Compile Data Set for Download or QSAR

Found 78 hits with Last Name = 'rodman' and Initial = 'ld'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5284 (4-{[4-(Methylsulfonyl)piperazin-1-yl]methyl}-N-(5-...) Show SMILES CS(=O)(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C20H23N5O2S2/c1-29(26,27)25-11-9-24(10-12-25)15-16-7-8-21-19(13-16)23-20-22-14-18(28-20)17-5-3-2-4-6-17/h2-8,13-14H,9-12,15H2,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5282 ((5-Phenylthiazol-2-yl)(4-pyrrolidin-1-ylmethylpyri...) Show SMILES C(N1CCCC1)c1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-12-15(8-9-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5358 (N-(6-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3OS/c1-19-14-9-5-8-13(17-14)18-15-16-10-12(20-15)11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5389 (2,4-Disubstituted Pyrimidine 3a | N-[3-methyl-5-(t...) Show SMILES Cc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F3N5/c1-14-11-16(21(22,23)24)13-17(12-14)27-20-26-8-7-18(28-20)29-10-9-25-19(29)15-5-3-2-4-6-15/h2-13H,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5384 (2,4-Disubstituted Pyrimidine 2h | N-(3,5-dimethoxy...) Show SMILES COc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(OC)c1 Show InChI InChI=1S/C21H19N5O2/c1-27-17-12-16(13-18(14-17)28-2)24-21-23-9-8-19(25-21)26-11-10-22-20(26)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5351 (N-(4-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3S/c1-11-7-8-16-14(9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5380 (2,4-Disubstituted Pyrimidine 2d | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5/c1-15-12-16(2)14-18(13-15)24-21-23-9-8-19(25-21)26-11-10-22-20(26)17-6-4-3-5-7-17/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5280 (5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5292 (2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyr...) Show SMILES CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N5O2S2/c1-25(22,23)14-3-6-21(7-4-14)11-12-2-5-18-15(8-12)20-16-19-10-13(9-17)24-16/h2,5,8,10,14H,3-4,6-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5287 (2-(4-Morpholin-4-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCOCC3)ccn2)s1 Show InChI InChI=1S/C14H15N5OS/c15-8-12-9-17-14(21-12)18-13-7-11(1-2-16-13)10-19-3-5-20-6-4-19/h1-2,7,9H,3-6,10H2,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5288 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES NC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C15H17N7OS/c16-8-12-9-19-15(24-12)20-13-7-11(1-2-18-13)10-21-3-5-22(6-4-21)14(17)23/h1-2,7,9H,3-6,10H2,(H2,17,23)(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5283 (1-[4-({2-[(5-phenyl-1,3-thiazol-2-yl)amino]pyridin...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C21H23N5OS/c1-16(27)26-11-9-25(10-12-26)15-17-7-8-22-20(13-17)24-21-23-14-19(28-21)18-5-3-2-4-6-18/h2-8,13-14H,9-12,15H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179427 (2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCCC3)CC2)s1 Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179415 (2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...) Show SMILES COCCN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5391 ((3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)pyrimid...) Show SMILES Cc1cc(CO)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5O/c1-15-11-16(14-27)13-18(12-15)24-21-23-8-7-19(25-21)26-10-9-22-20(26)17-5-3-2-4-6-17/h2-13,27H,14H2,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179418 (2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...) Show SMILES NC1CCCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5291 (2-[(4-{[4-(2-hydroxyacetyl)piperazin-1-yl]methyl}p...) Show SMILES OCC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6O2S/c17-8-13-9-19-16(25-13)20-14-7-12(1-2-18-14)10-21-3-5-22(6-4-21)15(24)11-23/h1-2,7,9,23H,3-6,10-11H2,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5353 (N-(6-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-14(17-11)18-15-16-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179417 (2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179413 (2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...) Show SMILES NC1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c14-6-10-7-16-13(21-10)19-11-5-12(18-8-17-11)20-3-1-9(15)2-4-20/h5,7-9H,1-4,15H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5387 (2,4-Disubstituted Pyrimidine 2k | 4-(2-phenyl-1H-i...) Show SMILES FC(F)(F)c1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H14F3N5/c21-20(22,23)15-7-4-8-16(13-15)26-19-25-10-9-17(27-19)28-12-11-24-18(28)14-5-2-1-3-6-14/h1-13H,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5289 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES CN(C)C(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C17H21N7OS/c1-22(2)17(25)24-7-5-23(6-8-24)12-13-3-4-19-15(9-13)21-16-20-11-14(10-18)26-16/h3-4,9,11H,5-8,12H2,1-2H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179420 (2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179427 (2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCCC3)CC2)s1 Show InChI InChI=1S/C18H24N8S/c19-12-15-13-20-18(27-15)23-16-11-17(22-14-21-16)26-9-7-25(8-10-26)6-5-24-3-1-2-4-24/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5357 (N-(4-methoxypyridin-2-yl)-5-phenyl-1,3-thiazol-2-a...) Show SMILES COc1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C15H13N3OS/c1-19-12-7-8-16-14(9-12)18-15-17-10-13(20-15)11-5-3-2-4-6-11/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5293 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]-3-methylpy...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2C)CC1 Show InChI InChI=1S/C17H21N7OS/c1-12-13(11-23-5-7-24(8-6-23)17(25)19-2)3-4-20-15(12)22-16-21-10-14(9-18)26-16/h3-4,10H,5-8,11H2,1-2H3,(H,19,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5290 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-4-y...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-19-14(8-12)21-15-20-10-13(9-17)25-15/h2-3,8,10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179414 (2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179416 (2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H15N7OS/c1-10(22)20-2-4-21(5-3-20)13-6-12(17-9-18-13)19-14-16-8-11(7-15)23-14/h6,8-9H,2-5H2,1H3,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5350 (N-(3-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1cccnc1Nc1ncc(s1)-c1ccccc1 Show InChI InChI=1S/C15H13N3S/c1-11-6-5-9-16-14(11)18-15-17-10-13(19-15)12-7-3-2-4-8-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5285 (2-({4-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6OS/c1-12(23)22-6-4-21(5-7-22)11-13-2-3-18-15(8-13)20-16-19-10-14(9-17)24-16/h2-3,8,10H,4-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5355 (N-(6-bromopyridin-2-yl)-5-phenyl-1,3-thiazol-2-ami...) Show SMILES Brc1cccc(Nc2ncc(s2)-c2ccccc2)n1 Show InChI InChI=1S/C14H10BrN3S/c15-12-7-4-8-13(17-12)18-14-16-9-11(19-14)10-5-2-1-3-6-10/h1-9H,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5286 (2-(4-Piperazin-1-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCNCC3)ccn2)s1 Show InChI InChI=1S/C14H16N6S/c15-8-12-9-18-14(21-12)19-13-7-11(1-2-17-13)10-20-5-3-16-4-6-20/h1-2,7,9,16H,3-6,10H2,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179418 (2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...) Show SMILES NC1CCCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C14H17N7S/c15-7-11-8-17-14(22-11)20-12-6-13(19-9-18-12)21-4-1-2-10(16)3-5-21/h6,8-10H,1-5,16H2,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179421 ((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...) Show SMILES NC1CCN(C1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179422 (2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCNCC2)s1 Show InChI InChI=1S/C12H13N7S/c13-6-9-7-15-12(20-9)18-10-5-11(17-8-16-10)19-3-1-14-2-4-19/h5,7-8,14H,1-4H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5378 (2,4-Disubstituted Pyrimidine 2b | N-(3-methylpheny...) Show SMILES Cc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H17N5/c1-15-6-5-9-17(14-15)23-20-22-11-10-18(24-20)25-13-12-21-19(25)16-7-3-2-4-8-16/h2-14H,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5352 (N-(5-methylpyridin-2-yl)-5-phenyl-1,3-thiazol-2-am...) Show SMILES Cc1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C15H13N3S/c1-11-7-8-14(16-9-11)18-15-17-10-13(19-15)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 2941-5 (2004) Article DOI: 10.1016/j.bmcl.2004.03.052 BindingDB Entry DOI: 10.7270/Q25H7DG7
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179414 (2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C18H24N8OS/c19-12-15-13-20-18(28-15)23-16-11-17(22-14-21-16)26-5-3-24(4-6-26)1-2-25-7-9-27-10-8-25/h11,13-14H,1-10H2,(H,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5382 (2,4-Disubstituted Pyrimidine 2f | N-(3-methoxyphen...) Show SMILES COc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H17N5O/c1-26-17-9-5-8-16(14-17)23-20-22-11-10-18(24-20)25-13-12-21-19(25)15-6-3-2-4-7-15/h2-14H,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179421 ((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...) Show SMILES NC1CCN(C1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C12H13N7S/c13-4-9-5-15-12(20-9)18-10-3-11(17-7-16-10)19-2-1-8(14)6-19/h3,5,7-8H,1-2,6,14H2,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179415 (2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...) Show SMILES COCCN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C15H19N7OS/c1-23-7-6-21-2-4-22(5-3-21)14-8-13(18-11-19-14)20-15-17-10-12(9-16)24-15/h8,10-11H,2-7H2,1H3,(H,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179417 (2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...) Show SMILES CN1CCN(CC1)c1cc(Nc2ncc(s2)C#N)ncn1 Show InChI InChI=1S/C13H15N7S/c1-19-2-4-20(5-3-19)12-6-11(16-9-17-12)18-13-15-8-10(7-14)21-13/h6,8-9H,2-5H2,1H3,(H,15,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179420 (2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCN(CCCN3CCOCC3)CC2)s1 Show InChI InChI=1S/C19H26N8OS/c20-13-16-14-21-19(29-16)24-17-12-18(23-15-22-17)27-6-4-25(5-7-27)2-1-3-26-8-10-28-11-9-26/h12,14-15H,1-11H2,(H,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assay				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5385 (2,4-Disubstituted Pyrimidine 2i | N-(3-chloropheny...) Show SMILES Clc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C19H14ClN5/c20-15-7-4-8-16(13-15)23-19-22-10-9-17(24-19)25-12-11-21-18(25)14-5-2-1-3-6-14/h1-13H,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5386 (2,4-Disubstituted Pyrimidine 2j | N-(3,5-dichlorop...) Show SMILES Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C19H13Cl2N5/c20-14-10-15(21)12-16(11-14)24-19-23-7-6-17(25-19)26-9-8-22-18(26)13-4-2-1-3-5-13/h1-12H,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50179423 (2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...) Show SMILES N#Cc1cnc(Nc2cc(ncn2)N2CCCNCC2)s1 Show InChI InChI=1S/C13H15N7S/c14-7-10-8-16-13(21-10)19-11-6-12(18-9-17-11)20-4-1-2-15-3-5-20/h6,8-9,15H,1-5H2,(H,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 1146-50 (2006) Article DOI: 10.1016/j.bmcl.2005.11.089 BindingDB Entry DOI: 10.7270/Q279448N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5392 (1-{4-[(3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)p...) Show SMILES CC(=O)N1CCN(Cc2cc(C)cc(Nc3nccc(n3)-n3ccnc3-c3ccccc3)c2)CC1 Show InChI InChI=1S/C27H29N7O/c1-20-16-22(19-32-12-14-33(15-13-32)21(2)35)18-24(17-20)30-27-29-9-8-25(31-27)34-11-10-28-26(34)23-6-4-3-5-7-23/h3-11,16-18H,12-15,19H2,1-2H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair

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