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Compile Data Set for Download or QSAR

Found 462 hits with Last Name = 'grychowska' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393371
PNG
(CHEMBL2159465)
Show SMILES CC(C)c1ccccc1OCCN1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN2O3S/c1-17(2)21-5-3-4-6-22(21)28-16-15-25-13-11-19(12-14-25)24-29(26,27)20-9-7-18(23)8-10-20/h3-10,17,19,24H,11-16H2,1-2H3
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0.300n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50174269
PNG
(1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole | ...)
Show SMILES O=S(=O)(c1ccccc1)n1ccc2c(cccc12)N1CCNCC1
Show InChI InChI=1S/C18H19N3O2S/c22-24(23,15-5-2-1-3-6-15)21-12-9-16-17(7-4-8-18(16)21)20-13-10-19-11-14-20/h1-9,12,19H,10-11,13-14H2
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0.300n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112765
BindingDB Entry DOI: 10.7270/Q2ZC86K7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50253281
PNG
(CHEMBL522691 | N-(4-Cyanophenylmethyl)-4-(2-diphen...)
Show SMILES O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NCc1ccc(cc1)C#N
Show InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)
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0.580n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50419052
PNG
(SB-399885)
Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)Nc1cc(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3
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0.700n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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0.800n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr


Eur J Med Chem 60: 42-50 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.042
BindingDB Entry DOI: 10.7270/Q21V5G98
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50579346
PNG
(CHEMBL4867565)
Show SMILES Fc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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0.930n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity to 5HT3 receptor (unknown origin)


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50098551
PNG
((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Show SMILES CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 |r|
Show InChI InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50318633
PNG
(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Show SMILES O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
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1.40n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6R expressed in HEK293 cell membranes after 1 hr


Bioorg Med Chem 26: 3588-3595 (2018)


Article DOI: 10.1016/j.bmc.2018.05.033
BindingDB Entry DOI: 10.7270/Q2BC4219
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM10989
PNG
((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Show SMILES C#CCN[C@@H]1CCc2ccccc12 |r|
Show InChI InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
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1.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112765
BindingDB Entry DOI: 10.7270/Q2ZC86K7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50318633
PNG
(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Show SMILES O=S(=O)(c1ccccc1)c1cnc2c(cccc2c1)N1CCNCC1
Show InChI InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
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1.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579342
PNG
(CHEMBL4872586)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2n(ccc12)S(=O)(=O)c1cccc(Cl)c1
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2n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579341
PNG
(CHEMBL4860809)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2n(ccc12)S(=O)(=O)c1cccc(F)c1
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2n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393395
PNG
(CHEMBL2159489)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r|
Show InChI InChI=1S/C24H25FN2O3S/c25-20-10-12-22(13-11-20)31(28,29)26-21-14-15-27(18-21)16-17-30-24-9-5-4-8-23(24)19-6-2-1-3-7-19/h1-13,21,26H,14-18H2/t21-/m1/s1
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2n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579339
PNG
(CHEMBL4865309)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2n(ccc12)S(=O)(=O)c1ccccc1
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2n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50274767
PNG
(CHEMBL4125735)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2c(N[C@H]3CCNC3)nc3ccccc3c12 |r|
Show InChI InChI=1S/C21H19ClN4O2S/c22-14-4-3-5-16(12-14)29(27,28)26-11-9-18-20(26)17-6-1-2-7-19(17)25-21(18)24-15-8-10-23-13-15/h1-7,9,11-12,15,23H,8,10,13H2,(H,24,25)/t15-/m0/s1
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3n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human 5-HT6R expressed in HEK293 cell membranes after 1 hr


Bioorg Med Chem 26: 3588-3595 (2018)


Article DOI: 10.1016/j.bmc.2018.05.033
BindingDB Entry DOI: 10.7270/Q2BC4219
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50274767
PNG
(CHEMBL4125735)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2c(N[C@H]3CCNC3)nc3ccccc3c12 |r|
Show InChI InChI=1S/C21H19ClN4O2S/c22-14-4-3-5-16(12-14)29(27,28)26-11-9-18-20(26)17-6-1-2-7-19(17)25-21(18)24-15-8-10-23-13-15/h1-7,9,11-12,15,23H,8,10,13H2,(H,24,25)/t15-/m0/s1
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3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50274767
PNG
(CHEMBL4125735)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2c(N[C@H]3CCNC3)nc3ccccc3c12 |r|
Show InChI InChI=1S/C21H19ClN4O2S/c22-14-4-3-5-16(12-14)29(27,28)26-11-9-18-20(26)17-6-1-2-7-19(17)25-21(18)24-15-8-10-23-13-15/h1-7,9,11-12,15,23H,8,10,13H2,(H,24,25)/t15-/m0/s1
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3n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114329
BindingDB Entry DOI: 10.7270/Q2RF6040
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579349
PNG
(CHEMBL4870374)
Show SMILES Cc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579348
PNG
(CHEMBL4862354)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579347
PNG
(CHEMBL4846153)
Show SMILES Clc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579346
PNG
(CHEMBL4867565)
Show SMILES Fc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50130261
PNG
(6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethy...)
Show SMILES Clc1ccc(OC2CCN(CC[C@H]3CCCN3S(=O)(=O)c3ccc4cc[nH]c4c3)CC2)cc1
Show InChI InChI=1S/C25H30ClN3O3S/c26-20-4-6-22(7-5-20)32-23-11-16-28(17-12-23)15-10-21-2-1-14-29(21)33(30,31)24-8-3-19-9-13-27-25(19)18-24/h3-9,13,18,21,23,27H,1-2,10-12,14-17H2/t21-/m1/s1
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3.20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579356
PNG
(CHEMBL4853195)
Show SMILES Fc1ccc(F)c(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393391
PNG
(CHEMBL2159485)
Show SMILES CC(C)c1ccccc1OCCN1CCC(C1)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H27ClN2O3S/c1-16(2)20-8-3-4-9-21(20)27-13-12-24-11-10-18(15-24)23-28(25,26)19-7-5-6-17(22)14-19/h3-9,14,16,18,23H,10-13,15H2,1-2H3
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393394
PNG
(CHEMBL2159488)
Show SMILES Clc1ccc(s1)S(=O)(=O)N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r|
Show InChI InChI=1S/C22H23ClN2O3S2/c23-21-10-11-22(29-21)30(26,27)24-18-12-13-25(16-18)14-15-28-20-9-5-4-8-19(20)17-6-2-1-3-7-17/h1-11,18,24H,12-16H2/t18-/m1/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393434
PNG
(CHEMBL2159322)
Show SMILES CSc1ccccc1OCCN1CCC(C1)NS(=O)(=O)c1ccc(Cl)s1
Show InChI InChI=1S/C17H21ClN2O3S3/c1-24-15-5-3-2-4-14(15)23-11-10-20-9-8-13(12-20)19-26(21,22)17-7-6-16(18)25-17/h2-7,13,19H,8-12H2,1H3
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393395
PNG
(CHEMBL2159489)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r|
Show InChI InChI=1S/C24H25FN2O3S/c25-20-10-12-22(13-11-20)31(28,29)26-21-14-15-27(18-21)16-17-30-24-9-5-4-8-23(24)19-6-2-1-3-7-19/h1-13,21,26H,14-18H2/t21-/m1/s1
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579345
PNG
(CHEMBL4868468)
Show SMILES Clc1ccccc1S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM163719
PNG
(3-Cyclohexyl-5-{4-[4-(2-methoxyphenyl)piperazin-1-...)
Show SMILES COc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)C2CCCCC2)CC1 |c:19|
Show InChI InChI=1S/C24H37N5O2/c1-31-22-13-6-5-12-21(22)29-17-15-28(16-18-29)14-8-7-11-20-24(30)27-26-23(25-20)19-9-3-2-4-10-19/h5-6,12-13,19-20H,2-4,7-11,14-18H2,1H3,(H,25,26)(H,27,30)
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5 -47.4n/an/an/an/an/an/a25



Jagiellonian University Medical College



Assay Description
All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...


Chem Biol Drug Des 86: 697-703 (2015)


Article DOI: 10.1111/cbdd.12539
BindingDB Entry DOI: 10.7270/Q2DR2T86
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM163721
PNG
(3-Cyclohexyl-5-{4-[4-(2,3-dichlorophenyl)piperazin...)
Show SMILES Clc1cccc(N2CCN(CCCCC3NC(=NNC3=O)C3CCCCC3)CC2)c1Cl |c:16|
Show InChI InChI=1S/C23H33Cl2N5O/c24-18-9-6-11-20(21(18)25)30-15-13-29(14-16-30)12-5-4-10-19-23(31)28-27-22(26-19)17-7-2-1-3-8-17/h6,9,11,17,19H,1-5,7-8,10,12-16H2,(H,26,27)(H,28,31)
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5 -47.4n/an/an/an/an/an/a25



Jagiellonian University Medical College



Assay Description
All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...


Chem Biol Drug Des 86: 697-703 (2015)


Article DOI: 10.1111/cbdd.12539
BindingDB Entry DOI: 10.7270/Q2DR2T86
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50393392
PNG
(CHEMBL2159486)
Show SMILES CSc1ccccc1OCCN1CCC(C1)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H23ClN2O3S2/c1-26-19-8-3-2-7-18(19)25-12-11-22-10-9-16(14-22)21-27(23,24)17-6-4-5-15(20)13-17/h2-8,13,16,21H,9-12,14H2,1H3
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM35254
PNG
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12 |t:8|
Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
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5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50130293
PNG
(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
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5.60n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 after 1 hr


Eur J Med Chem 60: 42-50 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.042
BindingDB Entry DOI: 10.7270/Q21V5G98
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50291285
PNG
(CHEMBL4161904)
Show SMILES O=S(=O)(c1ccccc1)n1ccc2c(nccc12)N1CCNCC1
Show InChI InChI=1S/C17H18N4O2S/c22-24(23,14-4-2-1-3-5-14)21-11-7-15-16(21)6-8-19-17(15)20-12-9-18-10-13-20/h1-8,11,18H,9-10,12-13H2
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6n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM163720
PNG
(3-Cyclohexyl-5-{4-[4-(2-(methylthio)phenyl)piperaz...)
Show SMILES CSc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)C2CCCCC2)CC1 |c:19|
Show InChI InChI=1S/C24H37N5OS/c1-31-22-13-6-5-12-21(22)29-17-15-28(16-18-29)14-8-7-11-20-24(30)27-26-23(25-20)19-9-3-2-4-10-19/h5-6,12-13,19-20H,2-4,7-11,14-18H2,1H3,(H,25,26)(H,27,30)
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6 -46.9n/an/an/an/an/an/a25



Jagiellonian University Medical College



Assay Description
All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...


Chem Biol Drug Des 86: 697-703 (2015)


Article DOI: 10.1111/cbdd.12539
BindingDB Entry DOI: 10.7270/Q2DR2T86
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393393
PNG
(CHEMBL2159487)
Show SMILES CC(C)c1ccccc1OCCN1CC[C@H](C1)NS(=O)(=O)c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C19H25ClN2O3S2/c1-14(2)16-5-3-4-6-17(16)25-12-11-22-10-9-15(13-22)21-27(23,24)19-8-7-18(20)26-19/h3-8,14-15,21H,9-13H2,1-2H3/t15-/m1/s1
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6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50556389
PNG
(CHEMBL4784859)
Show SMILES Clc1cccc(Cn2ccc3c(cccc23)N2CCNCC2)c1
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7n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta plate reader method


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112765
BindingDB Entry DOI: 10.7270/Q2ZC86K7
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))
BDBM50579350
PNG
(CHEMBL4863272)
Show SMILES COc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
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7n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method


Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00224
BindingDB Entry DOI: 10.7270/Q2X3528B
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393387
PNG
(CHEMBL2159481)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1
Show InChI InChI=1S/C24H24F2N2O3S/c25-22-11-10-20(16-23(22)26)32(29,30)27-19-12-13-28(17-19)14-15-31-24-9-5-4-8-21(24)18-6-2-1-3-7-18/h1-11,16,19,27H,12-15,17H2
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393393
PNG
(CHEMBL2159487)
Show SMILES CC(C)c1ccccc1OCCN1CC[C@H](C1)NS(=O)(=O)c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C19H25ClN2O3S2/c1-14(2)16-5-3-4-6-17(16)25-12-11-22-10-9-15(13-22)21-27(23,24)19-8-7-18(20)26-19/h3-8,14-15,21H,9-13H2,1-2H3/t15-/m1/s1
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393372
PNG
(CHEMBL2159466)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)CC1
Show InChI InChI=1S/C25H26F2N2O3S/c26-23-11-10-21(18-24(23)27)33(30,31)28-20-12-14-29(15-13-20)16-17-32-25-9-5-4-8-22(25)19-6-2-1-3-7-19/h1-11,18,20,28H,12-17H2
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM35254
PNG
(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Show SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12 |t:8|
Show InChI InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
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7n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human dopamine D2L receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50425434
PNG
(CHEMBL2312640)
Show SMILES Clc1cccc(N2CCN(CCCCNS(=O)(=O)c3cncc4ccccc34)CC2)c1Cl
Show InChI InChI=1S/C23H26Cl2N4O2S/c24-20-8-5-9-21(23(20)25)29-14-12-28(13-15-29)11-4-3-10-27-32(30,31)22-17-26-16-18-6-1-2-7-19(18)22/h1-2,5-9,16-17,27H,3-4,10-15H2
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8n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr


Eur J Med Chem 60: 42-50 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.042
BindingDB Entry DOI: 10.7270/Q21V5G98
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50393397
PNG
(CHEMBL2159491)
Show SMILES Clc1ccc(s1)S(=O)(=O)N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1 |r|
Show InChI InChI=1S/C22H23ClN2O3S2/c23-21-10-11-22(29-21)30(26,27)24-18-12-13-25(16-18)14-15-28-20-9-5-4-8-19(20)17-6-2-1-3-7-17/h1-11,18,24H,12-16H2/t18-/m0/s1
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8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human dopamine D2L receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50425437
PNG
(CHEMBL2312935)
Show SMILES Clc1cccc(N2CCN(CCCCNS(=O)(=O)c3cnc4ccccc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H26Cl2N4O2S/c24-20-7-5-9-22(23(20)25)29-14-12-28(13-15-29)11-4-3-10-27-32(30,31)19-16-18-6-1-2-8-21(18)26-17-19/h1-2,5-9,16-17,27H,3-4,10-15H2
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9n/an/an/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hr


Eur J Med Chem 60: 42-50 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.042
BindingDB Entry DOI: 10.7270/Q21V5G98
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM50393385
PNG
(CHEMBL2159479)
Show SMILES Fc1ccc(cc1)S(=O)(=O)NC1CCN(CCOc2ccccc2)C1
Show InChI InChI=1S/C18H21FN2O3S/c19-15-6-8-18(9-7-15)25(22,23)20-16-10-11-21(14-16)12-13-24-17-4-2-1-3-5-17/h1-9,16,20H,10-14H2
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9n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393389
PNG
(CHEMBL2159483)
Show SMILES Fc1ccc(F)c(c1)S(=O)(=O)NC1CCN(CCOc2ccccc2-c2ccccc2)C1
Show InChI InChI=1S/C24H24F2N2O3S/c25-19-10-11-22(26)24(16-19)32(29,30)27-20-12-13-28(17-20)14-15-31-23-9-5-4-8-21(23)18-6-2-1-3-7-18/h1-11,16,20,27H,12-15,17H2
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9n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))
BDBM163713
PNG
(5-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}-3-p...)
Show SMILES COc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)c2ccccc2)CC1 |c:19|
Show InChI InChI=1S/C24H31N5O2/c1-31-22-13-6-5-12-21(22)29-17-15-28(16-18-29)14-8-7-11-20-24(30)27-26-23(25-20)19-9-3-2-4-10-19/h2-6,9-10,12-13,20H,7-8,11,14-18H2,1H3,(H,25,26)(H,27,30)
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9 -45.9n/an/an/an/an/an/a25



Jagiellonian University Medical College



Assay Description
All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...


Chem Biol Drug Des 86: 697-703 (2015)


Article DOI: 10.1111/cbdd.12539
BindingDB Entry DOI: 10.7270/Q2DR2T86
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))
BDBM50393385
PNG
(CHEMBL2159479)
Show SMILES Fc1ccc(cc1)S(=O)(=O)NC1CCN(CCOc2ccccc2)C1
Show InChI InChI=1S/C18H21FN2O3S/c19-15-6-8-18(9-7-15)25(22,23)20-16-10-11-21(14-16)12-13-24-17-4-2-1-3-5-17/h1-9,16,20H,10-14H2
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9n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr


Eur J Med Chem 56: 348-360 (2012)


Article DOI: 10.1016/j.ejmech.2012.07.043
BindingDB Entry DOI: 10.7270/Q28P61N6
More data for this
Ligand-Target Pair
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