(82)83)71(110)97-59(70(109)90-41-64(81)103)34-45-15-7-6-8-16-45/h6-12,15-19,21,24-29,32,39-40,43-44,54,56-63,67,89,102H,4-5,13-14,20,22-23,30-31,33-38,41-42,80H2,1-3H3,(H2,81,103)(H,86,92)(H,90,109)(H,91,108)(H,93,104)(H,94,112)(H,95,115)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,113)(H,101,107)(H,105,106)(H4,82,83,87)(H4,84,85,88)/t54-,56-,57-,58-,59-,60?,61-,62-,63-,67-/m0/s1 | PDB
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| 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114078
(8-(3-Guanidino-propyl)-2-(3H-imidazol-4-ylmethyl)-...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C47H59N13O7/c48-42(63)35-13-5-6-19-52-40(61)15-7-16-41(62)56-39(24-32-26-51-27-55-32)46(67)59-37(22-28-17-18-29-9-1-2-10-30(29)21-28)44(65)58-36(14-8-20-53-47(49)50)43(64)60-38(45(66)57-35)23-31-25-54-34-12-4-3-11-33(31)34/h1-4,9-12,17-18,21,25-27,35-39,54H,5-8,13-16,19-20,22-24H2,(H2,48,63)(H,51,55)(H,52,61)(H,56,62)(H,57,66)(H,58,65)(H,59,67)(H,60,64)(H4,49,50,53)/t35-,36+,37-,38-,39+/m1/s1 | PDB
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| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50230827
(CHEMBL253364 | MK-9)Show SMILES N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |wU:15.15,11.70,1.0,wD:55.59,29.31,40.42,(27.17,-1.13,;27.07,-2.65,;28.33,-3.52,;29.72,-2.86,;30.99,-3.74,;30.88,-5.27,;34.1,-3.27,;34.1,-4.94,;32.82,-5.79,;32.91,-7.32,;31.62,-8.17,;31.71,-9.71,;30.43,-10.56,;29.05,-9.87,;28.96,-8.33,;27.77,-10.72,;27.85,-12.26,;29.23,-12.95,;30.52,-12.09,;31.55,-13.24,;31.01,-14.69,;31.57,-16.11,;30.62,-17.3,;29.09,-17.08,;28.54,-15.65,;29.5,-14.45,;26.39,-10.03,;25.1,-10.87,;25.19,-12.41,;23.31,-10.55,;22.46,-11.84,;23.15,-13.22,;22.31,-14.51,;22.98,-15.89,;22.14,-17.18,;22.82,-18.57,;20.6,-17.1,;23.48,-9.02,;22.63,-7.74,;24.03,-7.12,;21.38,-6.85,;19.97,-7.47,;19.82,-9.01,;21.06,-9.91,;20.91,-11.42,;19.5,-12.06,;19.36,-13.58,;17.96,-14.22,;16.7,-13.32,;16.85,-11.79,;18.26,-11.15,;18.41,-9.62,;21.5,-5.31,;22.89,-4.64,;24.16,-5.51,;23.01,-3.11,;21.74,-2.23,;20.35,-2.9,;20.06,-4.41,;18.55,-4.61,;17.87,-3.22,;18.99,-2.17,;24.4,-2.45,;25.68,-3.32,;25.55,-4.85,;33.09,-10.4,;33.18,-11.94,;34.38,-9.55,)| Show InChI InChI=1S/C47H60N14O7/c48-33-16-17-40(62)53-18-6-5-12-35(41(49)63)57-45(67)38(22-30-24-55-34-11-4-3-10-32(30)34)61-43(65)36(13-7-19-54-47(50)51)58-44(66)37(21-27-14-15-28-8-1-2-9-29(28)20-27)60-46(68)39(59-42(33)64)23-31-25-52-26-56-31/h1-4,8-11,14-15,20,24-26,33,35-39,55H,5-7,12-13,16-19,21-23,48H2,(H2,49,63)(H,52,56)(H,53,62)(H,57,67)(H,58,66)(H,59,64)(H,60,68)(H,61,65)(H4,50,51,54)/t33-,35-,36-,37-,38+,39-/m0/s1 | PDB
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PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC3 receptor expressed in HEK293 cells |
J Med Chem 51: 187-95 (2008)
Article DOI: 10.1021/jm070461w
BindingDB Entry DOI: 10.7270/Q2V125N2 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134954
(CHEMBL439128 | H-Tyr-Val-Nle-c[Cys-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C77H105N23O14S2/c1-4-5-21-53(94-75(114)64(43(2)3)100-65(104)51(78)31-46-25-27-49(101)28-26-46)70(109)98-60-40-115-116-41-61(74(113)93-55(24-15-30-86-77(82)83)68(107)95-56(66(105)88-38-62(79)102)32-44-16-8-6-9-17-44)99-72(111)58(34-47-36-87-52-22-13-12-20-50(47)52)97-69(108)54(23-14-29-85-76(80)81)92-71(110)57(33-45-18-10-7-11-19-45)96-73(112)59(35-48-37-84-42-90-48)91-63(103)39-89-67(60)106/h6-13,16-20,22,25-28,36-37,42-43,51,53-61,64,87,101H,4-5,14-15,21,23-24,29-35,38-41,78H2,1-3H3,(H2,79,102)(H,84,90)(H,88,105)(H,89,106)(H,91,103)(H,92,110)(H,93,113)(H,94,114)(H,95,107)(H,96,112)(H,97,108)(H,98,109)(H,99,111)(H,100,104)(H4,80,81,85)(H4,82,83,86)/t51-,53-,54-,55-,56-,57+,58-,59-,60+,61-,64-/m0/s1 | PDB
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PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114079
(15-(2-Acetylamino-hexanoylamino)-9-benzyl-6-(3-gua...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O |r| Show InChI InChI=1S/C51H71N15O9/c1-3-4-17-37(60-30(2)67)45(70)66-42-26-43(68)56-21-12-6-9-19-36(44(52)69)61-48(73)40(24-32-27-58-35-18-11-10-16-34(32)35)64-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-5-8-15-31)63-49(74)41(65-50(42)75)25-33-28-55-29-59-33/h5,7-8,10-11,14-16,18,27-29,36-42,58H,3-4,6,9,12-13,17,19-26H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57) | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114084
((O)C-(C6H4)-C(O)-c[His-D-Nal(2')-Arg-Trp-Lys]-NH2)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2ccccc2C(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C50H57N13O7/c51-43(64)38-16-7-8-20-55-44(65)35-13-3-4-14-36(35)45(66)61-42(25-33-27-54-28-58-33)49(70)62-40(23-29-18-19-30-10-1-2-11-31(30)22-29)47(68)60-39(17-9-21-56-50(52)53)46(67)63-41(48(69)59-38)24-32-26-57-37-15-6-5-12-34(32)37/h1-6,10-15,18-19,22,26-28,38-42,57H,7-9,16-17,20-21,23-25H2,(H2,51,64)(H,54,58)(H,55,65)(H,59,69)(H,60,68)(H,61,66)(H,62,70)(H,63,67)(H4,52,53,56)/t38-,39+,40-,41-,42+/m1/s1 | PDB
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| 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134951
(CHEMBL409636 | H-Tyr-Val-Nle-c[Asp-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C79H109N23O14/c1-4-5-23-55(96-77(116)66(45(2)3)102-67(106)53(80)35-48-28-30-51(103)31-29-48)70(109)101-63-40-65(105)87-32-15-14-25-56(69(108)93-57(26-16-33-88-78(82)83)71(110)97-59(68(107)91-43-64(81)104)36-46-18-8-6-9-19-46)94-74(113)61(38-49-41-90-54-24-13-12-22-52(49)54)99-72(111)58(27-17-34-89-79(84)85)95-73(112)60(37-47-20-10-7-11-21-47)98-75(114)62(100-76(63)115)39-50-42-86-44-92-50/h6-13,18-22,24,28-31,41-42,44-45,53,55-63,66,90,103H,4-5,14-17,23,25-27,32-40,43,80H2,1-3H3,(H2,81,104)(H,86,92)(H,87,105)(H,91,107)(H,93,108)(H,94,113)(H,95,112)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,115)(H,101,109)(H,102,106)(H4,82,83,88)(H4,84,85,89)/t53-,55-,56+,57-,58-,59-,60+,61+,62-,63-,66-/m0/s1 | PDB
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UniChem
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PubMed
| 8.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134951
(CHEMBL409636 | H-Tyr-Val-Nle-c[Asp-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C79H109N23O14/c1-4-5-23-55(96-77(116)66(45(2)3)102-67(106)53(80)35-48-28-30-51(103)31-29-48)70(109)101-63-40-65(105)87-32-15-14-25-56(69(108)93-57(26-16-33-88-78(82)83)71(110)97-59(68(107)91-43-64(81)104)36-46-18-8-6-9-19-46)94-74(113)61(38-49-41-90-54-24-13-12-22-52(49)54)99-72(111)58(27-17-34-89-79(84)85)95-73(112)60(37-47-20-10-7-11-21-47)98-75(114)62(100-76(63)115)39-50-42-86-44-92-50/h6-13,18-22,24,28-31,41-42,44-45,53,55-63,66,90,103H,4-5,14-17,23,25-27,32-40,43,80H2,1-3H3,(H2,81,104)(H,86,92)(H,87,105)(H,91,107)(H,93,108)(H,94,113)(H,95,112)(H,96,116)(H,97,110)(H,98,114)(H,99,111)(H,100,115)(H,101,109)(H,102,106)(H4,82,83,88)(H4,84,85,89)/t53-,55-,56+,57-,58-,59-,60+,61+,62-,63-,66-/m0/s1 | PDB
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| 9.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134944
(CHEMBL409049 | H-Tyr-Val-c[Pen-Gly-His-Phe-Arg-Trp...)Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CSSC1(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C73H98N22O13S2/c1-40(2)59(94-61(99)48(74)29-43-23-25-46(96)26-24-43)69(107)95-60-70(108)85-37-58(98)87-55(33-45-35-80-39-86-45)67(105)91-53(31-42-17-9-6-10-18-42)65(103)88-50(21-13-27-81-71(76)77)64(102)92-54(32-44-34-83-49-20-12-11-19-47(44)49)66(104)93-56(38-109-110-73(60,3)4)68(106)89-51(22-14-28-82-72(78)79)63(101)90-52(62(100)84-36-57(75)97)30-41-15-7-5-8-16-41/h5-12,15-20,23-26,34-35,39-40,48,50-56,59-60,83,96H,13-14,21-22,27-33,36-38,74H2,1-4H3,(H2,75,97)(H,80,86)(H,84,100)(H,85,108)(H,87,98)(H,88,103)(H,89,106)(H,90,101)(H,91,105)(H,92,102)(H,93,104)(H,94,99)(H,95,107)(H4,76,77,81)(H4,78,79,82)/t48-,50-,51-,52-,53+,54-,55-,56-,59-,60-/m0/s1 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114080
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H57N13O7/c47-41(62)34-12-5-6-18-51-39(60)16-17-40(61)55-38(23-31-25-50-26-54-31)45(66)58-36(21-27-14-15-28-8-1-2-9-29(28)20-27)43(64)57-35(13-7-19-52-46(48)49)42(63)59-37(44(65)56-34)22-30-24-53-33-11-4-3-10-32(30)33/h1-4,8-11,14-15,20,24-26,34-38,53H,5-7,12-13,16-19,21-23H2,(H2,47,62)(H,50,54)(H,51,60)(H,55,61)(H,56,65)(H,57,64)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36-,37-,38+/m1/s1 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134950
(CHEMBL2370967 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:8.22,91.97,wD:83.89,32.33,42.44,68.72,102.108,12.13,57.61,4.3,(.36,-20.35,;-.98,-19.59,;-.98,-18.08,;-2.32,-17.35,;-2.31,-15.84,;-3.66,-15.08,;-5.02,-15.82,;-5.03,-17.32,;-6.35,-15.06,;-7.72,-15.79,;-9.06,-15.03,;-9.06,-13.54,;-10.42,-15.79,;-11.76,-15.03,;-10.43,-17.29,;-9.08,-18.04,;-7.73,-17.3,;-6.38,-18.05,;-6.41,-19.56,;-5.05,-20.32,;-7.75,-20.31,;-9.08,-19.56,;-6.35,-13.55,;-7.69,-12.79,;-5,-12.81,;-.96,-15.09,;-.95,-13.58,;.39,-15.85,;1.74,-15.11,;3.08,-15.87,;3.06,-17.39,;4.45,-15.14,;5.79,-15.89,;5.44,-17.36,;5.44,-18.84,;4.02,-19.45,;4.16,-20.93,;5.68,-21.27,;6.48,-19.97,;7.13,-15.15,;7.16,-13.64,;8.48,-15.9,;9.83,-15.17,;9.83,-13.63,;9.42,-12.13,;10.52,-11.02,;10.11,-9.54,;8.61,-9.15,;8.2,-7.65,;6.69,-7.27,;5.62,-8.38,;6.02,-9.86,;7.53,-10.26,;7.94,-11.75,;11.19,-15.9,;11.17,-17.4,;12.53,-15.17,;13.87,-15.92,;13.87,-17.43,;15.21,-18.19,;15.2,-19.68,;16.54,-20.46,;16.53,-21.95,;17.88,-22.7,;15.18,-22.7,;15.24,-15.18,;15.24,-13.69,;16.57,-15.93,;17.94,-15.21,;17.94,-13.67,;17.53,-12.17,;18.64,-11.07,;18.22,-9.57,;16.72,-9.18,;16.3,-7.68,;14.8,-7.3,;13.71,-8.41,;14.13,-9.89,;15.61,-10.3,;16.04,-11.78,;19.27,-15.96,;19.26,-17.46,;20.63,-15.23,;21.98,-15.98,;21.97,-17.49,;23.28,-18.25,;24.65,-17.49,;23.28,-19.74,;23.33,-15.24,;23.34,-13.74,;24.68,-15.99,;26.02,-15.25,;26.03,-13.75,;27.4,-13.02,;27.41,-11.51,;28.75,-10.76,;28.78,-9.27,;30.11,-8.52,;27.43,-8.49,;27.37,-16.02,;27.37,-17.52,;28.72,-15.26,;30.07,-16.04,;30.05,-17.53,;31.39,-18.29,;32.76,-17.56,;34.09,-18.32,;34.09,-19.82,;32.73,-20.55,;31.39,-19.8,;31.42,-15.29,;31.44,-13.78,;32.76,-16.05,;34.12,-15.31,;35.46,-16.08,;36.82,-15.32,;35.46,-17.58,)| Show InChI InChI=1S/C81H105N21O15/c1-4-5-21-58(97-79(117)69(46(2)3)102-70(108)57(82)36-48-26-30-56(103)31-27-48)71(109)92-44-67(105)94-64(40-55-42-88-45-93-55)77(115)100-62(38-49-24-28-51-17-9-11-19-53(51)34-49)75(113)95-60(23-14-33-90-81(86)87)74(112)99-63(39-50-25-29-52-18-10-12-20-54(52)35-50)76(114)101-65(41-68(106)107)78(116)96-59(22-13-32-89-80(84)85)73(111)98-61(72(110)91-43-66(83)104)37-47-15-7-6-8-16-47/h6-12,15-20,24-31,34-35,42,45-46,57-65,69,103H,4-5,13-14,21-23,32-33,36-41,43-44,82H2,1-3H3,(H2,83,104)(H,88,93)(H,91,110)(H,92,109)(H,94,105)(H,95,113)(H,96,116)(H,97,117)(H,98,111)(H,99,112)(H,100,115)(H,101,114)(H,102,108)(H,106,107)(H4,84,85,89)(H4,86,87,90)/t57-,58-,59-,60-,61-,62?,63?,64-,65-,69-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134955
(CHEMBL2370968 | H-Tyr-Val-Nle-Gly-Pro-D-Nal(2')-Ar...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:4.4,79.84,65.68,54.57,wD:35.37,8.8,39.40,98.103,87.92,12.12,(2.89,-5.82,;3.92,-6.96,;3.45,-8.43,;4.48,-9.57,;4,-11.03,;2.49,-11.35,;1.46,-10.21,;1.94,-8.75,;-.04,-10.53,;-1.07,-9.39,;-2.58,-9.71,;-3.06,-11.17,;-3.61,-8.56,;-3.13,-7.1,;-5.12,-8.88,;-6.15,-7.74,;-5.67,-6.27,;-6.7,-5.13,;-8.21,-5.45,;-9.24,-4.3,;-8.68,-6.91,;-7.65,-8.06,;-.52,-12,;.51,-13.14,;-2.03,-12.32,;5.03,-12.18,;4.55,-13.64,;6.54,-11.86,;7.57,-13,;9.07,-12.68,;9.55,-11.22,;10.1,-13.83,;9.78,-15.33,;11.12,-16.1,;12.26,-15.07,;11.64,-13.67,;12.41,-12.33,;13.95,-12.33,;11.64,-11,;12.41,-9.67,;11.64,-8.33,;10.1,-8.33,;9.33,-9.67,;7.79,-9.67,;7.02,-8.33,;5.48,-8.33,;4.71,-7,;5.48,-5.66,;7.02,-5.66,;7.79,-7,;9.33,-7,;13.95,-9.67,;13.78,-8.13,;14.72,-11,;16.26,-11,;17.03,-9.67,;16.26,-8.33,;14.72,-8.33,;13.95,-7,;14.72,-5.66,;13.95,-4.33,;16.26,-5.66,;17.03,-12.33,;16.26,-13.67,;18.57,-12.33,;19.34,-11,;18.57,-9.67,;19.34,-8.33,;20.87,-8.17,;21.19,-6.66,;19.85,-5.89,;19.53,-4.39,;18.07,-3.91,;16.92,-4.94,;17.24,-6.45,;18.71,-6.92,;20.88,-11,;21.65,-9.67,;21.65,-12.33,;23.19,-12.33,;23.96,-11,;25.5,-11,;26.27,-9.67,;26.27,-12.33,;23.96,-13.67,;23.19,-15,;25.5,-13.67,;26.27,-15,;25.5,-16.33,;23.96,-16.33,;23.19,-17.67,;23.96,-19,;23.19,-20.33,;23.96,-21.67,;21.65,-20.33,;27.81,-15,;28.58,-13.67,;28.58,-16.33,;30.12,-16.33,;30.89,-17.67,;30.12,-19,;28.58,-19,;27.81,-20.33,;28.58,-21.67,;30.12,-21.67,;30.89,-20.33,;30.89,-15,;32.43,-15,;30.12,-13.67,;30.89,-12.33,;30.12,-11,;28.58,-11,;30.89,-9.67,)| Show InChI InChI=1S/C78H104N20O15/c1-4-5-21-55(92-76(113)66(44(2)3)97-67(104)53(79)36-46-27-30-51(99)31-28-46)68(105)89-43-64(101)98-34-15-25-62(98)75(112)96-59(38-47-26-29-48-18-9-10-19-49(48)35-47)72(109)90-57(24-14-33-86-78(83)84)71(108)94-60(39-50-41-87-54-22-12-11-20-52(50)54)73(110)95-61(40-65(102)103)74(111)91-56(23-13-32-85-77(81)82)70(107)93-58(69(106)88-42-63(80)100)37-45-16-7-6-8-17-45/h6-12,16-20,22,26-31,35,41,44,53,55-62,66,87,99H,4-5,13-15,21,23-25,32-34,36-40,42-43,79H2,1-3H3,(H2,80,100)(H,88,106)(H,89,105)(H,90,109)(H,91,111)(H,92,113)(H,93,107)(H,94,108)(H,95,110)(H,96,112)(H,97,104)(H,102,103)(H4,81,82,85)(H4,83,84,86)/t53-,55-,56-,57-,58-,59?,60-,61-,62-,66-/m0/s1 | PDB
UniProtKB/SwissProt
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PC cid
PC sid
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| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134947
(CHEMBL2370963 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-D-Na...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:42.44,8.22,87.92,wD:79.84,32.33,64.67,98.103,12.13,53.56,4.3,(.12,-14.56,;-1.22,-13.8,;-1.21,-12.3,;-2.57,-11.56,;-2.54,-10.05,;-3.91,-9.29,;-5.27,-10.03,;-5.27,-11.53,;-6.6,-9.26,;-7.96,-10.02,;-9.3,-9.26,;-9.3,-7.76,;-10.66,-10,;-11.99,-9.23,;-10.69,-11.5,;-9.33,-12.24,;-9.33,-13.76,;-7.99,-14.51,;-6.64,-13.77,;-5.3,-14.54,;-6.63,-12.27,;-7.97,-11.52,;-6.6,-7.77,;-5.24,-7.04,;-7.94,-7.01,;-1.19,-9.31,;-1.18,-7.8,;.15,-10.05,;1.51,-9.32,;2.85,-10.08,;2.84,-11.59,;4.21,-9.34,;5.54,-10.08,;5.54,-11.6,;6.89,-12.35,;8.32,-11.76,;9.34,-12.89,;8.55,-14.17,;7.05,-13.86,;6.9,-9.36,;6.92,-7.86,;8.26,-10.13,;9.62,-9.37,;9.6,-7.87,;10.7,-6.81,;10.28,-5.37,;11.38,-4.29,;12.89,-4.68,;13.29,-6.13,;12.21,-7.19,;10.96,-10.11,;10.93,-11.6,;12.31,-9.37,;13.66,-10.13,;13.66,-11.63,;14.99,-12.38,;14.98,-13.88,;16.32,-14.65,;16.31,-16.15,;17.66,-16.91,;14.96,-16.89,;15.02,-9.37,;15.02,-7.89,;16.35,-10.14,;17.71,-9.4,;17.73,-7.87,;16.95,-6.53,;15.41,-6.53,;14.62,-5.19,;15.39,-3.84,;14.62,-2.5,;15.39,-1.14,;16.95,-1.14,;17.73,-2.5,;16.95,-3.84,;17.73,-5.17,;19.08,-10.14,;19.07,-11.64,;20.43,-9.4,;21.77,-10.17,;21.77,-11.67,;23.11,-12.43,;24.47,-11.67,;23.11,-13.93,;23.13,-9.43,;23.13,-7.93,;24.47,-10.19,;25.83,-9.43,;25.83,-7.94,;27.21,-7.21,;27.22,-5.7,;28.57,-4.97,;28.58,-3.46,;29.93,-2.72,;27.24,-2.7,;27.18,-10.2,;27.16,-11.7,;28.52,-9.46,;29.89,-10.22,;29.88,-11.73,;31.22,-12.48,;32.57,-11.75,;33.92,-12.49,;33.92,-14,;32.55,-14.74,;31.21,-13.97,;31.24,-9.48,;31.25,-7.98,;32.58,-10.22,;33.94,-9.51,;35.28,-10.25,;36.64,-9.51,;35.28,-11.76,)| Show InChI InChI=1S/C77H103N21O15/c1-4-5-22-54(93-75(113)65(44(2)3)98-66(104)53(78)34-47-26-29-52(99)30-27-47)67(105)88-42-63(101)90-60(38-51-40-84-43-89-51)73(111)96-58(36-46-18-10-7-11-19-46)71(109)91-56(24-15-32-86-77(82)83)70(108)95-59(37-48-25-28-49-20-12-13-21-50(49)33-48)72(110)97-61(39-64(102)103)74(112)92-55(23-14-31-85-76(80)81)69(107)94-57(68(106)87-41-62(79)100)35-45-16-8-6-9-17-45/h6-13,16-21,25-30,33,40,43-44,53-61,65,99H,4-5,14-15,22-24,31-32,34-39,41-42,78H2,1-3H3,(H2,79,100)(H,84,89)(H,87,106)(H,88,105)(H,90,101)(H,91,109)(H,92,112)(H,93,113)(H,94,107)(H,95,108)(H,96,111)(H,97,110)(H,98,104)(H,102,103)(H4,80,81,85)(H4,82,83,86)/t53-,54-,55-,56-,57-,58-,59?,60-,61-,65-/m0/s1 | PDB
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KEGG
PC cid
PC sid
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Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134947
(CHEMBL2370963 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-D-Na...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O |wU:42.44,8.22,87.92,wD:79.84,32.33,64.67,98.103,12.13,53.56,4.3,(.12,-14.56,;-1.22,-13.8,;-1.21,-12.3,;-2.57,-11.56,;-2.54,-10.05,;-3.91,-9.29,;-5.27,-10.03,;-5.27,-11.53,;-6.6,-9.26,;-7.96,-10.02,;-9.3,-9.26,;-9.3,-7.76,;-10.66,-10,;-11.99,-9.23,;-10.69,-11.5,;-9.33,-12.24,;-9.33,-13.76,;-7.99,-14.51,;-6.64,-13.77,;-5.3,-14.54,;-6.63,-12.27,;-7.97,-11.52,;-6.6,-7.77,;-5.24,-7.04,;-7.94,-7.01,;-1.19,-9.31,;-1.18,-7.8,;.15,-10.05,;1.51,-9.32,;2.85,-10.08,;2.84,-11.59,;4.21,-9.34,;5.54,-10.08,;5.54,-11.6,;6.89,-12.35,;8.32,-11.76,;9.34,-12.89,;8.55,-14.17,;7.05,-13.86,;6.9,-9.36,;6.92,-7.86,;8.26,-10.13,;9.62,-9.37,;9.6,-7.87,;10.7,-6.81,;10.28,-5.37,;11.38,-4.29,;12.89,-4.68,;13.29,-6.13,;12.21,-7.19,;10.96,-10.11,;10.93,-11.6,;12.31,-9.37,;13.66,-10.13,;13.66,-11.63,;14.99,-12.38,;14.98,-13.88,;16.32,-14.65,;16.31,-16.15,;17.66,-16.91,;14.96,-16.89,;15.02,-9.37,;15.02,-7.89,;16.35,-10.14,;17.71,-9.4,;17.73,-7.87,;16.95,-6.53,;15.41,-6.53,;14.62,-5.19,;15.39,-3.84,;14.62,-2.5,;15.39,-1.14,;16.95,-1.14,;17.73,-2.5,;16.95,-3.84,;17.73,-5.17,;19.08,-10.14,;19.07,-11.64,;20.43,-9.4,;21.77,-10.17,;21.77,-11.67,;23.11,-12.43,;24.47,-11.67,;23.11,-13.93,;23.13,-9.43,;23.13,-7.93,;24.47,-10.19,;25.83,-9.43,;25.83,-7.94,;27.21,-7.21,;27.22,-5.7,;28.57,-4.97,;28.58,-3.46,;29.93,-2.72,;27.24,-2.7,;27.18,-10.2,;27.16,-11.7,;28.52,-9.46,;29.89,-10.22,;29.88,-11.73,;31.22,-12.48,;32.57,-11.75,;33.92,-12.49,;33.92,-14,;32.55,-14.74,;31.21,-13.97,;31.24,-9.48,;31.25,-7.98,;32.58,-10.22,;33.94,-9.51,;35.28,-10.25,;36.64,-9.51,;35.28,-11.76,)| Show InChI InChI=1S/C77H103N21O15/c1-4-5-22-54(93-75(113)65(44(2)3)98-66(104)53(78)34-47-26-29-52(99)30-27-47)67(105)88-42-63(101)90-60(38-51-40-84-43-89-51)73(111)96-58(36-46-18-10-7-11-19-46)71(109)91-56(24-15-32-86-77(82)83)70(108)95-59(37-48-25-28-49-20-12-13-21-50(49)33-48)72(110)97-61(39-64(102)103)74(112)92-55(23-14-31-85-76(80)81)69(107)94-57(68(106)87-41-62(79)100)35-45-16-8-6-9-17-45/h6-13,16-21,25-30,33,40,43-44,53-61,65,99H,4-5,14-15,22-24,31-32,34-39,41-42,78H2,1-3H3,(H2,79,100)(H,84,89)(H,87,106)(H,88,105)(H,90,101)(H,91,109)(H,92,112)(H,93,113)(H,94,107)(H,95,108)(H,96,111)(H,97,110)(H,98,104)(H,102,103)(H4,80,81,85)(H4,82,83,86)/t53-,54-,55-,56-,57-,58-,59?,60-,61-,65-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134953
(CHEMBL410168 | H-Tyr-Val-c[Cys-Gly-His-Phe-Arg-Trp...)Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C71H94N22O13S2/c1-39(2)59(93-60(97)47(72)27-42-21-23-45(94)24-22-42)69(106)92-55-36-107-108-37-56(68(105)87-50(20-12-26-80-71(76)77)63(100)88-51(61(98)82-34-57(73)95)28-40-13-5-3-6-14-40)91-66(103)53(30-43-32-81-48-18-10-9-17-46(43)48)90-64(101)49(19-11-25-79-70(74)75)86-65(102)52(29-41-15-7-4-8-16-41)89-67(104)54(31-44-33-78-38-84-44)85-58(96)35-83-62(55)99/h3-10,13-18,21-24,32-33,38-39,47,49-56,59,81,94H,11-12,19-20,25-31,34-37,72H2,1-2H3,(H2,73,95)(H,78,84)(H,82,98)(H,83,99)(H,85,96)(H,86,102)(H,87,105)(H,88,100)(H,89,104)(H,90,101)(H,91,103)(H,92,106)(H,93,97)(H4,74,75,79)(H4,76,77,80)/t47-,49-,50-,51-,52+,53-,54-,55+,56-,59-/m0/s1 | PDB
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| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114078
(8-(3-Guanidino-propyl)-2-(3H-imidazol-4-ylmethyl)-...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C47H59N13O7/c48-42(63)35-13-5-6-19-52-40(61)15-7-16-41(62)56-39(24-32-26-51-27-55-32)46(67)59-37(22-28-17-18-29-9-1-2-10-30(29)21-28)44(65)58-36(14-8-20-53-47(49)50)43(64)60-38(45(66)57-35)23-31-25-54-34-12-4-3-11-33(31)34/h1-4,9-12,17-18,21,25-27,35-39,54H,5-8,13-16,19-20,22-24H2,(H2,48,63)(H,51,55)(H,52,61)(H,56,62)(H,57,66)(H,58,65)(H,59,67)(H,60,64)(H4,49,50,53)/t35-,36+,37-,38-,39+/m1/s1 | PDB
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| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134954
(CHEMBL439128 | H-Tyr-Val-Nle-c[Cys-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C77H105N23O14S2/c1-4-5-21-53(94-75(114)64(43(2)3)100-65(104)51(78)31-46-25-27-49(101)28-26-46)70(109)98-60-40-115-116-41-61(74(113)93-55(24-15-30-86-77(82)83)68(107)95-56(66(105)88-38-62(79)102)32-44-16-8-6-9-17-44)99-72(111)58(34-47-36-87-52-22-13-12-20-50(47)52)97-69(108)54(23-14-29-85-76(80)81)92-71(110)57(33-45-18-10-7-11-19-45)96-73(112)59(35-48-37-84-42-90-48)91-63(103)39-89-67(60)106/h6-13,16-20,22,25-28,36-37,42-43,51,53-61,64,87,101H,4-5,14-15,21,23-24,29-35,38-41,78H2,1-3H3,(H2,79,102)(H,84,90)(H,88,105)(H,89,106)(H,91,103)(H,92,110)(H,93,113)(H,94,114)(H,95,107)(H,96,112)(H,97,108)(H,98,109)(H,99,111)(H,100,104)(H4,80,81,85)(H4,82,83,86)/t51-,53-,54-,55-,56-,57+,58-,59-,60+,61-,64-/m0/s1 | PDB
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134945
(CHEMBL438030 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-Trp-A...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C75H102N22O15/c1-4-5-21-52(92-73(112)63(42(2)3)97-64(103)50(76)31-45-25-27-48(98)28-26-45)65(104)87-40-61(100)89-58(35-47-38-82-41-88-47)71(110)94-56(33-44-18-10-7-11-19-44)69(108)90-54(24-15-30-84-75(80)81)68(107)95-57(34-46-37-85-51-22-13-12-20-49(46)51)70(109)96-59(36-62(101)102)72(111)91-53(23-14-29-83-74(78)79)67(106)93-55(66(105)86-39-60(77)99)32-43-16-8-6-9-17-43/h6-13,16-20,22,25-28,37-38,41-42,50,52-59,63,85,98H,4-5,14-15,21,23-24,29-36,39-40,76H2,1-3H3,(H2,77,99)(H,82,88)(H,86,105)(H,87,104)(H,89,100)(H,90,108)(H,91,111)(H,92,112)(H,93,106)(H,94,110)(H,95,107)(H,96,109)(H,97,103)(H,101,102)(H4,78,79,83)(H4,80,81,84)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50131874
(Ac-c[Cys-Glu-His-D-Nal(2')-Arg-Trp-Gly-Cys]-Pro-Pr...)Show SMILES CC(=O)[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)CN1CCC[C@H]1C(=O)CN[C@@H](CCCCN)C(=O)CN[C@@H](CC(O)=O)C(N)=O Show InChI InChI=1S/C74H99N19O17S2/c1-41(94)48-38-111-112-39-57(73(110)93-26-10-18-59(93)62(97)37-92-25-9-17-58(92)61(96)35-82-50(15-6-7-23-75)60(95)34-83-53(66(76)103)31-65(101)102)86-63(98)36-84-68(105)55(29-45-32-81-49-14-5-4-13-47(45)49)90-69(106)51(16-8-24-80-74(77)78)88-71(108)54(28-42-19-20-43-11-2-3-12-44(43)27-42)89-72(109)56(30-46-33-79-40-85-46)91-70(107)52(87-67(48)104)21-22-64(99)100/h2-5,11-14,19-20,27,32-33,40,48,50-59,81-83H,6-10,15-18,21-26,28-31,34-39,75H2,1H3,(H2,76,103)(H,79,85)(H,84,105)(H,86,98)(H,87,104)(H,88,108)(H,89,109)(H,90,106)(H,91,107)(H,99,100)(H,101,102)(H4,77,78,80)/t48-,50-,51-,52+,53-,54-,55+,56-,57-,58-,59-/m0/s1 | PDB
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| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibitory activity against human Melanocortin 3 receptor was determined |
J Med Chem 46: 3728-33 (2003)
Article DOI: 10.1021/jm030111j
BindingDB Entry DOI: 10.7270/Q2125TDT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114084
((O)C-(C6H4)-C(O)-c[His-D-Nal(2')-Arg-Trp-Lys]-NH2)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2ccccc2C(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C50H57N13O7/c51-43(64)38-16-7-8-20-55-44(65)35-13-3-4-14-36(35)45(66)61-42(25-33-27-54-28-58-33)49(70)62-40(23-29-18-19-30-10-1-2-11-31(30)22-29)47(68)60-39(17-9-21-56-50(52)53)46(67)63-41(48(69)59-38)24-32-26-57-37-15-6-5-12-34(32)37/h1-6,10-15,18-19,22,26-28,38-42,57H,7-9,16-17,20-21,23-25H2,(H2,51,64)(H,54,58)(H,55,65)(H,59,69)(H,60,68)(H,61,66)(H,62,70)(H,63,67)(H4,52,53,56)/t38-,39+,40-,41-,42+/m1/s1 | PDB
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| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114085
((O)C-(C6H4)-C(O)-c[His-D-Phe-Arg-Trp-Lys]-NH2) (MK...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)c2ccccc2C(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H55N13O7/c47-39(60)34-17-8-9-19-51-40(61)31-14-4-5-15-32(31)41(62)57-38(23-29-25-50-26-54-29)45(66)58-36(21-27-11-2-1-3-12-27)43(64)56-35(18-10-20-52-46(48)49)42(63)59-37(44(65)55-34)22-28-24-53-33-16-7-6-13-30(28)33/h1-7,11-16,24-26,34-38,53H,8-10,17-23H2,(H2,47,60)(H,50,54)(H,51,61)(H,55,65)(H,56,64)(H,57,62)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36-,37-,38+/m1/s1 | PDB
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| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50134945
(CHEMBL438030 | H-Tyr-Val-Nle-Gly-His-Phe-Arg-Trp-A...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C75H102N22O15/c1-4-5-21-52(92-73(112)63(42(2)3)97-64(103)50(76)31-45-25-27-48(98)28-26-45)65(104)87-40-61(100)89-58(35-47-38-82-41-88-47)71(110)94-56(33-44-18-10-7-11-19-44)69(108)90-54(24-15-30-84-75(80)81)68(107)95-57(34-46-37-85-51-22-13-12-20-49(46)51)70(109)96-59(36-62(101)102)72(111)91-53(23-14-29-83-74(78)79)67(106)93-55(66(105)86-39-60(77)99)32-43-16-8-6-9-17-43/h6-13,16-20,22,25-28,37-38,41-42,50,52-59,63,85,98H,4-5,14-15,21,23-24,29-36,39-40,76H2,1-3H3,(H2,77,99)(H,82,88)(H,86,105)(H,87,104)(H,89,100)(H,90,108)(H,91,111)(H,92,112)(H,93,106)(H,94,110)(H,95,107)(H,96,109)(H,97,103)(H,101,102)(H4,78,79,83)(H4,80,81,84)/t50-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1 | PDB
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| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against Melanocortin 4 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134953
(CHEMBL410168 | H-Tyr-Val-c[Cys-Gly-His-Phe-Arg-Trp...)Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C71H94N22O13S2/c1-39(2)59(93-60(97)47(72)27-42-21-23-45(94)24-22-42)69(106)92-55-36-107-108-37-56(68(105)87-50(20-12-26-80-71(76)77)63(100)88-51(61(98)82-34-57(73)95)28-40-13-5-3-6-14-40)91-66(103)53(30-43-32-81-48-18-10-9-17-46(43)48)90-64(101)49(19-11-25-79-70(74)75)86-65(102)52(29-41-15-7-4-8-16-41)89-67(104)54(31-44-33-78-38-84-44)85-58(96)35-83-62(55)99/h3-10,13-18,21-24,32-33,38-39,47,49-56,59,81,94H,11-12,19-20,25-31,34-37,72H2,1-2H3,(H2,73,95)(H,78,84)(H,82,98)(H,83,99)(H,85,96)(H,86,102)(H,87,105)(H,88,100)(H,89,104)(H,90,101)(H,91,103)(H,92,106)(H,93,97)(H4,74,75,79)(H4,76,77,80)/t47-,49-,50-,51-,52+,53-,54-,55+,56-,59-/m0/s1 | PDB
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| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114087
(9-Benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C42H55N13O7/c43-37(58)30-13-6-7-17-47-35(56)15-16-36(57)51-34(21-27-23-46-24-50-27)41(62)54-32(19-25-9-2-1-3-10-25)39(60)53-31(14-8-18-48-42(44)45)38(59)55-33(40(61)52-30)20-26-22-49-29-12-5-4-11-28(26)29/h1-5,9-12,22-24,30-34,49H,6-8,13-21H2,(H2,43,58)(H,46,50)(H,47,56)(H,51,57)(H,52,61)(H,53,60)(H,54,62)(H,55,59)(H4,44,45,48)/t30-,31+,32-,33-,34+/m1/s1 | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50114080
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H57N13O7/c47-41(62)34-12-5-6-18-51-39(60)16-17-40(61)55-38(23-31-25-50-26-54-31)45(66)58-36(21-27-14-15-28-8-1-2-9-29(28)20-27)43(64)57-35(13-7-19-52-46(48)49)42(63)59-37(44(65)56-34)22-30-24-53-33-11-4-3-10-32(30)33/h1-4,8-11,14-15,20,24-26,34-38,53H,5-7,12-13,16-19,21-23H2,(H2,47,62)(H,50,54)(H,51,60)(H,55,61)(H,56,65)(H,57,64)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36-,37-,38+/m1/s1 | PDB
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| 87 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-4 receptor (hMC4R) |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114082
(5-Benzyl-8-(3-guanidino-propyl)-2-(3H-imidazol-4-y...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C43H57N13O7/c44-38(59)31-14-6-7-18-48-36(57)16-8-17-37(58)52-35(22-28-24-47-25-51-28)42(63)55-33(20-26-10-2-1-3-11-26)40(61)54-32(15-9-19-49-43(45)46)39(60)56-34(41(62)53-31)21-27-23-50-30-13-5-4-12-29(27)30/h1-5,10-13,23-25,31-35,50H,6-9,14-22H2,(H2,44,59)(H,47,51)(H,48,57)(H,52,58)(H,53,62)(H,54,61)(H,55,63)(H,56,60)(H4,45,46,49)/t31-,32+,33-,34-,35+/m1/s1 | PDB
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| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50114086
(CHEMBL433413 | MK-11 | N-[1-(1-{1-[1-(5-Amino-1-ca...)Show SMILES NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(O)=O)C(N)=O Show InChI InChI=1S/C42H57N13O8/c43-17-7-6-13-30(37(44)59)52-40(62)33(20-26-22-49-29-12-5-4-11-28(26)29)55-38(60)31(14-8-18-48-42(45)46)53-39(61)32(19-25-9-2-1-3-10-25)54-41(63)34(21-27-23-47-24-50-27)51-35(56)15-16-36(57)58/h1-5,9-12,22-24,30-34,49H,6-8,13-21,43H2,(H2,44,59)(H,47,50)(H,51,56)(H,52,62)(H,53,61)(H,54,63)(H,55,60)(H,57,58)(H4,45,46,48)/t30-,31-,32+,33-,34-/m0/s1 | PDB
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human Melanocortin-3 receptor (hMC3R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50114080
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H57N13O7/c47-41(62)34-12-5-6-18-51-39(60)16-17-40(61)55-38(23-31-25-50-26-54-31)45(66)58-36(21-27-14-15-28-8-1-2-9-29(28)20-27)43(64)57-35(13-7-19-52-46(48)49)42(63)59-37(44(65)56-34)22-30-24-53-33-11-4-3-10-32(30)33/h1-4,8-11,14-15,20,24-26,34-38,53H,5-7,12-13,16-19,21-23H2,(H2,47,62)(H,50,54)(H,51,60)(H,55,61)(H,56,65)(H,57,64)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36-,37-,38+/m1/s1 | PDB
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity for human melanocortin 5 receptor (hMC5R) expressed in HEK293 cells |
J Med Chem 45: 2644-50 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75B3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134959
(CHEMBL438235 | H-Tyr-Val-Nle-c[Pen-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CSSC1(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C79H109N23O14S2/c1-6-7-23-54(96-75(115)64(44(2)3)101-66(106)52(80)33-47-27-29-50(103)30-28-47)70(110)102-65-76(116)91-41-63(105)93-60(37-49-39-86-43-92-49)73(113)98-58(35-46-20-12-9-13-21-46)71(111)94-55(25-16-31-87-77(82)83)69(109)99-59(36-48-38-89-53-24-15-14-22-51(48)53)72(112)100-61(42-117-118-79(65,4)5)74(114)95-56(26-17-32-88-78(84)85)68(108)97-57(67(107)90-40-62(81)104)34-45-18-10-8-11-19-45/h8-15,18-22,24,27-30,38-39,43-44,52,54-61,64-65,89,103H,6-7,16-17,23,25-26,31-37,40-42,80H2,1-5H3,(H2,81,104)(H,86,92)(H,90,107)(H,91,116)(H,93,105)(H,94,111)(H,95,114)(H,96,115)(H,97,108)(H,98,113)(H,99,109)(H,100,112)(H,101,106)(H,102,110)(H4,82,83,87)(H4,84,85,88)/t52-,54-,55-,56-,57-,58+,59-,60-,61+,64-,65-/m0/s1 | PDB
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PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50134944
(CHEMBL409049 | H-Tyr-Val-c[Pen-Gly-His-Phe-Arg-Trp...)Show SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CSSC1(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C73H98N22O13S2/c1-40(2)59(94-61(99)48(74)29-43-23-25-46(96)26-24-43)69(107)95-60-70(108)85-37-58(98)87-55(33-45-35-80-39-86-45)67(105)91-53(31-42-17-9-6-10-18-42)65(103)88-50(21-13-27-81-71(76)77)64(102)92-54(32-44-34-83-49-20-12-11-19-47(44)49)66(104)93-56(38-109-110-73(60,3)4)68(106)89-51(22-14-28-82-72(78)79)63(101)90-52(62(100)84-36-57(75)97)30-41-15-7-5-8-16-41/h5-12,15-20,23-26,34-35,39-40,48,50-56,59-60,83,96H,13-14,21-22,27-33,36-38,74H2,1-4H3,(H2,75,97)(H,80,86)(H,84,100)(H,85,108)(H,87,98)(H,88,103)(H,89,106)(H,90,101)(H,91,105)(H,92,102)(H,93,104)(H,94,99)(H,95,107)(H4,76,77,81)(H4,78,79,82)/t48-,50-,51-,52-,53+,54-,55-,56-,59-,60-/m0/s1 | PDB
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PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 3 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50134959
(CHEMBL438235 | H-Tyr-Val-Nle-c[Pen-His-Phe-Arg-Trp...)Show SMILES CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)N[C@H]1C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CSSC1(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(N)=O Show InChI InChI=1S/C79H109N23O14S2/c1-6-7-23-54(96-75(115)64(44(2)3)101-66(106)52(80)33-47-27-29-50(103)30-28-47)70(110)102-65-76(116)91-41-63(105)93-60(37-49-39-86-43-92-49)73(113)98-58(35-46-20-12-9-13-21-46)71(111)94-55(25-16-31-87-77(82)83)69(109)99-59(36-48-38-89-53-24-15-14-22-51(48)53)72(112)100-61(42-117-118-79(65,4)5)74(114)95-56(26-17-32-88-78(84)85)68(108)97-57(67(107)90-40-62(81)104)34-45-18-10-8-11-19-45/h8-15,18-22,24,27-30,38-39,43-44,52,54-61,64-65,89,103H,6-7,16-17,23,25-26,31-37,40-42,80H2,1-5H3,(H2,81,104)(H,86,92)(H,90,107)(H,91,116)(H,93,105)(H,94,111)(H,95,114)(H,96,115)(H,97,108)(H,98,113)(H,99,109)(H,100,112)(H,101,106)(H,102,110)(H4,82,83,87)(H4,84,85,88)/t52-,54-,55-,56-,57-,58+,59-,60-,61+,64-,65-/m0/s1 | PDB
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PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Binding affinity against human Melanocortin 5 receptor by gamma-MCH displacement. |
J Med Chem 46: 4965-73 (2003)
Article DOI: 10.1021/jm030119t
BindingDB Entry DOI: 10.7270/Q2SJ1K0P |
More data for this
Ligand-Target Pair | |
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