Found 134 hits with Last Name = 'rasamison' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365814
(CHEMBL1956993)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc5ncsc5c4)nc3c2=O)C1 |r| Show InChI InChI=1S/C24H27N5O2S/c1-15(2)28-10-4-5-17(12-28)13-29-16(3)26-20-8-9-22(27-23(20)24(29)30)31-18-6-7-19-21(11-18)32-14-25-19/h6-9,11,14-15,17H,4-5,10,12-13H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365815
(CHEMBL1956994)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(Br)cc4F)nc3c2=O)C1 |r| Show InChI InChI=1S/C23H26BrFN4O2/c1-14(2)28-10-4-5-16(12-28)13-29-15(3)26-19-7-9-21(27-22(19)23(29)30)31-20-8-6-17(24)11-18(20)25/h6-9,11,14,16H,4-5,10,12-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365831
(CHEMBL1957010)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(Br)cc4F)nc3c2=O)C1 |r| Show InChI InChI=1S/C22H25BrFN5O2/c1-13(2)28-8-4-5-15(11-28)12-29-14(3)26-21-20(22(29)30)27-19(10-25-21)31-18-7-6-16(23)9-17(18)24/h6-7,9-10,13,15H,4-5,8,11-12H2,1-3H3/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365822
(CHEMBL1957001)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc5ncsc5c4)cc3c2=O)C1 |r| Show InChI InChI=1S/C24H27N5O2S/c1-15(2)28-8-4-5-17(12-28)13-29-16(3)27-21-11-25-23(10-19(21)24(29)30)31-18-6-7-20-22(9-18)32-14-26-20/h6-7,9-11,14-15,17H,4-5,8,12-13H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365809
(CHEMBL1956990)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(Br)cc4F)cc3c2=O)C1 |r| Show InChI InChI=1S/C23H26BrFN4O2/c1-14(2)28-8-4-5-16(12-28)13-29-15(3)27-22-19(23(29)30)10-18(11-26-22)31-21-7-6-17(24)9-20(21)25/h6-7,9-11,14,16H,4-5,8,12-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365812
(CHEMBL1956991)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(Cl)cc4F)nc3c2=O)C1 |r| Show InChI InChI=1S/C23H26ClFN4O2/c1-14(2)28-10-4-5-16(12-28)13-29-15(3)26-19-7-9-21(27-22(19)23(29)30)31-20-8-6-17(24)11-18(20)25/h6-9,11,14,16H,4-5,10,12-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365820
(CHEMBL1956999)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc(Cl)cc4F)cc3c2=O)C1 |r| Show InChI InChI=1S/C23H26ClFN4O2/c1-14(2)28-8-4-5-16(12-28)13-29-15(3)27-20-11-26-22(10-18(20)23(29)30)31-21-7-6-17(24)9-19(21)25/h6-7,9-11,14,16H,4-5,8,12-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365828
(CHEMBL1957007)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc5ncsc5c4)nc3c2=O)C1 |r| Show InChI InChI=1S/C23H26N6O2S/c1-14(2)28-8-4-5-16(11-28)12-29-15(3)26-22-21(23(29)30)27-20(10-24-22)31-17-6-7-18-19(9-17)32-13-25-18/h6-7,9-10,13-14,16H,4-5,8,11-12H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365830
(CHEMBL1957009)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(cc4)-c4ccccc4)nc3c2=O)C1 |r| Show InChI InChI=1S/C28H31N5O2/c1-19(2)32-15-7-8-21(17-32)18-33-20(3)30-27-26(28(33)34)31-25(16-29-27)35-24-13-11-23(12-14-24)22-9-5-4-6-10-22/h4-6,9-14,16,19,21H,7-8,15,17-18H2,1-3H3/t21-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365821
(CHEMBL1957000)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc5OCOc5c4)cc3c2=O)C1 |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)27-8-4-5-17(12-27)13-28-16(3)26-20-11-25-23(10-19(20)24(28)29)32-18-6-7-21-22(9-18)31-14-30-21/h6-7,9-11,15,17H,4-5,8,12-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365818
(CHEMBL1956997)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(cc4)-c4ccccc4)nc3c2=O)C1 |r| Show InChI InChI=1S/C29H32N4O2/c1-20(2)32-17-7-8-22(18-32)19-33-21(3)30-26-15-16-27(31-28(26)29(33)34)35-25-13-11-24(12-14-25)23-9-5-4-6-10-23/h4-6,9-16,20,22H,7-8,17-19H2,1-3H3/t22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365824
(CHEMBL1957003)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc5n(C)cnc5c4)cc3c2=O)C1 |r| Show InChI InChI=1S/C25H30N6O2/c1-16(2)30-9-5-6-18(13-30)14-31-17(3)28-22-12-26-24(11-20(22)25(31)32)33-19-7-8-23-21(10-19)27-15-29(23)4/h7-8,10-12,15-16,18H,5-6,9,13-14H2,1-4H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365826
(CHEMBL1957005)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(Cl)cc4F)nc3c2=O)C1 |r| Show InChI InChI=1S/C22H25ClFN5O2/c1-13(2)28-8-4-5-15(11-28)12-29-14(3)26-21-20(22(29)30)27-19(10-25-21)31-18-7-6-16(23)9-17(18)24/h6-7,9-10,13,15H,4-5,8,11-12H2,1-3H3/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365813
(CHEMBL1956992)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc5OCOc5c4)nc3c2=O)C1 |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)27-10-4-5-17(12-27)13-28-16(3)25-19-7-9-22(26-23(19)24(28)29)32-18-6-8-20-21(11-18)31-14-30-20/h6-9,11,15,17H,4-5,10,12-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365827
(CHEMBL1957006)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc5OCOc5c4)nc3c2=O)C1 |r| Show InChI InChI=1S/C23H27N5O4/c1-14(2)27-8-4-5-16(11-27)12-28-15(3)25-22-21(23(28)29)26-20(10-24-22)32-17-6-7-18-19(9-17)31-13-30-18/h6-7,9-10,14,16H,4-5,8,11-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365810
(CHEMBL1956987)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(cc4)-c4ccccc4)cc3c2=O)C1 |r| Show InChI InChI=1S/C29H32N4O2/c1-20(2)32-15-7-8-22(18-32)19-33-21(3)31-28-27(29(33)34)16-26(17-30-28)35-25-13-11-24(12-14-25)23-9-5-4-6-10-23/h4-6,9-14,16-17,20,22H,7-8,15,18-19H2,1-3H3/t22-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365829
(CHEMBL1957008)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(F)c5cccnc45)nc3c2=O)C1 |r| Show InChI InChI=1S/C25H27FN6O2/c1-15(2)31-11-5-6-17(13-31)14-32-16(3)29-24-23(25(32)33)30-21(12-28-24)34-20-9-8-19(26)18-7-4-10-27-22(18)20/h4,7-10,12,15,17H,5-6,11,13-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365811
(CHEMBL1956988)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(F)cc4)nc3c2=O)C1 |r| Show InChI InChI=1S/C23H27FN4O2/c1-15(2)27-12-4-5-17(13-27)14-28-16(3)25-20-10-11-21(26-22(20)23(28)29)30-19-8-6-18(24)7-9-19/h6-11,15,17H,4-5,12-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365817
(CHEMBL1956996)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(F)c5cccnc45)nc3c2=O)C1 |r| Show InChI InChI=1S/C26H28FN5O2/c1-16(2)31-13-5-6-18(14-31)15-32-17(3)29-21-9-11-23(30-25(21)26(32)33)34-22-10-8-20(27)19-7-4-12-28-24(19)22/h4,7-12,16,18H,5-6,13-15H2,1-3H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365816
(CHEMBL1956995)Show SMILES COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C5)C(C)C)c(=O)c4n3)c2n1 |r| Show InChI InChI=1S/C27H31N5O3/c1-17(2)31-14-6-7-19(15-31)16-32-18(3)28-21-11-13-24(30-26(21)27(32)33)35-22-9-5-8-20-10-12-23(34-4)29-25(20)22/h5,8-13,17,19H,6-7,14-16H2,1-4H3/t19-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365825
(CHEMBL1957004)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(F)cc4)nc3c2=O)C1 |r| Show InChI InChI=1S/C22H26FN5O2/c1-14(2)27-10-4-5-16(12-27)13-28-15(3)25-21-20(22(28)29)26-19(11-24-21)30-18-8-6-17(23)7-9-18/h6-9,11,14,16H,4-5,10,12-13H2,1-3H3/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365819
(CHEMBL1956998)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc(F)cc4)cc3c2=O)C1 |r| Show InChI InChI=1S/C23H27FN4O2/c1-15(2)27-10-4-5-17(13-27)14-28-16(3)26-21-12-25-22(11-20(21)23(28)29)30-19-8-6-18(24)7-9-19/h6-9,11-12,15,17H,4-5,10,13-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222869
(6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-...)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(F)cc4)cc3c2=O)C1 Show InChI InChI=1S/C24H28FN3O2/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365832
(CHEMBL1957011)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc5n(C)cnc5c4)nc3c2=O)C1 |r| Show InChI InChI=1S/C24H29N7O2/c1-15(2)30-9-5-6-17(12-30)13-31-16(3)27-23-22(24(31)32)28-21(11-25-23)33-18-7-8-20-19(10-18)26-14-29(20)4/h7-8,10-11,14-15,17H,5-6,9,12-13H2,1-4H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365823
(CHEMBL1957002)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc(F)c5cccnc45)cc3c2=O)C1 |r| Show InChI InChI=1S/C26H28FN5O2/c1-16(2)31-11-5-6-18(14-31)15-32-17(3)30-22-13-29-24(12-20(22)26(32)33)34-23-9-8-21(27)19-7-4-10-28-25(19)23/h4,7-10,12-13,16,18H,5-6,11,14-15H2,1-3H3/t18-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50365808
(CHEMBL1956989)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ncc(Oc4ccc(F)cc4)cc3c2=O)C1 |r| Show InChI InChI=1S/C23H27FN4O2/c1-15(2)27-10-4-5-17(13-27)14-28-16(3)26-22-21(23(28)29)11-20(12-25-22)30-19-8-6-18(24)7-9-19/h6-9,11-12,15,17H,4-5,10,13-14H2,1-3H3/t17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362677
(CHEMBL1939618)Show SMILES Cn1c(OCC(C)(C)C(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H24N4O4/c1-25(2,23(31)32)15-33-24-28-27-21(29(24)3)17-10-12-20(13-11-17)26-22(30)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H,26,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362678
(CHEMBL1939480)Show SMILES CCC(Sc1nnc(-c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-3-16(19(28)29)30-20-25-24-17(26(20)2)11-4-7-13(8-5-11)23-18(27)12-6-9-14(21)15(22)10-12/h4-10,16H,3H2,1-2H3,(H,23,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362683
(CHEMBL1939476)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3cc4ccccc4s3)cc2)n1C)C(O)=O Show InChI InChI=1S/C21H18N4O3S2/c1-12(20(27)28)29-21-24-23-18(25(21)2)13-7-9-15(10-8-13)22-19(26)17-11-14-5-3-4-6-16(14)30-17/h3-12H,1-2H3,(H,22,26)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362685
(CHEMBL1939475)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O3S/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362675
(CHEMBL1939620)Show SMILES Cn1c(OCC(C)(C)C(N)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H25N5O3/c1-25(2,23(26)32)15-33-24-29-28-21(30(24)3)17-10-12-20(13-11-17)27-22(31)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H2,26,32)(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362676
(CHEMBL1939621)Show SMILES CN(C)C(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C27H29N5O3/c1-27(2,25(34)31(3)4)17-35-26-30-29-23(32(26)5)19-12-14-22(15-13-19)28-24(33)21-11-10-18-8-6-7-9-20(18)16-21/h6-16H,17H2,1-5H3,(H,28,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362667
(CHEMBL1939631)Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C27H24N2O4/c1-27(2,26(31)32)17-33-24-14-11-22(16-28-24)19-9-12-23(13-10-19)29-25(30)21-8-7-18-5-3-4-6-20(18)15-21/h3-16H,17H2,1-2H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362680
(CHEMBL1939478)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-11(19(28)29)30-20-25-24-18(26(20)2)13-4-6-14(7-5-13)23-17(27)10-12-3-8-15(21)16(22)9-12/h3-9,11H,10H2,1-2H3,(H,23,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362672
(CHEMBL1939622)Show SMILES CC(C)NC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C28H31N5O3/c1-18(2)29-26(35)28(3,4)17-36-27-32-31-24(33(27)5)20-12-14-23(15-13-20)30-25(34)22-11-10-19-8-6-7-9-21(19)16-22/h6-16,18H,17H2,1-5H3,(H,29,35)(H,30,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362667
(CHEMBL1939631)Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C27H24N2O4/c1-27(2,26(31)32)17-33-24-14-11-22(16-28-24)19-9-12-23(13-10-19)29-25(30)21-8-7-18-5-3-4-6-20(18)15-21/h3-16H,17H2,1-2H3,(H,29,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362673
(CHEMBL1939624)Show SMILES CN(C)CCNC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C29H34N6O3/c1-29(2,27(37)30-16-17-34(3)4)19-38-28-33-32-25(35(28)5)21-12-14-24(15-13-21)31-26(36)23-11-10-20-8-6-7-9-22(20)18-23/h6-15,18H,16-17,19H2,1-5H3,(H,30,37)(H,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362666
(CHEMBL1939628)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C28H26N2O4/c1-18-14-23(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)11-12-24(18)22-10-13-25(29-16-22)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362665
(CHEMBL1939632)Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C28H25NO4/c1-28(2,27(31)32)18-33-25-15-11-21(12-16-25)20-9-13-24(14-10-20)29-26(30)23-8-7-19-5-3-4-6-22(19)17-23/h3-17H,18H2,1-2H3,(H,29,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362665
(CHEMBL1939632)Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C28H25NO4/c1-28(2,27(31)32)18-33-25-15-11-21(12-16-25)20-9-13-24(14-10-20)29-26(30)23-8-7-19-5-3-4-6-22(19)17-23/h3-17H,18H2,1-2H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362671
(CHEMBL1939623)Show SMILES Cn1c(OCC(C)(C)C(=O)Nc2ccccc2)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C31H29N5O3/c1-31(2,29(38)33-25-11-5-4-6-12-25)20-39-30-35-34-27(36(30)3)22-15-17-26(18-16-22)32-28(37)24-14-13-21-9-7-8-10-23(21)19-24/h4-19H,20H2,1-3H3,(H,32,37)(H,33,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362669
(CHEMBL1939625)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-22(30-24(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-23(17)21-14-28-26(29-15-21)34-16-27(2,3)25(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362670
(CHEMBL1939627)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)cn1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-21(30-25(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-22(17)23-14-29-24(15-28-23)34-16-27(2,3)26(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362666
(CHEMBL1939628)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C28H26N2O4/c1-18-14-23(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)11-12-24(18)22-10-13-25(29-16-22)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50365820
(CHEMBL1956999)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3cnc(Oc4ccc(Cl)cc4F)cc3c2=O)C1 |r| Show InChI InChI=1S/C23H26ClFN4O2/c1-14(2)28-8-4-5-16(12-28)13-29-15(3)27-20-11-26-22(10-18(20)23(29)30)31-21-7-6-17(24)9-19(21)25/h6-7,9-11,14,16H,4-5,8,12-13H2,1-3H3/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human Erg by patch clamp assay |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50365817
(CHEMBL1956996)Show SMILES CC(C)N1CCC[C@H](Cn2c(C)nc3ccc(Oc4ccc(F)c5cccnc45)nc3c2=O)C1 |r| Show InChI InChI=1S/C26H28FN5O2/c1-16(2)31-13-5-6-18(14-31)15-32-17(3)29-21-9-11-23(30-25(21)26(32)33)34-22-10-8-20(27)19-7-4-12-28-24(19)22/h4,7-12,16,18H,5-6,13-15H2,1-3H3/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human Erg by patch clamp assay |
Bioorg Med Chem Lett 22: 2271-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.078
BindingDB Entry DOI: 10.7270/Q20G3KMP |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362687
(CHEMBL1939474)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc(C)cc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H20N4O3S/c1-12-4-6-15(7-5-12)18(25)21-16-10-8-14(9-11-16)17-22-23-20(24(17)3)28-13(2)19(26)27/h4-11,13H,1-3H3,(H,21,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362679
(CHEMBL1939617)Show SMILES CC(Oc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O4/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362674
(CHEMBL1939619)Show SMILES Cn1c(CCC(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C23H20N4O3/c1-27-20(12-13-21(28)29)25-26-22(27)16-8-10-19(11-9-16)24-23(30)18-7-6-15-4-2-3-5-17(15)14-18/h2-11,14H,12-13H2,1H3,(H,24,30)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362671
(CHEMBL1939623)Show SMILES Cn1c(OCC(C)(C)C(=O)Nc2ccccc2)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C31H29N5O3/c1-31(2,29(38)33-25-11-5-4-6-12-25)20-39-30-35-34-27(36(30)3)22-15-17-26(18-16-22)32-28(37)24-14-13-21-9-7-8-10-23(21)19-24/h4-19H,20H2,1-3H3,(H,32,37)(H,33,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Search and Browse
