Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50568138 (CHEMBL4854735) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]BNZA from Nav1.5 (unknown origin) | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128133 BindingDB Entry DOI: 10.7270/Q2CJ8J7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50568135 (CHEMBL4849813) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]BNZA from Nav1.5 (unknown origin) | Citation and Details Article DOI: 10.1016/j.bmcl.2021.128133 BindingDB Entry DOI: 10.7270/Q2CJ8J7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71464 (US9546164, 495 | US9694002, 495) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71464 (US9546164, 495 | US9694002, 495) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Mus musculus) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Nav1.7 channel in mouse CAD cells by whole-cell patch clamp assay | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71381 (US9546164, 440 | US9694002, 440) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71381 (US9546164, 440 | US9694002, 440) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169426 (CHEMBL3806065 | US9481677, 69) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71340 (US9546164, 411 | US9694002, 411) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71340 (US9546164, 411 | US9694002, 411) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM70845 (US9546164, 6 | US9694002, 27) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM70816 (US9546164, 4 | US9694002, 6) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM268527 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in... | J Med Chem 61: 4810-4831 (2018) Article DOI: 10.1021/acs.jmedchem.7b01826 BindingDB Entry DOI: 10.7270/Q2BV7K92 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71211 (US9546164, 312 | US9694002, 312) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71211 (US9546164, 312 | US9694002, 312) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71351 (US9546164, 422 | US9694002, 422) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71351 (US9546164, 422 | US9694002, 422) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71341 (US9546164, 412 | US9694002, 412) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71341 (US9546164, 412 | US9694002, 412) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71193 (US9546164, 300 | US9694002, 300) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71055 (US9546164, 202 | US9694002, 202) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71101 (US9546164, 236 | US9694002, 236) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71063 (US9546164, 208 | US9694002, 208) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM70878 (US9546164, 52 | US9694002, 52) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71193 (US9546164, 300 | US9694002, 300) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71055 (US9546164, 202 | US9694002, 202) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71063 (US9546164, 208 | US9694002, 208) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM70878 (US9546164, 52 | US9694002, 52) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71101 (US9546164, 236 | US9694002, 236) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM70836 (US9694002, 23) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71062 (US9546164, 207 | US9694002, 207) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71065 (US9546164, 210 | US9694002, 210) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71137 (US9546164, 260 | US9694002, 260) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71064 (US9546164, 209 | US9694002, 209) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71062 (US9546164, 207 | US9694002, 207) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169434 (CHEMBL3805837 | US9481677, 80) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169432 (CHEMBL3805973 | US9481677, 48) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71067 (US9546164, 211 | US9694002, 211) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71064 (US9546164, 209 | US9694002, 209) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71067 (US9546164, 211 | US9694002, 211) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169431 (CHEMBL3805722 | US9481677, 73) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM70848 (US9694002, 29) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71429 (US9694002, 475) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71061 (US9546164, 206 | US9694002, 206) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair |
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