Found 715 hits with Last Name = 'chaplan' and Initial = 'sr' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM20461
((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)Show InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant TRPV1 |
Bioorg Med Chem Lett 20: 7137-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50052442
((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)Show SMILES COc1cc(CC(=O)OCC2=C[C@H]3[C@H]4O[C@]5(Cc6ccccc6)O[C@]4(C[C@@H](C)[C@]3(O5)[C@@H]3C=C(C)C(=O)[C@@]3(O)C2)C(C)=C)ccc1O |r,t:10,35,THB:23:15:26.25.24:12| Show InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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PC sid
PDB
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| PDB
Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Binding affinity to human recombinant TRPV1 |
Bioorg Med Chem Lett 20: 7137-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163221
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-3-5-13(6-4-12)26-16(29)28-10-8-27(9-11-28)15-14(18(22,23)24)2-1-7-25-15/h1-7H,8-11H2,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
Displacement of [3H]resiniferatoxin from human Transient receptor potential vanilloid 1 receptor; (n=2) |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402675
(CHEMBL2207348)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254419
(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)Show SMILES Clc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)ncnc2s1 Show InChI InChI=1S/C21H18Cl2N6O2S2/c22-15-4-3-5-16(23)17(15)27-21-28-18-19(24-12-25-20(18)32-21)26-13-6-8-14(9-7-13)33(30,31)29-10-1-2-11-29/h3-9,12H,1-2,10-11H2,(H,27,28)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254080
((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)Show SMILES OCc1cc(Cl)c(Nc2nc3c(Nc4ccc(cc4)C(F)(F)F)ncnc3s2)c(Cl)c1 Show InChI InChI=1S/C19H12Cl2F3N5OS/c20-12-5-9(7-30)6-13(21)14(12)28-18-29-15-16(25-8-26-17(15)31-18)27-11-3-1-10(2-4-11)19(22,23)24/h1-6,8,30H,7H2,(H,28,29)(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402675
(CHEMBL2207348)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254325
(CHEMBL469302 | N7-(4-tert-butylphenyl)-N2-(2,6-dic...)Show SMILES CC(C)(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C21H19Cl2N5S/c1-21(2,3)12-7-9-13(10-8-12)26-18-17-19(25-11-24-18)29-20(28-17)27-16-14(22)5-4-6-15(16)23/h4-11H,1-3H3,(H,27,28)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254077
(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)Show SMILES CC(C)CNc1nc(Nc2ccc(cc2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1 Show InChI InChI=1S/C22H19Cl2F3N6S/c1-11(2)10-28-20-32-18(29-13-8-6-12(7-9-13)22(25,26)27)17-19(33-20)34-21(31-17)30-16-14(23)4-3-5-15(16)24/h3-9,11H,10H2,1-2H3,(H,30,31)(H2,28,29,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174997
(CHEMBL3809683)Show SMILES Clc1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc3cccnc3)c2)nc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-7-22(26-15-19)30-21-5-1-3-18(14-21)13-17-8-11-28(12-9-17)23(29)27-20-4-2-10-25-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50254080
((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)Show SMILES OCc1cc(Cl)c(Nc2nc3c(Nc4ccc(cc4)C(F)(F)F)ncnc3s2)c(Cl)c1 Show InChI InChI=1S/C19H12Cl2F3N5OS/c20-12-5-9(7-30)6-13(21)14(12)28-18-29-15-16(25-8-26-17(15)31-18)27-11-3-1-10(2-4-11)19(22,23)24/h1-6,8,30H,7H2,(H,28,29)(H,25,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50254419
(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)Show SMILES Clc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)ncnc2s1 Show InChI InChI=1S/C21H18Cl2N6O2S2/c22-15-4-3-5-16(23)17(15)27-21-28-18-19(24-12-25-20(18)32-21)26-13-6-8-14(9-7-13)33(30,31)29-10-1-2-11-29/h3-9,12H,1-2,10-11H2,(H,27,28)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50235441
(4-(1-(3-isopropylbenzyl)piperidin-4-yl)-1-(oxazol-...)Show InChI InChI=1S/C22H30N2O2/c1-17(2)20-7-3-6-19(15-20)16-24-12-9-18(10-13-24)5-4-8-21(25)22-23-11-14-26-22/h3,6-7,11,14-15,17-18H,4-5,8-10,12-13,16H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 18: 2109-13 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.091
BindingDB Entry DOI: 10.7270/Q2708287 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174990
(CHEMBL3809293)Show SMILES FC(F)(F)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C24H23F3N4O2/c25-24(26,27)19-6-8-21(9-7-19)33-22-5-1-3-18(15-22)17-30-11-13-31(14-12-30)23(32)29-20-4-2-10-28-16-20/h1-10,15-16H,11-14,17H2,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448310
(CHEMBL3121143)Show SMILES CCSc1ccc(cc1)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H21N3OS/c1-2-25-17-10-8-15(9-11-17)18-12-20(23-14-22-18)21-13-19(24)16-6-4-3-5-7-16/h3-12,14,19,24H,2,13H2,1H3,(H,21,22,23)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174984
(CHEMBL3809841)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)c2)cc1 Show InChI InChI=1S/C23H22Cl2N4O2/c24-18-4-6-19(7-5-18)31-20-3-1-2-17(14-20)16-28-10-12-29(13-11-28)23(30)27-22-15-26-9-8-21(22)25/h1-9,14-15H,10-13,16H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394620
(CHEMBL2164602)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394620
(CHEMBL2164602)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254154
(CHEMBL468470 | N2-(2-chloro-6-methylphenyl)-N7-(4-...)Show SMILES Cc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)C(F)(F)F)ncnc2s1 Show InChI InChI=1S/C19H13ClF3N5S/c1-10-3-2-4-13(20)14(10)27-18-28-15-16(24-9-25-17(15)29-18)26-12-7-5-11(6-8-12)19(21,22)23/h2-9H,1H3,(H,27,28)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254326
(2-(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]py...)Show SMILES CC(C)(C(O)=O)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C21H17Cl2N5O2S/c1-21(2,19(29)30)11-6-8-12(9-7-11)26-17-16-18(25-10-24-17)31-20(28-16)27-15-13(22)4-3-5-14(15)23/h3-10H,1-2H3,(H,27,28)(H,29,30)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254421
(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)Show SMILES Cc1nc(Nc2ccc(c(Cl)c2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1 Show InChI InChI=1S/C19H11Cl3F3N5S/c1-8-26-16(28-9-5-6-10(13(22)7-9)19(23,24)25)15-17(27-8)31-18(30-15)29-14-11(20)3-2-4-12(14)21/h2-7H,1H3,(H,29,30)(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50254077
(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)Show SMILES CC(C)CNc1nc(Nc2ccc(cc2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1 Show InChI InChI=1S/C22H19Cl2F3N6S/c1-11(2)10-28-20-32-18(29-13-8-6-12(7-9-13)22(25,26)27)17-19(33-20)34-21(31-17)30-16-14(23)4-3-5-15(16)24/h3-9,11H,10H2,1-2H3,(H,30,31)(H2,28,29,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50371898
(CHEMBL270189)Show InChI InChI=1S/C17H26N2O4/c1-17(2,3)23-16(21)19-10-7-13(8-11-19)5-4-6-14(20)15-18-9-12-22-15/h9,12-13H,4-8,10-11H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 18: 2109-13 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.091
BindingDB Entry DOI: 10.7270/Q2708287 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174988
(CHEMBL3808688)Show SMILES Brc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23BrN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50371893
(CHEMBL255146)Show InChI InChI=1S/C18H22N2O4S/c21-17(18-19-11-14-24-18)8-4-5-15-9-12-20(13-10-15)25(22,23)16-6-2-1-3-7-16/h1-3,6-7,11,14-15H,4-5,8-10,12-13H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 18: 2109-13 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.091
BindingDB Entry DOI: 10.7270/Q2708287 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163221
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-3-5-13(6-4-12)26-16(29)28-10-8-27(9-11-28)15-14(18(22,23)24)2-1-7-25-15/h1-7H,8-11H2,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50163224
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES [O-][N+](=O)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C17H16F3N5O3/c18-17(19,20)14-2-1-7-21-15(14)23-8-10-24(11-9-23)16(26)22-12-3-5-13(6-4-12)25(27)28/h1-7H,8-11H2,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50371894
(CHEMBL256009)Show InChI InChI=1S/C21H32N2O3/c24-19(21-22-13-16-26-21)8-4-7-18-11-14-23(15-12-18)20(25)10-9-17-5-2-1-3-6-17/h13,16-18H,1-12,14-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 18: 2109-13 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.091
BindingDB Entry DOI: 10.7270/Q2708287 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402692
(CHEMBL2207358)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccnc4nccn34)c2)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-19-4-6-20(7-5-19)33-21-3-1-2-18(16-21)17-29-12-14-30(15-13-29)24(32)28-22-8-9-26-23-27-10-11-31(22)23/h1-11,16H,12-15,17H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448297
(CHEMBL3121113)Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C21H20F3N3O2/c1-2-29-19-9-8-15(10-16(19)21(22,23)24)17-11-20(27-13-26-17)25-12-18(28)14-6-4-3-5-7-14/h3-11,13,18,28H,2,12H2,1H3,(H,25,26,27)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163227
(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2C(F)(F)F)nc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-5-6-15(25-11-12)26-16(29)28-9-7-27(8-10-28)14-4-2-1-3-13(14)18(22,23)24/h1-6,11H,7-10H2,(H,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163221
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-3-5-13(6-4-12)26-16(29)28-10-8-27(9-11-28)15-14(18(22,23)24)2-1-7-25-15/h1-7H,8-11H2,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50163227
(4-(2-Trifluoromethyl-phenyl)-piperazine-1-carboxyl...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2C(F)(F)F)nc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-5-6-15(25-11-12)26-16(29)28-9-7-27(8-10-28)14-4-2-1-3-13(14)18(22,23)24/h1-6,11H,7-10H2,(H,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163221
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C18H16F6N4O/c19-17(20,21)12-3-5-13(6-4-12)26-16(29)28-10-8-27(9-11-28)15-14(18(22,23)24)2-1-7-25-15/h1-7H,8-11H2,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
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UniChem
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254324
(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)Show SMILES CC(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C20H17Cl2N5S/c1-11(2)12-6-8-13(9-7-12)25-18-17-19(24-10-23-18)28-20(27-17)26-16-14(21)4-3-5-15(16)22/h3-11H,1-2H3,(H,26,27)(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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UniChem
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254376
(CHEMBL467851 | N2-(2,6-dichlorophenyl)-N7-(4-(meth...)Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C18H13Cl2N5O2S2/c1-29(26,27)11-7-5-10(6-8-11)23-16-15-17(22-9-21-16)28-18(25-15)24-14-12(19)3-2-4-13(14)20/h2-9H,1H3,(H,24,25)(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254078
(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)Show SMILES FC(F)(F)c1ccc(Nc2nc(NCC3CC3)nc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C22H17Cl2F3N6S/c23-14-2-1-3-15(24)16(14)30-21-31-17-18(29-13-8-6-12(7-9-13)22(25,26)27)32-20(33-19(17)34-21)28-10-11-4-5-11/h1-3,6-9,11H,4-5,10H2,(H,30,31)(H2,28,29,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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UniChem
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50163224
(4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-ca...)Show SMILES [O-][N+](=O)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)cc1 Show InChI InChI=1S/C17H16F3N5O3/c18-17(19,20)14-2-1-7-21-15(14)23-8-10-24(11-9-23)16(26)22-12-3-5-13(6-4-12)25(27)28/h1-7H,8-11H2,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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PC sid
UniChem
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PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L.L.C.
Curated by ChEMBL
| Assay Description
In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assay |
J Med Chem 48: 1857-72 (2005)
Article DOI: 10.1021/jm0495071
BindingDB Entry DOI: 10.7270/Q2KH0MT8 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50254421
(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)Show SMILES Cc1nc(Nc2ccc(c(Cl)c2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1 Show InChI InChI=1S/C19H11Cl3F3N5S/c1-8-26-16(28-9-5-6-10(13(22)7-9)19(23,24)25)15-17(27-8)31-18(30-15)29-14-11(20)3-2-4-12(14)21/h2-7H,1H3,(H,29,30)(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50254136
(CHEMBL469297 | N2-(2,6-dichlorophenyl)-N7-(4-(trif...)Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C18H10Cl2F3N5S/c19-11-2-1-3-12(20)13(11)27-17-28-14-15(24-8-25-16(14)29-17)26-10-6-4-9(5-7-10)18(21,22)23/h1-8H,(H,27,28)(H,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50254078
(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)Show SMILES FC(F)(F)c1ccc(Nc2nc(NCC3CC3)nc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1 Show InChI InChI=1S/C22H17Cl2F3N6S/c23-14-2-1-3-15(24)16(14)30-21-31-17-18(29-13-8-6-12(7-9-13)22(25,26)27)32-20(33-19(17)34-21)28-10-11-4-5-11/h1-3,6-9,11H,4-5,10H2,(H,30,31)(H2,28,29,32,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development LLC
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux |
Bioorg Med Chem Lett 19: 40-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448337
(CHEMBL3121116)Show SMILES CC(=O)c1ccc(cc1F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H18FN3O2/c1-13(25)16-8-7-15(9-17(16)21)18-10-20(24-12-23-18)22-11-19(26)14-5-3-2-4-6-14/h2-10,12,19,26H,11H2,1H3,(H,22,23,24)/t19-/m0/s1 | PDB
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| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174991
(CHEMBL3809071)Show SMILES Fc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)c2)cc1 Show InChI InChI=1S/C23H22ClFN4O2/c24-21-8-9-26-15-22(21)27-23(30)29-12-10-28(11-13-29)16-17-2-1-3-20(14-17)31-19-6-4-18(25)5-7-19/h1-9,14-15H,10-13,16H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
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PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402679
(CHEMBL2207344)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnc4[nH]ccc4c3)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-4-6-22(7-5-20)33-23-3-1-2-18(14-23)17-30-10-12-31(13-11-30)25(32)29-21-15-19-8-9-27-24(19)28-16-21/h1-9,14-16H,10-13,17H2,(H,27,28)(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50371900
(CHEMBL273152)Show InChI InChI=1S/C22H30N2O2/c1-17(2)20-8-6-19(7-9-20)16-24-13-10-18(11-14-24)4-3-5-21(25)22-23-12-15-26-22/h6-9,12,15,17-18H,3-5,10-11,13-14,16H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 18: 2109-13 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.091
BindingDB Entry DOI: 10.7270/Q2708287 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402694
(CHEMBL2203328)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnc4cccnn34)c2)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-19-6-8-20(9-7-19)33-21-4-1-3-18(15-21)17-29-11-13-30(14-12-29)24(32)28-23-16-26-22-5-2-10-27-31(22)23/h1-10,15-16H,11-14,17H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
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