Found 29 hits with Last Name = 'nutter' and Initial = 'se' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50130461
(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26) | PDB
Reactome pathway
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PC sid
UniChem
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| PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50130461
(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137539
(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cc(F)cc3F)nc12 Show InChI InChI=1S/C20H18F3N3O2/c1-26-6-4-11(5-7-26)13-10-28-16-2-3-17(24-19(13)16)25-20(27)18-14(22)8-12(21)9-15(18)23/h2-3,8-11H,4-7H2,1H3,(H,24,25,27) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137540
(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cccc3Cl)nc12 Show InChI InChI=1S/C20H19ClFN3O2/c1-25-9-7-12(8-10-25)13-11-27-16-5-6-17(23-19(13)16)24-20(26)18-14(21)3-2-4-15(18)22/h2-6,11-12H,7-10H2,1H3,(H,23,24,26) | PDB
Reactome pathway
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PC sid
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| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137538
(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3Cl)nc12 Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)15-11-27-17-4-5-18(23-19(15)17)24-20(26)14-3-2-13(22)10-16(14)21/h2-5,10-12H,6-9H2,1H3,(H,23,24,26) | PDB
Reactome pathway
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PC sid
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137541
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3)nc12 Show InChI InChI=1S/C20H20FN3O2/c1-24-10-8-13(9-11-24)16-12-26-17-6-7-18(22-19(16)17)23-20(25)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,23,25) | PDB
Reactome pathway
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PC sid
UniChem
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| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119543
(CHEMBL3617549)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H21FN2O2/c1-23-11-9-14(10-12-23)19(24)16-3-2-4-18(13-16)22-20(25)15-5-7-17(21)8-6-15/h2-8,13-14H,9-12H2,1H3,(H,22,25) | PDB
Reactome pathway
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PC cid
PC sid
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| Article
PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50130443
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-pyrrolo...)Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)nc12 Show InChI InChI=1S/C20H21FN4O/c1-25-10-8-13(9-11-25)16-12-22-17-6-7-18(23-19(16)17)24-20(26)14-2-4-15(21)5-3-14/h2-7,12-13,22H,8-11H2,1H3,(H,23,24,26) | PDB
Reactome pathway
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PC sid
UniChem
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| PubMed
| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137542
(CHEMBL178066 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)Show SMILES CN(C)CCc1c(C)[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C20H22FN3O/c1-13-17(10-11-24(2)3)18-12-16(8-9-19(18)22-13)23-20(25)14-4-6-15(21)7-5-14/h4-9,12,22H,10-11H2,1-3H3,(H,23,25) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| PubMed
| 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119542
(CHEMBL3617550)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1F Show InChI InChI=1S/C20H20F2N2O2/c1-24-11-9-13(10-12-24)19(25)16-3-2-4-17(18(16)22)23-20(26)14-5-7-15(21)8-6-14/h2-8,13H,9-12H2,1H3,(H,23,26) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119532
(CHEMBL3617557)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)n1 Show InChI InChI=1S/C19H20FN3O2/c1-23-11-9-13(10-12-23)18(24)16-3-2-4-17(21-16)22-19(25)14-5-7-15(20)8-6-14/h2-8,13H,9-12H2,1H3,(H,21,22,25) | PDB
Reactome pathway
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| 9.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137537
(CHEMBL369391 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)Show InChI InChI=1S/C19H20FN3O2/c1-12-15(10-11-23(2)3)18-16(25-12)8-9-17(21-18)22-19(24)13-4-6-14(20)7-5-13/h4-9H,10-11H2,1-3H3,(H,21,22,24) | PDB
Reactome pathway
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| PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50130461
(4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-...)Show SMILES CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12 Show InChI InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26) | PDB
UniProtKB/SwissProt
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to 5HT1A receptor (unknown origin) |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119540
(CHEMBL3617552)Show SMILES CN1CCC(CC1)C(=O)c1cc(F)cc(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H20F2N2O2/c1-24-8-6-13(7-9-24)19(25)15-10-17(22)12-18(11-15)23-20(26)14-2-4-16(21)5-3-14/h2-5,10-13H,6-9H2,1H3,(H,23,26) | PDB
Reactome pathway
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PC sid
UniChem
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| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119539
(CHEMBL3617553)Show SMILES CN1CCC(CC1)C(=O)c1ccc(F)c(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H20F2N2O2/c1-24-10-8-13(9-11-24)19(25)15-4-7-17(22)18(12-15)23-20(26)14-2-5-16(21)6-3-14/h2-7,12-13H,8-11H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 530 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119535
(CHEMBL3616488)Show SMILES COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 Show InChI InChI=1S/C21H23FN2O3/c1-24-12-10-14(11-13-24)19(25)17-4-3-5-18(20(17)27-2)23-21(26)15-6-8-16(22)9-7-15/h3-9,14H,10-13H2,1-2H3,(H,23,26) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119537
(CHEMBL3617555)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1C Show InChI InChI=1S/C21H23FN2O2/c1-14-18(20(25)15-10-12-24(2)13-11-15)4-3-5-19(14)23-21(26)16-6-8-17(22)9-7-16/h3-9,15H,10-13H2,1-2H3,(H,23,26) | PDB
Reactome pathway
KEGG
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PC sid
UniChem
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| Article
PubMed
| 870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119533
(CHEMBL3617556)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1O Show InChI InChI=1S/C20H21FN2O3/c1-23-11-9-13(10-12-23)18(24)16-3-2-4-17(19(16)25)22-20(26)14-5-7-15(21)8-6-14/h2-8,13,25H,9-12H2,1H3,(H,22,26) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119541
(CHEMBL3617551)Show SMILES CN1CCC(CC1)C(=O)c1cc(NC(=O)c2ccc(F)cc2)ccc1F Show InChI InChI=1S/C20H20F2N2O2/c1-24-10-8-13(9-11-24)19(25)17-12-16(6-7-18(17)22)23-20(26)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,23,26) | PDB
Reactome pathway
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PC sid
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Similars
| Article
PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119538
(CHEMBL3617554)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1Cl Show InChI InChI=1S/C20H20ClFN2O2/c1-24-11-9-13(10-12-24)19(25)16-3-2-4-17(18(16)21)23-20(26)14-5-7-15(22)8-6-14/h2-8,13H,9-12H2,1H3,(H,23,26) | PDB
Reactome pathway
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UniChem
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| Article
PubMed
| 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119530
(CHEMBL3617560)Show SMILES CN1CCC(CC1)C(=O)c1ccnc(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H20FN3O2/c1-23-10-7-13(8-11-23)18(24)15-6-9-21-17(12-15)22-19(25)14-2-4-16(20)5-3-14/h2-6,9,12-13H,7-8,10-11H2,1H3,(H,21,22,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119531
(CHEMBL3617559)Show SMILES CN1CCC(CC1)C(=O)c1cncc(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C19H20FN3O2/c1-23-8-6-13(7-9-23)18(24)15-10-17(12-21-11-15)22-19(25)14-2-4-16(20)5-3-14/h2-5,10-13H,6-9H2,1H3,(H,22,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to human 5HT1F receptor by radioligand binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137538
(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3Cl)nc12 Show InChI InChI=1S/C20H19ClFN3O2/c1-25-8-6-12(7-9-25)15-11-27-17-4-5-18(23-19(15)17)24-20(26)14-3-2-13(22)10-16(14)21/h2-5,10-12H,6-9H2,1H3,(H,23,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 277 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137540
(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cccc3Cl)nc12 Show InChI InChI=1S/C20H19ClFN3O2/c1-25-9-7-12(8-10-25)13-11-27-16-5-6-17(23-19(13)16)24-20(26)18-14(21)3-2-4-15(18)22/h2-6,11-12H,7-10H2,1H3,(H,23,24,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137539
(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3c(F)cc(F)cc3F)nc12 Show InChI InChI=1S/C20H18F3N3O2/c1-26-6-4-11(5-7-26)13-10-28-16-2-3-17(24-19(13)16)25-20(27)18-14(22)8-12(21)9-15(18)23/h2-3,8-11H,4-7H2,1H3,(H,24,25,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 92 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119532
(CHEMBL3617557)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)n1 Show InChI InChI=1S/C19H20FN3O2/c1-23-11-9-13(10-12-23)18(24)16-3-2-4-17(21-16)22-19(25)14-5-7-15(20)8-6-14/h2-8,13H,9-12H2,1H3,(H,21,22,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50137541
(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)Show SMILES CN1CCC(CC1)c1coc2ccc(NC(=O)c3ccc(F)cc3)nc12 Show InChI InChI=1S/C20H20FN3O2/c1-24-10-8-13(9-11-24)16-12-26-17-6-7-18(22-19(16)17)23-20(25)14-2-4-15(21)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,22,23,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 66 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor |
Bioorg Med Chem Lett 14: 167-70 (2003)
BindingDB Entry DOI: 10.7270/Q2S46RCF |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119543
(CHEMBL3617549)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1 Show InChI InChI=1S/C20H21FN2O2/c1-23-11-9-14(10-12-23)19(24)16-3-2-4-18(13-16)22-20(25)15-5-7-17(21)8-6-15/h2-8,13-14H,9-12H2,1H3,(H,22,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 87 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1F
(Homo sapiens (Human)) | BDBM50119542
(CHEMBL3617550)Show SMILES CN1CCC(CC1)C(=O)c1cccc(NC(=O)c2ccc(F)cc2)c1F Show InChI InChI=1S/C20H20F2N2O2/c1-24-11-9-13(10-12-24)19(25)16-3-2-4-17(18(16)22)23-20(26)14-5-7-15(21)8-6-14/h2-8,13H,9-12H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay |
Bioorg Med Chem Lett 25: 4337-41 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.042
BindingDB Entry DOI: 10.7270/Q2NC630T |
More data for this
Ligand-Target Pair | |
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