Found 69 hits with Last Name = 'greenberg' and Initial = 'ib' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081221
(4-{5-[(S)-2-Butyl-4-(3-chloro-phenyl)-5-oxo-pipera...)Show SMILES CCCC[C@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(Cl)c1 Show InChI InChI=1S/C26H28ClN5O/c1-2-3-6-24-17-32(23-7-4-5-22(27)12-23)26(33)18-30(24)16-25-14-29-19-31(25)15-21-10-8-20(13-28)9-11-21/h4-5,7-12,14,19,24H,2-3,6,15-18H2,1H3/t24-/m0/s1 | PDB
KEGG
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antibodypedia
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AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081212
(4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...)Show SMILES CCCC[C@H]1CN(Oc2cccc(c2)C(F)(F)F)C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C27H28F3N5O2/c1-2-3-6-23-17-35(37-25-7-4-5-22(12-25)27(28,29)30)26(36)18-33(23)16-24-14-32-19-34(24)15-21-10-8-20(13-31)9-11-21/h4-5,7-12,14,19,23H,2-3,6,15-18H2,1H3/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081215
(4-{5-[(S)-4-(3-Chloro-phenyl)-2-ethanesulfonylmeth...)Show SMILES CCS(=O)(=O)C[C@@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(Cl)c1 Show InChI InChI=1S/C25H26ClN5O3S/c1-2-35(33,34)17-24-15-31(22-5-3-4-21(26)10-22)25(32)16-29(24)14-23-12-28-18-30(23)13-20-8-6-19(11-27)7-9-20/h3-10,12,18,24H,2,13-17H2,1H3/t24-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081217
(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-5-oxo-pi...)Show SMILES CCCC[C@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(C)c1C Show InChI InChI=1S/C28H33N5O/c1-4-5-8-25-18-33(27-9-6-7-21(2)22(27)3)28(34)19-31(25)17-26-15-30-20-32(26)16-24-12-10-23(14-29)11-13-24/h6-7,9-13,15,20,25H,4-5,8,16-19H2,1-3H3/t25-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
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Similars
| PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081214
(CHEMBL340493 | [(S)-4-((S)-2-Amino-2-mercapto-ethy...)Show SMILES CCCC[C@H]1CN(CCN1C[C@@H](N)S)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C21H29N3OS/c1-2-3-9-17-14-24(13-12-23(17)15-20(22)26)21(25)19-11-6-8-16-7-4-5-10-18(16)19/h4-8,10-11,17,20,26H,2-3,9,12-15,22H2,1H3/t17-,20-/m0/s1 | PDB
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| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097071
(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2 | PDB
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Reactome pathway
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| DrugBank
MMDB
PDB
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100004
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES OCCOc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1 Show InChI InChI=1S/C30H28ClN5O4/c31-24-3-1-4-25(14-24)36-10-9-34(20-30(36)38)19-26-17-33-21-35(26)18-22-7-8-23(16-32)29(13-22)40-28-6-2-5-27(15-28)39-12-11-37/h1-8,13-15,17,21,37H,9-12,18-20H2 | PDB
MMDB
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100001
(5-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(Oc3ccccc3)c(c2)C#N)CC1=O Show InChI InChI=1S/C28H24ClN5O2/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-27(22(13-21)15-30)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
MMDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081213
(4-{5-[(S)-4-(3-Chloro-phenyl)-2-methyl-5-oxo-piper...)Show SMILES C[C@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(Cl)c1 Show InChI InChI=1S/C23H22ClN5O/c1-17-12-29(21-4-2-3-20(24)9-21)23(30)15-27(17)14-22-11-26-16-28(22)13-19-7-5-18(10-25)6-8-19/h2-9,11,16-17H,12-15H2,1H3/t17-/m0/s1 | PDB
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| CHEMBL
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099993
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3cccnc3)c2)CC1=O Show InChI InChI=1S/C27H23ClN6O2/c28-22-3-1-4-23(12-22)34-10-9-32(18-27(34)35)17-24-14-31-19-33(24)16-20-6-7-21(13-29)26(11-20)36-25-5-2-8-30-15-25/h1-8,11-12,14-15,19H,9-10,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081218
((S)-4-((5-((4-(1-naphthoyl)-2-butylpiperazin-1-yl)...)Show SMILES CCCC[C@H]1CN(CCN1Cc1cncn1Cc1ccc(cc1)C#N)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C31H33N5O/c1-2-3-9-27-21-35(31(37)30-11-6-8-26-7-4-5-10-29(26)30)17-16-34(27)22-28-19-33-23-36(28)20-25-14-12-24(18-32)13-15-25/h4-8,10-15,19,23,27H,2-3,9,16-17,20-22H2,1H3/t27-/m0/s1 | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100002
(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3Cl)c2)CC1=O Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-4-3-5-23(13-22)35-11-10-33(18-28(35)36)17-24-15-32-19-34(24)16-20-8-9-21(14-31)27(12-20)37-26-7-2-1-6-25(26)30/h1-9,12-13,15,19H,10-11,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099994
(4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)met...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4ccccc4c3)c2)CC1=O Show InChI InChI=1S/C32H26ClN5O2/c33-27-6-3-7-28(16-27)38-13-12-36(21-32(38)39)20-29-18-35-22-37(29)19-23-8-9-26(17-34)31(14-23)40-30-11-10-24-4-1-2-5-25(24)15-30/h1-11,14-16,18,22H,12-13,19-21H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099999
(1-(3-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imi...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C27H25ClN4O2/c28-22-7-5-8-23(15-22)32-13-12-30(19-27(32)33)18-24-16-29-20-31(24)17-21-6-4-11-26(14-21)34-25-9-2-1-3-10-25/h1-11,14-16,20H,12-13,17-19H2 | PDB
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antibodypedia
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PC sid
UniChem
Similars
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081216
(4-{5-[(R)-4-(3-Chloro-phenyl)-2-methyl-5-oxo-piper...)Show SMILES C[C@@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(Cl)c1 Show InChI InChI=1S/C23H22ClN5O/c1-17-12-29(21-4-2-3-20(24)9-21)23(30)15-27(17)14-22-11-26-16-28(22)13-19-7-5-18(10-25)6-8-19/h2-9,11,16-17H,12-15H2,1H3/t17-/m1/s1 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099997
(2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1 Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-3-1-5-24(12-22)35-10-9-33(18-28(35)36)17-25-15-32-19-34(25)16-20-7-8-21(14-31)27(11-20)37-26-6-2-4-23(30)13-26/h1-8,11-13,15,19H,9-10,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100006
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H24ClN5O2/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-22(15-30)27(13-21)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
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KEGG
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100000
(1-(4-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imi...)Show SMILES Clc1ccc(cc1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C27H25ClN4O2/c28-22-9-11-23(12-10-22)32-14-13-30(19-27(32)33)18-24-16-29-20-31(24)17-21-5-4-8-26(15-21)34-25-6-2-1-3-7-25/h1-12,15-16,20H,13-14,17-19H2 | PDB
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| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099995
(4-((1-(3-phenoxybenzyl)-1H-imidazol-5-yl)methyl)-1...)Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-9-11-23(12-10-22)35-14-13-33(19-27(35)36)18-24-16-32-20-34(24)17-21-5-4-8-26(15-21)37-25-6-2-1-3-7-25/h1-12,15-16,20H,13-14,17-19H2 | PDB
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antibodypedia
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PC sid
UniChem
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| n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099996
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Sc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H24ClN5OS/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-22(15-30)27(13-21)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 255 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100005
(2-(4-Benzyloxy-phenoxy)-4-{5-[4-(3-chloro-phenyl)-...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccc(OCc4ccccc4)cc3)c2)CC1=O Show InChI InChI=1S/C35H30ClN5O3/c36-29-7-4-8-30(18-29)41-16-15-39(23-35(41)42)22-31-20-38-25-40(31)21-27-9-10-28(19-37)34(17-27)44-33-13-11-32(12-14-33)43-24-26-5-2-1-3-6-26/h1-14,17-18,20,25H,15-16,21-24H2 | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 311 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100003
(2-(4-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1ccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)cc1 Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-6-8-26(9-7-22)37-27-12-20(4-5-21(27)14-31)16-34-19-32-15-25(34)17-33-10-11-35(28(36)18-33)24-3-1-2-23(30)13-24/h1-9,12-13,15,19H,10-11,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to displace 50% of a radiolabelled farnesyltransferase inhibitor from FPTase in cultured Ha-Ras transformed RAT1 cells |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081217
(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-5-oxo-pi...)Show SMILES CCCC[C@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(C)c1C Show InChI InChI=1S/C28H33N5O/c1-4-5-8-25-18-33(27-9-6-7-21(2)22(27)3)28(34)19-31(25)17-26-15-30-20-32(26)16-24-12-10-23(14-29)11-13-24/h6-7,9-13,15,20,25H,4-5,8,16-19H2,1-3H3/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081219
(CHEMBL125037 | [(S)-4-(3-Benzyl-3H-imidazol-4-ylme...)Show SMILES CCCC[C@H]1CN(CCN1Cc1cncn1Cc1ccccc1)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C30H34N4O/c1-2-3-14-26-21-33(30(35)29-16-9-13-25-12-7-8-15-28(25)29)18-17-32(26)22-27-19-31-23-34(27)20-24-10-5-4-6-11-24/h4-13,15-16,19,23,26H,2-3,14,17-18,20-22H2,1H3/t26-/m0/s1 | PDB
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| n/a | n/a | 495 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100000
(1-(4-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imi...)Show SMILES Clc1ccc(cc1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C27H25ClN4O2/c28-22-9-11-23(12-10-22)32-14-13-30(19-27(32)33)18-24-16-29-20-31(24)17-21-5-4-8-26(15-21)34-25-6-2-1-3-7-25/h1-12,15-16,20H,13-14,17-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100002
(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3Cl)c2)CC1=O Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-4-3-5-23(13-22)35-11-10-33(18-28(35)36)17-24-15-32-19-34(24)16-20-8-9-21(14-31)27(12-20)37-26-7-2-1-6-25(26)30/h1-9,12-13,15,19H,10-11,16-18H2 | PDB
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antibodypedia
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100001
(5-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(Oc3ccccc3)c(c2)C#N)CC1=O Show InChI InChI=1S/C28H24ClN5O2/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-27(22(13-21)15-30)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
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PC sid
UniChem
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| n/a | n/a | 809 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099994
(4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)met...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4ccccc4c3)c2)CC1=O Show InChI InChI=1S/C32H26ClN5O2/c33-27-6-3-7-28(16-27)38-13-12-36(21-32(38)39)20-29-18-35-22-37(29)19-23-8-9-26(17-34)31(14-23)40-30-11-10-24-4-1-2-5-25(24)15-30/h1-11,14-16,18,22H,12-13,19-21H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099999
(1-(3-Chloro-phenyl)-4-[3-(3-phenoxy-benzyl)-3H-imi...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C27H25ClN4O2/c28-22-7-5-8-23(15-22)32-13-12-30(19-27(32)33)18-24-16-29-20-31(24)17-21-6-4-11-26(14-21)34-25-9-2-1-3-10-25/h1-11,14-16,20H,12-13,17-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100004
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES OCCOc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1 Show InChI InChI=1S/C30H28ClN5O4/c31-24-3-1-4-25(14-24)36-10-9-34(20-30(36)38)19-26-17-33-21-35(26)18-22-7-8-23(16-32)29(13-22)40-28-6-2-5-27(15-28)39-12-11-37/h1-8,13-15,17,21,37H,9-12,18-20H2 | PDB
KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097070
(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-6-oxo-pi...)Show SMILES CCCC[C@H]1CN(CC(=O)N1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(C)c1C Show InChI InChI=1S/C28H33N5O/c1-4-5-8-25-17-31(27-9-6-7-21(2)22(27)3)19-28(34)33(25)18-26-15-30-20-32(26)16-24-12-10-23(14-29)11-13-24/h6-7,9-13,15,20,25H,4-5,8,16-19H2,1-3H3/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097071
(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2 | PDB
MMDB
Reactome pathway
KEGG
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| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097071
(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O Show InChI InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100004
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES OCCOc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1 Show InChI InChI=1S/C30H28ClN5O4/c31-24-3-1-4-25(14-24)36-10-9-34(20-30(36)38)19-26-17-33-21-35(26)18-22-7-8-23(16-32)29(13-22)40-28-6-2-5-27(15-28)39-12-11-37/h1-8,13-15,17,21,37H,9-12,18-20H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097069
(4-{5-[(S)-6-Butyl-4-(2,3-dimethyl-phenyl)-2,3-diox...)Show SMILES CCCC[C@H]1CN(C(=O)C(=O)N1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(C)c1C Show InChI InChI=1S/C28H31N5O2/c1-4-5-8-24-17-33(26-9-6-7-20(2)21(26)3)28(35)27(34)32(24)18-25-15-30-19-31(25)16-23-12-10-22(14-29)11-13-23/h6-7,9-13,15,19,24H,4-5,8,16-18H2,1-3H3/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099997
(2-(3-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1cccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)c1 Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-3-1-5-24(12-22)35-10-9-33(18-28(35)36)17-25-15-32-19-34(25)16-20-7-8-21(14-31)27(11-20)37-26-6-2-4-23(30)13-26/h1-8,11-13,15,19H,9-10,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099998
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4CCCCc4c3)c2)CC1=O Show InChI InChI=1S/C32H30ClN5O2/c33-27-6-3-7-28(16-27)38-13-12-36(21-32(38)39)20-29-18-35-22-37(29)19-23-8-9-26(17-34)31(14-23)40-30-11-10-24-4-1-2-5-25(24)15-30/h3,6-11,14-16,18,22H,1-2,4-5,12-13,19-21H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097075
(4-((5-((3-oxo-4-phenylpiperazin-1-yl)methyl)-1H-im...)Show InChI InChI=1S/C22H21N5O/c23-12-18-6-8-19(9-7-18)14-26-17-24-13-21(26)15-25-10-11-27(22(28)16-25)20-4-2-1-3-5-20/h1-9,13,17H,10-11,14-16H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099995
(4-((1-(3-phenoxybenzyl)-1H-imidazol-5-yl)methyl)-1...)Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cncn2Cc2cccc(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-9-11-23(12-10-22)35-14-13-33(19-27(35)36)18-24-16-32-20-34(24)17-21-5-4-8-26(15-21)37-25-6-2-1-3-7-25/h1-12,15-16,20H,13-14,17-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100006
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H24ClN5O2/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-22(15-30)27(13-21)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100002
(2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3ccccc3Cl)c2)CC1=O Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-4-3-5-23(13-22)35-11-10-33(18-28(35)36)17-24-15-32-19-34(24)16-20-8-9-21(14-31)27(12-20)37-26-7-2-1-6-25(26)30/h1-9,12-13,15,19H,10-11,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50081220
(CHEMBL125070 | [(S)-3-Butyl-4-(3H-imidazol-4-ylmet...)Show SMILES CCCC[C@H]1CN(CCN1Cc1cnc[nH]1)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C23H28N4O/c1-2-3-9-20-16-27(13-12-26(20)15-19-14-24-17-25-19)23(28)22-11-6-8-18-7-4-5-10-21(18)22/h4-8,10-11,14,17,20H,2-3,9,12-13,15-16H2,1H3,(H,24,25)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by Farnesyltransferase |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097075
(4-((5-((3-oxo-4-phenylpiperazin-1-yl)methyl)-1H-im...)Show InChI InChI=1S/C22H21N5O/c23-12-18-6-8-19(9-7-18)14-26-17-24-13-21(26)15-25-10-11-27(22(28)16-25)20-4-2-1-3-5-20/h1-9,13,17H,10-11,14-16H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081217
(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-5-oxo-pi...)Show SMILES CCCC[C@H]1CN(C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N)c1cccc(C)c1C Show InChI InChI=1S/C28H33N5O/c1-4-5-8-25-18-33(27-9-6-7-21(2)22(27)3)28(34)19-31(25)17-26-15-30-20-32(26)16-24-12-10-23(14-29)11-13-24/h6-7,9-13,15,20,25H,4-5,8,16-19H2,1-3H3/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human RhoA by Geranylgeranyl transferase type I |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097074
(4-{5-[4-(2,3-Dimethyl-phenyl)-3-oxo-piperazin-1-yl...)Show SMILES Cc1cccc(N2CCN(Cc3cncn3Cc3ccc(cc3)C#N)CC2=O)c1C Show InChI InChI=1S/C24H25N5O/c1-18-4-3-5-23(19(18)2)29-11-10-27(16-24(29)30)15-22-13-26-17-28(22)14-21-8-6-20(12-25)7-9-21/h3-9,13,17H,10-11,14-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50097073
(4-{5-[4-(3-Chloro-phenyl)-2,3-dioxo-piperazin-1-yl...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)C(=O)C1=O Show InChI InChI=1S/C22H18ClN5O2/c23-18-2-1-3-19(10-18)28-9-8-26(21(29)22(28)30)14-20-12-25-15-27(20)13-17-6-4-16(11-24)5-7-17/h1-7,10,12,15H,8-9,13-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ras-CVIM by human farnesyl transferase |
Bioorg Med Chem Lett 11: 537-40 (2001)
BindingDB Entry DOI: 10.7270/Q2TT4Q7P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099993
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Oc3cccnc3)c2)CC1=O Show InChI InChI=1S/C27H23ClN6O2/c28-22-3-1-4-23(12-22)34-10-9-32(18-27(34)35)17-24-14-31-19-33(24)16-20-6-7-21(13-29)26(11-20)36-25-5-2-8-30-15-25/h1-8,11-12,14-15,19H,9-10,16-18H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Farnesyltransferase catalyzed by incorporation of [3H]- FPP into recombinant Ras-CVIM |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50081212
(4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...)Show SMILES CCCC[C@H]1CN(Oc2cccc(c2)C(F)(F)F)C(=O)CN1Cc1cncn1Cc1ccc(cc1)C#N Show InChI InChI=1S/C27H28F3N5O2/c1-2-3-6-23-17-35(37-25-7-4-5-22(12-25)27(28,29)30)26(36)18-33(23)16-24-14-32-19-34(24)15-21-10-8-20(13-31)9-11-21/h4-5,7-12,14,19,23H,2-3,6,15-18H2,1H3/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-GGPP incorporation into recombinant human RhoA by Geranylgeranyl transferase type I |
J Med Chem 42: 3779-84 (1999)
BindingDB Entry DOI: 10.7270/Q2F47NB1 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50099996
(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)Show SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(C#N)c(Sc3ccccc3)c2)CC1=O Show InChI InChI=1S/C28H24ClN5OS/c29-23-5-4-6-24(14-23)34-12-11-32(19-28(34)35)18-25-16-31-20-33(25)17-21-9-10-22(15-30)27(13-21)36-26-7-2-1-3-8-26/h1-10,13-14,16,20H,11-12,17-19H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50100003
(2-(4-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-o...)Show SMILES Clc1ccc(Oc2cc(Cn3cncc3CN3CCN(C(=O)C3)c3cccc(Cl)c3)ccc2C#N)cc1 Show InChI InChI=1S/C28H23Cl2N5O2/c29-22-6-8-26(9-7-22)37-27-12-20(4-5-21(27)14-31)16-34-19-32-15-25(34)17-33-10-11-35(28(36)18-33)24-3-1-2-23(30)13-24/h1-9,12-13,15,19H,10-11,16-18H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition against human Geranylgeranyl transferase type I catalyzed by incorporation of [3H]- GGPP (geranylgeranyl pyrophosphate) into biot... |
Bioorg Med Chem Lett 11: 1411-5 (2001)
BindingDB Entry DOI: 10.7270/Q2MP52J0 |
More data for this
Ligand-Target Pair | |
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