Found 35 hits with Last Name = 'polsky-fisher' and Initial = 'sl' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248064
(2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C1CCCCC1O Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(29,30)26-11-9-22(10-12-26,18-5-3-4-6-20(18)27)15-25-21(28)17-8-7-16(23)14-19(17)24/h7-8,14,18,20,27H,2-6,9-13,15H2,1H3,(H,25,28) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248062
(2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CCCCO2)CC1 Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(28,29)26-10-8-22(9-11-26,15-18-5-3-4-12-30-18)16-25-21(27)19-7-6-17(23)14-20(19)24/h6-7,14,18H,2-5,8-13,15-16H2,1H3,(H,25,27) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248100
((2,4-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H25Cl2N3O3S/c1-2-13-30(28,29)26-11-8-21(9-12-26,19-5-3-4-10-24-19)15-25-20(27)17-7-6-16(22)14-18(17)23/h3-7,10,14H,2,8-9,11-13,15H2,1H3,(H,25,27) | PDB
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PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248128
(2,4-dichloro-N-((1-(2-fluoropropylsulfonyl)-4-(pyr...)Show SMILES CC(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H24Cl2FN3O3S/c1-15(24)13-31(29,30)27-10-7-21(8-11-27,19-4-2-3-9-25-19)14-26-20(28)17-6-5-16(22)12-18(17)23/h2-6,9,12,15H,7-8,10-11,13-14H2,1H3,(H,26,28) | PDB
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| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248097
(2-(4-((2,4-dichlorobenzamido)methyl)-1-(propylsulf...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C1CCCCC1OC(C)=O Show InChI InChI=1S/C24H34Cl2N2O5S/c1-3-14-34(31,32)28-12-10-24(11-13-28,20-6-4-5-7-22(20)33-17(2)29)16-27-23(30)19-9-8-18(25)15-21(19)26/h8-9,15,20,22H,3-7,10-14,16H2,1-2H3,(H,27,30) | PDB
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| Article
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248063
(2,4-dichloro-N-((4-(2-methoxyethyl)-1-(propylsulfo...)Show SMILES CCCS(=O)(=O)N1CCC(CCOC)(CNC(=O)c2ccc(Cl)cc2Cl)CC1 Show InChI InChI=1S/C19H28Cl2N2O4S/c1-3-12-28(25,26)23-9-6-19(7-10-23,8-11-27-2)14-22-18(24)16-5-4-15(20)13-17(16)21/h4-5,13H,3,6-12,14H2,1-2H3,(H,22,24) | PDB
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| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248099
(2,4-dichloro-N-((4-(cyclopropylmethyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 Show InChI InChI=1S/C20H28Cl2N2O3S/c1-2-11-28(26,27)24-9-7-20(8-10-24,13-15-3-4-15)14-23-19(25)17-6-5-16(21)12-18(17)22/h5-6,12,15H,2-4,7-11,13-14H2,1H3,(H,23,25) | PDB
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| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248098
(CHEMBL462148 | N-((4-(azetidin-1-yl)-1-(propylsulf...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)N1CCC1 Show InChI InChI=1S/C19H27Cl2N3O3S/c1-2-12-28(26,27)24-10-6-19(7-11-24,23-8-3-9-23)14-22-18(25)16-5-4-15(20)13-17(16)21/h4-5,13H,2-3,6-12,14H2,1H3,(H,22,25) | PDB
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PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248130
(2,4-dichloro-N-((1-(ethylsulfonyl)-4-(pyridin-2-yl...)Show SMILES CCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C20H23Cl2N3O3S/c1-2-29(27,28)25-11-8-20(9-12-25,18-5-3-4-10-23-18)14-24-19(26)16-7-6-15(21)13-17(16)22/h3-7,10,13H,2,8-9,11-12,14H2,1H3,(H,24,26) | PDB
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PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248162
(2,4-dichloro-N-((1-(N,N-dimethylsulfamoyl)-4-(pyri...)Show SMILES CN(C)S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C20H24Cl2N4O3S/c1-25(2)30(28,29)26-11-8-20(9-12-26,18-5-3-4-10-23-18)14-24-19(27)16-7-6-15(21)13-17(16)22/h3-7,10,13H,8-9,11-12,14H2,1-2H3,(H,24,27) | PDB
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| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248127
(2,4-dichloro-N-((1-(2-hydroxypropylsulfonyl)-4-(py...)Show SMILES CC(O)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H25Cl2N3O4S/c1-15(27)13-31(29,30)26-10-7-21(8-11-26,19-4-2-3-9-24-19)14-25-20(28)17-6-5-16(22)12-18(17)23/h2-6,9,12,15,27H,7-8,10-11,13-14H2,1H3,(H,25,28) | PDB
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| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248159
(CHEMBL463024 | N-((1-(butylsulfonyl)-4-(pyridin-2-...)Show SMILES CCCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C22H27Cl2N3O3S/c1-2-3-14-31(29,30)27-12-9-22(10-13-27,20-6-4-5-11-25-20)16-26-21(28)18-8-7-17(23)15-19(18)24/h4-8,11,15H,2-3,9-10,12-14,16H2,1H3,(H,26,28) | PDB
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| Article
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248160
(2,4-dichloro-N-((1-(cyclopropylsulfonyl)-4-(pyridi...)Show SMILES Clc1ccc(C(=O)NCC2(CCN(CC2)S(=O)(=O)C2CC2)c2ccccn2)c(Cl)c1 Show InChI InChI=1S/C21H23Cl2N3O3S/c22-15-4-7-17(18(23)13-15)20(27)25-14-21(19-3-1-2-10-24-19)8-11-26(12-9-21)30(28,29)16-5-6-16/h1-4,7,10,13,16H,5-6,8-9,11-12,14H2,(H,25,27) | PDB
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PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248161
(2,4-dichloro-N-((1-(isopropylsulfonyl)-4-(pyridin-...)Show SMILES CC(C)S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H25Cl2N3O3S/c1-15(2)30(28,29)26-11-8-21(9-12-26,19-5-3-4-10-24-19)14-25-20(27)17-7-6-16(22)13-18(17)23/h3-7,10,13,15H,8-9,11-12,14H2,1-2H3,(H,25,27) | PDB
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PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248129
(2,4-dichloro-N-((1-(methylsulfonyl)-4-(pyridin-2-y...)Show SMILES CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C19H21Cl2N3O3S/c1-28(26,27)24-10-7-19(8-11-24,17-4-2-3-9-22-17)13-23-18(25)15-6-5-14(20)12-16(15)21/h2-6,9,12H,7-8,10-11,13H2,1H3,(H,23,25) | PDB
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PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248208
(2,4-dichloro-N-((4-(pyridin-2-yl)-1-(2,2,2-trifluo...)Show SMILES FC(F)(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C20H20Cl2F3N3O3S/c21-14-4-5-15(16(22)11-14)18(29)27-12-19(17-3-1-2-8-26-17)6-9-28(10-7-19)32(30,31)13-20(23,24)25/h1-5,8,11H,6-7,9-10,12-13H2,(H,27,29) | PDB
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| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Homo sapiens (Human)) | BDBM50248207
(2,4-dichloro-N-((4-(pyridin-2-yl)-1-(trifluorometh...)Show SMILES FC(F)(F)S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C19H18Cl2F3N3O3S/c20-13-4-5-14(15(21)11-13)17(28)26-12-18(16-3-1-2-8-25-16)6-9-27(10-7-18)31(29,30)19(22,23)24/h1-5,8,11H,6-7,9-10,12H2,(H,26,28) | PDB
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| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt1 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248064
(2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C1CCCCC1O Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(29,30)26-11-9-22(10-12-26,18-5-3-4-6-20(18)27)15-25-21(28)17-8-7-16(23)14-19(17)24/h7-8,14,18,20,27H,2-6,9-13,15H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248130
(2,4-dichloro-N-((1-(ethylsulfonyl)-4-(pyridin-2-yl...)Show SMILES CCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C20H23Cl2N3O3S/c1-2-29(27,28)25-11-8-20(9-12-25,18-5-3-4-10-23-18)14-24-19(26)16-7-6-15(21)13-17(16)22/h3-7,10,13H,2,8-9,11-12,14H2,1H3,(H,24,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248100
((2,4-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H25Cl2N3O3S/c1-2-13-30(28,29)26-11-8-21(9-12-26,19-5-3-4-10-24-19)15-25-20(27)17-7-6-16(22)14-18(17)23/h3-7,10,14H,2,8-9,11-13,15H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248099
(2,4-dichloro-N-((4-(cyclopropylmethyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 Show InChI InChI=1S/C20H28Cl2N2O3S/c1-2-11-28(26,27)24-9-7-20(8-10-24,13-15-3-4-15)14-23-19(25)17-6-5-16(21)12-18(17)22/h5-6,12,15H,2-4,7-11,13-14H2,1H3,(H,23,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248063
(2,4-dichloro-N-((4-(2-methoxyethyl)-1-(propylsulfo...)Show SMILES CCCS(=O)(=O)N1CCC(CCOC)(CNC(=O)c2ccc(Cl)cc2Cl)CC1 Show InChI InChI=1S/C19H28Cl2N2O4S/c1-3-12-28(25,26)23-9-6-19(7-10-23,8-11-27-2)14-22-18(24)16-5-4-15(20)13-17(16)21/h4-5,13H,3,6-12,14H2,1-2H3,(H,22,24) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248160
(2,4-dichloro-N-((1-(cyclopropylsulfonyl)-4-(pyridi...)Show SMILES Clc1ccc(C(=O)NCC2(CCN(CC2)S(=O)(=O)C2CC2)c2ccccn2)c(Cl)c1 Show InChI InChI=1S/C21H23Cl2N3O3S/c22-15-4-7-17(18(23)13-15)20(27)25-14-21(19-3-1-2-10-24-19)8-11-26(12-9-21)30(28,29)16-5-6-16/h1-4,7,10,13,16H,5-6,8-9,11-12,14H2,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248062
(2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CCCCO2)CC1 Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(28,29)26-10-8-22(9-11-26,15-18-5-3-4-12-30-18)16-25-21(27)19-7-6-17(23)14-20(19)24/h6-7,14,18H,2-5,8-13,15-16H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248063
(2,4-dichloro-N-((4-(2-methoxyethyl)-1-(propylsulfo...)Show SMILES CCCS(=O)(=O)N1CCC(CCOC)(CNC(=O)c2ccc(Cl)cc2Cl)CC1 Show InChI InChI=1S/C19H28Cl2N2O4S/c1-3-12-28(25,26)23-9-6-19(7-10-23,8-11-27-2)14-22-18(24)16-5-4-15(20)13-17(16)21/h4-5,13H,3,6-12,14H2,1-2H3,(H,22,24) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248064
(2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C1CCCCC1O Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(29,30)26-11-9-22(10-12-26,18-5-3-4-6-20(18)27)15-25-21(28)17-8-7-16(23)14-19(17)24/h7-8,14,18,20,27H,2-6,9-13,15H2,1H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248099
(2,4-dichloro-N-((4-(cyclopropylmethyl)-1-(propylsu...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 Show InChI InChI=1S/C20H28Cl2N2O3S/c1-2-11-28(26,27)24-9-7-20(8-10-24,13-15-3-4-15)14-23-19(25)17-6-5-16(21)12-18(17)22/h5-6,12,15H,2-4,7-11,13-14H2,1H3,(H,23,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248100
((2,4-dichloro-N-((1-(propylsulfonyl)-4-(pyridin-2-...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H25Cl2N3O3S/c1-2-13-30(28,29)26-11-8-21(9-12-26,19-5-3-4-10-24-19)15-25-20(27)17-7-6-16(22)14-18(17)23/h3-7,10,14H,2,8-9,11-13,15H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248129
(2,4-dichloro-N-((1-(methylsulfonyl)-4-(pyridin-2-y...)Show SMILES CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C19H21Cl2N3O3S/c1-28(26,27)24-10-7-19(8-11-24,17-4-2-3-9-22-17)13-23-18(25)15-6-5-14(20)12-16(15)21/h2-6,9,12H,7-8,10-11,13H2,1H3,(H,23,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248130
(2,4-dichloro-N-((1-(ethylsulfonyl)-4-(pyridin-2-yl...)Show SMILES CCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C20H23Cl2N3O3S/c1-2-29(27,28)25-11-8-20(9-12-25,18-5-3-4-10-23-18)14-24-19(26)16-7-6-15(21)13-17(16)22/h3-7,10,13H,2,8-9,11-12,14H2,1H3,(H,24,26) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248160
(2,4-dichloro-N-((1-(cyclopropylsulfonyl)-4-(pyridi...)Show SMILES Clc1ccc(C(=O)NCC2(CCN(CC2)S(=O)(=O)C2CC2)c2ccccn2)c(Cl)c1 Show InChI InChI=1S/C21H23Cl2N3O3S/c22-15-4-7-17(18(23)13-15)20(27)25-14-21(19-3-1-2-10-24-19)8-11-26(12-9-21)30(28,29)16-5-6-16/h1-4,7,10,13,16H,5-6,8-9,11-12,14H2,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50248128
(2,4-dichloro-N-((1-(2-fluoropropylsulfonyl)-4-(pyr...)Show SMILES CC(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H24Cl2FN3O3S/c1-15(24)13-31(29,30)27-10-7-21(8-11-27,19-4-2-3-9-25-19)14-26-20(28)17-6-5-16(22)12-18(17)23/h2-6,9,12,15H,7-8,10-11,13-14H2,1H3,(H,26,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of taurine transporter |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248129
(2,4-dichloro-N-((1-(methylsulfonyl)-4-(pyridin-2-y...)Show SMILES CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C19H21Cl2N3O3S/c1-28(26,27)24-10-7-19(8-11-24,17-4-2-3-9-22-17)13-23-18(25)15-6-5-14(20)12-16(15)21/h2-6,9,12H,7-8,10-11,13H2,1H3,(H,23,25) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248128
(2,4-dichloro-N-((1-(2-fluoropropylsulfonyl)-4-(pyr...)Show SMILES CC(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)c1ccccn1 Show InChI InChI=1S/C21H24Cl2FN3O3S/c1-15(24)13-31(29,30)27-10-7-21(8-11-27,19-4-2-3-9-25-19)14-26-20(28)17-6-5-16(22)12-18(17)23/h2-6,9,12,15H,7-8,10-11,13-14H2,1H3,(H,26,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 2
(Homo sapiens (Human)) | BDBM50248062
(2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CCCCO2)CC1 Show InChI InChI=1S/C22H32Cl2N2O4S/c1-2-13-31(28,29)26-10-8-22(9-11-26,15-18-5-3-4-12-30-18)16-25-21(27)19-7-6-17(23)14-20(19)24/h6-7,14,18H,2-5,8-13,15-16H2,1H3,(H,25,27) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of Glyt2 |
Bioorg Med Chem Lett 19: 1492-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.015
BindingDB Entry DOI: 10.7270/Q2B27V5N |
More data for this
Ligand-Target Pair | |
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