Compile Data Set for Download or QSAR

Found 77 hits with Last Name = 'gallaschun' and Initial = 'rj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity of the compound against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovine				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 2 (RAT)	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246465 (US9447114, 26) Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H20ClF3N2O4S/c1-29-22-19(21(32)30(23(29)33)10-3-11-31)18(12-14-6-8-16(25)9-7-14)20(35-22)15-4-2-5-17(13-15)34-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246466 (US9447114, 27) Show SMILES Cn1c2oc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H20Cl2N2O4/c1-26-22-19(21(29)27(23(26)30)10-3-11-28)18(12-14-6-8-16(24)9-7-14)20(31-22)15-4-2-5-17(25)13-15/h2,4-9,13,28H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246446 (US9447114, 2) Show SMILES Cn1c2sc(Oc3cccc(Cl)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O Show InChI InChI=1S/C23H20Cl2N2O4S/c1-26-21-19(20(29)27(23(26)30)10-3-11-28)18(12-14-6-8-15(24)9-7-14)22(32-21)31-17-5-2-4-16(25)13-17/h2,4-9,13,28H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246445 (US9447114, 1) Show SMILES Cn1c2sc(Oc3cccc(OC(F)(F)F)c3)c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O Show InChI InChI=1S/C24H20ClF3N2O5S/c1-29-21-19(20(32)30(23(29)33)10-3-11-31)18(12-14-6-8-15(25)9-7-14)22(36-21)34-16-4-2-5-17(13-16)35-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246463 (US9447114, 24) Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H20Cl2N2O3S/c1-26-22-19(21(29)27(23(26)30)11-2-12-28)18(13-14-3-7-16(24)8-4-14)20(31-22)15-5-9-17(25)10-6-15/h3-10,28H,2,11-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.84	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246465 (US9447114, 26) Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(OC(F)(F)F)c1 Show InChI InChI=1S/C24H20ClF3N2O4S/c1-29-22-19(21(32)30(23(29)33)10-3-11-31)18(12-14-6-8-16(25)9-7-14)20(35-22)15-4-2-5-17(13-15)34-24(26,27)28/h2,4-9,13,31H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.91	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20954 (2-(4-methoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C Show InChI InChI=1S/C21H29NO3/c1-8-17(9-2)24-19-12-15(5)22-21(16(19)6)25-20-13(3)10-18(23-7)11-14(20)4/h10-12,17H,8-9H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20950 (2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C Show InChI InChI=1S/C20H26BrNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20959 (2-Aryloxy-4-alkoxy-pyridine, 40 | 2-[4-(methoxymet...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C Show InChI InChI=1S/C22H31NO3/c1-8-19(9-2)25-20-12-16(5)23-22(17(20)6)26-21-14(3)10-18(13-24-7)11-15(21)4/h10-12,19H,8-9,13H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20971 (2-Arylamino-4-alkyloxypyridine, 13 | 3,6-dimethyl-...) Show SMILES CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)24-19-12-16(6)22-21(17(19)7)23-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20966 (2-Aryloxy-4-alkylaminopyridine, 3a | 3,6-dimethyl-...) Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50058163 (Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...) Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of binding of 70 pM [125I]-Try0-o-Corticotropin-releasing Factor (CFR) to Corticotropin releasing hormone receptor 1 in Rat brain membrane				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20949 (2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C Show InChI InChI=1S/C20H26ClNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20968 (2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-N-(pe...) Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C Show InChI InChI=1S/C20H27BrN2O/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20969 (2-Aryloxy-4-alkylaminopyridine, 5a | methyl 2-(4-c...) Show SMILES CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC |r| Show InChI InChI=1S/C20H25ClN2O4/c1-6-15(10-24)23-16-9-13(4)22-19(17(16)20(25)26-5)27-18-11(2)7-14(21)8-12(18)3/h7-9,15,24H,6,10H2,1-5H3,(H,22,23)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20933 (3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20933 (3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20967 (2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-N-(p...) Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C Show InChI InChI=1S/C20H27ClN2O/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM50058164 (But-2-enyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl...) Show SMILES CCN(C\C=C\C)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(7.05,-2.18,;6.86,-3.71,;5.44,-4.3,;4.32,-3.2,;2.85,-3.59,;1.76,-2.5,;.26,-2.9,;5.44,-5.84,;4.11,-6.61,;4.11,-8.15,;2.78,-8.92,;5.44,-8.92,;6.77,-8.15,;8.24,-8.63,;9.15,-7.38,;8.24,-6.12,;8.72,-4.67,;6.77,-6.61,;8.73,-10.1,;7.7,-11.23,;6.19,-10.92,;8.17,-12.7,;9.67,-13.02,;10.16,-14.49,;10.71,-11.86,;10.23,-10.41,;11.25,-9.26,)| Show InChI InChI=1S/C23H30N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h8,10,12-14H,9,11H2,1-7H3/b10-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of binding of 70 pM [125I]-Try0-o-Corticotropin-releasing Factor (CFR) to Corticotropin releasing hormone receptor 1 in Rat brain membrane				J Med Chem 40: 1749-54 (1997) Article DOI: 10.1021/jm960861b BindingDB Entry DOI: 10.7270/Q2SJ1JQP
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20935 (2-Aryloxy-4-alkoxy-pyridine, 16 | 3-ethyl-6-methyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1CC Show InChI InChI=1S/C22H31NO2/c1-8-18(9-2)24-20-13-17(7)23-22(19(20)10-3)25-21-15(5)11-14(4)12-16(21)6/h11-13,18H,8-10H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20947 (2-(2,6-dimethyl-4-propylphenoxy)-3,6-dimethyl-4-(p...) Show SMILES CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 Show InChI InChI=1S/C23H33NO2/c1-8-11-19-12-15(4)22(16(5)13-19)26-23-18(7)21(14-17(6)24-23)25-20(9-2)10-3/h12-14,20H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20941 (2-Aryloxy-4-alkoxy-pyridine, 22 | 3-bromo-6-methyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br Show InChI InChI=1S/C20H26BrNO2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20965 (2-pyridinoxy-4-alkoxy-pyridine, 14 | 3,6-dimethyl-...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)nc2C)c1C Show InChI InChI=1S/C20H28N2O2/c1-8-17(9-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)10-13(4)21-16(19)7/h10-11,17H,8-9H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20962 (2-Aryloxy-4-alkoxy-pyridine, 43 | 4-[(1-methoxybut...) Show SMILES CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C21H29NO3/c1-8-18(12-23-7)24-19-11-16(5)22-21(17(19)6)25-20-14(3)9-13(2)10-15(20)4/h9-11,18H,8,12H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20946 (2-(4-ethyl-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CC)cc2C)c1C Show InChI InChI=1S/C22H31NO2/c1-8-18-11-14(4)21(15(5)12-18)25-22-17(7)20(13-16(6)23-22)24-19(9-2)10-3/h11-13,19H,8-10H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20951 (2-(4-iodo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pen...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C Show InChI InChI=1S/C20H26INO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20939 (2-Aryloxy-4-alkoxy-pyridine, 20 | 6-methyl-4-(pent...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N Show InChI InChI=1S/C20H28N2O2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8,21H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20938 (2-Aryloxy-4-alkoxy-pyridine, 19 | 6-methyl-3-nitro...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+]([O-])=O Show InChI InChI=1S/C20H26N2O4/c1-7-16(8-2)25-17-11-15(6)21-20(18(17)22(23)24)26-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246464 (US9447114, 25) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(8-3-9-21)17(23)19(2)16(13)24-14(10)11-4-6-12(18)7-5-11/h4-7,21H,3,8-9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.7	n/a	n/a	n/a	n/a	7.2	n/a
Hydra Biosciences, Inc. US Patent					Assay Description TRPC5 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20964 (2-Aryloxy-4-alkoxy-pyridine, 13 | 3,6-dimethyl-4-[...) Show SMILES CC\C(Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C)=C/C Show InChI InChI=1S/C21H27NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h8,10-12H,9H2,1-7H3/b18-8+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20952 (2-Aryloxy-4-alkoxy-pyridine, 33 | 4-{[3,6-dimethyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(N)=O)c1C Show InChI InChI=1S/C21H28N2O3/c1-7-17(8-2)25-18-11-14(5)23-21(15(18)6)26-19-12(3)9-16(20(22)24)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H2,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20955 (2-(4-ethoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...) Show SMILES CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1 Show InChI InChI=1S/C22H31NO3/c1-8-18(9-2)25-20-13-16(6)23-22(17(20)7)26-21-14(4)11-19(24-10-3)12-15(21)5/h11-13,18H,8-10H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246453 (US9447114, 13) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H17F3N2O4S/c1-10-13-15(25)23(8-5-9-24)17(26)22(2)16(13)28-14(10)11-6-3-4-7-12(11)27-18(19,20)21/h3-4,6-7,24H,5,8-9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<21	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20940 (2-Aryloxy-4-alkoxy-pyridine, 21 | N,N,6-trimethyl-...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C Show InChI InChI=1S/C22H32N2O2/c1-9-18(10-2)25-19-13-17(6)23-22(20(19)24(7)8)26-21-15(4)11-14(3)12-16(21)5/h11-13,18H,9-10H2,1-8H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246462 (US9447114, 23) Show SMILES Cn1c2sc(c(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H20Cl2N2O3S/c1-26-22-19(21(29)27(23(26)30)10-3-11-28)18(12-14-6-8-16(24)9-7-14)20(31-22)15-4-2-5-17(25)13-15/h2,4-9,13,28H,3,10-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246458 (US9447114, 18) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(F)c1 Show InChI InChI=1S/C17H17FN2O3S/c1-10-13-15(22)20(7-4-8-21)17(23)19(2)16(13)24-14(10)11-5-3-6-12(18)9-11/h3,5-6,9,21H,4,7-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246450 (US9447114, 6) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C18H16F4N2O3S/c1-9-13-15(26)24(6-3-7-25)17(27)23(2)16(13)28-14(9)10-4-5-12(19)11(8-10)18(20,21)22/h4-5,8,25H,3,6-7H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246456 (US9447114, 16) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccccc1Cl Show InChI InChI=1S/C17H17ClN2O3S/c1-10-13-15(22)20(8-5-9-21)17(23)19(2)16(13)24-14(10)11-6-3-4-7-12(11)18/h3-4,6-7,21H,5,8-9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246449 (US9447114, 5) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H16Cl2N2O3S/c1-9-13-15(23)21(6-3-7-22)17(24)20(2)16(13)25-14(9)10-4-5-11(18)12(19)8-10/h4-5,8,22H,3,6-7H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<27	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20961 (2-Aryloxy-4-alkoxy-pyridine, 42 | 4-(butan-2-yloxy...) Show SMILES CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C Show InChI InChI=1S/C20H27NO2/c1-8-16(6)22-18-11-15(5)21-20(17(18)7)23-19-13(3)9-12(2)10-14(19)4/h9-11,16H,8H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20970 (2-(4-chloro-2,6-dimethylphenoxy)-4-{[(2S)-1-hydrox...) Show SMILES CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC |r| Show InChI InChI=1S/C20H26ClN3O3/c1-6-15(10-25)24-16-9-13(4)23-20(17(16)19(26)22-5)27-18-11(2)7-14(21)8-12(18)3/h7-9,15,25H,6,10H2,1-5H3,(H,22,26)(H,23,24)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1385-92 (2008) Article DOI: 10.1021/jm070579c BindingDB Entry DOI: 10.7270/Q29C6VQ7
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246457 (US9447114, 17) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C17H16Cl2N2O3S/c1-9-12-15(23)21(7-4-8-22)17(24)20(2)16(12)25-14(9)10-5-3-6-11(18)13(10)19/h3,5-6,22H,4,7-8H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.6	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20948 (2-(4-fluoro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C Show InChI InChI=1S/C20H26FNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246451 (US9447114, 7) Show SMILES Cc1c(sc2n(C)c(=O)n(CCCO)c(=O)c12)-c1ccc2ccccc2c1 Show InChI InChI=1S/C21H20N2O3S/c1-13-17-19(25)23(10-5-11-24)21(26)22(2)20(17)27-18(13)16-9-8-14-6-3-4-7-15(14)12-16/h3-4,6-9,12,24H,5,10-11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.9	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20957 (2-Aryloxy-4-alkoxy-pyridine, 38 | 4-{[3,6-dimethyl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C Show InChI InChI=1S/C21H27NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-12,18H,7-8H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20960 (2-(4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(C)(C)O)c1C Show InChI InChI=1S/C23H33NO3/c1-9-19(10-2)26-20-13-16(5)24-22(17(20)6)27-21-14(3)11-18(12-15(21)4)23(7,8)25/h11-13,19,25H,9-10H2,1-8H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair
Short transient receptor potential channel 5 (Homo sapiens (Human))	BDBM246448 (US9447114, 4) Show SMILES Cn1c2sc(c(C(O)c3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C23H20Cl2N2O4S/c1-26-22-18(21(30)27(23(26)31)10-3-11-28)17(19(29)13-6-8-15(24)9-7-13)20(32-22)14-4-2-5-16(25)12-14/h2,4-9,12,19,28-29H,3,10-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.4	25
Hydra Biosciences, Inc. US Patent					Assay Description The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC5 construct and screened by conventional calcium imaging t...				US Patent US9447114 (2016) BindingDB Entry DOI: 10.7270/Q2ST7NRD
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20958 ((4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl]o...) Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C Show InChI InChI=1S/C21H29NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-11,18,23H,7-8,12H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	7.0	22
Pfizer					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 51: 1377-84 (2008) Article DOI: 10.1021/jm070578k BindingDB Entry DOI: 10.7270/Q2F47MDH
					More data for this Ligand-Target Pair

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