Found 218 hits with Last Name = 'yamada' and Initial = 'a' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036542
(CHEMBL3353600)Show SMILES CC(C)(C)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C24H22ClF3N2O4S/c1-23(2,3)17-8-4-15(5-9-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-10-6-16(7-11-19)22(31)32/h4-13H,14H2,1-3H3,(H,31,32) | PDB
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| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036544
(CHEMBL3353601)Show SMILES CC(C)(c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1)C(F)(F)F Show InChI InChI=1S/C24H19ClF6N2O4S/c1-22(2,24(29,30)31)16-7-3-14(4-8-16)13-33(20-19(25)11-17(12-32-20)23(26,27)28)38(36,37)18-9-5-15(6-10-18)21(34)35/h3-12H,13H2,1-2H3,(H,34,35) | PDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036517
(CHEMBL3353597)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036555
(CHEMBL3353610 | US9434711, 497)Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-19(20(25)12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31) | PDB
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| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036545
(CHEMBL3353602)Show SMILES CC1(CC1)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C24H20ClF3N2O4S/c1-23(10-11-23)17-6-2-15(3-7-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-8-4-16(5-9-19)22(31)32/h2-9,12-13H,10-11,14H2,1H3,(H,31,32) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036517
(CHEMBL3353597)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036537
(CHEMBL3353594)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O4S/c22-17-9-15(21(26,27)28)10-29-18(17)30(11-12-1-5-14(6-2-12)20(23,24)25)35(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036554
(CHEMBL3353609)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C20H13Cl2F3N2O4S/c21-15-9-17(22)18(26-10-15)27(11-12-1-5-14(6-2-12)20(23,24)25)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036554
(CHEMBL3353609)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C20H13Cl2F3N2O4S/c21-15-9-17(22)18(26-10-15)27(11-12-1-5-14(6-2-12)20(23,24)25)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50299467
((5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidaz...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C(N)=O |r| Show InChI InChI=1S/C60H81N13O14S2/c1-35(2)25-43(55(82)67-41(52(62)79)21-23-88-4)66-49(74)33-64-59(86)48(28-38-19-13-8-14-20-38)73(3)60(87)47(27-37-17-11-7-12-18-37)72-56(83)44(26-36-15-9-6-10-16-36)69-58(85)46(31-51(77)78)71-57(84)45(29-39-32-63-34-65-39)70-54(81)42(22-24-89-5)68-53(80)40(61)30-50(75)76/h6-20,32,34-35,40-48H,21-31,33,61H2,1-5H3,(H2,62,79)(H,63,65)(H,64,86)(H,66,74)(H,67,82)(H,68,80)(H,69,85)(H,70,81)(H,71,84)(H,72,83)(H,75,76)(H,77,78)/t40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1 | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036541
(CHEMBL3353599)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H12ClF7N2O4S/c22-16-8-13(20(24,25)26)9-30-18(16)31(10-11-1-6-17(23)15(7-11)21(27,28)29)36(34,35)14-4-2-12(3-5-14)19(32)33/h1-9H,10H2,(H,32,33) | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036551
(CHEMBL3353606)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc2occc2c1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H14ClF3N2O5S/c23-18-10-16(22(24,25)26)11-27-20(18)28(12-13-1-6-19-15(9-13)7-8-33-19)34(31,32)17-4-2-14(3-5-17)21(29)30/h1-11H,12H2,(H,29,30) | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036553
(CHEMBL3353608)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C20H12Cl2F4N2O4S/c21-13-8-16(22)18(27-9-13)28(10-11-1-6-17(23)15(7-11)20(24,25)26)33(31,32)14-4-2-12(3-5-14)19(29)30/h1-9H,10H2,(H,29,30) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036552
(CHEMBL3353607)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc2ccoc2c1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H14ClF3N2O5S/c23-18-10-16(22(24,25)26)11-27-20(18)28(12-13-1-2-14-7-8-33-19(14)9-13)34(31,32)17-5-3-15(4-6-17)21(29)30/h1-11H,12H2,(H,29,30) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50028014
(CHEMBL3361397)Show SMILES CSCC[C@H](N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |r| | PDB
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036534
(CHEMBL3353592)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O4S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-13-3-1-2-4-16(13)21(26,27)28)35(33,34)15-7-5-12(6-8-15)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036552
(CHEMBL3353607)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc2ccoc2c1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H14ClF3N2O5S/c23-18-10-16(22(24,25)26)11-27-20(18)28(12-13-1-2-14-7-8-33-19(14)9-13)34(31,32)17-5-3-15(4-6-17)21(29)30/h1-11H,12H2,(H,29,30) | PDB
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203153
(CHEMBL3927163)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H14F3NO3S/c20-19(21,22)14-5-4-8-18(13-14)27(24,25)23-15-9-11-17(12-10-15)26-16-6-2-1-3-7-16/h1-13,23H | PDB
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B.MOAD
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| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036540
(CHEMBL3353598)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H13ClF4N2O4S/c21-17-9-14(20(23,24)25)10-26-18(17)27(11-12-1-5-15(22)6-2-12)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203153
(CHEMBL3927163)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C19H14F3NO3S/c20-19(21,22)14-5-4-8-18(13-14)27(24,25)23-15-9-11-17(12-10-15)26-16-6-2-1-3-7-16/h1-13,23H | PDB
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| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Displacement of [1,2,6,7-3H]-PG from recombinant human GST-tagged PR-LBD (657 to 933 residues) expressed in baculovirus infected insect cells measure... |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036536
(CHEMBL3353593)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1cccc(c1)C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O4S/c22-17-9-15(21(26,27)28)10-29-18(17)30(11-12-2-1-3-14(8-12)20(23,24)25)35(33,34)16-6-4-13(5-7-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036521
(CHEMBL3353573)Show SMILES OCc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H16ClF3N2O3S/c21-18-10-16(20(22,23)24)11-25-19(18)26(12-14-4-2-1-3-5-14)30(28,29)17-8-6-15(13-27)7-9-17/h1-11,27H,12-13H2 | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036540
(CHEMBL3353598)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H13ClF4N2O4S/c21-17-9-14(20(23,24)25)10-26-18(17)27(11-12-1-5-15(22)6-2-12)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50028015
(CHEMBL3361398)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O |r| | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036549
(CHEMBL3353605)Show SMILES CCn1ncc2cc(CN(c3ncc(cc3Cl)C(F)(F)F)S(=O)(=O)c3ccc(cc3)C(O)=O)ccc12 Show InChI InChI=1S/C23H18ClF3N4O4S/c1-2-30-20-8-3-14(9-16(20)11-29-30)13-31(21-19(24)10-17(12-28-21)23(25,26)27)36(34,35)18-6-4-15(5-7-18)22(32)33/h3-12H,2,13H2,1H3,(H,32,33) | PDB
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| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203179
(CHEMBL3917144)Show InChI InChI=1S/C18H14BrNO3S/c19-14-5-4-8-18(13-14)24(21,22)20-15-9-11-17(12-10-15)23-16-6-2-1-3-7-16/h1-13,20H | PDB
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| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Displacement of [1,2,6,7-3H]-PG from recombinant human GST-tagged PR-LBD (657 to 933 residues) expressed in baculovirus infected insect cells measure... |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036530
(CHEMBL3353589)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CCCc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H18ClF3N2O4S/c23-19-13-17(22(24,25)26)14-27-20(19)28(12-4-7-15-5-2-1-3-6-15)33(31,32)18-10-8-16(9-11-18)21(29)30/h1-3,5-6,8-11,13-14H,4,7,12H2,(H,29,30) | PDB
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| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50028021
(CHEMBL3361404)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)\C=C\CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C41H56N6O10S/c1-26(2)22-29(38(54)45-30(37(42)53)19-21-58-4)16-11-20-43-40(56)33(24-28-14-9-6-10-15-28)47(3)41(57)32(23-27-12-7-5-8-13-27)46-39(55)31(25-36(51)52)44-34(48)17-18-35(49)50/h5-16,26,29-33H,17-25H2,1-4H3,(H2,42,53)(H,43,56)(H,44,48)(H,45,54)(H,46,55)(H,49,50)(H,51,52)/b16-11+/t29-,30-,31-,32-,33-/m0/s1 | PDB
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Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50052524
((S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-m...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O Show InChI InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1 | PDB
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| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036519
(CHEMBL3353575)Show SMILES CNC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H17ClF3N3O3S/c1-26-20(29)15-7-9-17(10-8-15)32(30,31)28(13-14-5-3-2-4-6-14)19-18(22)11-16(12-27-19)21(23,24)25/h2-12H,13H2,1H3,(H,26,29) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036539
(CHEMBL3353596)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1cccc(OC(F)(F)F)c1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-2-1-3-15(8-12)35-21(26,27)28)36(33,34)16-6-4-13(5-7-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Neuromedin-K receptor
(Homo sapiens (Human)) | BDBM50028016
(CHEMBL3361399)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O)C(N)=O |r| Show InChI InChI=1S/C45H60N8O9S/c1-28(2)22-34(42(59)50-33(40(47)57)20-21-63-4)49-38(54)27-48-44(61)37(25-31-18-12-7-13-19-31)53(3)45(62)36(24-30-16-10-6-11-17-30)52-43(60)35(23-29-14-8-5-9-15-29)51-41(58)32(46)26-39(55)56/h5-19,28,32-37H,20-27,46H2,1-4H3,(H2,47,57)(H,48,61)(H,49,54)(H,50,59)(H,51,58)(H,52,60)(H,55,56)/t32-,33-,34-,35-,36-,37-/m0/s1 | PDB
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| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description
Displacement of [125I]His3, MePhe7 from human NK3R expressed in CHO cell membranes by scintillation counting |
J Med Chem 57: 8646-51 (2014)
Article DOI: 10.1021/jm500771w
BindingDB Entry DOI: 10.7270/Q2W66NCT |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036522
(CHEMBL3353572)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H14ClF3N2O4S/c21-17-10-15(20(22,23)24)11-25-18(17)26(12-13-4-2-1-3-5-13)31(29,30)16-8-6-14(7-9-16)19(27)28/h1-11H,12H2,(H,27,28) | PDB
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| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203158
(CHEMBL3912293)Show InChI InChI=1S/C18H14ClNO3S/c19-14-5-4-8-18(13-14)24(21,22)20-15-9-11-17(12-10-15)23-16-6-2-1-3-7-16/h1-13,20H | PDB
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Displacement of [1,2,6,7-3H]-PG from recombinant human GST-tagged PR-LBD (657 to 933 residues) expressed in baculovirus infected insect cells measure... |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036547
(CHEMBL3353603)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C1(CC1)C#N)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C24H17ClF3N3O4S/c25-20-11-18(24(26,27)28)12-30-21(20)31(36(34,35)19-7-3-16(4-8-19)22(32)33)13-15-1-5-17(6-2-15)23(14-29)9-10-23/h1-8,11-12H,9-10,13H2,(H,32,33) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036518
(CHEMBL3353576)Show SMILES CN(C)C(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H19ClF3N3O3S/c1-28(2)21(30)16-8-10-18(11-9-16)33(31,32)29(14-15-6-4-3-5-7-15)20-19(23)12-17(13-27-20)22(24,25)26/h3-13H,14H2,1-2H3 | PDB
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| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036520
(CHEMBL3353574)Show SMILES NC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H15ClF3N3O3S/c21-17-10-15(20(22,23)24)11-26-19(17)27(12-13-4-2-1-3-5-13)31(29,30)16-8-6-14(7-9-16)18(25)28/h1-11H,12H2,(H2,25,28) | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036538
(CHEMBL3353595)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1OC(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-16-9-14(20(23,24)25)10-29-18(16)30(11-13-3-1-2-4-17(13)35-21(26,27)28)36(33,34)15-7-5-12(6-8-15)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036531
(CHEMBL3353590)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(CC1CCCCC1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C20H20ClF3N2O4S/c21-17-10-15(20(22,23)24)11-25-18(17)26(12-13-4-2-1-3-5-13)31(29,30)16-8-6-14(7-9-16)19(27)28/h6-11,13H,1-5,12H2,(H,27,28) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203195
(CHEMBL3942784)Show InChI InChI=1S/C18H14ClNO2S/c19-16-7-4-8-18(13-16)23(21,22)20-17-11-9-15(10-12-17)14-5-2-1-3-6-14/h1-13,20H | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Displacement of [1,2,6,7-3H]-PG from recombinant human GST-tagged PR-LBD (657 to 933 residues) expressed in baculovirus infected insect cells measure... |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203179
(CHEMBL3917144)Show InChI InChI=1S/C18H14BrNO3S/c19-14-5-4-8-18(13-14)24(21,22)20-15-9-11-17(12-10-15)23-16-6-2-1-3-7-16/h1-13,20H | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036561
(CHEMBL3353582)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)-c1ccccc1 Show InChI InChI=1S/C25H19ClN2O4S/c26-23-15-21(19-9-5-2-6-10-19)16-27-24(23)28(17-18-7-3-1-4-8-18)33(31,32)22-13-11-20(12-14-22)25(29)30/h1-16H,17H2,(H,29,30) | PDB
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| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203170
(CHEMBL3936121)Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C18H14N2O5S/c21-20(22)15-5-4-8-18(13-15)26(23,24)19-14-9-11-17(12-10-14)25-16-6-2-1-3-7-16/h1-13,19H | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203170
(CHEMBL3936121)Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)Nc1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C18H14N2O5S/c21-20(22)15-5-4-8-18(13-15)26(23,24)19-14-9-11-17(12-10-14)25-16-6-2-1-3-7-16/h1-13,19H | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Displacement of [1,2,6,7-3H]-PG from recombinant human GST-tagged PR-LBD (657 to 933 residues) expressed in baculovirus infected insect cells measure... |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203158
(CHEMBL3912293)Show InChI InChI=1S/C18H14ClNO3S/c19-14-5-4-8-18(13-14)24(21,22)20-15-9-11-17(12-10-15)23-16-6-2-1-3-7-16/h1-13,20H | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036525
(CHEMBL3353569)Show SMILES FC(F)(F)c1cnc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c(Cl)c1 Show InChI InChI=1S/C19H14ClF3N2O2S/c20-17-11-15(19(21,22)23)12-24-18(17)25(13-14-7-3-1-4-8-14)28(26,27)16-9-5-2-6-10-16/h1-12H,13H2 | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50203171
(CHEMBL3893240)Show SMILES O=S(=O)(Nc1ccc(Oc2ccccc2)cc1)c1cccc2ccccc12 Show InChI InChI=1S/C22H17NO3S/c24-27(25,22-12-6-8-17-7-4-5-11-21(17)22)23-18-13-15-20(16-14-18)26-19-9-2-1-3-10-19/h1-16,23H | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Medical and Dental University
Curated by ChEMBL
| Assay Description
Antagonist activity at progesterone receptor in human T47D cells incubated for 24 hrs in presence of P4 by alkaline phosphatase assay |
ACS Med Chem Lett 7: 1028-1033 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00184
BindingDB Entry DOI: 10.7270/Q22Z17HW |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036565
(CHEMBL3353579)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C19H14Cl2N2O4S/c20-15-10-17(21)18(22-11-15)23(12-13-4-2-1-3-5-13)28(26,27)16-8-6-14(7-9-16)19(24)25/h1-11H,12H2,(H,24,25) | PDB
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| n/a | n/a | 201 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036560
(CHEMBL3353583)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1F)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O4S/c21-17-10-15(20(22,23)24)11-25-18(17)26(12-13-4-2-1-3-5-13)31(29,30)16-8-6-14(7-9-16)19(27)28/h1-11H,12H2,(H,27,28) | PDB
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| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036567
(CHEMBL3353577)Show SMILES OCCNC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H19ClF3N3O4S/c23-19-12-17(22(24,25)26)13-28-20(19)29(14-15-4-2-1-3-5-15)34(32,33)18-8-6-16(7-9-18)21(31)27-10-11-30/h1-9,12-13,30H,10-11,14H2,(H,27,31) | PDB
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| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
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