Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50004704 ((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479923 (CHEMBL521744) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479922 (CHEMBL489002) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479921 (CHEMBL508166) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C (RAT) | BDBM50475854 (CHEMBL386435) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 3.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Perugia Curated by ChEMBL | Assay Description Inhibition of [3H]diltiazem binding to Sprague-Dawley rat cardiomyocytes | J Med Chem 49: 5206-16 (2006) Article DOI: 10.1021/jm0604373 BindingDB Entry DOI: 10.7270/Q2KP84W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479920 (CHEMBL523271) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50004704 ((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in Wistar rat tail artery smooth muscle cells assessed as blockade of barium-sensitive inward rectifying current... | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479921 (CHEMBL508166) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in Wistar rat tail artery smooth muscle cells assessed as blockade of barium-sensitive inward rectifying current... | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus) | BDBM50479922 (CHEMBL489002) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Bologna Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel in Wistar rat tail artery smooth muscle cells assessed as blockade of barium-sensitive inward rectifying current... | J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C | |||||||||||
More data for this Ligand-Target Pair |