Found 307 hits with Last Name = 'prosser' and Initial = 'a' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM82517
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1 Show InChI InChI=1S/C23H27N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-5,8-11H,6-7,12-17H2,1H3 | PDB
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PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50072775
(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)Show SMILES CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 |r| Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1 | PDB
Reactome pathway
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| PDB
Article
PubMed
| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50072775
(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)Show SMILES CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 |r| Show InChI InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1 | PDB
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| PDB
Article
PubMed
| 0.316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM21392
(3-(2-aminoethyl)-1H-indole-5-carboxamide | 5-CT | ...)Show InChI InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) | PDB
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| 0.450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478160
(CHEMBL260767)Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CC[C@H](Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O Show InChI InChI=1S/C29H40N4O4/c1-20(2)26(37-27-18-23(36-5)11-10-21(27)3)14-17-31-15-12-22(13-16-31)33-25-9-7-6-8-24(25)32(29(33)35)19-28(34)30-4/h6-11,18,20,22,26H,12-17,19H2,1-5H3,(H,30,34)/t26-/m0/s1 | PDB
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| PC cid
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| Article
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| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM78940
(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3 | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50416472
(CHEMBL1209708)Show SMILES COc1cccc2c(cn(CC3CCCCC3)c12)C(=O)N1C[C@H](C)N(C)[C@H](C)C1 |r| Show InChI InChI=1S/C24H35N3O2/c1-17-13-27(14-18(2)25(17)3)24(28)21-16-26(15-19-9-6-5-7-10-19)23-20(21)11-8-12-22(23)29-4/h8,11-12,16-19H,5-7,9-10,13-15H2,1-4H3/t17-,18+ | PDB
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| Article
PubMed
| 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478179
(CHEMBL260556)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)26(38-27-17-23(37-4)10-9-21(27)3)13-16-33-14-11-22(12-15-33)35-25-8-6-5-7-24(25)34(29(35)36)18-28-30-19-31-32-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3,(H,30,31,32) | PDB
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| PC cid
PC sid
UniChem
| Article
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| 0.891 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478179
(CHEMBL260556)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)26(38-27-17-23(37-4)10-9-21(27)3)13-16-33-14-11-22(12-15-33)35-25-8-6-5-7-24(25)34(29(35)36)18-28-30-19-31-32-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3,(H,30,31,32) | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 0.891 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50200592
((+)-2-(3-{1-[3-(5-methoxy-2-methyl-phenoxy)-4-meth...)Show SMILES CNC(=O)Cn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O |w:19.20| Show InChI InChI=1S/C29H40N4O4/c1-20(2)26(37-27-18-23(36-5)11-10-21(27)3)14-17-31-15-12-22(13-16-31)33-25-9-7-6-8-24(25)32(29(33)35)19-28(34)30-4/h6-11,18,20,22,26H,12-17,19H2,1-5H3,(H,30,34) | PDB
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| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478171
(CHEMBL259263)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cscn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O3S/c1-21(2)28(37-29-17-25(36-4)10-9-22(29)3)13-16-32-14-11-24(12-15-32)34-27-8-6-5-7-26(27)33(30(34)35)18-23-19-38-20-31-23/h5-10,17,19-21,24,28H,11-16,18H2,1-4H3 | PDB
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| PC cid
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| Article
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| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50416472
(CHEMBL1209708)Show SMILES COc1cccc2c(cn(CC3CCCCC3)c12)C(=O)N1C[C@H](C)N(C)[C@H](C)C1 |r| Show InChI InChI=1S/C24H35N3O2/c1-17-13-27(14-18(2)25(17)3)24(28)21-16-26(15-19-9-6-5-7-10-19)23-20(21)11-8-12-22(23)29-4/h8,11-12,16-19H,5-7,9-10,13-15H2,1-4H3/t17-,18+ | PDB
NCI pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478190
(CHEMBL260169)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cccs3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N3O3S/c1-22(2)29(37-30-20-25(36-4)12-11-23(30)3)15-18-32-16-13-24(14-17-32)34-28-10-6-5-9-27(28)33(31(34)35)21-26-8-7-19-38-26/h5-12,19-20,22,24,29H,13-18,21H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478170
(CHEMBL259511)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ccsc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N3O3S/c1-22(2)29(37-30-19-26(36-4)10-9-23(30)3)13-17-32-15-11-25(12-16-32)34-28-8-6-5-7-27(28)33(31(34)35)20-24-14-18-38-21-24/h5-10,14,18-19,21-22,25,29H,11-13,15-17,20H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478177
(CHEMBL261839)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncsn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H37N5O3S/c1-20(2)26(37-27-17-23(36-4)10-9-21(27)3)13-16-32-14-11-22(12-15-32)34-25-8-6-5-7-24(25)33(29(34)35)18-28-30-19-38-31-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478188
(CHEMBL411643)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3cncn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-21(2)27(38-28-17-24(37-4)10-9-22(28)3)13-16-32-14-11-23(12-15-32)35-26-8-6-5-7-25(26)34(29(35)36)20-33-19-30-18-31-33/h5-10,17-19,21,23,27H,11-16,20H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478166
(CHEMBL260768)Show SMILES COCCn1c2ccccc2n(C2CCN(CC[C@H](Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O Show InChI InChI=1S/C29H41N3O4/c1-21(2)27(36-28-20-24(35-5)11-10-22(28)3)14-17-30-15-12-23(13-16-30)32-26-9-7-6-8-25(26)31(29(32)33)18-19-34-4/h6-11,20-21,23,27H,12-19H2,1-5H3/t27-/m0/s1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478178
(CHEMBL259048)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncon3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H37N5O4/c1-20(2)26(38-27-17-23(36-4)10-9-21(27)3)13-16-32-14-11-22(12-15-32)34-25-8-6-5-7-24(25)33(29(34)35)18-28-30-19-37-31-28/h5-10,17,19-20,22,26H,11-16,18H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478167
(CHEMBL262064)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cocn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O4/c1-21(2)28(38-29-17-25(36-4)10-9-22(29)3)13-16-32-14-11-24(12-15-32)34-27-8-6-5-7-26(27)33(30(34)35)18-23-19-37-20-31-23/h5-10,17,19-21,24,28H,11-16,18H2,1-4H3 | PDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM21281
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r| Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1 | PDB
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| PDB
Article
PubMed
| 2.51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50027065
((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)Show SMILES CN1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O |r,c:4| Show InChI InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1 | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478161
(CHEMBL428253)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3cccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-22(2)28(38-29-20-25(37-4)11-10-23(29)3)14-19-32-17-12-24(13-18-32)35-27-9-6-5-8-26(27)34(30(35)36)21-33-16-7-15-31-33/h5-11,15-16,20,22,24,28H,12-14,17-19,21H2,1-4H3 | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478162
(CHEMBL259120)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3c(C)noc3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H42N4O4/c1-21(2)30(39-31-19-26(38-6)12-11-22(31)3)15-18-34-16-13-25(14-17-34)36-29-10-8-7-9-28(29)35(32(36)37)20-27-23(4)33-40-24(27)5/h7-12,19,21,25,30H,13-18,20H2,1-6H3 | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478186
(CHEMBL410257)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3c[nH]cn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-21(2)28(38-29-17-25(37-4)10-9-22(29)3)13-16-33-14-11-24(12-15-33)35-27-8-6-5-7-26(27)34(30(35)36)19-23-18-31-20-32-23/h5-10,17-18,20-21,24,28H,11-16,19H2,1-4H3,(H,31,32) | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478182
(CHEMBL262062)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncco3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H38N4O4/c1-21(2)27(38-28-19-24(36-4)10-9-22(28)3)13-17-32-15-11-23(12-16-32)34-26-8-6-5-7-25(26)33(30(34)35)20-29-31-14-18-37-29/h5-10,14,18-19,21,23,27H,11-13,15-17,20H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50380719
(CHEMBL1682275)Show SMILES OCCNC(=O)C1CCN(Cc2nc(no2)-c2cn(CC3CCOCC3)c3c(Cl)cccc23)CC1 Show InChI InChI=1S/C25H32ClN5O4/c26-21-3-1-2-19-20(15-31(23(19)21)14-17-6-12-34-13-7-17)24-28-22(35-29-24)16-30-9-4-18(5-10-30)25(33)27-8-11-32/h1-3,15,17-18,32H,4-14,16H2,(H,27,33) | PDB
NCI pathway
Reactome pathway
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| Article
PubMed
| 3.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB1 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50418012
(CHEMBL1682272)Show SMILES CN(CC(N)=O)Cc1nc(no1)-c1cn(CC2CCOCC2)c2c(Cl)cccc12 Show InChI InChI=1S/C20H24ClN5O3/c1-25(11-17(22)27)12-18-23-20(24-29-18)15-10-26(9-13-5-7-28-8-6-13)19-14(15)3-2-4-16(19)21/h2-4,10,13H,5-9,11-12H2,1H3,(H2,22,27) | PDB
NCI pathway
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50200595
((+)-1-(2-methoxy-ethyl)-3-{1-[3-(5-methoxy-2-methy...)Show SMILES COCCn1c2ccccc2n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c1=O |w:18.19| Show InChI InChI=1S/C29H41N3O4/c1-21(2)27(36-28-20-24(35-5)11-10-22(28)3)14-17-30-15-12-23(13-16-30)32-26-9-7-6-8-25(26)31(29(32)33)18-19-34-4/h6-11,20-21,23,27H,12-19H2,1-5H3 | PDB
Reactome pathway
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478180
(CHEMBL260784)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3ccnc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H39N5O3/c1-22(2)28(38-29-19-25(37-4)10-9-23(29)3)13-17-32-15-11-24(12-16-32)35-27-8-6-5-7-26(27)34(30(35)36)21-33-18-14-31-20-33/h5-10,14,18-20,22,24,28H,11-13,15-17,21H2,1-4H3 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478176
(CHEMBL406647)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cn3ccnc3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H41N5O3/c1-22(2)29(39-30-20-26(38-5)11-10-23(30)3)14-18-33-16-12-25(13-17-33)36-28-9-7-6-8-27(28)35(31(36)37)21-34-19-15-32-24(34)4/h6-11,15,19-20,22,25,29H,12-14,16-18,21H2,1-5H3 | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478165
(CHEMBL408909)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ccccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H40N4O3/c1-23(2)30(39-31-21-27(38-4)13-12-24(31)3)16-20-34-18-14-26(15-19-34)36-29-11-6-5-10-28(29)35(32(36)37)22-25-9-7-8-17-33-25/h5-13,17,21,23,26,30H,14-16,18-20,22H2,1-4H3 | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | PDB
Reactome pathway
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478187
(CHEMBL259964)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cnccn3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H39N5O3/c1-22(2)29(39-30-19-26(38-4)10-9-23(30)3)13-18-34-16-11-25(12-17-34)36-28-8-6-5-7-27(28)35(31(36)37)21-24-20-32-14-15-33-24/h5-10,14-15,19-20,22,25,29H,11-13,16-18,21H2,1-4H3 | PDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478183
(CHEMBL259291)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3n[nH]c(=O)[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O4/c1-19(2)25(39-26-17-22(38-4)10-9-20(26)3)13-16-33-14-11-21(12-15-33)35-24-8-6-5-7-23(24)34(29(35)37)18-27-30-28(36)32-31-27/h5-10,17,19,21,25H,11-16,18H2,1-4H3,(H2,30,31,32,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50380717
(CHEMBL2017678)Show SMILES COc1cccc2c(cn(CC3CCOCC3)c12)-c1nsc(CN2CCN(CC(N)=O)CC2)n1 Show InChI InChI=1S/C24H32N6O3S/c1-32-20-4-2-3-18-19(14-30(23(18)20)13-17-5-11-33-12-6-17)24-26-22(34-27-24)16-29-9-7-28(8-10-29)15-21(25)31/h2-4,14,17H,5-13,15-16H2,1H3,(H2,25,31) | PDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB1 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50418012
(CHEMBL1682272)Show SMILES CN(CC(N)=O)Cc1nc(no1)-c1cn(CC2CCOCC2)c2c(Cl)cccc12 Show InChI InChI=1S/C20H24ClN5O3/c1-25(11-17(22)27)12-18-23-20(24-29-18)15-10-26(9-13-5-7-28-8-6-13)19-14(15)3-2-4-16(19)21/h2-4,10,13H,5-9,11-12H2,1H3,(H2,22,27) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB2 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478172
(CHEMBL259292)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cnn[nH]3)c2=O)C(C)C)c1 Show InChI InChI=1S/C29H38N6O3/c1-20(2)27(38-28-17-24(37-4)10-9-21(28)3)13-16-33-14-11-23(12-15-33)35-26-8-6-5-7-25(26)34(29(35)36)19-22-18-30-32-31-22/h5-10,17-18,20,23,27H,11-16,19H2,1-4H3,(H,30,31,32) | PDB
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| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM78940
(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)Show InChI InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3 | PDB
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| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50024204
(1H-imidazo[4,5-c]pyridine derivative | 2N-[4,7-dim...)Show SMILES CN(C)S(=O)(=O)N[C@H]1C[C@H]2[C@@H](Cc3cn(C)c4cccc2c34)N(C)C1 Show InChI InChI=1S/C18H26N4O2S/c1-20(2)25(23,24)19-13-9-15-14-6-5-7-16-18(14)12(10-21(16)3)8-17(15)22(4)11-13/h5-7,10,13,15,17,19H,8-9,11H2,1-4H3/t13-,15+,17+/m0/s1 | PDB
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| 9.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478181
(CHEMBL258781)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3cccnc3)c2=O)C(C)C)c1 Show InChI InChI=1S/C32H40N4O3/c1-23(2)30(39-31-20-27(38-4)12-11-24(31)3)15-19-34-17-13-26(14-18-34)36-29-10-6-5-9-28(29)35(32(36)37)22-25-8-7-16-33-21-25/h5-12,16,20-21,23,26,30H,13-15,17-19,22H2,1-4H3 | PDB
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| 9.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478184
(CHEMBL260555)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3ncnn3C)c2=O)C(C)C)c1 Show InChI InChI=1S/C30H40N6O3/c1-21(2)27(39-28-18-24(38-5)11-10-22(28)3)14-17-34-15-12-23(13-16-34)36-26-9-7-6-8-25(26)35(30(36)37)19-29-31-20-32-33(29)4/h6-11,18,20-21,23,27H,12-17,19H2,1-5H3 | PDB
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM21281
((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2cccc3OC[C@@H](CN4CCOCC4)n1c23 |r| Show InChI InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1 | PDB
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| 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP55940 from human cannabinoid CB1 receptor expressed in insect Sf9 cells |
Bioorg Med Chem Lett 21: 1748-53 (2011)
Article DOI: 10.1016/j.bmcl.2011.01.082
BindingDB Entry DOI: 10.7270/Q2HD7WWG |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50380717
(CHEMBL2017678)Show SMILES COc1cccc2c(cn(CC3CCOCC3)c12)-c1nsc(CN2CCN(CC(N)=O)CC2)n1 Show InChI InChI=1S/C24H32N6O3S/c1-32-20-4-2-3-18-19(14-30(23(18)20)13-17-5-11-33-12-6-17)24-26-22(34-27-24)16-29-9-7-28(8-10-29)15-21(25)31/h2-4,14,17H,5-13,15-16H2,1H3,(H2,25,31) | PDB
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| 15.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB2 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM30704
((phenylmethyl) N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a...)Show SMILES CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]2[C@H]1Cc1cn(C)c3cccc2c13 Show InChI InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1 | PDB
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| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50031942
((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)Show SMILES CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34 |r,c:24| Show InChI InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50027065
((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...)Show SMILES CN1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O |r,c:4| Show InChI InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute
Curated by PDSP Ki Database
| |
Neuron 11: 449-58 (1993)
Article DOI: 10.1016/0896-6273(93)90149-l
BindingDB Entry DOI: 10.7270/Q269723D |
More data for this
Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50478169
(CHEMBL406926)Show SMILES COc1ccc(C)c(OC(CCN2CCC(CC2)n2c3ccccc3n(Cc3csc(C)n3)c2=O)C(C)C)c1 Show InChI InChI=1S/C31H40N4O3S/c1-21(2)29(38-30-18-26(37-5)11-10-22(30)3)14-17-33-15-12-25(13-16-33)35-28-9-7-6-8-27(28)34(31(35)36)19-24-20-39-23(4)32-24/h6-11,18,20-21,25,29H,12-17,19H2,1-5H3 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]nociceptin from human NOP receptor expressed in CHO cells |
Bioorg Med Chem 16: 2829-51 (2008)
Article DOI: 10.1016/j.bmc.2008.01.005
BindingDB Entry DOI: 10.7270/Q2C82D2D |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 1
(Homo sapiens (Human)) | BDBM50380718
(CHEMBL2017684)Show SMILES NC(=O)CN1CCN(Cc2nc(no2)-c2cn(CC3CCOCC3)c3c(Cl)cccc23)CC1 Show InChI InChI=1S/C23H29ClN6O3/c24-19-3-1-2-17-18(13-30(22(17)19)12-16-4-10-32-11-5-16)23-26-21(33-27-23)15-29-8-6-28(7-9-29)14-20(25)31/h1-3,13,16H,4-12,14-15H2,(H2,25,31) | PDB
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| 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB1 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50380719
(CHEMBL1682275)Show SMILES OCCNC(=O)C1CCN(Cc2nc(no2)-c2cn(CC3CCOCC3)c3c(Cl)cccc23)CC1 Show InChI InChI=1S/C25H32ClN5O4/c26-21-3-1-2-19-20(15-31(23(19)21)14-17-6-12-34-13-7-17)24-28-22(35-29-24)16-30-9-4-18(5-10-30)25(33)27-8-11-32/h1-3,15,17-18,32H,4-14,16H2,(H,27,33) | PDB
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| 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB2 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
Cannabinoid receptor 2
(Homo sapiens (Human)) | BDBM50380720
(CHEMBL2017682)Show SMILES OCCNC(=O)[C@H]1CCCN(Cc2nc(ns2)-c2cn(CC3CCS(=O)(=O)CC3)c3c(Cl)cccc23)C1 |r| Show InChI InChI=1S/C25H32ClN5O4S2/c26-21-5-1-4-19-20(15-31(23(19)21)13-17-6-11-37(34,35)12-7-17)24-28-22(36-29-24)16-30-9-2-3-18(14-30)25(33)27-8-10-32/h1,4-5,15,17-18,32H,2-3,6-14,16H2,(H,27,33)/t18-/m0/s1 | PDB
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| 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [3H]CP 55,940 from human CB2 receptor expressed in insect sf9 membranes |
Bioorg Med Chem Lett 22: 2932-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.02.048
BindingDB Entry DOI: 10.7270/Q2PV6MDJ |
More data for this
Ligand-Target Pair | |
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