Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 126.0 BDBM50011181Purchase

Wt: 122.9 BDBM50027536Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 41 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 7 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	5.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA7 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards human membrane associated carbonic anhydrase IV				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA IV				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA4 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 13 (Mus musculus (mouse))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of mouse recombinant CA13 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.29E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA12 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 6 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.81E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA6 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA9 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity owards recombinant human transmembrane carbonic anhydrase IX				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA IX				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 14 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	3.60E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA14 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 5B, mitochondrial (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.18E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA5B by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA II				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA2 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards human cytosolic carbonic anhydrase II				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.41E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of cloned human CA1 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	4.17E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA5A by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.17E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Université Montpellier II Curated by ChEMBL					Assay Description Binding affinity towards recombinant human mitochondrial carbonic anhydrase V				Bioorg Med Chem Lett 15: 1683-6 (2005) Article DOI: 10.1016/j.bmcl.2005.01.049 BindingDB Entry DOI: 10.7270/Q2NC60PJ
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Varicella-zoster virus (strain Dumas) (HHV-3) (Hum...)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	<280	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of Varicella-Zoster virus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 ...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase M184V mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation ...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase p66/p51 polymerase using PPT57 DNA/Cy5-labeled PPT24 as template/primer preincubated for 10 mins followed by...				Bioorg Med Chem 26: 1713-1726 (2018) Article DOI: 10.1016/j.bmc.2018.02.017 BindingDB Entry DOI: 10.7270/Q270842C
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Life Science Research Center Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 reverse transcriptase				J Med Chem 40: 2363-73 (1997) Article DOI: 10.1021/jm9607921 BindingDB Entry DOI: 10.7270/Q2TB161T
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity ass...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human cytomegalovirus (HCMV strain AD169) )	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of HCMV DNA polymerase by scintillation proximity assay				Bioorg Med Chem Lett 17: 3349-53 (2007) Article DOI: 10.1016/j.bmcl.2007.03.102 BindingDB Entry DOI: 10.7270/Q2HX1DHN
					More data for this Ligand-Target Pair
DNA polymerase catalytic subunit (Human cytomegalovirus (HCMV strain AD169) )	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase K65R mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation p...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA/DNAM duplex primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV1 RT mediated DNA-dependent DNA synthesis initiation using RNA PPT primed substrate by scintillation proximity assay				J Biol Chem 282: 8005-10 (2007) Article DOI: 10.1074/jbc.m608274200 BindingDB Entry DOI: 10.7270/Q2PG1VH3
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of wild type HIV1 reverse transcriptase E89T mutant assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation p...				J Med Chem 57: 7435-49 (2014) Article DOI: 10.1021/jm501010f BindingDB Entry DOI: 10.7270/Q20R9R32
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Life Science Research Center Curated by ChEMBL					Assay Description Inhibitory effect of the compound on Molony Murine Leukemia virus (mo-MuLv) Recombiannt Reverse transcriptase				J Med Chem 40: 2363-73 (1997) Article DOI: 10.1021/jm9607921 BindingDB Entry DOI: 10.7270/Q2TB161T
					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
DNA polymerase delta catalytic subunit (Homo sapiens (Human))	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
Pharmacia Corporation Curated by ChEMBL					Assay Description Inhibition of human delta DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...				J Med Chem 48: 5794-804 (2005) Article DOI: 10.1021/jm050162b BindingDB Entry DOI: 10.7270/Q2G44R39
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Química Médica (C.S.I.C.) Curated by ChEMBL					Assay Description Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand				J Med Chem 47: 3418-26 (2004) Article DOI: 10.1021/jm031045o BindingDB Entry DOI: 10.7270/Q2B857KW
					More data for this Ligand-Target Pair				3D Structure (crystal)
DNA polymerase catalytic subunit (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay				J Med Chem 26: 264-70 (1983) BindingDB Entry DOI: 10.7270/Q2RN36VT
					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in presence of Mg2+ ions by band shift assay				J Biol Chem 282: 3337-46 (2007) Article DOI: 10.1074/jbc.m607710200 BindingDB Entry DOI: 10.7270/Q2T43WW0
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50011181 ((PFA)dihydroxyphosphinecarboxylic acid oxide | CHE...) Show SMILES OC(=O)P(O)(O)=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.39E+4	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in absence of Mg2+ ions by band shift assay				J Biol Chem 282: 3337-46 (2007) Article DOI: 10.1074/jbc.m607710200 BindingDB Entry DOI: 10.7270/Q2T43WW0
					More data for this Ligand-Target Pair