Compile Data Set for Download or QSAR

Found 71 hits Enz. Inhib. hit(s) with Target = 'Small conductance calcium-activated potassium channel protein 2'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50356161 (CHEMBL1909931) Show SMILES CC(C)c1cccc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)c3)c12 Show InChI InChI=1S/C34H38N2/c1-23(2)29-14-8-12-27-16-18-35(5)31(33(27)29)21-25-10-7-11-26(20-25)22-32-34-28(17-19-36(32)6)13-9-15-30(34)24(3)4/h7-20,23-24H,21-22H2,1-6H3/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50356159 (CHEMBL1909929) Show SMILES CC(C)c1cccc2cc[n+](C)c(CCCCc3[n+](C)ccc4cccc(C(C)C)c34)c12 Show InChI InChI=1S/C30H38N2/c1-21(2)25-13-9-11-23-17-19-31(5)27(29(23)25)15-7-8-16-28-30-24(18-20-32(28)6)12-10-14-26(30)22(3)4/h9-14,17-22H,7-8,15-16H2,1-6H3/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	194	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50356162 (CHEMBL1909932) Show SMILES CC(C)c1cccc2cc[n+](C)c(Cc3ccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)cc3)c12 Show InChI InChI=1S/C34H38N2/c1-23(2)29-11-7-9-27-17-19-35(5)31(33(27)29)21-25-13-15-26(16-14-25)22-32-34-28(18-20-36(32)6)10-8-12-30(34)24(3)4/h7-20,23-24H,21-22H2,1-6H3/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	397	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50356158 (CHEMBL1909928) Show SMILES CC(C)c1cccc2cc[n+](C)c(CCCc3[n+](C)ccc4cccc(C(C)C)c34)c12 Show InChI InChI=1S/C29H36N2/c1-20(2)24-12-7-10-22-16-18-30(5)26(28(22)24)14-9-15-27-29-23(17-19-31(27)6)11-8-13-25(29)21(3)4/h7-8,10-13,16-21H,9,14-15H2,1-6H3/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	593	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50356160 (CHEMBL1909930) Show SMILES CC(C)c1cccc2cc[n+](C)c(CCCCCc3[n+](C)ccc4cccc(C(C)C)c34)c12 Show InChI InChI=1S/C31H40N2/c1-22(2)26-14-10-12-24-18-20-32(5)28(30(24)26)16-8-7-9-17-29-31-25(19-21-33(29)6)13-11-15-27(31)23(3)4/h10-15,18-23H,7-9,16-17H2,1-6H3/q+2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	878	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50263327 (CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...) Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1 Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50263327 (CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...) Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1 Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084848 (BIs-cyclo(4N-pentyl-1-(4-methylbenzyl)-4-quinolini...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(Cc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C43H48N4/c1-2-4-6-12-28-45-41-26-30-47(43-16-10-8-14-39(41)43)33-37-23-19-35(20-24-37)31-34-17-21-36(22-18-34)32-46-29-25-40(44-27-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-26,29-30,44-45H,1-6,11-12,27-28,31-33H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50289333 (21,35-diazonia-2,13-diazaoctacyclo[33.6.2.214,21.1...) Show SMILES C1c2cc3Cn4cc[c+](NCCCCCCCCCCN[c+]5ccn(Cc6ccc(c1c6)-c2cc3)c1ccccc51)c1ccccc41 Show InChI InChI=1S/C43H46N4/c1-2-4-6-12-24-45-41-22-26-47(43-16-10-8-14-39(41)43)31-33-18-20-37-35(28-33)29-34-27-32(17-19-36(34)37)30-46-25-21-40(44-23-11-5-3-1)38-13-7-9-15-42(38)46/h7-10,13-22,25-28,44-45H,1-6,11-12,23-24,29-31H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084852 (1,14-diazonia-22,33-diazaheptacyclo[32.6.2.214,21....) Show SMILES C1CCCCCN[c+]2ccn(Cc3cccc(c3)-c3cccc(Cn4cc[c+](NCCCC1)c1ccccc41)c3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-26-44-40-24-28-46(42-22-10-8-20-38(40)42)32-34-16-14-18-36(30-34)35-17-13-15-33(29-35)31-45-27-23-39(43-25-11-5-3-1)37-19-7-9-21-41(37)45/h7-10,13-24,27-30,43-44H,1-6,11-12,25-26,31-32H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084849 (Bis-quinolinium cyclophane analogue | CHEMBL258254...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)\C=C/c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 |c:19| Show InChI InChI=1S/C44H48N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-28,31-32,45-46H,1-6,11-12,29-30,33-34H2/q+2/b18-17-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084839 (Bis-quinolinium cyclophane analogue | CHEMBL6266 |...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(cc3)-c3ccc(Cn4cc[c+](NCCCC1)c1ccccc41)cc3)c1ccccc21 Show InChI InChI=1S/C42H46N4/c1-2-4-6-12-28-44-40-26-30-46(42-16-10-8-14-38(40)42)32-34-19-23-36(24-20-34)35-21-17-33(18-22-35)31-45-29-25-39(43-27-11-5-3-1)37-13-7-9-15-41(37)45/h7-10,13-26,29-30,43-44H,1-6,11-12,27-28,31-32H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084851 (Bis-quinolinium cyclophane analogue | CHEMBL266885...) Show SMILES C1CCCCCN[c+]2ccn(Cc3ccc(CCc4ccc(Cn5cc[c+](NCCCC1)c1ccccc51)cc4)cc3)c1ccccc21 Show InChI InChI=1S/C44H50N4/c1-2-4-6-12-30-46-42-28-32-48(44-16-10-8-14-40(42)44)34-38-25-21-36(22-26-38)18-17-35-19-23-37(24-20-35)33-47-31-27-41(45-29-11-5-3-1)39-13-7-9-15-43(39)47/h7-10,13-16,19-28,31-32,45-46H,1-6,11-12,17-18,29-30,33-34H2/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054105 ((Z)-1.1'-[stilbene-4,4'-diylbis(methylene)]bis(4-a...) Show SMILES [NH2+]=c1ccn(Cc2ccc(\C=C/c3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C34H28N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-22,35-36H,23-24H2/p+2/b10-9-,35-31?,36-32?	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054098 (1,1'-[biphenyl-3,3'-diylbis(methylene)]-bis(4-amin...) Show SMILES [NH2+]=c1ccn(Cc2cccc(c2)-c2cccc(Cn3ccc(=[NH2+])c4ccccc34)c2)c2ccccc12 Show InChI InChI=1S/C32H26N4/c33-29-15-17-35(31-13-3-1-11-27(29)31)21-23-7-5-9-25(19-23)26-10-6-8-24(20-26)22-36-18-16-30(34)28-12-2-4-14-32(28)36/h1-20,33-34H,21-22H2/p+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50084846 (1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluoreny...) Show SMILES [NH2+]=c1ccn(Cc2ccc-3c(Cc4cc(Cn5ccc(=[NH2+])c6ccccc56)ccc-34)c2)c2ccccc12 Show InChI InChI=1S/C33H26N4/c34-30-13-15-36(32-7-3-1-5-28(30)32)20-22-9-11-26-24(17-22)19-25-18-23(10-12-27(25)26)21-37-16-14-31(35)29-6-2-4-8-33(29)37/h1-18,34-35H,19-21H2/p+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054103 (1,1'-[biphenyl-4,4'-diylbis(methylene)]-bis(4-amin...) Show SMILES [NH2+]=c1ccn(Cc2ccc(cc2)-c2ccc(Cn3ccc(=[NH2+])c4ccccc34)cc2)c2ccccc12 Show InChI InChI=1S/C32H26N4/c33-29-17-19-35(31-7-3-1-5-27(29)31)21-23-9-13-25(14-10-23)26-15-11-24(12-16-26)22-36-20-18-30(34)28-6-2-4-8-32(28)36/h1-20,33-34H,21-22H2/p+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054095 (1-{4-[4-(4-amino-1-quinoliniumylmethyl)phenethyl]b...) Show SMILES [NH2+]=c1ccn(Cc2ccc(CCc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C34H30N4/c35-31-19-21-37(33-7-3-1-5-29(31)33)23-27-15-11-25(12-16-27)9-10-26-13-17-28(18-14-26)24-38-22-20-32(36)30-6-2-4-8-34(30)38/h1-8,11-22,35-36H,9-10,23-24H2/p+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50054096 (1-{4-[4-(4-amino-1-quinoliniumylmethyl)benzyl]benz...) Show SMILES [NH2+]=c1ccn(Cc2ccc(Cc3ccc(Cn4ccc(=[NH2+])c5ccccc45)cc3)cc2)c2ccccc12 Show InChI InChI=1S/C33H28N4/c34-30-17-19-36(32-7-3-1-5-28(30)32)22-26-13-9-24(10-14-26)21-25-11-15-27(16-12-25)23-37-20-18-31(35)29-6-2-4-8-33(29)37/h1-20,34-35H,21-23H2/p+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50275960 (5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...) Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1 Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5694-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.026 BindingDB Entry DOI: 10.7270/Q2TM79Z6
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50264020 (CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...) Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	543	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells				Bioorg Med Chem Lett 18: 5316-9 (2008) Article DOI: 10.1016/j.bmcl.2008.08.023 BindingDB Entry DOI: 10.7270/Q2N87BP1
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50048412 (4N-[10-(1-benzyl-4-quinoliniumylamino)decyl]-1-ben...) Show SMILES C(CCCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12)CCCC\[NH+]=c1/ccn(Cc2ccccc2)c2ccccc12 Show InChI InChI=1S/C42H46N4/c1(3-5-17-29-43-39-27-31-45(33-35-19-9-7-10-20-35)41-25-15-13-23-37(39)41)2-4-6-18-30-44-40-28-32-46(34-36-21-11-8-12-22-36)42-26-16-14-24-38(40)42/h7-16,19-28,31-32H,1-6,17-18,29-30,33-34H2/p+2/b43-39+,44-40+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cult...				Bioorg Med Chem Lett 7: 7-10 (1997) Article DOI: 10.1016/S0960-894X(96)00568-9 BindingDB Entry DOI: 10.7270/Q22B8Z1R
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50275792 (CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...) Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1 Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assay				Bioorg Med Chem Lett 18: 5694-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.026 BindingDB Entry DOI: 10.7270/Q2TM79Z6
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50356161 (CHEMBL1909931) Show SMILES CC(C)c1cccc2cc[n+](C)c(Cc3cccc(Cc4[n+](C)ccc5cccc(C(C)C)c45)c3)c12 Show InChI InChI=1S/C34H38N2/c1-23(2)29-14-8-12-27-16-18-35(5)31(33(27)29)21-25-10-7-11-26(20-25)22-32-34-28(17-19-36(32)6)13-9-15-30(34)24(3)4/h7-20,23-24H,21-22H2,1-6H3/q+2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Inhibition of cloned rat SK2 channel expressed in human HEK293 cells by patch clamp assay in the presence of 1 uM intracellular Ca2+				Bioorg Med Chem Lett 21: 6756-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.043 BindingDB Entry DOI: 10.7270/Q2R211S7
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50377863 (AG-525 | CHEMBL257156) Show SMILES COc1cc2CCN(C)[C@@H](CCC[C@@H]3N(C)CCc4cc(OC)c(OC)cc34)c2cc1OC |r| Show InChI InChI=1S/C27H38N2O4/c1-28-12-10-18-14-24(30-3)26(32-5)16-20(18)22(28)8-7-9-23-21-17-27(33-6)25(31-4)15-19(21)11-13-29(23)2/h14-17,22-23H,7-13H2,1-6H3/t22-,23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Li£ge Curated by ChEMBL					Assay Description Inhibition of SK2 expressed in CHO FlipIn cells by whole cell patch-clamp assay				Bioorg Med Chem Lett 18: 3440-5 (2008) Article DOI: 10.1016/j.bmcl.2008.03.069 BindingDB Entry DOI: 10.7270/Q2N29XTJ
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50507839 (PF-6305591 | Pf-06305591) Show SMILES C[C@H]([C@H](N)c1nc2ccc(cc2[nH]1)C(C)(C)C)C(N)=O Show InChI InChI=1S/C15H22N4O/c1-8(13(17)20)12(16)14-18-10-6-5-9(15(2,3)4)7-11(10)19-14/h5-8,12H,16H2,1-4H3,(H2,17,20)(H,18,19)/t8-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of SK2 (unknown origin)				Bioorg Med Chem 27: 230-239 (2019) Article DOI: 10.1016/j.bmc.2018.12.002 BindingDB Entry DOI: 10.7270/Q2ZK5KZN
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Homo sapiens (Human))	BDBM50275090 ((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...) Show SMILES Clc1cc2CCCC(Nc3nc4ccccc4[nH]3)c2cc1Cl Show InChI InChI=1S/C17H15Cl2N3/c18-12-8-10-4-3-7-14(11(10)9-13(12)19)20-17-21-15-5-1-2-6-16(15)22-17/h1-2,5-6,8-9,14H,3-4,7H2,(H2,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a
NeuroSearch A/S Curated by ChEMBL					Assay Description Inhibition of human SK2 channel by inside-out patch clamp technique				J Med Chem 51: 7625-34 (2009) Article DOI: 10.1021/jm800809f BindingDB Entry DOI: 10.7270/Q28S4QT0
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM168436 (US9675591, SKA-19) Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1 Show InChI InChI=1S/C8H5F3N2S2/c9-8(10,11)15-4-1-2-5-6(3-4)14-7(12)13-5/h1-3H,(H2,12,13)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	7.35	25
The Regents of the University of California US Patent					Assay Description All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...				US Patent US9675591 (2017) BindingDB Entry DOI: 10.7270/Q26T0JSP
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50561183 (CHEMBL4787693) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0240	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00300 BindingDB Entry DOI: 10.7270/Q24B351Z
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50561184 (CHEMBL4762592) Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)CNC1=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00300 BindingDB Entry DOI: 10.7270/Q24B351Z
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50561185 (CHEMBL4749661) Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O)[C@@H](C)O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.0270	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant rat SK2 expressed in HEK293 cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ...				Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00300 BindingDB Entry DOI: 10.7270/Q24B351Z
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583231 (CHEMBL5094656) Show SMILES Cc1cc(C)n(n1)-c1cc(C)c(Nc2ccc(F)c(Cl)c2)nn1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.32E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583213 (CHEMBL5086997) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cc(Cl)ccc2F)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583211 (CHEMBL5078247) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(F)c(Cl)c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells assessed as increase in calcium response at -90 mV holding potential measured at 1 to 2 days by...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583196 (CHEMBL5084004) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](O)CC2)n1 |r,wD:14.14,17.18,(12.25,-10.26,;10.72,-10.43,;9.95,-11.76,;8.44,-11.44,;7.3,-12.48,;8.28,-9.91,;9.69,-9.28,;6.94,-9.15,;5.61,-9.92,;4.27,-9.15,;2.94,-9.92,;4.28,-7.61,;5.6,-6.84,;5.6,-5.3,;6.93,-4.52,;6.93,-2.98,;8.26,-2.21,;9.59,-2.97,;10.92,-2.2,;9.6,-4.51,;8.27,-5.29,;6.94,-7.6,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583197 (CHEMBL5079951) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](N)CC2)n1 |r,wD:14.14,17.18,(30.83,-10.14,;29.3,-10.3,;28.53,-11.64,;27.02,-11.32,;25.88,-12.35,;26.86,-9.79,;28.27,-9.16,;25.53,-9.03,;24.19,-9.8,;22.85,-9.03,;21.52,-9.8,;22.86,-7.48,;24.18,-6.71,;24.18,-5.17,;25.51,-4.4,;25.51,-2.86,;26.84,-2.08,;28.17,-2.85,;29.51,-2.08,;28.18,-4.39,;26.85,-5.16,;25.52,-7.48,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583198 (CHEMBL5090455) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](CO)CC2)n1 |r,wD:14.14,17.18,(49.78,-10.62,;48.25,-10.79,;47.48,-12.12,;45.97,-11.8,;44.83,-12.83,;45.81,-10.27,;47.21,-9.64,;44.47,-9.51,;43.13,-10.28,;41.8,-9.51,;40.47,-10.28,;41.8,-7.96,;43.13,-7.19,;43.13,-5.65,;44.46,-4.88,;44.45,-3.34,;45.78,-2.57,;47.12,-3.33,;48.45,-2.56,;49.79,-3.32,;47.13,-4.87,;45.79,-5.65,;44.47,-7.96,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583199 (CHEMBL5074647) Show SMILES CO[C@@H]1CC[C@@H](CC1)Nc1cc(C)nc(n1)-n1nc(C)cc1C |r,wD:5.8,2.1,(69.87,-2.91,;68.53,-2.15,;67.2,-2.92,;67.21,-4.46,;65.88,-5.23,;64.54,-4.47,;64.54,-2.93,;65.87,-2.15,;63.21,-5.24,;63.21,-6.78,;61.88,-7.55,;61.88,-9.1,;60.55,-9.87,;63.22,-9.87,;64.55,-9.1,;64.55,-7.55,;65.89,-9.86,;67.3,-9.23,;68.33,-10.37,;69.86,-10.21,;67.56,-11.71,;66.05,-11.39,;64.91,-12.42,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.97E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583200 (CHEMBL5093708) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H]2CC[C@H](F)CC2)n1 |r,wD:14.14,17.18,(87.17,-10.49,;85.64,-10.65,;84.87,-11.99,;83.37,-11.67,;82.22,-12.7,;83.2,-10.14,;84.61,-9.51,;81.87,-9.38,;80.53,-10.15,;79.2,-9.38,;77.86,-10.15,;79.2,-7.83,;80.53,-7.06,;80.52,-5.52,;81.85,-4.75,;81.85,-3.21,;83.18,-2.43,;84.52,-3.2,;85.85,-2.43,;84.52,-4.74,;83.19,-5.51,;81.86,-7.83,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583201 (CHEMBL5080805) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@H]2CC[C@H](CC2)[N+]([O-])=O)n1 |r,wD:14.14,17.21,(13.14,-30.4,;11.61,-30.56,;10.84,-31.9,;9.33,-31.58,;8.19,-32.61,;9.17,-30.05,;10.57,-29.42,;7.83,-29.29,;6.49,-30.06,;5.16,-29.29,;3.83,-30.06,;5.16,-27.74,;6.49,-26.97,;6.49,-25.43,;7.82,-24.66,;9.15,-25.42,;10.48,-24.65,;10.48,-23.11,;9.14,-22.34,;7.81,-23.12,;11.81,-22.34,;13.15,-23.1,;11.81,-20.79,;7.83,-27.74,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50275157 (CHEMBL453730 | N-cyclohexyl-2-(3,5-dimethyl-1H-pyr...) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(NC2CCCCC2)n1 Show InChI InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.48E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583202 (CHEMBL5083279) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(NCCc2ccc(cc2)[N+]([O-])=O)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583203 (CHEMBL5081876) Show SMILES COc1cc2nc(Nc3cc(C)nc(n3)-n3nc(C)cc3C)[nH]c2cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583204 (CHEMBL5075501) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(cc2)C#N)C(O)=O)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583205 (CHEMBL5069418) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(O)cc2)C(O)=O)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583206 (CHEMBL5079218) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(N[C@@H](Cc2ccc(F)c(F)c2)C(O)=O)n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583207 (CHEMBL5088689) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(S)cc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583208 (CHEMBL5089976) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(Nc2ccc(cc2)[N+]([O-])=O)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2 (Rattus norvegicus (Rat))	BDBM50583209 (CHEMBL5082158) Show SMILES Cc1cc(C)n(n1)-c1nc(C)cc(Nc2cccc(F)c2F)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.03E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of rat KCa2.2a expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01473 BindingDB Entry DOI: 10.7270/Q28919R5
					More data for this Ligand-Target Pair

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