Compile Data Set for Download or QSAR

Found 102 hits with Last Name = 'burgin' and Initial = 'ab'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049413 (CHEMBL3313945 | US11401286, Example 52) Show SMILES CCc1nc(Nc2ccc(CC#N)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H16ClN5/c1-2-17-23-18(14-4-3-5-15(20)12-14)25-19(24-17)22-16-8-6-13(7-9-16)10-11-21/h3-9,12H,2,10H2,1H3,(H,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049407 (CHEMBL3315271 | US11401286, Example 51) Show SMILES CCc1nc(Nc2ccc(cc2)C#N)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H14ClN5/c1-2-16-22-17(13-4-3-5-14(19)10-13)24-18(23-16)21-15-8-6-12(11-20)7-9-15/h3-10H,2H2,1H3,(H,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049407 (CHEMBL3315271 | US11401286, Example 51) Show SMILES CCc1nc(Nc2ccc(cc2)C#N)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H14ClN5/c1-2-16-22-17(13-4-3-5-14(19)10-13)24-18(23-16)21-15-8-6-12(11-20)7-9-15/h3-10H,2H2,1H3,(H,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049410 (CHEMBL3315265 | US11401286, Example 41) Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-3-1-2-13(10-14)17-22-16(11-4-5-11)23-19(24-17)21-15-8-6-12(7-9-15)18(25)26/h1-3,6-11H,4-5H2,(H,25,26)(H,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50073854 (2,10-dihydroxy-12-(3,4,5-trihydroxy-6-hydroxymethy...) Show SMILES OCC1OC(C(O)C(O)C1O)n1c2cc(O)ccc2c2c3C(=O)NC(=O)c3c3c4ccc(O)cc4[nH]c3c12 Show InChI InChI=1S/C26H21N3O9/c30-7-14-21(33)22(34)23(35)26(38-14)29-13-6-9(32)2-4-11(13)16-18-17(24(36)28-25(18)37)15-10-3-1-8(31)5-12(10)27-19(15)20(16)29/h1-6,14,21-23,26-27,30-35H,7H2,(H,28,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
deCODE BioStructures Curated by ChEMBL					Assay Description Inhibition of topoisomerase I-DNA complex in trapping assay				J Med Chem 48: 2336-45 (2005) Article DOI: 10.1021/jm049146p BindingDB Entry DOI: 10.7270/Q2CF9QVT
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049410 (CHEMBL3315265 | US11401286, Example 41) Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-3-1-2-13(10-14)17-22-16(11-4-5-11)23-19(24-17)21-15-8-6-12(7-9-15)18(25)26/h1-3,6-11H,4-5H2,(H,25,26)(H,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50008935 ((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O |r| Show InChI InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
deCODE BioStructures Curated by ChEMBL					Assay Description Inhibition of topoisomerase I-DNA complex in trapping assay				J Med Chem 48: 2336-45 (2005) Article DOI: 10.1021/jm049146p BindingDB Entry DOI: 10.7270/Q2CF9QVT
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50346121 (2-(4-(2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpy...) Show SMILES CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1)-c1ccc(Cl)s1 Show InChI InChI=1S/C19H18ClN3O2S/c1-3-14-11(2)21-19(15-8-9-16(20)26-15)23-18(14)22-13-6-4-12(5-7-13)10-17(24)25/h4-9H,3,10H2,1-2H3,(H,24,25)(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B1				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049416 (CHEMBL3315273) Show SMILES CCc1nc(Nc2ccc(Cc3nnn[nH]3)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN8/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17-25-27-28-26-17/h3-9,11H,2,10H2,1H3,(H,21,22,23,24)(H,25,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294161 ((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrro...) Show SMILES OC(=O)CCCN1CCC[C@@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C21H24ClNO4/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25/h5-12,17H,1-4,13-15H2,(H,24,25)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049416 (CHEMBL3315273) Show SMILES CCc1nc(Nc2ccc(Cc3nnn[nH]3)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN8/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17-25-27-28-26-17/h3-9,11H,2,10H2,1H3,(H,21,22,23,24)(H,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294161 ((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrro...) Show SMILES OC(=O)CCCN1CCC[C@@H]1COc1ccc(Oc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C21H24ClNO4/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25/h5-12,17H,1-4,13-15H2,(H,24,25)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294162 ((R)-(4-(pyrrolidin-2-ylmethoxy)phenyl)(4-(thiophen...) Show SMILES O=C(c1ccc(OC[C@H]2CCCN2)cc1)c1ccc(cc1)-c1ccsc1 |r| Show InChI InChI=1S/C22H21NO2S/c24-22(17-5-3-16(4-6-17)19-11-13-26-15-19)18-7-9-21(10-8-18)25-14-20-2-1-12-23-20/h3-11,13,15,20,23H,1-2,12,14H2/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049418 (CHEMBL3315275 | US11401286, Example 59) Show SMILES CCc1nc(Nc2ccc(cc2)C(C)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN4O2/c1-3-17-23-18(14-5-4-6-15(21)11-14)25-20(24-17)22-16-9-7-13(8-10-16)12(2)19(26)27/h4-12H,3H2,1-2H3,(H,26,27)(H,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049417 (CHEMBL3315272) Show SMILES CCc1nc(Nc2ccc(cc2)-c2nnn[nH]2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN8/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17-24-26-27-25-17/h3-10H,2H2,1H3,(H,20,21,22,23)(H,24,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049417 (CHEMBL3315272) Show SMILES CCc1nc(Nc2ccc(cc2)-c2nnn[nH]2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN8/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17-24-26-27-25-17/h3-10H,2H2,1H3,(H,20,21,22,23)(H,24,25,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049415 (CHEMBL3315267 | US11401286, Example 49) Show SMILES Clc1cccc(c1)C1=NC(NC2CCC(=O)NC2)=NC(N1)C1CC1 |c:19,t:8| Show InChI InChI=1S/C17H20ClN5O/c18-12-3-1-2-11(8-12)16-21-15(10-4-5-10)22-17(23-16)20-13-6-7-14(24)19-9-13/h1-3,8,10,13,15H,4-7,9H2,(H,19,24)(H2,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049411 (CHEMBL3315266 | US11401286, Example 38) Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2ccc(Cl)cc2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-7-3-12(4-8-14)17-22-16(11-1-2-11)23-19(24-17)21-15-9-5-13(6-10-15)18(25)26/h3-11H,1-2H2,(H,25,26)(H,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294163 ((R)-N-benzyl-4-(pyrrolidin-2-ylmethoxy)aniline | C...) Show SMILES C(Nc1ccc(OC[C@H]2CCCN2)cc1)c1ccccc1 |r| Show InChI InChI=1S/C18H22N2O/c1-2-5-15(6-3-1)13-20-16-8-10-18(11-9-16)21-14-17-7-4-12-19-17/h1-3,5-6,8-11,17,19-20H,4,7,12-14H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049412 (CHEMBL3315274) Show SMILES CCc1nc(Nc2ccc(NS(N)(=O)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN6O2S/c1-2-15-21-16(11-4-3-5-12(18)10-11)23-17(22-15)20-13-6-8-14(9-7-13)24-27(19,25)26/h3-10,24H,2H2,1H3,(H2,19,25,26)(H,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049413 (CHEMBL3313945 | US11401286, Example 52) Show SMILES CCc1nc(Nc2ccc(CC#N)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H16ClN5/c1-2-17-23-18(14-4-3-5-15(20)12-14)25-19(24-17)22-16-8-6-13(7-9-16)10-11-21/h3-9,12H,2,10H2,1H3,(H,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	165	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294162 ((R)-(4-(pyrrolidin-2-ylmethoxy)phenyl)(4-(thiophen...) Show SMILES O=C(c1ccc(OC[C@H]2CCCN2)cc1)c1ccc(cc1)-c1ccsc1 |r| Show InChI InChI=1S/C22H21NO2S/c24-22(17-5-3-16(4-6-17)19-11-13-26-15-19)18-7-9-21(10-8-18)25-14-20-2-1-12-23-20/h3-11,13,15,20,23H,1-2,12,14H2/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50294163 ((R)-N-benzyl-4-(pyrrolidin-2-ylmethoxy)aniline | C...) Show SMILES C(Nc1ccc(OC[C@H]2CCCN2)cc1)c1ccccc1 |r| Show InChI InChI=1S/C18H22N2O/c1-2-5-15(6-3-1)13-20-16-8-10-18(11-9-16)21-14-17-7-4-12-19-17/h1-3,5-6,8-11,17,19-20H,4,7,12-14H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
deCODE biostructures, Inc. Curated by ChEMBL					Assay Description Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE				J Med Chem 52: 4694-715 (2009) Article DOI: 10.1021/jm900259h BindingDB Entry DOI: 10.7270/Q2F47P6N
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049253 (CHEMBL3315262 | US11401286, Example 28) Show SMILES CCc1nc(Nc2ccc(F)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H12ClFN4S/c1-2-13-19-14(11-7-8-12(16)22-11)21-15(20-13)18-10-5-3-9(17)4-6-10/h3-8H,2H2,1H3,(H,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049408 (CHEMBL3315270 | US11401286, Example 40) Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN4O2/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17(24)25/h3-10H,2H2,1H3,(H,24,25)(H,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	213	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049406 (CHEMBL3315263 | US11401286, Example 29) Show SMILES CC(C)c1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-9(2)14-20-15(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)16(23)24/h3-9H,1-2H3,(H,23,24)(H,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049406 (CHEMBL3315263 | US11401286, Example 29) Show SMILES CC(C)c1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-9(2)14-20-15(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)16(23)24/h3-9H,1-2H3,(H,23,24)(H,19,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049146 (CHEMBL3315251 | US11401286, Example 36) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C20H17ClN4O2/c21-15-3-1-2-14(11-15)19-23-18(13-6-7-13)24-20(25-19)22-16-8-4-12(5-9-16)10-17(26)27/h1-5,8-9,11,13H,6-7,10H2,(H,26,27)(H,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	237	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049408 (CHEMBL3315270 | US11401286, Example 40) Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H15ClN4O2/c1-2-15-21-16(12-4-3-5-13(19)10-12)23-18(22-15)20-14-8-6-11(7-9-14)17(24)25/h3-10H,2H2,1H3,(H,24,25)(H,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	241	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049211 (CHEMBL3315261 | US11401286, Example 30) Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C16H13ClN4O2S/c1-2-13-19-14(11-7-8-12(17)24-11)21-16(20-13)18-10-5-3-9(4-6-10)15(22)23/h3-8H,2H2,1H3,(H,22,23)(H,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049102 (CHEMBL3315250 | US11401286, Example 34) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2ccc(Cl)s2)C2CC2)cc1 Show InChI InChI=1S/C18H15ClN4O2S/c19-14-8-7-13(26-14)17-21-16(11-3-4-11)22-18(23-17)20-12-5-1-10(2-6-12)9-15(24)25/h1-2,5-8,11H,3-4,9H2,(H,24,25)(H,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049211 (CHEMBL3315261 | US11401286, Example 30) Show SMILES CCc1nc(Nc2ccc(cc2)C(O)=O)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C16H13ClN4O2S/c1-2-13-19-14(11-7-8-12(17)24-11)21-16(20-13)18-10-5-3-9(4-6-10)15(22)23/h3-8H,2H2,1H3,(H,22,23)(H,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049415 (CHEMBL3315267 | US11401286, Example 49) Show SMILES Clc1cccc(c1)C1=NC(NC2CCC(=O)NC2)=NC(N1)C1CC1 |c:19,t:8| Show InChI InChI=1S/C17H20ClN5O/c18-12-3-1-2-11(8-12)16-21-15(10-4-5-10)22-17(23-16)20-13-6-7-14(24)19-9-13/h1-3,8,10,13,15H,4-7,9H2,(H,19,24)(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	268	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049411 (CHEMBL3315266 | US11401286, Example 38) Show SMILES OC(=O)c1ccc(Nc2nc(nc(n2)-c2ccc(Cl)cc2)C2CC2)cc1 Show InChI InChI=1S/C19H15ClN4O2/c20-14-7-3-12(4-8-14)17-22-16(11-1-2-11)23-19(24-17)21-15-9-5-13(6-10-15)18(25)26/h3-11H,1-2H2,(H,25,26)(H,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	268	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
DNA topoisomerase 1 (Homo sapiens (Human))	BDBM50008923 ((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...) Show SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r| Show InChI InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
deCODE BioStructures Curated by ChEMBL					Assay Description Inhibition of topoisomerase I-DNA complex in trapping assay				J Med Chem 48: 2336-45 (2005) Article DOI: 10.1021/jm049146p BindingDB Entry DOI: 10.7270/Q2CF9QVT
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049070 (CHEMBL3315248 | US11401286, Example 27) Show SMILES CCc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-2-14-20-16(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)9-15(23)24/h3-8H,2,9H2,1H3,(H,23,24)(H,19,20,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049412 (CHEMBL3315274) Show SMILES CCc1nc(Nc2ccc(NS(N)(=O)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H17ClN6O2S/c1-2-15-21-16(11-4-3-5-12(18)10-11)23-17(22-15)20-13-6-8-14(9-7-13)24-27(19,25)26/h3-10,24H,2H2,1H3,(H2,19,25,26)(H,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	402	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049419 (CHEMBL3315276 | US11401286, Example 60) Show SMILES CCc1nc(Nc2ccc(cc2)C(C)(C)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H21ClN4O2/c1-4-17-24-18(13-6-5-7-15(22)12-13)26-20(25-17)23-16-10-8-14(9-11-16)21(2,3)19(27)28/h5-12H,4H2,1-3H3,(H,27,28)(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049409 (CHEMBL3315269 | US11401286, Example 39) Show SMILES CCc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN4O2/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17(25)26/h3-9,11H,2,10H2,1H3,(H,25,26)(H,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	681	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049153 (CHEMBL3315258) Show SMILES OC(=O)Cc1ccc(CNc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C21H19ClN4O2/c22-17-3-1-2-16(11-17)20-24-19(15-8-9-15)25-21(26-20)23-12-14-6-4-13(5-7-14)10-18(27)28/h1-7,11,15H,8-10,12H2,(H,27,28)(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	726	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049150 (CHEMBL3315255) Show SMILES CCc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H17FN4O2/c1-2-16-22-18(13-5-7-14(20)8-6-13)24-19(23-16)21-15-9-3-12(4-10-15)11-17(25)26/h3-10H,2,11H2,1H3,(H,25,26)(H,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	727	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049409 (CHEMBL3315269 | US11401286, Example 39) Show SMILES CCc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C19H17ClN4O2/c1-2-16-22-18(13-4-3-5-14(20)11-13)24-19(23-16)21-15-8-6-12(7-9-15)10-17(25)26/h3-9,11H,2,10H2,1H3,(H,25,26)(H,21,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	781	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049153 (CHEMBL3315258) Show SMILES OC(=O)Cc1ccc(CNc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C21H19ClN4O2/c22-17-3-1-2-16(11-17)20-24-19(15-8-9-15)25-21(26-20)23-12-14-6-4-13(5-7-14)10-18(27)28/h1-7,11,15H,8-10,12H2,(H,27,28)(H,23,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	845	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049152 (CHEMBL3315257) Show SMILES OC(=O)Cc1ccc(CNc2nc(nc(n2)-c2ccc(Cl)cc2)C2CC2)cc1 Show InChI InChI=1S/C21H19ClN4O2/c22-17-9-7-16(8-10-17)20-24-19(15-5-6-15)25-21(26-20)23-12-14-3-1-13(2-4-14)11-18(27)28/h1-4,7-10,15H,5-6,11-12H2,(H,27,28)(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	859	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049070 (CHEMBL3315248 | US11401286, Example 27) Show SMILES CCc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C17H15ClN4O2S/c1-2-14-20-16(12-7-8-13(18)25-12)22-17(21-14)19-11-5-3-10(4-6-11)9-15(23)24/h3-8H,2,9H2,1H3,(H,23,24)(H,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	865	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049414 (CHEMBL3315264 | US11401286, Example 26) Show SMILES CC(C)c1nc(Nc2ccc(F)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C16H14ClFN4S/c1-9(2)14-20-15(12-7-8-13(17)23-12)22-16(21-14)19-11-5-3-10(18)4-6-11/h3-9H,1-2H3,(H,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	886	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049418 (CHEMBL3315275 | US11401286, Example 59) Show SMILES CCc1nc(Nc2ccc(cc2)C(C)C(O)=O)nc(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H19ClN4O2/c1-3-17-23-18(14-5-4-6-15(21)11-14)25-20(24-17)22-16-9-7-13(8-10-16)12(2)19(26)27/h4-12H,3H2,1-2H3,(H,26,27)(H,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50049146 (CHEMBL3315251 | US11401286, Example 36) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C20H17ClN4O2/c21-15-3-1-2-14(11-15)19-23-18(13-6-7-13)24-20(25-19)22-16-8-4-12(5-9-16)10-17(26)27/h1-5,8-9,11,13H,6-7,10H2,(H,26,27)(H,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4D				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049068 (CHEMBL3315246 | US11401286, Example 22) Show SMILES Cc1nc(Nc2ccc(CC(O)=O)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C16H13ClN4O2S/c1-9-18-15(12-6-7-13(17)24-12)21-16(19-9)20-11-4-2-10(3-5-11)8-14(22)23/h2-7H,8H2,1H3,(H,22,23)(H,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50049253 (CHEMBL3315262 | US11401286, Example 28) Show SMILES CCc1nc(Nc2ccc(F)cc2)nc(n1)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H12ClFN4S/c1-2-13-19-14(11-7-8-12(16)22-11)21-15(20-13)18-10-5-3-9(17)4-6-10/h3-8H,2H2,1H3,(H,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Northern Illinois University Curated by ChEMBL					Assay Description Inhibition of human PDE4B				Bioorg Med Chem Lett 24: 4031-4 (2014) Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD
					More data for this Ligand-Target Pair

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