Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Myeloperoxidase (Homo sapiens (Human)) | BDBM217354 (2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch | Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM217355 (4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch | Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoperoxidase (Bos taurus (Bovine)) | BDBM217355 (4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid peroxidase (Homo sapiens (Human)) | BDBM217355 (4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM92469 (2-Thioxanthine, TX4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D | Assay Description The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. | J Biol Chem 286: 37578-89 (2011) Article DOI: 10.1074/jbc.M111.266981 BindingDB Entry DOI: 10.7270/Q2M32TCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM92467 (2-Thioxanthine, TX2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D | Assay Description The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. | J Biol Chem 286: 37578-89 (2011) Article DOI: 10.1074/jbc.M111.266981 BindingDB Entry DOI: 10.7270/Q2M32TCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM92470 (2-Thioxanthine, TX5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D | Assay Description The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. | J Biol Chem 286: 37578-89 (2011) Article DOI: 10.1074/jbc.M111.266981 BindingDB Entry DOI: 10.7270/Q2M32TCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lactoperoxidase (Bos taurus (Bovine)) | BDBM50015089 (2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM92468 (2-Thioxanthine, TX3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D | Assay Description The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. | J Biol Chem 286: 37578-89 (2011) Article DOI: 10.1074/jbc.M111.266981 BindingDB Entry DOI: 10.7270/Q2M32TCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM217356 (2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch | Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM92466 (2-Thioxanthine, TX1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 21 |
AstraZeneca R&D | Assay Description The chlorination activity of MPO was determined by measuring the production of hypocholorous acid. | J Biol Chem 286: 37578-89 (2011) Article DOI: 10.1074/jbc.M111.266981 BindingDB Entry DOI: 10.7270/Q2M32TCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Thyroid peroxidase (Homo sapiens (Human)) | BDBM217354 (2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid peroxidase (Homo sapiens (Human)) | BDBM217356 (2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyroid peroxidase (Homo sapiens (Human)) | BDBM50015089 (2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoperoxidase (Bos taurus (Bovine)) | BDBM217356 (2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactoperoxidase (Bos taurus (Bovine)) | BDBM217354 (2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch | Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM50015089 (2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch | Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM217355 (4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 63 | n/a | n/a | n/a | 5.0 | n/a |
University of Otago Christchurch | Assay Description Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM217354 (2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 15.8 | n/a | n/a | n/a | 5.0 | n/a |
University of Otago Christchurch | Assay Description Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Myeloperoxidase (Homo sapiens (Human)) | BDBM217356 (2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | 5.0 | n/a |
University of Otago Christchurch | Assay Description Binding kinetics were determined by surface plasmon resonance (SPR) using a Biacore S51 (Biacore, Uppsala, Sweden). MPO (50 μg/ml dissolved in 1... | J Biol Chem 288: 36636-47 (2013) Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH | |||||||||||
More data for this Ligand-Target Pair |