Compile Data Set for Download or QSAR

Found 266 hits with Last Name = 'sham' and Initial = 'kk'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50052027 ((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...) Show SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 Show InChI InChI=1S/C23H19Cl2NO3S/c24-18-7-4-8-19(25)23(18)30-15-17-9-11-21(20(26-17)10-12-22(27)28)29-14-13-16-5-2-1-3-6-16/h1-12H,13-15H2,(H,27,28)/b12-10+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053354 ((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[2-...) Show SMILES COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2\C=C\C(O)=O)cc1 Show InChI InChI=1S/C24H21Cl2NO4S/c1-30-18-8-5-16(6-9-18)13-14-31-22-11-7-17(27-21(22)10-12-23(28)29)15-32-24-19(25)3-2-4-20(24)26/h2-12H,13-15H2,1H3,(H,28,29)/b12-10+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053350 ((E)-3-[3-[2-(4-Chloro-phenyl)-ethoxy]-6-(2,6-dichl...) Show SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 Show InChI InChI=1S/C23H18Cl3NO3S/c24-16-6-4-15(5-7-16)12-13-30-21-10-8-17(27-20(21)9-11-22(28)29)14-31-23-18(25)2-1-3-19(23)26/h1-11H,12-14H2,(H,28,29)/b11-9+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053353 ((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-(3-...) Show SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 Show InChI InChI=1S/C24H21Cl2NO3S/c25-19-9-4-10-20(26)24(19)31-16-18-11-13-22(21(27-18)12-14-23(28)29)30-15-5-8-17-6-2-1-3-7-17/h1-4,6-7,9-14H,5,8,15-16H2,(H,28,29)/b14-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053351 ((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[4-...) Show SMILES COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2\C=C\C(O)=O)cc1 Show InChI InChI=1S/C26H25Cl2NO4S/c1-32-20-11-8-18(9-12-20)5-2-3-16-33-24-14-10-19(29-23(24)13-15-25(30)31)17-34-26-21(27)6-4-7-22(26)28/h4,6-15H,2-3,5,16-17H2,1H3,(H,30,31)/b15-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053355 ((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[2-...) Show SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 Show InChI InChI=1S/C23H18Cl2FNO3S/c24-18-2-1-3-19(25)23(18)31-14-17-8-10-21(20(27-17)9-11-22(28)29)30-13-12-15-4-6-16(26)7-5-15/h1-11H,12-14H2,(H,28,29)/b11-9+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053356 ((E)-3-{3-[4-(4-Methoxy-phenyl)-butoxy]-6-phenylsul...) Show SMILES COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2\C=C\C(O)=O)cc1 Show InChI InChI=1S/C26H27NO4S/c1-30-22-13-10-20(11-14-22)7-5-6-18-31-25-16-12-21(27-24(25)15-17-26(28)29)19-32-23-8-3-2-4-9-23/h2-4,8-17H,5-7,18-19H2,1H3,(H,28,29)/b17-15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50042182 ((E)-3-{6-(3-Amino-benzenesulfinylmethyl)-3-[8-(4-m...) Show SMILES COc1ccc(CCCCCCCCOc2ccc(CS(=O)c3cccc(N)c3)nc2C=CC(O)=O)cc1 |w:32.34| Show InChI InChI=1S/C30H36N2O5S/c1-36-26-15-12-23(13-16-26)9-6-4-2-3-5-7-20-37-29-18-14-25(32-28(29)17-19-30(33)34)22-38(35)27-11-8-10-24(31)21-27/h8,10-19,21H,2-7,9,20,22,31H2,1H3,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50037385 (3-{6-((E)-2-Carboxy-vinyl)-5-[6-(4-methoxy-phenyl)...) Show SMILES COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(c3)C(O)=O)nc2\C=C\C(O)=O)cc1 Show InChI InChI=1S/C32H37NO6S/c1-38-28-15-12-24(13-16-28)9-6-4-2-3-5-7-20-39-30-18-14-27(33-29(30)17-19-31(34)35)23-40-22-25-10-8-11-26(21-25)32(36)37/h8,10-19,21H,2-7,9,20,22-23H2,1H3,(H,34,35)(H,36,37)/b19-17+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
Leukotriene B4 receptor 1 (Homo sapiens (Human))	BDBM50053352 ((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-(4-...) Show SMILES OC(=O)\C=C\c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 Show InChI InChI=1S/C22H16Cl2FNO3S/c23-17-2-1-3-18(24)22(17)30-13-16-8-10-20(19(26-16)9-11-21(27)28)29-12-14-4-6-15(25)7-5-14/h1-11H,12-13H2,(H,27,28)/b11-9+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of [3H]-LTB4 binding to human neutrophils				J Med Chem 39: 3837-41 (1996) Article DOI: 10.1021/jm960248s BindingDB Entry DOI: 10.7270/Q2VX0FKP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144689 (US8952037, 62) Show SMILES NC(=O)c1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C22H19N5O2S/c23-20(28)18-8-7-13(12-25-18)16-4-3-9-24-21(16)29-15-10-14(11-15)26-22-27-17-5-1-2-6-19(17)30-22/h1-9,12,14-15H,10-11H2,(H2,23,28)(H,26,27)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.129	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47125 (US8952027, 63) Show SMILES NC(=O)c1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.93,;-4.94,.38,;-6.28,-.38,;-7.61,.38,;-7.61,1.93,;-6.28,-1.93,;-7.61,-2.69,;-7.61,-4.23,;-6.28,-5,;-4.94,-4.23,;-4.94,-2.69,;-3.61,-1.93,;-2.28,-2.69,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C24H21N5O2/c25-23(30)21-9-7-16(14-27-21)19-5-3-11-26-24(19)31-18-12-17(13-18)28-22-10-8-15-4-1-2-6-20(15)29-22/h1-11,14,17-18H,12-13H2,(H2,25,30)(H,28,29)/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144650 (US8952037, 17) Show SMILES O=C([C@H]1CC(C1)Oc1ncccc1C1CCOCC1)c1nc2ccccc2[nH]1 |r,wD:2.1,(1.24,-4.39,;1.24,-2.85,;-.1,-2.08,;-.5,-.6,;-1.98,-1,;-1.58,-2.48,;-3.32,-.23,;-4.65,-1,;-4.65,-2.54,;-5.98,-3.31,;-7.32,-2.54,;-7.32,-1,;-5.98,-.23,;-5.98,1.31,;-4.65,2.08,;-4.65,3.62,;-5.98,4.39,;-7.32,3.62,;-7.32,2.08,;2.57,-2.08,;2.73,-.55,;4.24,-.23,;5.01,1.1,;6.55,1.1,;7.32,-.23,;6.55,-1.57,;5.01,-1.57,;3.98,-2.71,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.413	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144685 (US8952037, 58 | US8952037, 59) Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,5.45,;-5.98,3.91,;-5.98,2.37,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-1.58,-4.57,;-.1,-4.17,;-.5,-2.68,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C22H17N5OS/c23-12-15-8-7-14(13-25-15)18-4-3-9-24-21(18)28-17-10-16(11-17)26-22-27-19-5-1-2-6-20(19)29-22/h1-9,13,16-17H,10-11H2,(H,26,27)/t16-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144718 (US8952037, 95) Show SMILES N#C[C@@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:2.1,wD:14.15,16.20,(-3.42,10.22,;-4.31,8.96,;-5.19,7.7,;-6.75,7.61,;-7.23,6.15,;-5.98,5.24,;-4.74,6.15,;-5.98,3.7,;-7.32,2.93,;-7.32,1.39,;-5.98,.62,;-4.65,1.39,;-4.65,2.93,;-3.32,3.7,;-1.98,2.93,;-.5,3.33,;-.1,1.84,;-1.58,1.44,;1.24,1.07,;2.57,1.84,;2.73,3.37,;4.24,3.69,;5.01,5.03,;6.55,5.03,;7.32,3.69,;6.55,2.36,;5.01,2.36,;3.98,1.22,)| Show InChI InChI=1S/C20H20N6OS/c21-11-13-5-8-26(12-13)18-19(23-7-6-22-18)27-15-9-14(10-15)24-20-25-16-3-1-2-4-17(16)28-20/h1-4,6-7,13-15H,5,8-10,12H2,(H,24,25)/t13-,14-,15+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.728	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144659 (US8952037, 26) Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2s1 |r,wU:3.4,1.19,(-1.73,-3.03,;-.24,-2.63,;-.64,-1.14,;-2.12,-1.54,;-3.46,-.77,;-4.79,-1.54,;-4.79,-3.08,;-6.12,-3.85,;-7.46,-3.08,;-7.46,-1.54,;-6.12,-.77,;-6.12,.77,;-4.79,1.54,;-4.79,3.08,;-6.12,3.85,;-7.46,3.08,;-7.46,1.54,;1.1,-3.4,;2.43,-2.63,;2.91,-1.16,;4.45,-1.16,;5.48,-.02,;6.98,-.34,;7.46,-1.8,;6.43,-2.95,;4.92,-2.63,;3.68,-3.53,)| Show InChI InChI=1S/C21H23N3O2S/c1-2-6-19-18(5-1)24-21(27-19)23-15-12-16(13-15)26-20-17(4-3-9-22-20)14-7-10-25-11-8-14/h1-6,9,14-16H,7-8,10-13H2,(H,23,24)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.751	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144699 (US8952037, 72) Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:18.19,20.24,(-2.28,5.01,;-3.61,4.24,;-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C26H30N4O3/c1-32-17-25(31)30-13-10-18(11-14-30)22-6-4-12-27-26(22)33-21-15-20(16-21)28-24-9-8-19-5-2-3-7-23(19)29-24/h2-9,12,18,20-21H,10-11,13-17H2,1H3,(H,28,29)/t20-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.948	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144703 (US8952037, 78) Show SMILES N#CC1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-3.42,4.77,;-4.31,3.51,;-5.19,2.25,;-6.75,2.16,;-7.23,.7,;-5.98,-.21,;-4.74,.7,;-5.98,-1.75,;-7.32,-2.52,;-7.32,-4.06,;-5.98,-4.83,;-4.65,-4.06,;-4.65,-2.52,;-3.32,-1.75,;-1.98,-2.52,;-.5,-2.12,;-.1,-3.61,;-1.58,-4.01,;1.24,-4.38,;2.57,-3.61,;2.73,-2.08,;4.24,-1.76,;5.01,-.42,;6.55,-.42,;7.32,-1.76,;6.55,-3.09,;5.01,-3.09,;3.98,-4.23,)| Show InChI InChI=1S/C20H20N6OS/c21-11-13-5-8-26(12-13)18-19(23-7-6-22-18)27-15-9-14(10-15)24-20-25-16-3-1-2-4-17(16)28-20/h1-4,6-7,13-15H,5,8-10,12H2,(H,24,25)/t13?,14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.07	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144721 (US8952037, 104) Show SMILES N#CC1CCN(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-5.71,5.83,;-5.71,4.29,;-5.71,2.75,;-4.37,1.93,;-4.37,.39,;-5.71,-.38,;-7.04,.39,;-7.04,1.93,;-5.71,-1.92,;-7.04,-2.69,;-7.04,-4.23,;-5.71,-5,;-4.37,-4.23,;-4.37,-2.69,;-3.04,-1.92,;-1.95,-3.01,;-.41,-3.01,;-.41,-4.55,;-1.95,-4.55,;.68,-5.64,;2.01,-4.87,;2.49,-3.41,;4.03,-3.41,;5.06,-2.26,;6.56,-2.58,;7.04,-4.05,;6.01,-5.19,;4.5,-4.87,;3.26,-5.78,)| Show InChI InChI=1S/C22H23N5OS/c23-14-15-7-10-27(11-8-15)19-5-3-9-24-21(19)28-17-12-16(13-17)25-22-26-18-4-1-2-6-20(18)29-22/h1-6,9,15-17H,7-8,10-13H2,(H,25,26)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.25	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144682 (US8952037, 55) Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.39,;-6.28,3.85,;-6.28,2.31,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C24H19N5O/c25-14-18-9-7-17(15-27-18)21-5-3-11-26-24(21)30-20-12-19(13-20)28-23-10-8-16-4-1-2-6-22(16)29-23/h1-11,15,19-20H,12-13H2,(H,28,29)/t19-,20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.29	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144696 (US8952037, 69) Show SMILES COCC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:18.19,20.24,(-1.56,5.77,;-2.89,5,;-4.22,5.77,;-5.56,5,;-6.65,6.09,;-5.56,3.46,;-6.89,2.69,;-6.89,1.15,;-5.56,.38,;-4.22,1.15,;-4.22,2.69,;-5.56,-1.16,;-6.89,-1.93,;-6.89,-3.47,;-5.56,-4.24,;-4.22,-3.47,;-4.22,-1.93,;-2.89,-1.16,;-1.8,-2.24,;-.26,-2.24,;-.26,-3.78,;-1.8,-3.78,;.83,-4.87,;2.16,-4.1,;2.32,-2.57,;3.83,-2.25,;4.6,-.92,;6.14,-.92,;6.91,-2.25,;6.14,-3.58,;4.6,-3.58,;3.57,-4.73,)| Show InChI InChI=1S/C24H28N4O3S/c1-30-15-22(29)28-11-8-16(9-12-28)19-5-4-10-25-23(19)31-18-13-17(14-18)26-24-27-20-6-2-3-7-21(20)32-24/h2-7,10,16-18H,8-9,11-15H2,1H3,(H,26,27)/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.29	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144698 (US8952037, 71) Show SMILES CC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C25H28N4O2/c1-17(30)29-13-10-18(11-14-29)22-6-4-12-26-25(22)31-21-15-20(16-21)27-24-9-8-19-5-2-3-7-23(19)28-24/h2-9,12,18,20-21H,10-11,13-16H2,1H3,(H,27,28)/t20-,21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.32	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144666 (US8952037, 39) Show SMILES Fc1ccc2nc(N[C@H]3C[C@H](C3)Oc3ncc(F)cc3C3CCOCC3)sc2c1 |r,wU:10.12,8.7,(8.75,-.78,;7.21,-.78,;6.44,.56,;4.9,.56,;4.13,-.78,;2.63,-1.1,;2.47,-2.63,;1.13,-3.4,;-.2,-2.63,;-1.69,-3.03,;-2.09,-1.54,;-.6,-1.14,;-3.42,-.77,;-4.75,-1.54,;-4.75,-3.08,;-6.09,-3.85,;-7.42,-3.08,;-8.75,-3.85,;-7.42,-1.54,;-6.09,-.77,;-6.09,.77,;-7.42,1.54,;-7.42,3.08,;-6.09,3.85,;-4.75,3.08,;-4.75,1.54,;3.87,-3.26,;4.9,-2.11,;6.44,-2.11,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-1-2-18-19(8-13)29-21(26-18)25-15-9-16(10-15)28-20-17(7-14(23)11-24-20)12-3-5-27-6-4-12/h1-2,7-8,11-12,15-16H,3-6,9-10H2,(H,25,26)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.44	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144729 (US8952037, 112) Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1ccc2ccccc2n1 |r,wD:3.4,1.19,(-.79,-1.14,;-.39,-2.63,;-1.88,-3.03,;-2.28,-1.54,;-3.61,-.77,;-4.94,-1.54,;-4.94,-3.08,;-6.28,-3.85,;-7.61,-3.08,;-7.61,-1.54,;-6.28,-.77,;-6.28,.77,;-4.94,1.54,;-4.94,3.08,;-6.28,3.85,;-7.61,3.08,;-7.61,1.54,;.94,-3.4,;2.28,-2.63,;2.28,-1.09,;3.61,-.32,;4.94,-1.09,;6.28,-.32,;7.61,-1.09,;7.61,-2.63,;6.28,-3.4,;4.94,-2.63,;3.61,-3.4,)| Show InChI InChI=1S/C23H25N3O2/c1-2-6-21-17(4-1)7-8-22(26-21)25-18-14-19(15-18)28-23-20(5-3-11-24-23)16-9-12-27-13-10-16/h1-8,11,16,18-19H,9-10,12-15H2,(H,25,26)/t18-,19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144654 (US8952037, 21) Show SMILES C1[C@@H](C[C@@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2[nH]1 |r,wU:3.4,1.19,(-1.8,-3.09,;-.26,-3.09,;-.26,-1.55,;-1.8,-1.55,;-2.89,-.46,;-4.37,-.86,;-4.77,-2.35,;-6.26,-2.75,;-7.35,-1.66,;-6.95,-.17,;-5.46,.23,;-5.06,1.71,;-3.58,2.11,;-3.18,3.6,;-4.27,4.69,;-5.75,4.29,;-6.15,2.8,;.83,-4.18,;2.32,-3.78,;2.8,-2.32,;4.34,-2.32,;5.37,-1.17,;6.87,-1.49,;7.35,-2.96,;6.32,-4.1,;4.81,-3.78,;3.57,-4.69,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.53	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144676 (US8952037, 49) Show SMILES Cc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-1.58,-3.03,;-.1,-2.63,;-.5,-1.14,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H19N5OS/c1-13-16(5-4-8-22-13)19-20(24-10-9-23-19)27-15-11-14(12-15)25-21-26-17-6-2-3-7-18(17)28-21/h2-10,14-15H,11-12H2,1H3,(H,25,26)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.94	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144713 (US8952037, 88) Show SMILES N#CC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:15.16,17.21,(-6.28,5.39,;-6.28,3.85,;-6.28,2.31,;-4.94,1.54,;-4.94,,;-6.28,-.77,;-7.61,,;-7.61,1.54,;-6.28,-2.31,;-7.61,-3.08,;-7.61,-4.62,;-6.28,-5.39,;-4.94,-4.62,;-4.94,-3.08,;-3.61,-2.31,;-2.28,-3.08,;-.79,-2.68,;-.39,-4.17,;-1.88,-4.57,;.94,-4.94,;2.28,-4.17,;2.28,-2.63,;3.61,-1.86,;4.94,-2.63,;6.28,-1.86,;7.61,-2.63,;7.61,-4.17,;6.28,-4.94,;4.94,-4.17,;3.61,-4.94,)| Show InChI InChI=1S/C23H24N6O/c24-15-16-7-11-29(12-8-16)22-23(26-10-9-25-22)30-19-13-18(14-19)27-21-6-5-17-3-1-2-4-20(17)28-21/h1-6,9-10,16,18-19H,7-8,11-14H2,(H,27,28)/t18-,19+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.26	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144711 (US8952037, 86) Show SMILES N#CC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-5.98,5.39,;-5.98,3.85,;-5.98,2.31,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C21H22N6OS/c22-13-14-5-9-27(10-6-14)19-20(24-8-7-23-19)28-16-11-15(12-16)25-21-26-17-3-1-2-4-18(17)29-21/h1-4,7-8,14-16H,5-6,9-12H2,(H,25,26)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.31	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144680 (US8952037, 53) Show SMILES Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ncc2ccccc2n1 |r,wD:14.15,16.20,(-6.28,4.62,;-6.28,3.08,;-4.94,2.31,;-4.94,.77,;-6.28,,;-7.61,.77,;-7.61,2.31,;-6.28,-1.54,;-7.61,-2.31,;-7.61,-3.85,;-6.28,-4.62,;-4.94,-3.85,;-4.94,-2.31,;-3.61,-1.54,;-2.28,-2.31,;-.79,-1.91,;-.39,-3.4,;-1.88,-3.8,;.94,-4.17,;2.28,-3.4,;2.28,-1.86,;3.61,-1.09,;4.94,-1.86,;6.28,-1.09,;7.61,-1.86,;7.61,-3.4,;6.28,-4.17,;4.94,-3.4,;3.61,-4.17,)| Show InChI InChI=1S/C22H20N6O/c1-14-6-7-16(13-25-14)20-21(24-9-8-23-20)29-18-10-17(11-18)27-22-26-12-15-4-2-3-5-19(15)28-22/h2-9,12-13,17-18H,10-11H2,1H3,(H,26,27,28)/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.43	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144667 (US8952037, 40) Show SMILES Fc1cnc(O[C@@H]2C[C@@H](C2)Nc2nc3cccc(F)c3s2)c(c1)C1CCOCC1 |r,wU:6.5,8.10,(-7.98,-3.85,;-6.65,-3.08,;-5.32,-3.85,;-3.98,-3.08,;-3.98,-1.54,;-2.65,-.77,;-1.32,-1.54,;-.92,-3.03,;.57,-2.63,;.17,-1.14,;1.9,-3.4,;3.24,-2.63,;3.4,-1.1,;4.9,-.78,;5.67,.56,;7.21,.56,;7.98,-.78,;7.21,-2.11,;7.98,-3.44,;5.67,-2.11,;4.64,-3.26,;-5.32,-.77,;-6.65,-1.54,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-8-16(12-4-6-27-7-5-12)20(24-11-13)28-15-9-14(10-15)25-21-26-18-3-1-2-17(23)19(18)29-21/h1-3,8,11-12,14-15H,4-7,9-10H2,(H,25,26)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.45	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144655 (US8952037, 22) Show SMILES C1[C@@H](C[C@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2[nH]1 |r,wU:3.4,wD:1.19,(-.26,-1.55,;-.26,-3.09,;-1.8,-3.09,;-1.8,-1.55,;-2.89,-.46,;-4.37,-.86,;-4.77,-2.35,;-6.26,-2.75,;-7.35,-1.66,;-6.95,-.17,;-5.46,.23,;-5.06,1.71,;-3.58,2.11,;-3.18,3.6,;-4.27,4.69,;-5.75,4.29,;-6.15,2.8,;.83,-4.18,;2.32,-3.78,;2.8,-2.32,;4.34,-2.32,;5.37,-1.17,;6.87,-1.49,;7.35,-2.96,;6.32,-4.1,;4.81,-3.78,;3.57,-4.69,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.63	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144677 (US8952037, 50) Show SMILES CC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:18.22,16.17,(-.02,-5.71,;1.52,-5.71,;2.29,-7.05,;2.29,-4.38,;1.52,-3.05,;2.29,-1.71,;3.83,-1.71,;4.6,-3.05,;3.83,-4.38,;4.6,-.38,;6.14,-.38,;6.91,.95,;6.14,2.29,;4.6,2.29,;3.83,.95,;2.29,.95,;1.52,2.29,;1.92,3.78,;.43,4.17,;.04,2.69,;-.34,5.51,;-1.88,5.51,;-2.78,4.26,;-4.25,4.74,;-5.58,3.97,;-6.91,4.74,;-6.91,6.28,;-5.58,7.05,;-4.25,6.28,;-2.78,6.75,)| Show InChI InChI=1S/C22H19N5O2S/c1-13(28)17-7-6-14(12-25-17)20-21(24-9-8-23-20)29-16-10-15(11-16)26-22-27-18-4-2-3-5-19(18)30-22/h2-9,12,15-16H,10-11H2,1H3,(H,26,27)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.74	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144647 (US8952037, 14) Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-1.58,-4.18,;-.1,-3.78,;-.5,-2.3,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C22H25N5O2S/c1-14(28)27-10-6-15(7-11-27)20-21(24-9-8-23-20)29-17-12-16(13-17)25-22-26-18-4-2-3-5-19(18)30-22/h2-5,8-9,15-17H,6-7,10-13H2,1H3,(H,25,26)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.77	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144731 (US8952037, 92) Show SMILES OC[C@@H]1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:2.1,wD:15.16,17.21,(-1.98,8.15,;-3.32,8.92,;-4.65,8.15,;-5.98,8.92,;-7.32,8.15,;-7.32,6.61,;-5.98,5.84,;-4.65,6.61,;-5.98,4.3,;-7.32,3.53,;-7.32,1.99,;-5.98,1.22,;-4.65,1.99,;-4.65,3.53,;-3.32,4.3,;-1.98,3.53,;-.5,3.92,;-.1,2.44,;-1.58,2.04,;1.24,1.67,;2.57,2.44,;2.73,3.97,;4.24,4.29,;5.01,5.62,;6.55,5.62,;7.32,4.29,;6.55,2.96,;5.01,2.96,;3.98,1.81,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-4-3-9-26(12-14)19-20(23-8-7-22-19)28-16-10-15(11-16)24-21-25-17-5-1-2-6-18(17)29-21/h1-2,5-8,14-16,27H,3-4,9-13H2,(H,24,25)/t14-,15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.81	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144687 (US8952037, 60) Show SMILES NC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:16.17,18.22,(-4.65,5,;-5.98,4.23,;-7.32,5,;-5.98,2.69,;-4.65,1.93,;-4.65,.38,;-5.98,-.38,;-7.32,.38,;-7.32,1.93,;-5.98,-1.93,;-7.32,-2.69,;-7.32,-4.23,;-5.98,-5,;-4.65,-4.23,;-4.65,-2.69,;-3.32,-1.93,;-1.98,-2.69,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C21H18N6O2S/c22-19(28)16-6-5-12(11-25-16)18-20(24-8-7-23-18)29-14-9-13(10-14)26-21-27-15-3-1-2-4-17(15)30-21/h1-8,11,13-14H,9-10H2,(H2,22,28)(H,26,27)/t13-,14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.96	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144685 (US8952037, 58 | US8952037, 59) Show SMILES N#Cc1ccc(cn1)-c1cccnc1O[C@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:17.21,wD:15.16,(-5.98,5.45,;-5.98,3.91,;-5.98,2.37,;-4.65,1.54,;-4.65,,;-5.98,-.77,;-7.32,,;-7.32,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-1.58,-4.57,;-.1,-4.17,;-.5,-2.68,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C22H17N5OS/c23-12-15-8-7-14(13-25-15)18-4-3-9-24-21(18)28-17-10-16(11-17)26-22-27-19-5-1-2-6-20(19)29-22/h1-9,13,16-17H,10-11H2,(H,26,27)/t16-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.97	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144700 (US8952037, 75) Show SMILES OCC1CCN(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-7.32,5.01,;-5.98,4.23,;-5.98,2.69,;-7.32,1.92,;-7.32,.38,;-5.98,-.39,;-4.65,.38,;-4.65,1.92,;-5.98,-1.93,;-7.32,-2.7,;-7.32,-4.24,;-5.98,-5.01,;-4.65,-4.24,;-4.65,-2.7,;-3.32,-1.93,;-1.98,-2.7,;-.5,-2.3,;-.1,-3.78,;-1.58,-4.18,;1.24,-4.55,;2.57,-3.78,;2.73,-2.25,;4.24,-1.93,;5.01,-.6,;6.55,-.6,;7.32,-1.93,;6.55,-3.27,;5.01,-3.27,;3.98,-4.41,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-5-9-26(10-6-14)19-20(23-8-7-22-19)28-16-11-15(12-16)24-21-25-17-3-1-2-4-18(17)29-21/h1-4,7-8,14-16,27H,5-6,9-13H2,(H,24,25)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144697 (US8952037, 70) Show SMILES COC(=O)N1CCC(CC1)c1cccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:17.18,19.23,(-3.32,3.91,;-4.65,4.68,;-5.98,3.91,;-7.07,4.99,;-5.98,2.37,;-7.32,1.54,;-7.32,,;-5.98,-.77,;-4.65,,;-4.65,1.54,;-5.98,-2.31,;-7.32,-3.08,;-7.32,-4.62,;-5.98,-5.39,;-4.65,-4.62,;-4.65,-3.08,;-3.32,-2.31,;-1.98,-3.08,;-.5,-2.68,;-.1,-4.17,;-1.58,-4.57,;1.24,-4.94,;2.57,-4.17,;2.73,-2.64,;4.24,-2.32,;5.01,-.98,;6.55,-.98,;7.32,-2.32,;6.55,-3.65,;5.01,-3.65,;3.98,-4.8,)| Show InChI InChI=1S/C23H26N4O3S/c1-29-23(28)27-11-8-15(9-12-27)18-5-4-10-24-21(18)30-17-13-16(14-17)25-22-26-19-6-2-3-7-20(19)31-22/h2-7,10,15-17H,8-9,11-14H2,1H3,(H,25,26)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.18	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144658 (US8952037, 25) Show SMILES C1[C@@H](C[C@H]1Oc1ncccc1C1CCOCC1)Nc1nc2ccccc2s1 |r,wU:3.4,wD:1.19,(-.64,-1.14,;-.24,-2.63,;-1.73,-3.03,;-2.12,-1.54,;-3.46,-.77,;-4.79,-1.54,;-4.79,-3.08,;-6.12,-3.85,;-7.46,-3.08,;-7.46,-1.54,;-6.12,-.77,;-6.12,.77,;-4.79,1.54,;-4.79,3.08,;-6.12,3.85,;-7.46,3.08,;-7.46,1.54,;1.1,-3.4,;2.43,-2.63,;2.91,-1.16,;4.45,-1.16,;5.48,-.02,;6.98,-.34,;7.46,-1.8,;6.43,-2.95,;4.92,-2.63,;3.68,-3.53,)| Show InChI InChI=1S/C21H23N3O2S/c1-2-6-19-18(5-1)24-21(27-19)23-15-12-16(13-15)26-20-17(4-3-9-22-20)14-7-10-25-11-8-14/h1-6,9,14-16H,7-8,10-13H2,(H,23,24)/t15-,16-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.19	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144717 (US8952037, 93) Show SMILES C[C@@H]1CCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:1.0,wD:13.14,15.19,(-4.44,9.51,;-5.21,8.18,;-6.75,8.18,;-7.23,6.72,;-5.98,5.81,;-4.74,6.72,;-5.98,4.27,;-7.32,3.5,;-7.32,1.96,;-5.98,1.19,;-4.65,1.96,;-4.65,3.5,;-3.32,4.27,;-1.98,3.5,;-.5,3.9,;-.1,2.41,;-1.58,2.01,;1.24,1.64,;2.57,2.41,;2.73,3.94,;4.24,4.26,;5.01,5.6,;6.55,5.6,;7.32,4.26,;6.55,2.93,;5.01,2.93,;3.98,1.79,)| Show InChI InChI=1S/C20H23N5OS/c1-13-6-9-25(12-13)18-19(22-8-7-21-18)26-15-10-14(11-15)23-20-24-16-4-2-3-5-17(16)27-20/h2-5,7-8,13-15H,6,9-12H2,1H3,(H,23,24)/t13-,14-,15+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.24	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144673 (US8952037, 46) Show SMILES Cc1ncc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:16.20,14.15,(1.52,-6.38,;2.29,-5.05,;1.52,-3.71,;2.29,-2.38,;3.83,-2.38,;4.6,-3.71,;3.83,-5.05,;4.6,-1.05,;6.14,-1.05,;6.91,.29,;6.14,1.62,;4.6,1.62,;3.83,.29,;2.29,.29,;1.52,1.62,;1.92,3.11,;.43,3.51,;.04,2.02,;-.34,4.84,;-1.88,4.84,;-2.78,3.6,;-4.25,4.07,;-5.58,3.3,;-6.91,4.07,;-6.91,5.61,;-5.58,6.38,;-4.25,5.61,;-2.78,6.09,)| Show InChI InChI=1S/C20H18N6OS/c1-12-23-10-13(11-24-12)18-19(22-7-6-21-18)27-15-8-14(9-15)25-20-26-16-4-2-3-5-17(16)28-20/h2-7,10-11,14-15H,8-9H2,1H3,(H,25,26)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.25	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144671 (US8952037, 44) Show SMILES Cc1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-5.98,4.62,;-5.98,3.08,;-4.65,2.31,;-4.65,.77,;-5.98,,;-7.32,.77,;-7.32,2.31,;-5.98,-1.54,;-7.32,-2.31,;-7.32,-3.85,;-5.98,-4.62,;-4.65,-3.85,;-4.65,-2.31,;-3.32,-1.54,;-1.98,-2.31,;-1.58,-3.8,;-.1,-3.4,;-.5,-1.91,;1.24,-4.17,;2.57,-3.4,;2.73,-1.87,;4.24,-1.55,;5.01,-.21,;6.55,-.21,;7.32,-1.55,;6.55,-2.88,;5.01,-2.88,;3.98,-4.03,)| Show InChI InChI=1S/C21H19N5OS/c1-13-6-7-14(12-24-13)19-20(23-9-8-22-19)27-16-10-15(11-16)25-21-26-17-4-2-3-5-18(17)28-21/h2-9,12,15-16H,10-11H2,1H3,(H,25,26)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.39	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144665 (US8952037, 38) Show SMILES Fc1ccc2sc(N[C@H]3C[C@H](C3)Oc3ncc(F)cc3C3CCOCC3)nc2c1 |r,wD:10.12,8.7,(7.98,1.89,;7.21,.56,;7.98,-.78,;7.21,-2.11,;5.67,-2.11,;4.64,-3.26,;3.24,-2.63,;1.9,-3.4,;.57,-2.63,;.17,-1.14,;-1.32,-1.54,;-.92,-3.03,;-2.65,-.77,;-3.98,-1.54,;-3.98,-3.08,;-5.32,-3.85,;-6.65,-3.08,;-7.98,-3.85,;-6.65,-1.54,;-5.32,-.77,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,;3.4,-1.1,;4.9,-.78,;5.67,.56,)| Show InChI InChI=1S/C21H21F2N3O2S/c22-13-1-2-19-18(8-13)26-21(29-19)25-15-9-16(10-15)28-20-17(7-14(23)11-24-20)12-3-5-27-6-4-12/h1-2,7-8,11-12,15-16H,3-6,9-10H2,(H,25,26)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.49	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144668 (US8952037, 41) Show SMILES Clc1ccc(C2=CCOCC2)c(O[C@@H]2C[C@@H](C2)Nc2nc3ccccc3s2)n1 |r,wU:13.13,15.18,t:5,(-5.98,-4.62,;-5.98,-3.08,;-7.32,-2.31,;-7.32,-.77,;-5.98,,;-5.98,1.54,;-7.32,2.31,;-7.32,3.85,;-5.98,4.62,;-4.65,3.85,;-4.65,2.31,;-4.65,-.77,;-3.32,,;-1.98,-.77,;-1.58,-2.26,;-.1,-1.86,;-.5,-.37,;1.24,-2.63,;2.57,-1.86,;2.73,-.33,;4.24,-.01,;5.01,1.33,;6.55,1.33,;7.32,-.01,;6.55,-1.34,;5.01,-1.34,;3.98,-2.49,;-4.65,-2.31,)| Show InChI InChI=1S/C21H20ClN3O2S/c22-19-6-5-16(13-7-9-26-10-8-13)20(25-19)27-15-11-14(12-15)23-21-24-17-3-1-2-4-18(17)28-21/h1-7,14-15H,8-12H2,(H,23,24)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.55	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144705 (US8952037, 80) Show SMILES OCC1CCCN(C1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:15.16,17.21,(-1.98,3.08,;-3.32,3.85,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-4.65,1.54,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H25N5O2S/c27-13-14-4-3-9-26(12-14)19-20(23-8-7-22-19)28-16-10-15(11-16)24-21-25-17-5-1-2-6-18(17)29-21/h1-2,5-8,14-16,27H,3-4,9-13H2,(H,24,25)/t14?,15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.62	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144688 (US8952037, 61) Show SMILES NC(=O)c1ccc(cn1)-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wU:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-4.94,1.92,;-4.94,.38,;-6.28,-.39,;-7.61,.38,;-7.61,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-1.88,-4.18,;-.39,-3.78,;-.79,-2.3,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C23H20N6O2/c24-22(30)19-7-5-15(13-27-19)21-23(26-10-9-25-21)31-17-11-16(12-17)28-20-8-6-14-3-1-2-4-18(14)29-20/h1-10,13,16-17H,11-12H2,(H2,24,30)(H,28,29)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144672 (US8952037, 45) Show SMILES COc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:15.16,17.21,(-8.65,1.54,;-7.32,.77,;-5.98,1.54,;-5.98,3.08,;-4.65,3.85,;-3.32,3.08,;-3.32,1.54,;-4.65,.77,;-4.65,-.77,;-5.98,-1.54,;-5.98,-3.08,;-4.65,-3.85,;-3.32,-3.08,;-3.32,-1.54,;-1.98,-.77,;-.65,-1.54,;-.25,-3.03,;1.24,-2.63,;.84,-1.14,;2.57,-3.4,;3.9,-2.63,;4.07,-1.1,;5.57,-.78,;6.34,.56,;7.88,.56,;8.65,-.78,;7.88,-2.11,;6.34,-2.11,;5.31,-3.26,)| Show InChI InChI=1S/C21H19N5O2S/c1-27-19-15(5-4-8-23-19)18-20(24-10-9-22-18)28-14-11-13(12-14)25-21-26-16-6-2-3-7-17(16)29-21/h2-10,13-14H,11-12H2,1H3,(H,25,26)/t13-,14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.11	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144669 (US8952037, 42) Show SMILES Cc1cnccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-.5,-1.14,;-.1,-2.63,;-1.58,-3.03,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)| Show InChI InChI=1S/C21H19N5OS/c1-13-12-22-7-6-16(13)19-20(24-9-8-23-19)27-15-10-14(11-15)25-21-26-17-4-2-3-5-18(17)28-21/h2-9,12,14-15H,10-11H2,1H3,(H,25,26)/t14-,15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.23	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47126 (US8952027, 64) Show SMILES COC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wD:19.23,17.18,(-.43,-2.36,;-1.77,-1.59,;-3.1,-2.36,;-4.43,-1.59,;-3.1,-3.9,;-1.77,-4.67,;-1.77,-6.21,;-3.1,-6.98,;-4.43,-6.21,;-4.43,-4.67,;-3.1,-8.52,;-4.43,-9.29,;-4.43,-10.83,;-3.1,-11.59,;-1.77,-10.83,;-1.77,-9.29,;-.43,-8.52,;.9,-9.29,;2.39,-8.89,;2.79,-10.37,;1.3,-10.77,;4.12,-11.14,;5.45,-10.37,;5.62,-8.84,;7.13,-8.53,;7.9,-7.19,;9.44,-7.2,;10.21,-8.53,;9.43,-9.86,;7.89,-9.86,;6.86,-11,)| Show InChI InChI=1S/C22H25N5O3S/c1-29-22(28)27-10-6-14(7-11-27)19-20(24-9-8-23-19)30-16-12-15(13-16)25-21-26-17-4-2-3-5-18(17)31-21/h2-5,8-9,14-16H,6-7,10-13H2,1H3,(H,25,26)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.24	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144694 (US8952037, 67) Show SMILES CC(=O)N1CCC(CC1)c1nccnc1O[C@@H]1C[C@@H](C1)Nc1ccc2ccccc2n1 |r,wD:16.17,18.22,(-4.94,5,;-6.28,4.23,;-7.61,5,;-6.28,2.69,;-7.61,1.92,;-7.61,.38,;-6.28,-.39,;-4.94,.38,;-4.94,1.92,;-6.28,-1.93,;-7.61,-2.7,;-7.61,-4.24,;-6.28,-5.01,;-4.94,-4.24,;-4.94,-2.7,;-3.61,-1.93,;-2.28,-2.7,;-.79,-2.3,;-.39,-3.78,;-1.88,-4.18,;.94,-4.55,;2.28,-3.78,;2.28,-2.24,;3.61,-1.47,;4.94,-2.24,;6.28,-1.47,;7.61,-2.24,;7.61,-3.78,;6.28,-4.55,;4.94,-3.78,;3.61,-4.55,)| Show InChI InChI=1S/C24H27N5O2/c1-16(30)29-12-8-18(9-13-29)23-24(26-11-10-25-23)31-20-14-19(15-20)27-22-7-6-17-4-2-3-5-21(17)28-22/h2-7,10-11,18-20H,8-9,12-15H2,1H3,(H,27,28)/t19-,20+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.93	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
					More data for this Ligand-Target Pair

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