Compile Data Set for Download or QSAR

Found 31 hits with Last Name = 'steinbrecher' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085599 (CHEMBL3427725 | US11419874, Example 29) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(COCC(F)(F)F)ccc1Cl Show InChI InChI=1S/C18H13ClF3N5O/c1-10-16-25-26-17(27(16)15-7-23-5-4-14(15)24-10)12-6-11(2-3-13(12)19)8-28-9-18(20,21)22/h2-7H,8-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085602 (CHEMBL3427722) Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-3-4-9-26-13-5-6-15(20)14(10-13)19-24-23-18-12(2)22-16-7-8-21-11-17(16)25(18)19/h5-8,10-11H,3-4,9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085598 (CHEMBL3425534) Show SMILES CC(C)OCc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-11(2)26-10-13-4-5-15(20)14(8-13)19-24-23-18-12(3)22-16-6-7-21-9-17(16)25(18)19/h4-9,11H,10H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085693 (CHEMBL1915969 | US9540379, 32) Show SMILES Cc1nc2ccccc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C16H11ClN4/c1-10-15-19-20-16(11-6-2-3-7-12(11)17)21(15)14-9-5-4-8-13(14)18-10/h2-9H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085656 (CHEMBL3425540 | US11419874, Example 12) Show SMILES Cc1nc2cccnc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-13-19-20-14(10-5-2-3-6-11(10)16)21(13)15-12(18-9)7-4-8-17-15/h2-8H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085600 (CHEMBL3427724) Show SMILES CCCOCc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-3-8-26-11-13-4-5-15(20)14(9-13)19-24-23-18-12(2)22-16-6-7-21-10-17(16)25(18)19/h4-7,9-10H,3,8,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085595 (CHEMBL3425539 | US11419874, Example 30) Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C18H18N6O/c1-3-4-7-25-14-8-13(9-20-10-14)18-23-22-17-12(2)21-15-5-6-19-11-16(15)24(17)18/h5-6,8-11H,3-4,7H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085601 (CHEMBL3427723) Show SMILES COCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C18H16ClN5O2/c1-11-17-22-23-18(24(17)16-10-20-6-5-15(16)21-11)13-9-12(3-4-14(13)19)26-8-7-25-2/h3-6,9-10H,7-8H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085596 (CHEMBL3425536) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(OC(F)(F)F)ccc1Cl Show InChI InChI=1S/C16H9ClF3N5O/c1-8-14-23-24-15(25(14)13-7-21-5-4-12(13)22-8)10-6-9(2-3-11(10)17)26-16(18,19)20/h2-7H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085603 (CHEMBL3425541) Show SMILES Cc1nc2ncccc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-5-2-3-6-11(10)16)21(14)12-7-4-8-17-13(12)18-9/h2-8H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085597 (CHEMBL3425535) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(ccc1Cl)N1CCOCC1 Show InChI InChI=1S/C19H17ClN6O/c1-12-18-23-24-19(26(18)17-11-21-5-4-16(17)22-12)14-10-13(2-3-15(14)20)25-6-8-27-9-7-25/h2-5,10-11H,6-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50375784 (CHEMBL408621) Show SMILES CC1(C)C2CC[C@]1(C)C(C2)OC(=O)\C=C\c1cc(O)c(O)c(O)c1 |w:8.11,3.10,TEB:10:8:1:4.5| Show InChI InChI=1S/C19H24O5/c1-18(2)12-6-7-19(18,3)15(10-12)24-16(22)5-4-11-8-13(20)17(23)14(21)9-11/h4-5,8-9,12,15,20-21,23H,6-7,10H2,1-3H3/b5-4+/t12?,15?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-Universit£t Freiburg Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase				Bioorg Med Chem 16: 2385-90 (2008) Article DOI: 10.1016/j.bmc.2007.11.070 BindingDB Entry DOI: 10.7270/Q2CC11K7
					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50375785 (CHEMBL261166) Show SMILES CC1(C)C2CC[C@]1(C)C(C2)OC(=O)\C=C\c1ccc(O)c(O)c1 |w:8.11,3.10,TEB:10:8:1:4.5| Show InChI InChI=1S/C19H24O4/c1-18(2)13-8-9-19(18,3)16(11-13)23-17(22)7-5-12-4-6-14(20)15(21)10-12/h4-7,10,13,16,20-21H,8-9,11H2,1-3H3/b7-5+/t13?,16?,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-Universit£t Freiburg Curated by ChEMBL					Assay Description Inhibition of human neutrophil elastase				Bioorg Med Chem 16: 2385-90 (2008) Article DOI: 10.1016/j.bmc.2007.11.070 BindingDB Entry DOI: 10.7270/Q2CC11K7
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085599 (CHEMBL3427725 | US11419874, Example 29) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(COCC(F)(F)F)ccc1Cl Show InChI InChI=1S/C18H13ClF3N5O/c1-10-16-25-26-17(27(16)15-7-23-5-4-14(15)24-10)12-6-11(2-3-13(12)19)8-28-9-18(20,21)22/h2-7H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085819 (CHEMBL3425538) Show SMILES Cc1ccncc1-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C15H12N6/c1-9-3-5-16-7-11(9)15-20-19-14-10(2)18-12-4-6-17-8-13(12)21(14)15/h3-8H,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085595 (CHEMBL3425539 | US11419874, Example 30) Show SMILES CCCCOc1cncc(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C18H18N6O/c1-3-4-7-25-14-8-13(9-20-10-14)18-23-22-17-12(2)21-15-5-6-19-11-16(15)24(17)18/h5-6,8-11H,3-4,7H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085600 (CHEMBL3427724) Show SMILES CCCOCc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-3-8-26-11-13-4-5-15(20)14(9-13)19-24-23-18-12(2)22-16-6-7-21-10-17(16)25(18)19/h4-7,9-10H,3,8,11H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085602 (CHEMBL3427722) Show SMILES CCCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-3-4-9-26-13-5-6-15(20)14(10-13)19-24-23-18-12(2)22-16-7-8-21-11-17(16)25(18)19/h5-8,10-11H,3-4,9H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50085924 (CHEMBL3425537) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cncc(Cl)c1 Show InChI InChI=1S/C14H9ClN6/c1-8-13-19-20-14(9-4-10(15)6-17-5-9)21(13)12-7-16-3-2-11(12)18-8/h2-7H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE2A expressed in Sf9 cells using [3H]cGMP incubated for 40 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE4D3 expressed in Sf9 cells by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085598 (CHEMBL3425534) Show SMILES CC(C)OCc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C19H18ClN5O/c1-11(2)26-10-13-4-5-15(20)14(8-13)19-24-23-18-12(3)22-16-6-7-21-9-17(16)25(18)19/h4-9,11H,10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of full length human PDE11A4 expressed in HEK cells by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085596 (CHEMBL3425536) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(OC(F)(F)F)ccc1Cl Show InChI InChI=1S/C16H9ClF3N5O/c1-8-14-23-24-15(25(14)13-7-21-5-4-12(13)22-8)10-6-9(2-3-11(10)17)26-16(18,19)20/h2-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085601 (CHEMBL3427723) Show SMILES COCCOc1ccc(Cl)c(c1)-c1nnc2c(C)nc3ccncc3n12 Show InChI InChI=1S/C18H16ClN5O2/c1-11-17-22-23-18(24(17)16-10-20-6-5-15(16)21-11)13-9-12(3-4-14(13)19)26-8-7-25-2/h3-6,9-10H,7-8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE7A1 expressed in Sf9 cells by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085597 (CHEMBL3425535) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(ccc1Cl)N1CCOCC1 Show InChI InChI=1S/C19H17ClN6O/c1-12-18-23-24-19(26(18)17-11-21-5-4-16(17)22-12)14-10-13(2-3-15(14)20)25-6-8-27-9-7-25/h2-5,10-11H,6-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged human recombinant PDE9A1 expressed in Sf9 cells by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of human PDE1A by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human))	BDBM162879 (US11419874, Example 28 | US9056863, Example Ic1) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C15H10ClN5/c1-9-14-19-20-15(10-4-2-3-5-11(10)16)21(14)13-8-17-7-6-12(13)18-9/h2-8H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of human PDE3B by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
					More data for this Ligand-Target Pair