BindingDB logo
myBDB logout

34 molecules are shown

Wt: 290.3
BDBM50446069Purchase		Wt: 304.3
BDBM50446070Purchase		Wt: 318.4
BDBM50446072Purchase		Wt: 292.3
BDBM50446076Purchase
<<  First   |  Previous   |  Displayed 31 to 34 (of 34 total )

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50446069,50446070,50446072,50446076   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
P2X purinoceptor 4


(Homo sapiens (Human))		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.41E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Mus musculus)		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2X4 receptor assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP ad...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Homo sapiens (Human))		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.38E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Homo sapiens (Human))		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.14E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.08E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.98E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 3


(Homo sapiens (Human))		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.98E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 3


(Homo sapiens (Human))		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.98E+3n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 3


(Homo sapiens (Human))		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.80E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 3


(Homo sapiens (Human))		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.42E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 2


(Homo sapiens (Human))		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 2


(Homo sapiens (Human))		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 2


(Homo sapiens (Human))		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 2


(Homo sapiens (Human))		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 1


(Homo sapiens (Human))		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.88E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 1


(Homo sapiens (Human))		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.07E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 1


(Homo sapiens (Human))		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.96E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 1


(Homo sapiens (Human))		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.52E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X1 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(RAT)		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6.93E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at rat P2X4 receptor assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins followed by ATP addition by Fl...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(RAT)		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.58E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at rat P2X4 receptor assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins followed by ATP addition by Fl...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(RAT)		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.09E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at rat P2X4 receptor assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins followed by ATP addition by Fl...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(RAT)		BDBM50446076
PNG
(CHEMBL1483754)
Show SMILES CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc12 |c:15|
Show InChI InChI=1S/C19H20N2O/c1-3-20(4-2)19(22)21-17-11-7-5-9-15(17)13-14-16-10-6-8-12-18(16)21/h5-14H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.30E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at rat P2X4 receptor assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins followed by ATP addition by Fl...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Mus musculus)		BDBM50446069
PNG
(CHEMBL3103372)
Show SMILES O=C(N1CCCC1)N1c2ccccc2C=Cc2ccccc12 |c:16|
Show InChI InChI=1S/C19H18N2O/c22-19(20-13-5-6-14-20)21-17-9-3-1-7-15(17)11-12-16-8-2-4-10-18(16)21/h1-4,7-12H,5-6,13-14H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.23E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2X4 receptor assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP ad...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Mus musculus)		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.02E+5n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2X4 receptor assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP ad...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Mus musculus)		BDBM50446072
PNG
(CHEMBL3103369)
Show SMILES O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:18|
Show InChI InChI=1S/C21H22N2O/c24-21(22-18-10-2-1-3-11-18)23-19-12-6-4-8-16(19)14-15-17-9-5-7-13-20(17)23/h4-9,12-15,18H,1-3,10-11H2,(H,22,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.84E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2X4 receptor assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP ad...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair
P2X purinoceptor 4


(Homo sapiens (Human))		BDBM50446070
PNG
(CHEMBL3103371)
Show SMILES O=C(N1CCCCC1)N1c2ccccc2C=Cc2ccccc12 |c:17|
Show InChI InChI=1S/C20H20N2O/c23-20(21-14-6-1-7-15-21)22-18-10-4-2-8-16(18)12-13-17-9-3-5-11-19(17)22/h2-5,8-13H,1,6-7,14-15H2
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.37E+4n/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...

Bioorg Med Chem 22: 1077-88 (2014)


Article DOI: 10.1016/j.bmc.2013.12.035
BindingDB Entry DOI: 10.7270/Q21R6S09
More data for this
Ligand-Target Pair