Compile Data Set for Download or QSAR

Found 231 hits with Last Name = 'normandin' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Type-1 angiotensin II receptor B (RAT)	BDBM50282324 (2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...) Show SMILES OC(=O)c1c(Oc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(nc2cccnc12)C1CC1 Show InChI InChI=1S/C25H18N6O3/c32-25(33)20-22-19(6-3-13-26-22)27-21(15-7-8-15)23(20)34-16-11-9-14(10-12-16)17-4-1-2-5-18(17)24-28-30-31-29-24/h1-6,9-13,15H,7-8H2,(H,32,33)(H,28,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50049201 (2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-...) Show SMILES OC(=O)c1c(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(nc2ccccc12)C1CC1 Show InChI InChI=1S/C27H21N5O3/c33-27(34)23-21-7-3-4-8-22(21)28-24(18-13-14-18)25(23)35-15-16-9-11-17(12-10-16)19-5-1-2-6-20(19)26-29-31-32-30-26/h1-12,18H,13-15H2,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282318 (2-Methyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...) Show SMILES Cc1nc2ccccc2c(C(O)=O)c1Oc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C24H17N5O3/c1-14-22(21(24(30)31)19-8-4-5-9-20(19)25-14)32-16-12-10-15(11-13-16)17-6-2-3-7-18(17)23-26-28-29-27-23/h2-13H,1H3,(H,30,31)(H,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282322 (2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...) Show SMILES CCCc1nc2ccccc2c(C(O)=O)c1Oc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C26H21N5O3/c1-2-7-22-24(23(26(32)33)20-10-5-6-11-21(20)27-22)34-17-14-12-16(13-15-17)18-8-3-4-9-19(18)25-28-30-31-29-25/h3-6,8-15H,2,7H2,1H3,(H,32,33)(H,28,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282316 (2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...) Show SMILES OC(=O)c1c(Oc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(nc2ncccc12)C1CC1 Show InChI InChI=1S/C25H18N6O3/c32-25(33)20-19-6-3-13-26-23(19)27-21(15-7-8-15)22(20)34-16-11-9-14(10-12-16)17-4-1-2-5-18(17)24-28-30-31-29-24/h1-6,9-13,15H,7-8H2,(H,32,33)(H,28,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282315 (2-Ethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy]...) Show SMILES CCc1nc2ccccc2c(C(O)=O)c1Oc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C25H19N5O3/c1-2-20-23(22(25(31)32)19-9-5-6-10-21(19)26-20)33-16-13-11-15(12-14-16)17-7-3-4-8-18(17)24-27-29-30-28-24/h3-14H,2H2,1H3,(H,31,32)(H,27,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282317 (2-Cyclopropyl-5-methyl-3-[2'-(2H-tetrazol-5-yl)-bi...) Show SMILES Cc1cccc2nc(C3CC3)c(Oc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(C(O)=O)c12 Show InChI InChI=1S/C27H21N5O3/c1-15-5-4-8-21-22(15)23(27(33)34)25(24(28-21)17-9-10-17)35-18-13-11-16(12-14-18)19-6-2-3-7-20(19)26-29-31-32-30-26/h2-8,11-14,17H,9-10H2,1H3,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282319 (2-Cyclopropyl-6-fluoro-3-[2'-(2H-tetrazol-5-yl)-bi...) Show SMILES OC(=O)c1c(Oc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(nc2ccc(F)cc12)C1CC1 Show InChI InChI=1S/C26H18FN5O3/c27-16-9-12-21-20(13-16)22(26(33)34)24(23(28-21)15-5-6-15)35-17-10-7-14(8-11-17)18-3-1-2-4-19(18)25-29-31-32-30-25/h1-4,7-13,15H,5-6H2,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062397 (3N-cyanoimino(tert-pentylamino)methyl-3-pyridinami...) Show SMILES CCC(C)(C)NC(NC#N)=Nc1cccnc1 |w:10.10| Show InChI InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282321 (7-Chloro-2-cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-bi...) Show SMILES OC(=O)c1c(Oc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(nc2cc(Cl)ccc12)C1CC1 Show InChI InChI=1S/C26H18ClN5O3/c27-16-9-12-20-21(13-16)28-23(15-5-6-15)24(22(20)26(33)34)35-17-10-7-14(8-11-17)18-3-1-2-4-19(18)25-29-31-32-30-25/h1-4,7-13,15H,5-6H2,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282313 (2-Cyclopropyl-6-methoxy-3-[2'-(2H-tetrazol-5-yl)-b...) Show SMILES COc1ccc2nc(C3CC3)c(Oc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(C(O)=O)c2c1 Show InChI InChI=1S/C27H21N5O4/c1-35-18-12-13-22-21(14-18)23(27(33)34)25(24(28-22)16-6-7-16)36-17-10-8-15(9-11-17)19-4-2-3-5-20(19)26-29-31-32-30-26/h2-5,8-14,16H,6-7H2,1H3,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062402 (1N-cyanoimino(tert-pentylamino)methyl-3-azido-4-io...) Show SMILES CCC(C)(C)NC(Nc1ccc(I)c(c1)N=[N+]=[N-])=NC#N |w:18.19| Show InChI InChI=1S/C13H16IN7/c1-4-13(2,3)19-12(17-8-15)18-9-5-6-10(14)11(7-9)20-21-16/h5-7H,4H2,1-3H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	57	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM403460 (US10335399, Example 2-5 | US10806724, Example 2-5) Show SMILES CC1(C)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C17H16F2N2O2/c1-17(2)6-5-11-12(10-4-3-9(18)7-13(10)19)8-14(15(20)22)21-16(11)23-17/h3-4,7-8H,5-6H2,1-2H3,(H2,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02004 BindingDB Entry DOI: 10.7270/Q2TQ65FG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM403460 (US10335399, Example 2-5 | US10806724, Example 2-5) Show SMILES CC1(C)CCc2c(O1)nc(cc2-c1ccc(F)cc1F)C(N)=O Show InChI InChI=1S/C17H16F2N2O2/c1-17(2)6-5-11-12(10-4-3-9(18)7-13(10)19)8-14(15(20)22)21-16(11)23-17/h3-4,7-8H,5-6H2,1-2H3,(H2,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	59	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02004 BindingDB Entry DOI: 10.7270/Q2TQ65FG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50584759 (CHEMBL5089623) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2OC(C)(C)CCc12)C(N)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02004 BindingDB Entry DOI: 10.7270/Q2TQ65FG
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50584759 (CHEMBL5089623) Show SMILES COc1ccc(c(F)c1)-c1cc(nc2OC(C)(C)CCc12)C(N)=O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02004 BindingDB Entry DOI: 10.7270/Q2TQ65FG
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062394 (1N-cyanoimino(tert-pentylamino)methyl-4-iodoanilin...) Show SMILES CCC(C)(C)NC(Nc1ccc(I)cc1)=NC#N |w:15.16| Show InChI InChI=1S/C13H17IN4/c1-4-13(2,3)18-12(16-9-15)17-11-7-5-10(14)6-8-11/h5-8H,4H2,1-3H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	74	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062396 (4-cyanoimino(1,2,2-trimethylpropylamino)methylamin...) Show SMILES CC(NC(Nc1ccc(cc1)C#N)=NC#N)C(C)(C)C |w:13.14| Show InChI InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282323 (2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...) Show SMILES OC(=O)c1cccc2nc(C3CC3)c(Oc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(C(O)=O)c12 Show InChI InChI=1S/C27H19N5O5/c33-26(34)19-6-3-7-20-21(19)22(27(35)36)24(23(28-20)15-8-9-15)37-16-12-10-14(11-13-16)17-4-1-2-5-18(17)25-29-31-32-30-25/h1-7,10-13,15H,8-9H2,(H,33,34)(H,35,36)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50012957 (1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...) Show SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1 Show InChI InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair				3D Structure (crystal)
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062398 (4-cyanoimino(tert-pentylamino)methylaminobenzonitr...) Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N |w:16.17| Show InChI InChI=1S/C14H17N5/c1-4-14(2,3)19-13(17-10-16)18-12-7-5-11(9-15)6-8-12/h5-8H,4H2,1-3H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50240750 (()-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylprop...) Show SMILES CC(NC(NC#N)=Nc1ccncc1)C(C)(C)C |w:7.7| Show InChI InChI=1S/C13H19N5/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11/h5-8,10H,1-4H3,(H2,15,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062393 (3-cyanoimino(1,2,2-trimethylpropylamino)methylamin...) Show SMILES CC(NC(Nc1cccc(c1)C#N)=NC#N)C(C)(C)C |w:13.14| Show InChI InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-6-12(8-13)9-16/h5-8,11H,1-4H3,(H2,18,19,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062399 (4-[tert-butylamino(cyanoimino)methylamino]benzonit...) Show SMILES CC(C)(C)NC(Nc1ccc(cc1)C#N)=NC#N |w:15.16| Show InChI InChI=1S/C13H15N5/c1-13(2,3)18-12(16-9-15)17-11-6-4-10(8-14)5-7-11/h4-7H,1-3H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062400 (1N-cyanoimino(1,2,2-trimethylpropylamino)methylani...) Show SMILES CC(NC(Nc1ccccc1)=NC#N)C(C)(C)C |w:11.12| Show InChI InChI=1S/C14H20N4/c1-11(14(2,3)4)17-13(16-10-15)18-12-8-6-5-7-9-12/h5-9,11H,1-4H3,(H2,16,17,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	680	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
Type-1 angiotensin II receptor B (RAT)	BDBM50282320 (2-Cyclopropyl-8-methyl-3-[2'-(2H-tetrazol-5-yl)-bi...) Show SMILES Cc1cccc2c(C(O)=O)c(Oc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(nc12)C1CC1 Show InChI InChI=1S/C27H21N5O3/c1-15-5-4-8-21-22(27(33)34)25(24(17-9-10-17)28-23(15)21)35-18-13-11-16(12-14-18)19-6-2-3-7-20(19)26-29-31-32-30-26/h2-8,11-14,17H,9-10H2,1H3,(H,33,34)(H,29,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membrane				Bioorg Med Chem Lett 4: 195-200 (1994) Article DOI: 10.1016/S0960-894X(01)81146-X BindingDB Entry DOI: 10.7270/Q2Z60P13
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062392 (4-isopropylamino(cyanoimino)methylaminobenzonitril...) Show SMILES CC(C)NC(Nc1ccc(cc1)C#N)=NC#N |w:14.15| Show InChI InChI=1S/C12H13N5/c1-9(2)16-12(15-8-14)17-11-5-3-10(7-13)4-6-11/h3-6,9H,1-2H3,(H2,15,16,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062395 (1N-cyanoimino(tert-pentylamino)methyl-3-hexahydro-...) Show SMILES CCC(C)(C)NC(Nc1cccc(c1)S(=O)(=O)N1CCCCC1)=NC#N |w:23.25| Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-9-8-10-16(13-15)26(24,25)23-11-6-5-7-12-23/h8-10,13H,4-7,11-12H2,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062391 (1N-cyanoimino(tert-pentylamino)methyl-4-hexahydro-...) Show SMILES CCC(C)(C)NC(Nc1ccc(cc1)S(=O)(=O)N1CCCCC1)=NC#N |w:23.25| Show InChI InChI=1S/C18H27N5O2S/c1-4-18(2,3)22-17(20-14-19)21-15-8-10-16(11-9-15)26(24,25)23-12-6-5-7-13-23/h8-11H,4-7,12-13H2,1-3H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50062401 (4-methylamino(cyanoimino)methylaminobenzonitrile |...) Show SMILES CNC(Nc1ccc(cc1)C#N)=NC#N |w:12.13| Show InChI InChI=1S/C10H9N5/c1-13-10(14-7-12)15-9-4-2-8(6-11)3-5-9/h2-5H,1H3,(H2,13,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50044253 ((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...) Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N |r| Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 (Homo sapiens (Human))	BDBM50044253 ((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...) Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N |r| Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes				J Med Chem 41: 271-5 (1998) Article DOI: 10.1021/jm970762d BindingDB Entry DOI: 10.7270/Q2FN159P
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50123474 (1-[9-(3-Chloro-4-methoxy-benzylamino)-3-ethyl-3H-2...) Show SMILES CCn1ncc2c1ncc1c(nnc(NCc3ccc(OC)c(Cl)c3)c21)N1CCC(CC1)C(O)=O Show InChI InChI=1S/C24H26ClN7O3/c1-3-32-22-17(13-28-32)20-16(12-27-22)23(31-8-6-15(7-9-31)24(33)34)30-29-21(20)26-11-14-4-5-19(35-2)18(25)10-14/h4-5,10,12-13,15H,3,6-9,11H2,1-2H3,(H,26,29)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50141580 (4-(3-Chloro-4-methoxy-benzylamino)-8-ethyl-3-hydro...) Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c(CO)cnc12)C#N Show InChI InChI=1S/C21H20ClN3O2/c1-3-15-6-14(9-23)7-17-20(15)25-11-16(12-26)21(17)24-10-13-4-5-19(27-2)18(22)8-13/h4-8,11,26H,3,10,12H2,1-2H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 from human platelets				Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50123477 (CHEMBL344018 | N*9*-(3-Chloro-4-methoxy-benzyl)-3-...) Show SMILES CCn1ncc2c1ncc1c(NCc3ccncc3)nnc(NCc3ccc(OC)c(Cl)c3)c21 Show InChI InChI=1S/C24H23ClN8O/c1-3-33-24-18(14-30-33)21-17(13-29-24)22(27-11-15-6-8-26-9-7-15)31-32-23(21)28-12-16-4-5-20(34-2)19(25)10-16/h4-10,13-14H,3,11-12H2,1-2H3,(H,27,31)(H,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50023921 (CHEMBL2112876) Show SMILES CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4ccc(F)cc4)c3cc2c(=O)[nH]1)S(=O)(=O)N1CC[C@H](C1)N(C)C |r| Show InChI InChI=1S/C31H33FN6O4S/c1-4-13-42-29-10-9-23(43(40,41)38-12-11-22(18-38)36(2)3)14-25(29)30-34-26-16-27-28(15-24(26)31(39)35-30)37(19-33-27)17-20-5-7-21(32)8-6-20/h5-10,14-16,19,22H,4,11-13,17-18H2,1-3H3,(H,34,35,39)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determined				J Med Chem 43: 5037-43 (2001) BindingDB Entry DOI: 10.7270/Q2862FP8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50123473 (1-[9-(3-Chloro-4-methoxy-benzylamino)-3-ethyl-3H-2...) Show SMILES CCn1ncc2c1ncc1c(nnc(NCc3ccc(OC)c(Cl)c3)c21)-n1cnc(c1)C(=O)NC Show InChI InChI=1S/C23H22ClN9O2/c1-4-33-21-15(10-29-33)19-14(9-27-21)22(32-11-17(28-12-32)23(34)25-2)31-30-20(19)26-8-13-5-6-18(35-3)16(24)7-13/h5-7,9-12H,4,8H2,1-3H3,(H,25,34)(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50104208 (8-[5-((R)-3-Dimethylamino-pyrrolidine-1-sulfonyl)-...) Show SMILES CCCOc1ccc(cc1-c1nc2c3c[nH]nc3nc(NCc3ccc(F)cc3)c2c(=O)[nH]1)S(=O)(=O)N1CC[C@H](C1)N(C)C Show InChI InChI=1S/C30H33FN8O4S/c1-4-13-43-24-10-9-21(44(41,42)39-12-11-20(17-39)38(2)3)14-22(24)27-34-26-23-16-33-37-28(23)35-29(25(26)30(40)36-27)32-15-18-5-7-19(31)8-6-18/h5-10,14,16,20H,4,11-13,15,17H2,1-3H3,(H,34,36,40)(H2,32,33,35,37)/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE5 from human platelets				Bioorg Med Chem Lett 11: 2461-4 (2001) BindingDB Entry DOI: 10.7270/Q2BK1BM5
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50141584 (4-(3-Chloro-4-methoxy-benzylamino)-8-ethyl-quinoli...) Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)ccnc12)C#N Show InChI InChI=1S/C20H18ClN3O/c1-3-15-8-14(11-22)9-16-18(6-7-23-20(15)16)24-12-13-4-5-19(25-2)17(21)10-13/h4-10H,3,12H2,1-2H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 from human platelets				Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50086873 (3-[1-(4-Fluoro-benzyl)-8-oxo-7,8-dihydro-1H-imidaz...) Show SMILES CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4ccc(F)cc4)c3cc2c(=O)[nH]1)C(N)=O Show InChI InChI=1S/C26H22FN5O3/c1-2-9-35-23-8-5-16(24(28)33)10-19(23)25-30-20-12-21-22(11-18(20)26(34)31-25)32(14-29-21)13-15-3-6-17(27)7-4-15/h3-8,10-12,14H,2,9,13H2,1H3,(H2,28,33)(H,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determined				J Med Chem 43: 5037-43 (2001) BindingDB Entry DOI: 10.7270/Q2862FP8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50141588 (4-(3-Chloro-4-methoxy-benzylamino)-3-hydroxymethyl...) Show SMILES COc1ccc(CNc2c(CO)cnc3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C19H16ClN3O2/c1-25-18-5-3-13(7-16(18)20)9-23-19-14(11-24)10-22-17-4-2-12(8-21)6-15(17)19/h2-7,10,24H,9,11H2,1H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 from human platelets				Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50086873 (3-[1-(4-Fluoro-benzyl)-8-oxo-7,8-dihydro-1H-imidaz...) Show SMILES CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4ccc(F)cc4)c3cc2c(=O)[nH]1)C(N)=O Show InChI InChI=1S/C26H22FN5O3/c1-2-9-35-23-8-5-16(24(28)33)10-19(23)25-30-20-12-21-22(11-18(20)26(34)31-25)32(14-29-21)13-15-3-6-17(27)7-4-15/h3-8,10-12,14H,2,9,13H2,1H3,(H2,28,33)(H,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase type 5 (PDE5) of human platelets				J Med Chem 43: 1257-63 (2001) BindingDB Entry DOI: 10.7270/Q2125RW8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50023922 (CHEMBL2112881) Show SMILES CCCOc1ccc(cc1-c1nc(O)c2cc3n(Cc4ccc(Cl)cc4)cnc3cc2n1)S(=O)(=O)N1CC[C@H](C1)N(C)C |r| Show InChI InChI=1S/C31H33ClN6O4S/c1-4-13-42-29-10-9-23(43(40,41)38-12-11-22(18-38)36(2)3)14-25(29)30-34-26-16-27-28(15-24(26)31(39)35-30)37(19-33-27)17-20-5-7-21(32)8-6-20/h5-10,14-16,19,22H,4,11-13,17-18H2,1-3H3,(H,34,35,39)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determined				J Med Chem 43: 5037-43 (2001) BindingDB Entry DOI: 10.7270/Q2862FP8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50141586 (4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-8-ethyl...) Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c(cnc12)C(=O)NCc1ccccn1)C#N Show InChI InChI=1S/C27H24ClN5O2/c1-3-19-10-18(13-29)11-21-25(19)32-16-22(27(34)33-15-20-6-4-5-9-30-20)26(21)31-14-17-7-8-24(35-2)23(28)12-17/h4-12,16H,3,14-15H2,1-2H3,(H,31,32)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 from human platelets				Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50089814 (4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...) Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50089814 (4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...) Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of PDE5 of human platelets				J Med Chem 44: 1025-7 (2001) BindingDB Entry DOI: 10.7270/Q2154G8J
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50141583 (4-(3-Chloro-4-methoxy-benzylamino)-6-cyano-8-ethyl...) Show SMILES CCOC(=O)c1cnc2c(CC)cc(cc2c1NCc1ccc(OC)c(Cl)c1)C#N Show InChI InChI=1S/C23H22ClN3O3/c1-4-16-8-15(11-25)9-17-21(16)27-13-18(23(28)30-5-2)22(17)26-12-14-6-7-20(29-3)19(24)10-14/h6-10,13H,4-5,12H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 5 from human platelets				Bioorg Med Chem Lett 14: 1577-80 (2004) Article DOI: 10.1016/j.bmcl.2003.12.090 BindingDB Entry DOI: 10.7270/Q2G1607Q
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50095727 (6-[5-(4-Ethyl-piperazine-1-sulfonyl)-2-propoxy-phe...) Show SMILES CCCOc1ccc(cc1-c1nc2cc3ncn(Cc4ccccc4OC)c3cc2c(=O)[nH]1)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C32H36N6O5S/c1-4-16-43-30-11-10-23(44(40,41)38-14-12-36(5-2)13-15-38)17-25(30)31-34-26-19-27-28(18-24(26)32(39)35-31)37(21-33-27)20-22-8-6-7-9-29(22)42-3/h6-11,17-19,21H,4-5,12-16,20H2,1-3H3,(H,34,35,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determined				J Med Chem 43: 5037-43 (2001) BindingDB Entry DOI: 10.7270/Q2862FP8
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50123475 (1-[9-(3-Chloro-4-methoxy-benzylamino)-3-ethyl-3H-2...) Show SMILES CCn1ncc2c1ncc1c(nnc(NCc3ccc(OC)c(Cl)c3)c21)N1CCC(O)CC1 Show InChI InChI=1S/C23H26ClN7O2/c1-3-31-22-17(13-27-31)20-16(12-26-22)23(30-8-6-15(32)7-9-30)29-28-21(20)25-11-14-4-5-19(33-2)18(24)10-14/h4-5,10,12-13,15,32H,3,6-9,11H2,1-2H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM14776 (2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...) Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human platelets				J Med Chem 46: 457-60 (2003) Article DOI: 10.1021/jm0256068 BindingDB Entry DOI: 10.7270/Q2125S1G
					More data for this Ligand-Target Pair				3D Structure (crystal)

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