Found 47 hits with Last Name = 'vlattas' and Initial = 'i' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287714
((3R)-3-(fluoromethyl)-3-hydroxy-5-{[(phosphonatoox...)Show SMILES O[C@](CF)(CCOP([O-])(=O)OP([O-])([O-])=O)CC([O-])=O Show InChI InChI=1S/C6H13FO10P2/c7-4-6(10,3-5(8)9)1-2-16-19(14,15)17-18(11,12)13/h10H,1-4H2,(H,8,9)(H,14,15)(H2,11,12,13)/p-4/t6-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287713
([methyl(2-{[(phosphonatooxy)phosphinato]oxy}ethyl)...)Show SMILES CN(CCOP([O-])(=O)OP([O-])([O-])=O)CC([O-])=O Show InChI InChI=1S/C5H13NO9P2/c1-6(4-5(7)8)2-3-14-17(12,13)15-16(9,10)11/h2-4H2,1H3,(H,7,8)(H,12,13)(H2,9,10,11)/p-4 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50003795
(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)Show SMILES OC(=O)CCCCO\N=C(\c1cccnc1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)15-7-3-5-13(11-15)17(14-6-4-9-22-12-14)23-26-10-2-1-8-16(24)25/h3-7,9,11-12H,1-2,8,10H2,(H,24,25)/b23-17+ | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
UniChem
Similars
| DrugBank
Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50025953
(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid | CGS-1...)Show InChI InChI=1S/C13H16N2O2/c16-13(17)8-3-1-2-5-11-6-4-7-12-9-14-10-15(11)12/h4,6-7,9-10H,1-3,5,8H2,(H,16,17) | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287710
((2S)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)Show SMILES [O-]C(=O)[C@@H]1CCCN1C(=O)COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C7H13NO10P2/c9-6(8-3-1-2-5(8)7(10)11)4-17-20(15,16)18-19(12,13)14/h5H,1-4H2,(H,10,11)(H,15,16)(H2,12,13,14)/p-4/t5-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283042
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283049
((Z)-7-[(1R,2R,3S,5S)-5-(Biphenyl-4-ylmethoxy)-3-hy...)Show SMILES O[C@H]1C[C@H](OCc2ccc(cc2)-c2ccccc2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1 Show InChI InChI=1S/C30H39NO4/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34)/b2-1-/t26-,27-,28-,30+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287715
((2R)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)Show SMILES [O-]C(=O)[C@H]1CCCN1C(=O)COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C7H13NO10P2/c9-6(8-3-1-2-5(8)7(10)11)4-17-20(15,16)18-19(12,13)14/h5H,1-4H2,(H,10,11)(H,15,16)(H2,12,13,14)/p-4/t5-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287715
((2R)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)Show SMILES [O-]C(=O)[C@H]1CCCN1C(=O)COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C7H13NO10P2/c9-6(8-3-1-2-5(8)7(10)11)4-17-20(15,16)18-19(12,13)14/h5H,1-4H2,(H,10,11)(H,15,16)(H2,12,13,14)/p-4/t5-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against MevPP decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50003776
(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)Show SMILES OC(=O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 Show InChI InChI=1S/C22H29ClN2O4S/c23-20-10-12-21(13-11-20)30(28,29)25-16-2-1-5-18(9-14-22(26)27)6-3-7-19-8-4-15-24-17-19/h4,8,10-13,15,17-18,25H,1-3,5-7,9,14,16H2,(H,26,27) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283047
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS(=O)(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO5S/c31-28(32)13-7-2-1-6-12-26-27(21-36(33,34)29(26)25-11-8-18-30-19-25)35-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283050
((Z)-7-[(2S,3R,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | KEGG
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283048
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS(=O)(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO5S/c31-28(32)13-7-2-1-6-12-26-27(21-36(33,34)29(26)25-11-8-18-30-19-25)35-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | PDB
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283051
((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | PDB
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283052
((Z)-7-[(2R,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29-/m0/s1 | KEGG
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283045
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1,3-6,8-11,14-19,26-27,29H,2,7,12-13,20-21H2,(H,31,32)/b6-1-/t26-,27+,29+/m0/s1 | KEGG
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283042
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | PDB
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283046
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | PDB
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283043
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1-oxo-2...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+,35?/m0/s1 | PDB
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| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283053
((Z)-7-[(2R,3R,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CO[C@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29-/m0/s1 | KEGG
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| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of the compound against thromboxane synthase |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50403283
(CHEMBL2115559)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](C[S@@](=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+,35+/m0/s1 | PDB
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283050
((Z)-7-[(2S,3R,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CO[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | PDB
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| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283043
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1-oxo-2...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+,35?/m0/s1 | KEGG
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| CHEMBL
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| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50403282
(CHEMBL2115518)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](C[S@](=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+,35-/m0/s1 | PDB
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| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287712
([(2-{[(phosphonatooxy)phosphinato]oxy}ethyl)thio]a...)Show InChI InChI=1S/C4H10O9P2S/c5-4(6)3-16-2-1-12-15(10,11)13-14(7,8)9/h1-3H2,(H,5,6)(H,10,11)(H2,7,8,9)/p-4 | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
antibodypedia
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| KEGG
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PC sid
UniChem
| Article
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50403283
(CHEMBL2115559)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](C[S@@](=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+,35+/m0/s1 | KEGG
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| CHEMBL
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| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283048
((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CS(=O)(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO5S/c31-28(32)13-7-2-1-6-12-26-27(21-36(33,34)29(26)25-11-8-18-30-19-25)35-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29+/m0/s1 | KEGG
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50283047
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CS(=O)(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO5S/c31-28(32)13-7-2-1-6-12-26-27(21-36(33,34)29(26)25-11-8-18-30-19-25)35-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+/m0/s1 | KEGG
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane-A synthase
(Homo sapiens (Human)) | BDBM50403282
(CHEMBL2115518)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](C[S@](=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4S/c31-28(32)13-7-2-1-6-12-26-27(21-35(33)29(26)25-11-8-18-30-19-25)34-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29+,35-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of thromboxane synthase |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283045
((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H](CS[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO3S/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1,3-6,8-11,14-19,26-27,29H,2,7,12-13,20-21H2,(H,31,32)/b6-1-/t26-,27+,29+/m0/s1 | PDB
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| n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2067-2072 (1994)
Article DOI: 10.1016/S0960-894X(01)80103-7
BindingDB Entry DOI: 10.7270/Q2GX4BG6 |
More data for this
Ligand-Target Pair | |
Diphosphomevalonate decarboxylase
(Homo sapiens (Human)) | BDBM50287711
([methyl({[(phosphonatooxy)phosphinato]oxy}acetyl)a...)Show SMILES CN(CC([O-])=O)C(=O)COP([O-])(=O)OP([O-])([O-])=O Show InChI InChI=1S/C5H11NO10P2/c1-6(2-5(8)9)4(7)3-15-18(13,14)16-17(10,11)12/h2-3H2,1H3,(H,8,9)(H,13,14)(H2,10,11,12)/p-4 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound was evaluated for its inhibitory activity against MevPP decarboxylase |
Bioorg Med Chem Lett 6: 2091-2096 (1996)
Article DOI: 10.1016/0960-894X(96)00374-5
BindingDB Entry DOI: 10.7270/Q2930TPB |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283052
((Z)-7-[(2R,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@H](CO[C@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27-,29-/m0/s1 | PDB
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| n/a | n/a | 795 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50283053
((Z)-7-[(2R,3R,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)Show SMILES OC(=O)CC\C=C/CC[C@H]1[C@@H](CO[C@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C29H31NO4/c31-28(32)13-7-2-1-6-12-26-27(21-34-29(26)25-11-8-18-30-19-25)33-20-22-14-16-24(17-15-22)23-9-4-3-5-10-23/h1-5,8-11,14-19,26-27,29H,6-7,12-13,20-21H2,(H,31,32)/b2-1-/t26-,27+,29-/m0/s1 | PDB
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
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| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
Thromboxane A2 receptor
(Homo sapiens (Human)) | BDBM50003795
(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)Show SMILES OC(=O)CCCCO\N=C(\c1cccnc1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C18H17F3N2O3/c19-18(20,21)15-7-3-5-13(11-15)17(14-6-4-9-22-12-14)23-26-10-2-1-8-16(24)25/h3-7,9,11-12H,1-2,8,10H2,(H,24,25)/b23-17+ | PDB
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| Purchase
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PC cid
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Similars
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| n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro thromboxane receptor antagonist against U-46619 induced aggregation of washed human platelets |
Bioorg Med Chem Lett 4: 2073-2076 (1994)
Article DOI: 10.1016/S0960-894X(01)80104-9
BindingDB Entry DOI: 10.7270/Q2C53KS7 |
More data for this
Ligand-Target Pair | |
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