Compile Data Set for Download or QSAR

Found 379 hits with Last Name = 'eidam' and Initial = 'p'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384444 (CHEMBL2035510) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2cccc(F)c2c1 Show InChI InChI=1S/C21H17FN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-8-9-17(23-18(15)25)13-7-6-12-4-3-5-16(22)14(12)10-13/h3-11H,1-2H3,(H,23,25)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (RAT)	BDBM50384444 (CHEMBL2035510) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2cccc(F)c2c1 Show InChI InChI=1S/C21H17FN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-8-9-17(23-18(15)25)13-7-6-12-4-3-5-16(22)14(12)10-13/h3-11H,1-2H3,(H,23,25)(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384443 (CHEMBL1770317) Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.01	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to human EP3				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483809 (CHEMBL1770337) Show SMILES CC(C)C1(OC(=O)NC1=O)c1cc(C)c([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C22H20N2O4/c1-12(2)22(20(26)24-21(27)28-22)17-10-13(3)18(23-19(17)25)16-9-8-14-6-4-5-7-15(14)11-16/h4-12H,1-3H3,(H,23,25)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384445 (CHEMBL2035508) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2n(C)ccc2c1 Show InChI InChI=1S/C20H19N3O4/c1-11(2)20(18(25)22-19(26)27-20)14-5-6-15(21-17(14)24)12-4-7-16-13(10-12)8-9-23(16)3/h4-11H,1-3H3,(H,21,24)(H,22,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483821 (CHEMBL1770320) Show SMILES O=C1NC(=O)C(O1)(C1CCCCC1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C24H22N2O4/c27-21-19(24(18-8-2-1-3-9-18)22(28)26-23(29)30-24)12-13-20(25-21)17-11-10-15-6-4-5-7-16(15)14-17/h4-7,10-14,18H,1-3,8-9H2,(H,25,27)(H,26,28,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483823 (CHEMBL1770341) Show SMILES CC(C)[C@]1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483814 (CHEMBL1770319) Show SMILES O=C1NC(=O)C(O1)(C1CCCC1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C23H20N2O4/c26-20-18(23(17-7-3-4-8-17)21(27)25-22(28)29-23)11-12-19(24-20)16-10-9-14-5-1-2-6-15(14)13-16/h1-2,5-6,9-13,17H,3-4,7-8H2,(H,24,26)(H,25,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (RAT)	BDBM50384445 (CHEMBL2035508) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2n(C)ccc2c1 Show InChI InChI=1S/C20H19N3O4/c1-11(2)20(18(25)22-19(26)27-20)14-5-6-15(21-17(14)24)12-4-7-16-13(10-12)8-9-23(16)3/h4-11H,1-3H3,(H,21,24)(H,22,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.94	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384443 (CHEMBL1770317) Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384443 (CHEMBL1770317) Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (RAT)	BDBM50384443 (CHEMBL1770317) Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (RAT)	BDBM50384446 (CHEMBL2035509) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C19H20N2O4/c1-10(2)19(17(23)21-18(24)25-19)14-7-8-15(20-16(14)22)13-6-5-11(3)12(4)9-13/h5-10H,1-4H3,(H,20,22)(H,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483827 (CHEMBL1770322) Show SMILES O=C1NC(=O)C(Cc2ccccc2)(O1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C25H18N2O4/c28-22-20(25(23(29)27-24(30)31-25)15-16-6-2-1-3-7-16)12-13-21(26-22)19-11-10-17-8-4-5-9-18(17)14-19/h1-14H,15H2,(H,26,28)(H,27,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384446 (CHEMBL2035509) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C19H20N2O4/c1-10(2)19(17(23)21-18(24)25-19)14-7-8-15(20-16(14)22)13-6-5-11(3)12(4)9-13/h5-10H,1-4H3,(H,20,22)(H,21,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483811 (CHEMBL1770340) Show SMILES CC(C)[C@@]1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483812 (CHEMBL1770316) Show SMILES CC1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H14N2O4/c1-19(17(23)21-18(24)25-19)14-8-9-15(20-16(14)22)13-7-6-11-4-2-3-5-12(11)10-13/h2-10H,1H3,(H,20,22)(H,21,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483815 (CHEMBL1770321) Show SMILES O=C1NC(=O)C(O1)(c1ccccc1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C24H16N2O4/c27-21-19(24(18-8-2-1-3-9-18)22(28)26-23(29)30-24)12-13-20(25-21)17-11-10-15-6-4-5-7-16(15)14-17/h1-14H,(H,25,27)(H,26,28,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483818 (CHEMBL1770328) Show SMILES CC1(CNC(=O)N1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H17N3O2/c1-19(11-20-18(24)22-19)15-8-9-16(21-17(15)23)14-7-6-12-4-2-3-5-13(12)10-14/h2-10H,11H2,1H3,(H,21,23)(H2,20,22,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483808 (CHEMBL1770336) Show SMILES CC(C)C1(OC(=O)NC1=O)c1cc(Br)c([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H17BrN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-10-16(22)17(23-18(15)25)14-8-7-12-5-3-4-6-13(12)9-14/h3-11H,1-2H3,(H,23,25)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483829 (CHEMBL1770335) Show SMILES CC(C)C1(OC(=O)NC1=O)c1cc(Cl)c([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H17ClN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-10-16(22)17(23-18(15)25)14-8-7-12-5-3-4-6-13(12)9-14/h3-11H,1-2H3,(H,23,25)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483813 (CHEMBL1770318) Show SMILES O=C1NC(=O)C(O1)(C1CC1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H16N2O4/c24-18-16(21(15-7-8-15)19(25)23-20(26)27-21)9-10-17(22-18)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,9-11,15H,7-8H2,(H,22,24)(H,23,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483822 (CHEMBL1770329) Show SMILES CC1(CNC(=O)O1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H16N2O3/c1-19(11-20-18(23)24-19)15-8-9-16(21-17(15)22)14-7-6-12-4-2-3-5-13(12)10-14/h2-10H,11H2,1H3,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483824 (CHEMBL1770323) Show SMILES FC(F)(F)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H11F3N2O4/c20-19(21,22)18(16(26)24-17(27)28-18)13-7-8-14(23-15(13)25)12-6-5-10-3-1-2-4-11(10)9-12/h1-9H,(H,23,25)(H,24,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483816 (CHEMBL1770324) Show SMILES O=C1NC(=O)C(O1)(C1CCOCC1)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C23H20N2O5/c26-20-18(23(17-9-11-29-12-10-17)21(27)25-22(28)30-23)7-8-19(24-20)16-6-5-14-3-1-2-4-15(14)13-16/h1-8,13,17H,9-12H2,(H,24,26)(H,25,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50384442 (CHEMBL2035507) Show SMILES Oc1[nH]c(=O)oc1-c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C18H12N2O4/c21-16-13(15-17(22)20-18(23)24-15)7-8-14(19-16)12-6-5-10-3-1-2-4-11(10)9-12/h1-9,22H,(H,19,21)(H,20,23)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483825 (CHEMBL1770327) Show SMILES CC1(NC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H15N3O3/c1-19(17(24)21-18(25)22-19)14-8-9-15(20-16(14)23)13-7-6-11-4-2-3-5-12(11)10-13/h2-10H,1H3,(H,20,23)(H2,21,22,24,25)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (RAT)	BDBM50384442 (CHEMBL2035507) Show SMILES Oc1[nH]c(=O)oc1-c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C18H12N2O4/c21-16-13(15-17(22)20-18(23)24-15)7-8-14(19-16)12-6-5-10-3-1-2-4-11(10)9-12/h1-9,22H,(H,19,21)(H,20,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs...				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483817 (CHEMBL1770325) Show SMILES CN1C(=O)OC(C)(C1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H16N2O4/c1-20(18(24)22(2)19(25)26-20)15-9-10-16(21-17(15)23)14-8-7-12-5-3-4-6-13(12)11-14/h3-11H,1-2H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483810 (CHEMBL1770339) Show SMILES CC(C)C1(OC(=O)NC1=O)c1cc(c([nH]c1=O)-c1ccc2ccccc2c1)C(F)(F)F Show InChI InChI=1S/C22H17F3N2O4/c1-11(2)21(19(29)27-20(30)31-21)16-10-15(22(23,24)25)17(26-18(16)28)14-8-7-12-5-3-4-6-13(12)9-14/h3-11H,1-2H3,(H,26,28)(H,27,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483807 (CHEMBL1770333) Show SMILES CC(C)C1(OC(=O)NC1=O)c1c[nH]c(cc1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-11-22-17(10-18(16)24)15-8-7-13-5-3-4-6-14(13)9-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483831 (CHEMBL1770331) Show SMILES CC1(OC(=O)NC1=O)c1ccc(cc1O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H15NO4/c1-20(18(23)21-19(24)25-20)16-9-8-15(11-17(16)22)14-7-6-12-4-2-3-5-13(12)10-14/h2-11,22H,1H3,(H,21,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483828 (CHEMBL1770326) Show SMILES CC(C)N1C(=O)OC(C)(C1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C22H20N2O4/c1-13(2)24-20(26)22(3,28-21(24)27)17-10-11-18(23-19(17)25)16-9-8-14-6-4-5-7-15(14)12-16/h4-13H,1-3H3,(H,23,25)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483826 (CHEMBL1770338) Show SMILES CC(C)C1(OC(=O)NC1=O)c1cc(-c2ccccc2)c([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C27H22N2O4/c1-16(2)27(25(31)29-26(32)33-27)22-15-21(18-9-4-3-5-10-18)23(28-24(22)30)20-13-12-17-8-6-7-11-19(17)14-20/h3-16H,1-2H3,(H,28,30)(H,29,31,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483819 (CHEMBL1770330) Show SMILES COc1cc(ccc1C1(C)OC(=O)NC1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H17NO4/c1-21(19(23)22-20(24)26-21)17-10-9-16(12-18(17)25-2)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,23,24)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM50384442 (CHEMBL2035507) Show SMILES Oc1[nH]c(=O)oc1-c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C18H12N2O4/c21-16-13(15-17(22)20-18(23)24-15)7-8-14(19-16)12-6-5-10-3-1-2-4-11(10)9-12/h1-9,22H,(H,19,21)(H,20,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assay				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483820 (CHEMBL1770332) Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc(nc1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H18N2O3/c1-13(2)21(19(24)23-20(25)26-21)17-9-10-18(22-12-17)16-8-7-14-5-3-4-6-15(14)11-16/h3-13H,1-2H3,(H,23,24,25)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype (Homo sapiens (Human))	BDBM50483830 (CHEMBL1770334) Show SMILES Cn1c(ccc(c1=O)C1(C)OC(=O)NC1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H16N2O4/c1-20(18(24)21-19(25)26-20)15-9-10-16(22(2)17(15)23)14-8-7-12-5-3-4-6-13(12)11-14/h3-11H,1-2H3,(H,21,24,25)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium concentrati...				Bioorg Med Chem Lett 21: 2806-11 (2011) Article DOI: 10.1016/j.bmcl.2011.03.107 BindingDB Entry DOI: 10.7270/Q2NZ8BGM
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human))	BDBM50384443 (CHEMBL1770317) Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at EP1 receptor in human U2OS cells expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs by FLIPR assay				ACS Med Chem Lett 1: 316-320 (2010) Article DOI: 10.1021/ml100077x BindingDB Entry DOI: 10.7270/Q2BG2Q1F
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233227 (CHEMBL4067372) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)o2)C1=O |r| Show InChI InChI=1S/C21H19N3O4/c1-24-17-9-5-6-10-18(17)27-13-16(21(24)26)23-19(25)20-22-12-15(28-20)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,25)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50159697 (CHEMBL3785745) Show SMILES CN1c2ccccc2SC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| Show InChI InChI=1S/C21H19N3O3S/c1-24-18-9-5-6-10-19(18)28-13-17(21(24)26)22-20(25)16-12-15(27-23-16)11-14-7-3-2-4-8-14/h2-10,12,17H,11,13H2,1H3,(H,22,25)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233256 (CHEMBL4093220) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnn(Cc3ccccc3)n2)C1=O |r| Show InChI InChI=1S/C19H18N6O3/c1-24-15-9-5-6-10-16(15)28-12-14(19(24)27)20-18(26)17-21-23-25(22-17)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,20,26)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50159696 (CHEMBL3786997) Show SMILES CN1c2ccccc2CC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| Show InChI InChI=1S/C22H21N3O3/c1-25-20-10-6-5-9-16(20)11-12-18(22(25)27)23-21(26)19-14-17(28-24-19)13-15-7-3-2-4-8-15/h2-10,14,18H,11-13H2,1H3,(H,23,26)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233248 (CHEMBL4096224) Show SMILES COC(=O)Nc1ccc2OC[C@H](NC(=O)c3cc(Cc4ccccc4)on3)C(=O)N(C)c2c1 |r| Show InChI InChI=1S/C23H22N4O6/c1-27-19-11-15(24-23(30)31-2)8-9-20(19)32-13-18(22(27)29)25-21(28)17-12-16(33-26-17)10-14-6-4-3-5-7-14/h3-9,11-12,18H,10,13H2,1-2H3,(H,24,30)(H,25,28)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233244 (CHEMBL4068954) Show SMILES CN1c2cc(NC(C)=O)ccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| Show InChI InChI=1S/C23H22N4O5/c1-14(28)24-16-8-9-21-20(11-16)27(2)23(30)19(13-31-21)25-22(29)18-12-17(32-26-18)10-15-6-4-3-5-7-15/h3-9,11-12,19H,10,13H2,1-2H3,(H,24,28)(H,25,29)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50502339 (CHEMBL4452233) Show SMILES Fc1cc(F)c2NC(=O)[C@H](CCc2c1)NC(=O)c1n[nH]c(Cc2ccccc2)n1 |r| Show InChI InChI=1S/C20H17F2N5O2/c21-13-9-12-6-7-15(19(28)25-17(12)14(22)10-13)23-20(29)18-24-16(26-27-18)8-11-4-2-1-3-5-11/h1-5,9-10,15H,6-8H2,(H,23,29)(H,25,28)(H,24,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated MIP-1 beta mRNA overexpression measured at 21 ...				ACS Med Chem Lett 10: 857-862 (2019) Article DOI: 10.1021/acsmedchemlett.9b00108 BindingDB Entry DOI: 10.7270/Q2VT1WB8
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50502339 (CHEMBL4452233) Show SMILES Fc1cc(F)c2NC(=O)[C@H](CCc2c1)NC(=O)c1n[nH]c(Cc2ccccc2)n1 |r| Show InChI InChI=1S/C20H17F2N5O2/c21-13-9-12-6-7-15(19(28)25-17(12)14(22)10-13)23-20(29)18-24-16(26-27-18)8-11-4-2-1-3-5-11/h1-5,9-10,15H,6-8H2,(H,23,29)(H,25,28)(H,24,26,27)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated MIP-1 beta cytokine overproduction measured at...				ACS Med Chem Lett 10: 857-862 (2019) Article DOI: 10.1021/acsmedchemlett.9b00108 BindingDB Entry DOI: 10.7270/Q2VT1WB8
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233255 (CHEMBL4069318) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cn(Cc3ccccc3)cn2)C1=O |r| Show InChI InChI=1S/C21H20N4O3/c1-24-18-9-5-6-10-19(18)28-13-17(21(24)27)23-20(26)16-12-25(14-22-16)11-15-7-3-2-4-8-15/h2-10,12,14,17H,11,13H2,1H3,(H,23,26)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233228 (CHEMBL4060644) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)n(C)n2)C1=O |r| Show InChI InChI=1S/C22H22N4O3/c1-25-19-10-6-7-11-20(19)29-14-18(22(25)28)23-21(27)17-13-16(26(2)24-17)12-15-8-4-3-5-9-15/h3-11,13,18H,12,14H2,1-2H3,(H,23,27)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50233225 (CHEMBL4071864) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)C1=O |r| Show InChI InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Queen Mary University of London Curated by ChEMBL					Assay Description Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis at 21 hrs post-st...				J Med Chem 60: 1247-1261 (2017) Article DOI: 10.1021/acs.jmedchem.6b01751 BindingDB Entry DOI: 10.7270/Q2SQ92NR
					More data for this Ligand-Target Pair

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