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Compile Data Set for Download or QSAR

Found 62 hits with Last Name = 'naiman' and Initial = 'n'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM82517
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM82517
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3
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 0.600n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50007173
PNG
(2-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butyl]-iso...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cccc3ccccc23)C(=O)c2ccccc12
Show InChI InChI=1S/C26H27N3O2/c30-25-22-11-3-4-12-23(22)26(31)29(25)15-6-5-14-27-16-18-28(19-17-27)24-13-7-9-20-8-1-2-10-21(20)24/h1-4,7-13H,5-6,14-19H2
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 1n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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 1.20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016737
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dip...)
Show SMILES CCCN(CCC)C1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C17H27NO/c1-4-11-18(12-5-2)15-10-9-14-7-6-8-17(19-3)16(14)13-15/h6-8,15H,4-5,9-13H2,1-3H3
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 1.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016743
PNG
(7-(3-Phenyl-propylamino)-5,6,7,8-tetrahydro-naphth...)
Show SMILES Oc1cccc2CCC(Cc12)NCCCc1ccccc1
Show InChI InChI=1S/C19H23NO/c21-19-10-4-9-16-11-12-17(14-18(16)19)20-13-5-8-15-6-2-1-3-7-15/h1-4,6-7,9-10,17,20-21H,5,8,11-14H2
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 1.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50007180
PNG
(CHEMBL26188 | N-(4-(4-(2-methoxyphenyl)piperazin-1...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1
Show InChI InChI=1S/C22H29N3O2/c1-27-21-12-6-5-11-20(21)25-17-15-24(16-18-25)14-8-7-13-23-22(26)19-9-3-2-4-10-19/h2-6,9-12H,7-8,13-18H2,1H3,(H,23,26)
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 2n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016740
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-met...)
Show SMILES COc1cccc2CCC(Cc12)N(C)CCCc1ccccc1
Show InChI InChI=1S/C21H27NO/c1-22(15-7-10-17-8-4-3-5-9-17)19-14-13-18-11-6-12-21(23-2)20(18)16-19/h3-6,8-9,11-12,19H,7,10,13-16H2,1-2H3
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 2n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016745
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-met...)
Show SMILES CCCN(C)C1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C15H23NO/c1-4-10-16(2)13-9-8-12-6-5-7-15(17-3)14(12)11-13/h5-7,13H,4,8-11H2,1-3H3
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 2.10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016736
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-pro...)
Show SMILES CCCNC1CCc2cccc(OC)c2C1
Show InChI InChI=1S/C14H21NO/c1-3-9-15-12-8-7-11-5-4-6-14(16-2)13(11)10-12/h4-6,12,15H,3,7-10H2,1-2H3
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 2.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016738
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(3-...)
Show SMILES COc1cccc2CCC(Cc12)NCCCc1ccccc1
Show InChI InChI=1S/C20H25NO/c1-22-20-11-5-10-17-12-13-18(15-19(17)20)21-14-6-9-16-7-3-2-4-8-16/h2-5,7-8,10-11,18,21H,6,9,12-15H2,1H3
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 2.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM82087
PNG
(2-(5-methoxy-1H-indol-3-yl)ethanamine | 5-MT | 5-M...)
Show SMILES COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
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 3.20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018459
PNG
(1-(7-Methoxy-naphthalen-1-yl)-piperazine | 4-(7-Me...)
Show SMILES COc1ccc2cccc(N3CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-18-13-6-5-12-3-2-4-15(14(12)11-13)17-9-7-16-8-10-17/h2-6,11,16H,7-10H2,1H3
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 3.30n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018456
PNG
(2-{5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-pentyl}...)
Show SMILES COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C24H29N3O3/c1-30-22-12-6-5-11-21(22)26-17-15-25(16-18-26)13-7-2-8-14-27-23(28)19-9-3-4-10-20(19)24(27)29/h3-6,9-12H,2,7-8,13-18H2,1H3
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 5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-HT 1A receptor by measuring ability to displace [3H]-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat stria...

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016744
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(4-...)
Show SMILES COc1cccc2CCC(Cc12)NCCCCc1ccccc1
Show InChI InChI=1S/C21H27NO/c1-23-21-12-7-11-18-13-14-19(16-20(18)21)22-15-6-5-10-17-8-3-2-4-9-17/h2-4,7-9,11-12,19,22H,5-6,10,13-16H2,1H3
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 5.60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016741
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-met...)
Show SMILES COc1cccc2CCC(Cc12)N(C)CCc1ccccc1
Show InChI InChI=1S/C20H25NO/c1-21(14-13-16-7-4-3-5-8-16)18-12-11-17-9-6-10-20(22-2)19(17)15-18/h3-10,18H,11-15H2,1-2H3
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 7.90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018452
PNG
(2-[5-(4-Phenyl-piperazin-1-yl)-pentyl]-isoindole-1...)
Show SMILES O=C1N(CCCCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C23H27N3O2/c27-22-20-11-5-6-12-21(20)23(28)26(22)14-8-2-7-13-24-15-17-25(18-16-24)19-9-3-1-4-10-19/h1,3-6,9-12H,2,7-8,13-18H2
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 8.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018452
PNG
(2-[5-(4-Phenyl-piperazin-1-yl)-pentyl]-isoindole-1...)
Show SMILES O=C1N(CCCCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C23H27N3O2/c27-22-20-11-5-6-12-21(20)23(28)26(22)14-8-2-7-13-24-15-17-25(18-16-24)19-9-3-1-4-10-19/h1,3-6,9-12H,2,7-8,13-18H2
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 8.5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018458
PNG
(2-[4-(4-Phenyl-piperazin-1-yl)-butyl]-isoindole-1,...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C22H25N3O2/c26-21-19-10-4-5-11-20(19)22(27)25(21)13-7-6-12-23-14-16-24(17-15-23)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
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 10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018458
PNG
(2-[4-(4-Phenyl-piperazin-1-yl)-butyl]-isoindole-1,...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C22H25N3O2/c26-21-19-10-4-5-11-20(19)22(27)25(21)13-7-6-12-23-14-16-24(17-15-23)18-8-2-1-3-9-18/h1-5,8-11H,6-7,12-17H2
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 10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM30707
PNG
(2-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-ethanamin...)
Show SMILES COc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2O/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
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 10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016735
PNG
((8-Benzyloxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(...)
Show SMILES C(CNC1CCc2cccc(OCc3ccccc3)c2C1)Cc1ccccc1
Show InChI InChI=1S/C26H29NO/c1-3-9-21(10-4-1)13-8-18-27-24-17-16-23-14-7-15-26(25(23)19-24)28-20-22-11-5-2-6-12-22/h1-7,9-12,14-15,24,27H,8,13,16-20H2
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 10n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018449
PNG
(2-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-isoindole-1,...)
Show SMILES O=C1N(CCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C20H21N3O2/c24-19-17-8-4-5-9-18(17)20(25)23(19)15-12-21-10-13-22(14-11-21)16-6-2-1-3-7-16/h1-9H,10-15H2
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 11n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50022717
PNG
(CHEMBL27393 | N-[4-(4-Phenyl-piperazin-1-yl)-butyl...)
Show SMILES O=C(NCCCCN1CCN(CC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27N3O/c25-21(19-9-3-1-4-10-19)22-13-7-8-14-23-15-17-24(18-16-23)20-11-5-2-6-12-20/h1-6,9-12H,7-8,13-18H2,(H,22,25)
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 11n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50007407
PNG
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES C1CN(CCN1)c1cccc2ccccc12
Show InChI InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
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 11n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50006980
PNG
((3-Phenyl-propyl)-(1,2,3,4-tetrahydro-naphthalen-2...)
Show SMILES C(CNC1CCc2ccccc2C1)Cc1ccccc1
Show InChI InChI=1S/C19H23N/c1-2-7-16(8-3-1)9-6-14-20-19-13-12-17-10-4-5-11-18(17)15-19/h1-5,7-8,10-11,19-20H,6,9,12-15H2
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 13n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001859
PNG
((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
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 15n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016742
PNG
(CHEMBL26484 | Propyl-(1,2,3,4-tetrahydro-naphthale...)
Show SMILES CCCNC1CCc2ccccc2C1
Show InChI InChI=1S/C13H19N/c1-2-9-14-13-8-7-11-5-3-4-6-12(11)10-13/h3-6,13-14H,2,7-10H2,1H3
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 19n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018457
PNG
(2-{4-[2-(5-Methoxy-1H-indol-3-yl)-ethylamino]-buty...)
Show SMILES COc1ccc2[nH]cc(CCNCCCCN3C(=O)c4ccccc4C3=O)c2c1
Show InChI InChI=1S/C23H25N3O3/c1-29-17-8-9-21-20(14-17)16(15-25-21)10-12-24-11-4-5-13-26-22(27)18-6-2-3-7-19(18)23(26)28/h2-3,6-9,14-15,24-25H,4-5,10-13H2,1H3
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 20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018451
PNG
(2-{4-[3-(Naphthalen-1-yloxy)-propylamino]-butyl}-i...)
Show SMILES O=C1N(CCCCNCCCOc2cccc3ccccc23)C(=O)c2ccccc12
Show InChI InChI=1S/C25H26N2O3/c28-24-21-12-3-4-13-22(21)25(29)27(24)17-6-5-15-26-16-8-18-30-23-14-7-10-19-9-1-2-11-20(19)23/h1-4,7,9-14,26H,5-6,8,15-18H2
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 25n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018463
PNG
(1-(2-Methoxy-naphthalen-1-yl)-piperazine | CHEMBL2...)
Show SMILES COc1ccc2ccccc2c1N1CCNCC1
Show InChI InChI=1S/C15H18N2O/c1-18-14-7-6-12-4-2-3-5-13(12)15(14)17-10-8-16-9-11-17/h2-7,16H,8-11H2,1H3
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 34n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50019422
PNG
(2-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-isoi...)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)c2ccccc12
Show InChI InChI=1S/C20H23N5O2/c26-18-16-6-1-2-7-17(16)19(27)25(18)11-4-3-10-23-12-14-24(15-13-23)20-21-8-5-9-22-20/h1-2,5-9H,3-4,10-15H2
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 36n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016734
PNG
((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-phe...)
Show SMILES COc1cccc2CCC(Cc12)NCCc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-21-19-9-5-8-16-10-11-17(14-18(16)19)20-13-12-15-6-3-2-4-7-15/h2-9,17,20H,10-14H2,1H3
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 44n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018468
PNG
(2-{3-[3-(Naphthalen-1-yloxy)-propylamino]-propyl}-...)
Show SMILES O=C1N(CCCNCCCOc2cccc3ccccc23)C(=O)c2ccccc12
Show InChI InChI=1S/C24H24N2O3/c27-23-20-11-3-4-12-21(20)24(28)26(23)16-6-14-25-15-7-17-29-22-13-5-9-18-8-1-2-10-19(18)22/h1-5,8-13,25H,6-7,14-17H2
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 45n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-HT 1A receptor by measuring ability to displace [3H]-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat stria...

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018454
PNG
(2-[3-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES COc1cccc2CCC(Cc12)NCCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C22H24N2O3/c1-27-20-9-4-6-15-10-11-16(14-19(15)20)23-12-5-13-24-21(25)17-7-2-3-8-18(17)22(24)26/h2-4,6-9,16,23H,5,10-14H2,1H3
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 48n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016733
PNG
(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine ...)
Show SMILES COc1cccc2CCC(N)Cc12
Show InChI InChI=1S/C11H15NO/c1-13-11-4-2-3-8-5-6-9(12)7-10(8)11/h2-4,9H,5-7,12H2,1H3
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 53n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50022719
PNG
(CHEMBL27526 | N-[4-(4-Pyrimidin-2-yl-piperazin-1-y...)
Show SMILES O=C(NCCCCN1CCN(CC1)c1ncccn1)c1ccccc1
Show InChI InChI=1S/C19H25N5O/c25-18(17-7-2-1-3-8-17)20-9-4-5-12-23-13-15-24(16-14-23)19-21-10-6-11-22-19/h1-3,6-8,10-11H,4-5,9,12-16H2,(H,20,25)
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 60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018466
PNG
(2-[4-(3-Phenyl-propylamino)-butyl]-isoindole-1,3-d...)
Show SMILES O=C1N(CCCCNCCCc2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C21H24N2O2/c24-20-18-12-4-5-13-19(18)21(25)23(20)16-7-6-14-22-15-8-11-17-9-2-1-3-10-17/h1-5,9-10,12-13,22H,6-8,11,14-16H2
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 65n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001862
PNG
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Show SMILES COc1ccccc1N1CCNCC1
Show InChI InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
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 68n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50005132
PNG
(4,4-Dimethyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Show SMILES CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1
Show InChI InChI=1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
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 70n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016739
PNG
(Benzyl-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-...)
Show SMILES COc1cccc2CCC(Cc12)N(C)Cc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-20(14-15-7-4-3-5-8-15)17-12-11-16-9-6-10-19(21-2)18(16)13-17/h3-10,17H,11-14H2,1-2H3
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 78n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity at [3H]-8-OH-DPAT-Labeled 5-hydroxytryptamine 1A receptor sites in rat brain hippocampal membranes

J Med Chem 32: 253-6 (1989)


BindingDB Entry DOI: 10.7270/Q2M907NQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018462
PNG
(2-{4-[3-(2-Methoxy-phenyl)-propylamino]-butyl}-iso...)
Show SMILES COc1ccccc1CCCNCCCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C22H26N2O3/c1-27-20-13-5-2-9-17(20)10-8-15-23-14-6-7-16-24-21(25)18-11-3-4-12-19(18)22(24)26/h2-5,9,11-13,23H,6-8,10,14-16H2,1H3
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 110n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001915
PNG
(1-(3-chlorophenyl)piperazine | CHEMBL478 | m-Chlor...)
Show SMILES Clc1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
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 130n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018461
PNG
(2-(4-{[3-(2-Methoxy-phenyl)-propyl]-methyl-amino}-...)
Show SMILES COc1ccccc1CCCN(C)CCCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C23H28N2O3/c1-24(16-9-11-18-10-3-6-14-21(18)28-2)15-7-8-17-25-22(26)19-12-4-5-13-20(19)23(25)27/h3-6,10,12-14H,7-9,11,15-17H2,1-2H3
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 170n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50007406
PNG
(1-(3-(trifluoromethyl)phenyl)piperazine | 1-(3-Tri...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
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 175n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018464
PNG
(2-[3-(4-Phenyl-piperazin-1-yl)-propyl]-isoindole-1...)
Show SMILES O=C1N(CCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C21H23N3O2/c25-20-18-9-4-5-10-19(18)21(26)24(20)12-6-11-22-13-15-23(16-14-22)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2
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 200n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018464
PNG
(2-[3-(4-Phenyl-piperazin-1-yl)-propyl]-isoindole-1...)
Show SMILES O=C1N(CCCN2CCN(CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C21H23N3O2/c25-20-18-9-4-5-10-19(18)21(26)24(20)12-6-11-22-13-15-23(16-14-22)17-7-2-1-3-8-17/h1-5,7-10H,6,11-16H2
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 200n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018460
PNG
(2-(4-Phenethylamino-butyl)-isoindole-1,3-dione | C...)
Show SMILES O=C1N(CCCCNCCc2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C20H22N2O2/c23-19-17-10-4-5-11-18(17)20(24)22(19)15-7-6-13-21-14-12-16-8-2-1-3-9-16/h1-5,8-11,21H,6-7,12-15H2
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 240n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50018450
PNG
(2-[2-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES COc1cccc2CCC(Cc12)NCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H22N2O3/c1-26-19-8-4-5-14-9-10-15(13-18(14)19)22-11-12-23-20(24)16-6-2-3-7-17(16)21(23)25/h2-8,15,22H,9-13H2,1H3
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 250n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-hydroxytryptamine 1A receptor in rat striatal membranes by [3H]-OH-DPAT displacement.

J Med Chem 32: 1921-6 (1989)


BindingDB Entry DOI: 10.7270/Q2J67FWB
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50022716
PNG
(CHEMBL27555 | N-[4-(4-Phenyl-piperazin-1-yl)-butyl...)
Show SMILES CC(=O)NCCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C16H25N3O/c1-15(20)17-9-5-6-10-18-11-13-19(14-12-18)16-7-3-2-4-8-16/h2-4,7-8H,5-6,9-14H2,1H3,(H,17,20)
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 250n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain

J Med Chem 31: 1968-71 (1988)


BindingDB Entry DOI: 10.7270/Q2F18XR2
More data for this
Ligand-Target Pair
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